SERVIC pe SERVICES - S¢ DEPARTMENT OF HEALTH & HUMAN SERVICES Public Health Service HEALTH io ty, * na National institutes of Health ue National institute of Allergy and Infectious Diseases Bethesda, Maryland 20892 July 6, 1999 Joshua Lederberg, Ph.D. Sackler Foundation Scholar Rockefeller University 1230 York Avenue New York, NY 10021-6399 Dear Joshua: Thank you for agreeing to participate in the July 26-27 meeting of NIAID’s Strategic Plan Task Force. The purpose of the meeting is to identify research priorities and plan the Institute’s activities over the next 3 to 5 years. The NIAID believes that outside advice is critical for setting informed research priorities, and we routinely call upon the research community, professional organizations, academic associations, industry, patient advocacy groups, and other public representatives to provide advice and contribute to the development and oversight of its research activities. Two primary motivations drive the development of an NIAID strategic plan. The first motivation is the accelerating pace of discovery in the biomedical sciences. In particular, NIAID’s investment in basic research creates countless opportunities for remarkable advances in medicine—opportunities that compete with each other for limited resources. The second motivation stems from the 1998 Institute of Medicine Report, Scientific Opportunities and Public Health Needs: Improving Priority Setting at the National Institutes of Health, which recommended that the NIH Director receive a strategic plan from each Institute and Center (IC). To address this recommendation, Dr. Varmus asked each IC to develop, with public input, a 2-5 year strategic plan. The primary audiences for the plans are members of Congress and the public. After considerable discussion among Institute staff, we have developed a framework for the strategic plan to convey concisely our broad-based research priorities. In a subsequent mailing, we will provide a detailed outline of the strategic plan, organized around four broad areas that constitute the NIAID research portfolio—immune-mediated diseases, AIDS, emerging infectious diseases, and vaccines. We will ask you to review the outline, and provide suggestions on how we can best delineate a strategy to respond to scientific opportunities and public health needs. To assist you in the review, we will also provide background information and other materials used in shaping the outline. Page 2 - Joshua Lederberg, Ph.D. The meeting will be held at the Holiday Inn in Bethesda, Maryland, beginning at 5:30 PM on Monday, July 26 and ending at 3:30 PM on Tuesday, July 27. NIAID’s contractor, IQ Solutions, will be in touch with you to provide further information on meeting logistics. The NIAID will reimburse your travel expenses and provide an honorarium. If you have any questions about the meeting, please do not hesitate to contact Dr. La Montagne or me. | look forward to meeting with you on July 26. Best personal regards. Sincerely, ka Anthony Sf Fauci, M.D. Director National Institute of Allergy and Infectious Diseases