EVANSTON HOSPITAL NORTHWESTERN UNIVERSITY 2650 RIDGE AVENUE Evanston, ILLINOIS 60201 DEPARTMENT OF Immunocuemistey ReskaRcn September 28, 1967 Professor Joshua Lederberg Department of Genetics Stanford University Medical Sehool Palo Alto, Caltfornia 94304 Dear Professor Lederberg: I have learned that you have recently complained about the impure state of vaceines. I fully agree with your statement and enclose coptes of some of our work with influenza virus vaccine. Bestdes of being an extremely impure product, the efficiency of this vaccine has not been established beyond doubt. Although the U.S. Publte Health Service confirmed my findings (Influenza Survetllance Report No. 73: Influenza vaccine and ABO tnecompatibtility. Communicable Disease Center. U. S. Dept. of Health, Education and Welfare, > Public Health Service. IV, pp. 12-14, 1962), they harassed me a great deal. * ’ Furthermore, I was forced to publish most of the eltnically important aspects ors petal : ! of our work abroad. ure I enclose coptes of our work in this area and would not only apprectate your comnents but would also be grateful to learn about your endeavors in this dtrectton. . Very sincerely yours, Georg F. Springer, M.D. Professor of Microbiology Director, Department of Immunochemistry Research GFS/guw Enclosures WIDM Yds