THE ROCKEFELLER INSTITUTE FOR MEDICAL RESEARCH

66TH STREET AND YORK AVENUE
NEW YORK @21,N.Y.

THE JOURNAL OF EXPERIMENTAL MEDICINE April 1, 1958.

Dear Doctor Nethans:

The editors of the Journal of Experimental Medicine will be gled
to publish the paper by you end your associates if some minor changes
deemed by us essential meet your approval.

The title should be concrete not diffuse, if only for the reason
that it should tell readers of bibliographies what the paper is / precisely
about. Hence we believe that the title of your paper should read
something like this, "The Formation of Myeloma Protein by the Cells
of a Mouse Myeloma."

In your first paregreph you stute, that it has not been established
whether the myeloma protein in plasma is produced by the tumor cells
themselves or is a response of other tissues to the effect of the tumor.
Your experiments prove with beautiful clerity thet the tumor cells then
selves produce = great deal of it, but they do not answer the question
whether some may not come from elsewhere. In our view you would do
well to recognize this possibility in your Discussion. The first page
of your manuscript and also page 9 are here enclosed for any change you
may care to make.

Here and there you use what have been well called wsgon-train
phrases, linking on words to the extent of your need. "Plesma myeloma
protein pool size" is a good example, and "plesma protein specific
ectivities" is another. These are on pages 6 and 7. We are changing
them so that they will read, "the pool size of the plasma myeloma
protein" and "specific activity of the plssms protein" respectively.

Cen you state more in the finsl sentence of your Discussion then
this, "The results indicate that the plasma cell tumor is en important
site of synthesis of the myeloms. protein"? We leave it to you.

With very real congratulations on the work,

Sincerely yours,
Peyton Rous, M.D.,

Co-editor of the Journal
of Experimental Medicine

P.S. When e paper is put together with clips its pages have to be separated
for ease in editing. The clips are ell very well though for charts and
their legends.

Dr. Deniel Nathans
Presbyterian Hospitel
622 West 168th Street
New York 32, N. Y.