THE INSTITUTE FOR CANCER RESEARCH tT7O1 BURHOLME AVENUE FOX CHASE- PHILADELPHIA, PENNSYLVANIA 10111 (215) G42-1000-CABLE ADDRESS: CANSEARCH ALFRED G. KNUDSON, JR.. M.D., PH. D. DIRECTOR 215-728-2490 March 31, 1980 Dr. Joshua Lederberg Rockefeller University 1230 York Avenue New York, New York 10021 Dear Josh: I write with a plea for advice. We are faced with some newly proposed guidelines for support grants from NCI. As you probably know we have always viewed that such grants could be abused and have therefore geared them solely for the support of peer reviewed investigators and their resources. We perceive that the magnitude of the change in our support that would result from the new guidelines would be disastrous. I have sent the enclosed letter to Bill Terry. I do not know whether there are other steps that should be taken and would greatly appreciate any comments you might have. If you think it would be useful to discuss the matter directly I would be pleased to meet with you at the Rockefeller. I plan to be in New York Lo City April 8-10 for other reasons, including a visit to Sloan-Kettering. Best regards. Sincerely yours, Deo a0 — Nin ica At Alfred G. Knudson, Jr. Sf Aik Sune . Director Rand fone Ie the wy Ty d “e ee ful iin beitcitiow AGK: jd Ss Enclosure oA Nyaminet ow tre fener i Lal loaner THE POX CHASE CANCER CENTER oF ined cs by Tas“ Hffyo run Jee.