Table of Contents Part I. Title Page Part II. Description of Program Activities ILA. Scientific Subprojects Il.A.1. Collaborative Research and Service I].A.2. Core Research and Development IL.A.3. Training II.B. Books, Papers, Abstracts I1.C. Resource Summary Table Part OI. Narrative Description Tii.A. Summary of Research Progress TIL.A.1. Service II].A.1.a. Scientific Consulting: Class I, I and IV Support II.A.1.b. Service IJ.A.1.c. Scientific Case Studies Using BIONET II.A.1.d. Comments from the Community Ii.A.1.e. PC/BIONET Communications - Distribution of the Resource I.A.1.f. System Help Utilities Il.A.2. Collaborative Research HT.A.2.a. DEC-2060 Software Contributors IlI.A.2.b. PC-Based Software IlJ.A.2.c. Liaison with Other Resources Ill.A.2.d. Bulletin Boards I.A.3. Core Research II].A.3.a. Multiple Sequence Alignment Ill.A.3.b. BIONET Satellite Program II.A.3.c. Hardware Text Searching Machines II].A.4. BIONET Training Program IlI.A.5. Resource Facilities Il.A.5.a. Computer and Telecommunication Networks HI.A.5.b. Summary Statistics on Machine Use III.A.5.c. Computer Software - Core Library IIl.A.5.d. Computer Software - System Library HII.A.5.e. Computer Software - Contributed Library IIl.A.5.f. Database Library IH.B. Highlights IlI.C. Administrative Changes III.D. Resource Advisory Committee and Allocation of Resources III.E. Dissemination of Information of Resource’s Capabilities Il].E.1. Community Interactions and Awareness IH.E.2. Electronic Communications Il.E.2.a. Bulletin Boards III.F. Suggestions and Comments I. BIONET RESOURCES REAPPLICATION IJ. ON-LINE HELP MENUS Il. XMULTAN ALIGNMENT IV. PROGRAMS CONTAINED ON THE IBM AND MAC DIRECTORIES V. DISPLAY BY THOMPSON’S MOLECULE PROGRAM 5 U41 RRO1685-03 BK Orarow oN - 23 aaonaan ana fk hk kh wD WWW WWW wh Wwe SHODDARDRODSOOM ANAL EEODOHXOERS N 2 OOO He On fk © il 5 U41 RRO1685-03 VI. MAILER FOR BIONET TRAINING SESSIONS 72 VII. TRAINING SCHEDULES 73 VUI. BIONET APPLICATION 82 IX. ADVERTISMENT FOR BIONET TRAINING SESSION 91 X. RENEWAL NEWSLETTER 92 XI. BULLETIN BOARD LEADER AD 100 Figure II-1: Figure II-2: Figure IL-3: Figure II-4: Figure III-5: Figure III-6: Figure II-7: Figure III-8: Figure III-9: iii List of Figures Pieslice Allocations of the DEC-2060 Computer Actual use of the DEC-2060 for the Month of October, 1986 BIONET’s Percentage Use of the DEC-2060, 12/85 - 11/86 BIONET’s Prime Time Use of the DEC-2060 12/85 - 11/86 BIONET’s Non-Prime Time Use of the DEC-2060, 12/85 - 11/86 BIONET’s Total Use of the DEC-2060, 12/85 - 11/86 Total Telenet and UNINET Network Use, 12/85-11/86 Size and Release Dates of the NIH GenBank Database Size and Release Dates of the EMBL DNA Sequence Database Figure III-10: Size and Release Dates of the PIR Protein Database 5 U41 RRO1685-03 38 39 40 43 45 47 48 52 53 54 iv 5 U41 RRO1685-03 List of Tables Table -1: Summary of the BIONET User Community 3 Table III-1: Summary of Monthly Rates of Inquiries 15 Table III-2: Summary of Monthly Rates of Questions for Programs and Databases. 16 Table II-3: BIONET Prime Time CPU Minutes 42 Table II-4: BIONET Prime Time Connect Hours 42 Table II-5: BIONET Non-Prime Time CPU Minutes 44 Table 01-6: BIONET Non-Prime Time Connect Hours 44 Table II-7: BIONET Total CPU Minutes 46 Table DI-8: BIONET Total Connect Hours 46