THE UNIVERSITY OF TENNESSEE

CENTER FOR THE HEALTH SCIENCES
MEMPHIS, TENNESSEE 38163

DEPARTMENT OF BIOCHEMISTRY November 6, 1974

PHONE 528-6150

Dr. Joshua Lederberg

Department of Genetics

Stanford University School of Medicine
Stanford, California 94305

Dear Doctor Lederberg:

This preliminary note is enclosed with two reprints on the arginase
deficient children. A more detailed letter will be forthcoming, but I
wanted to get the two articles in the mail. I don't have a brochure for
the meeting itself so I have included a Memorandum from the Program Com-
mittee Chairperson. The message on the Memorandum is not relevant, but
the letterhead gives information on name, dates etc for the meeting.

The comment by Krebs (see page 251 in article entitled Argininaemia)
on tissue distribution of arginase is a point in favor of the experiment
which I had not appreciated. My recent visit to Germany confirmed my
initial impression that the attempted treatment was a soundly conceived plan
which was formulated and executed by a competent group of scientists. Follow-
ing our telephone conversation I reconfirmed the informed consent with Stan
Rogers. Both verbally and on paper, the parents were thoroughly informed
and gave their consent.

This proposed symposium is an attempt to document the attempted
treatment from the point of view of science and history. Your advice will
be eagerly awaited, but I think that this attempted treatment could be the
basis of the right program in front of the right audience at the right time.
Dr. Columbo as the expert on urea cycle defects, Dr. Terheggen as the pedia-
trician and Dr. Rogers as the Shope virus expert would be the proposed back-
bone of the program. We both know Stan's work and Terheggen and Columbo are
both very solid. Any suggestion would be most welcome, but my proposal would
include an additional speaker to discuss the ethical and scientific issues
of such an experimental approach. The half-day session might end with a
round table discussion focused on the possibility of discovering another
family with the same defect.

je Joryon3s ° 3S yo3O>

Sincerely yours,

eG C

wlb/dm titiam E Forme Ph.D.
Professor and Chairman and
Encl: Reprints Director, Brain Research Institute

Memorandum