.nf
.na
.ps 18
.vs 20
.ft B

.ce
Specific syndromes of aging

\(bu Cardiovascular disease
	cholesterol deposits

\(bu Alzheimer's
	amyloid deposits

\(bu Cancer
	cumulative mutation
	attrition of defense mechanisms

\(bu Cataract and other diabetic pathology
	glucose adducts to proteins

\(bu Menopause
	after atresia in fetus, 400-500 ova at birth
	depleted month by month

\(bu Autoimmune disease
	cumulative break-through of autotolerance

\(bu Emboli, strokes, aneurysms
	cumulative mechanical obstructions or tears
	
\(bu Attrition of immune systems
	???

.bp
.nf
.na
.ps 18
.vs 20
.ft B
.ce 

Systemic Gerobiology

\(bu Cellular senescence

	?? relevance to body aging

	telomere shortening
	protein crosslinks and oxidation
	DNA damage
		8-oxoguanine

\(bu Builtin (evolution-selected) limits to life span?

	Programmed senescence
	Just what is selected in human evolution?


.ps 20
.vs 26

.ce 2
Homo sapiens
is already an uncommonly long-lived species
.ex
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