UNIVERSITY OF CAMBRIDGE

TELEPHONE 2708 DEPARTMENT OF ZOOLOGY DOWNING STREET
CAMBRIDGE

17th July, 1953.

Dr. Joshua Lederberg,
Department of Genetics,
College of Agriculture,
University of Wisconsin,
Madison 6,

Wisconsin, U.S.A.

Dear Dr. Lederberg,
Thank you very much for your letter of June 30th.

Your suggestion of trying to re-"plate" rough
cells is certainly worth attempting. I vaguely recall
trying something of this sort some years ago, but not having
my notes here I am uncertain as to just what kinds of
experiments I performed. All that I know is that it was
with pneumococci. The 5S. typhi system sounds very interesting
and I shall certainly look into it when I have the opportunity.

I agree that a new terminology might te useful. In
the paper on fertilization and immunity I proposed, perhaps
not too seriously, the terms alleloplasts and alleloplastology.
that Sterling Emerson suggested. One might make some sort of
concerted effort to introduce a new terminology, but I wonder
if it is worth the effort. Immunologists have, as you know,
been broadening their outlook considerably, particularly in
recent years, and I believe that in time, more or less
automatically, either the old terminolovy will be accepted
as applicable or a new general designation will evolve for
the systems of mutually complementary interacting substances
with which we are concerned,

Sincerely yours,

Albert Tyler.