DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service National Institutes of Health Division of Research Resources Biomedical Research Technology Program Annual Progress Report PART I, TITLE PAGE 1. PHS AWARD NUMBER: | s/U/4/a]/r{r{ofifeis}|s5 |~fo 13 2. TITLE OF AWARD BIONET NATIONAL COMPUTER RESOURCE FOR MOLECULAR BIOLOGY 3. NAME OF RECIPIENT INSTITUTION: IntelliGenetics, Inc. 4. HEALTH PROFESSIONAL SCHOOL (If applicable): 5. REPORTING PERIOD: 5a. FROM (Month, Day, Year): | O} 3} ~| Of 1] —j 8 [6 5b. TO (Month, Day, Year): | of 2] ~} 2] sf—{[8f7 6. PRINCIPAL INVESTIGATOR: 6a. NAME: Dr. Michael J. Kelly 6b. TITLE: President, IntelliGenetics éc. sicwature: “YYUp Lf & WEE NO —L / v 7. DATE SIGNED (Month, Day, Yearly, $2 -]2- £6 8. TELEPHONE (Include Area Code): 2 5 U41 RRO1685-03 Part Il. Description of Program Activities This section of our Annual Report provides statistical information on the use of the BIONET'™ Resource. The period covered is 12/85 - 11/86, to coincide with the dates of preparation of our Report and to follow our procedure of providing a full year’s statistical information to compare with previous years’ Reports. Individual sections are prepared under guidelines discussed previously with BRTP staff and used in our previous Reports. We use a format for reporting the hundreds of individual Principal Investigators’ use that is easy for us to generate while retaining the critical information necessary for BRTP in its internal and governmental reporting requirements. Complete research abstracts are kept at IntelliGenetics and are available upon request. The BIONET User community is divided into different classes, representing different levels of use of the computer system and staff resources, as follows: e Class I. Class I users represent the Service component of the scientific community. They participate in the electronic communications facilities of BIONET (bulletin boards and electronic mail), and use the Core and Contributed Software libraries to pursue their research; e Class II. Class II users represent the Collaborative component of the user community. Scientists in Class II enjoy all benefits of Class I use, and in addition contribute software and expertise to BIONET, working closely with BIONET staff. This category also includes bulletin board leaders, accounts by courtesy with other, related Resources (GenBank, NBRF/PIR, Dana Farber, etc.), National Advisory Committee members and accounts for communication with BIONET Satellites. e Class III. The category of Class II access has been reserved for system managers of local computer facilities. Such persons might not qualify as Principal Investigators, but are willing to work closely with other researchers of BIONET at a local site to help them learn to use the system and telecommunications effectively. They share Class II privileges. e Class IV. Class IV users consist of those scientists who wish access only to the electronic communication facilities of BIONET. They are given access to the electronic mail and bulletin board facilities. Information on number of PI’s by Class is summarized in Table II-1. The total number of investigators with access to BIONET, 489, is about 40 less than the total presented in our last annual report. During the past year about 170 investigators chose not to renew their accounts primarily because of their anticipated lack of need for access to BIONET and the imposition of the subscription fee. During the year we have added about 130 new investigators to the Resource. We expect that the trend of bringing substantial numbers of new users on to the system will continue. Attrition in the future will not, however, be as heavy because all new users come to BIONET with full knowledge of 3 5 U41 RRO1685-03 Table H-1: Summary of the BIONET User Community Class I 444 Class II 37 Class III 4 Ciass IV 4 Total 480 the subscription fee. Rather, we expect that the growing use of locally-available sequence analysis software, provided through the BIONET Satellite program or PI’s purchase of microcomputer software, will diminish the load per PI on BIONET, enabling us to support a larger number of users. I.A. Scientific Subprojects II.A.1. Collaborative Research and Service In the following section we report the use of the BIONET Resource for Class I-IV users. The "Usage Factor" is reported as both central processor unit (cpu) time, in minutes and connect time in hours, for each Principal Investigator. These values are the sum of all usage by the PI and his or her group members ("Sub-I’s"). We report data only on those PI groups that have used the Resource during the past 12 months. Of the 489 PI’s, 418, representing about 1463 individual investigators, have accessed BIONET. Detailed statistics on the use by each individual are maintained by the BIONET computer and are available to interested parties. We do not report Resource staff hours nor BRTP funds allocated for individual PI’s because it is impossible to allocate these rationally to such a large user community. Summary information on allocation of staff hours is given in Section ILC, the Resource Summary Table. 5 5 U41 RRO1685-03 II.A.2. Core Research and Development We report on the standard form the summary information for our Core Research projects. The Resource Technology used is the DEC-2060 computer for all projects. The Usage Factor is reported as minutes of cpu time used for the project. This number is derived for each investigator by multiplying the fractional time ("FT") spent on the project times the total cpu time used during the past twelve months. Resource Staff Hours are based on the same FT multiplied times the total hours spent on BIONET for the last twelve months. "BRTP Funds Allocated" are calculated as followed, from the sum of the following components: ¢ Actual Personnel Costs. The personnel costs for each project are derived by multiplying the above FT for each BIONET staff person’s time spent on the project times their respective annual salary plus fringe benefits; the actual personnel cost is the sum of these individual figures. e Consultant Costs. The FT spent by a Co-Investigator involved in a project is multiplied times the total consulting cost for the Co-I; these are summed for each project where appropriate. e Fraction of Awarded Funds. The fraction of total awarded funds for each project is derived by multiplying the fractional time spent on the project by the awarded funds (defined below). The fractional time is determined from the sum of hours spent on the project by all investigators divided by the sum of hours spent on BIONET by all investigators. In computation of awarded funds, we include the grant categories of Supplies, Travel, and Other Expenses. The categories of Personnel and Consultants are accounted for in the previous two computations. For this calculation we have used the actual time spent in the last twelve months and a cost basis of the estimated total expenditures in the above categories for this grant year. Although these are three months out of phase, we do not think the fractional time spent will change significantly during the next three months of the current grant period. “TF o8ed ‘suopjonnsyr seg = *peen sepfoToupaL somosay simoH eaTD /G *pesn sepfojoupaL somosey at ISI; at COLUMBIA; at SUMEX; , , and all at SIMTEL-20, at DEC Marlboro etc. We will support access to these compilations of programs by publishing bulletins and procedures for accessing these computers via file transfer protocols. We will also maintain lists of programs available at each of these sites. With the advent of these resources directly available on ARPANET we will probably stop local maintenance of the and directories.