Ta SGD. Fibo ROOD REG IV D dane ay l?, 1954
“adison, disconsin
Januury 15, 1958
Dr, Josesh Lein
tristol Laboratories Ins,
Syracuse, New Tork

Dear Joos

Thank you for your note of the 3rd, for the antiblotic samples, and for ths
transoript, all of which arrived satisfactorily, ‘e have hed ome prol‘minory
look both at the kanauyoin and the novobicoin effect om E. galt and so far
find no norvholegieal psquliarity in the courso of the aation of either drug,
but wa will have to look again,

My incidental expenses for the last trip came to only $15, since the hot1
bill and the aajor part of the air fare were already taken care of, If you
would prefer to wait until I send you anothor acqouni for the dictating
machine and supslies there for, that would be all right with me.

fan sorry if the dictating ia giving you any trouble, I am trying to Look
into that, but the losal service agent is rather hard to get hold of, I
sometines use the department machine and I will have to make sure that both
are in good order,

From the blurb in the Drug Trade News you might think that tye and Goertl
are onto the idea of using colominic aeid as an anglogue, Sut I think you
Will notice that thoy are still thinking in terns of * synthesising a new
compound" which is a little different fron the proposal at hand, T heave
gotten hold of what should be a good producing culture of £234 and will esond
this right away. You wtit have to look out for colonial variation in this
culture, m understanding being thet it is the nost opaque variance yhich
produsge the largest amount of the colominie acid, However, it would est to
test this inherently, eapecially since thare is a fairly straight forward
shanieal test for the material,

I suspose that anything that you want to do with these tranacriptions would
be all right with me, but frankly I have a little hesitation about then
getting too far avay fror: psracnal conversations, Of course, you will went
to consult with Bernie regarding any suggestions that come up, but for

my own part, I would rathor that you suggested them yourself and then tought
Bernie inte them, rather than sending eripts dircetly to him, I think
in ths long run, this would be most advantageous to yourself, sinee there
might be sone pogsivility of the two of us becoming a little bit contertious
if we go inte detail directly with one another even through the asdiun of
transcription, Furtharnore, I think we would be doing you a poor service

by ralieving you of the task of thinking ebout the proposals that we each
have to anke, So I don't think I have any right to objset to what other
procedure you would like to follow, but for the good of the whole enterprise
I would rather recommend that you digest our conversation and consult Sernie
on those particular points that you think you would like more advige upon,

T would ba vary happy to react reciprocally, I think, too, that the vary
informality of these conversations vould be best conservsd b- keeping then
more or lesa entre=new although, of course, I realize that thay are elreulated
anon; the reat of your staff. is a matter of fact, I think you would be well
advised to adit those remarks to the extent of resoving tho mare peraonal
references bofore they are cireulated, 1 will tr; te organise then in auch a
fern oa to snke this saslest,
Lederberg Transoription
J, Lein 2 1/15/58

I do hope I made the point strongly enough about my suggested application
ef ascorbic acid, There are any nunber of products on the market now
which include ascorbic acid as som sort of cold pill, It ia difficult
to see any rational juatifleation for aseorbie acid in auch a dosage
form, I have in mind the possibility of ineluding ascorbic aaid in

a gough drop or life saver sort of thing where there would bo sone
possibility of a topical antibacterial and antiviral effect,

I inagine this may arrive at Syracuse while you are still away in
Japan, so I will hops you have had the most interesting of trips,

Sincerely yours,

Joshus Lederberg
JLtac