:f 4/P/328.001119
Chiang Mai -- Dengue conference 11/19/00

Cardinal Rules of parasite behavior

-0o Go Forth  - disseminate

&
o Multiply - be the fittest per Malthus

o {Secure lodgment in host -- Fight off local defenses }
establish reservoir for dissemination is all that is material

pace host interactions --> symptoms (DISEASE)
:inflammation, cough, diarrhea
zhost behavior
seven malignancy *
! odds are these are contrived by the parasite to
maximize its inclusive fitness

BUT
o Don’t kill the host, at least not too often, too soon

o Fight off competing genotypes
defend the host -- OR -- synergize with other parasites.
dampen superinfection (concomitant immunity)

[o] Fuse with the host: become another gene!
* malignancy (EBV; HPV) a puzzle. May confer a tribal

advantage, if not to the oncogenic particle.
?? "unintended consequence"