Reprinted from, the MEDICAL BRIEF, July, 1887. Four Cases of Craniotomy. A Contribution to the Surgery of the Skull and Meninges, ■With some Remarks on the Antiseptic Treatment of .Ve.iiis. Prof. A. C. BERNAYS, ST. LOUIS, MO. With the Compliments of THE Myron E. Meyer Mfg. So., Of Milwaukee, Wis., By the kind permission of the Author. Smith & Owens Printing Co., 318 N. Third Street, St. Louis, Mo. Reprinted from the Medical Brief, July, 1887. A CONTRIBUTION TO THE SURGERY OF THE SKULL AND MENINGES. Four Cases of Craniotomy with Chisel and Saw, in Old Cases of Depressed Fracture of the Skull. With Some Remarks on the Antiseptic Method of the Treatment of Wounds. confuse him in conversation. About seven weeks after the accident, he was constantly troubled with double vision. Strabismus internus of the left eye was developed, and was very troublesome at first, but slowly seemed to get better BY AUGUSTUS C. BERNAYS, A. M.; M. D., Heidelberg; M R. C. S., England; P. R. M. 8., London; Member German Society Sur- geons of Berlin; Prof, of Anatomy St. Louis College Physicians and Surgeons; Con- sulting Surgeon St. Louis City Hos- pital and Female Hospital. The objective examination which I conducted, with the assistance of the oculist, Dr. Chas. Barck, demon- strated the following condition on the day of his reception at the hospital; Strabismus internus paralyticus; memory still deficient; complains of a heavy feeling of pressure in his head, and finds it difficult to think. There is a depression over the left temporal bone, extending upwards to the anterior inferior angle of the pa- rietal bone, which is so deep that the index finger could be easily buried in it. Case I.—Mr. E. 8., fifty-nine years of age, came to St. Louis on the 12th day of July, 1884, and was received as a patient in my private hospital. Four months previously he fell from an ice-wagon and struck his head against the tire of the wheel. He was taken home and remained unconscious eight days. There was no external wound. After recovering conscious- ness, it was observed that his memory was much impaired, regarding all oc- currences of his previous life, for sev- eral weeks. This loss of memory was only transient; he gradually regained his mental power, with the exception of the names and appellations of dif- ferent objects, which still bother and I determined to cut down and ele- vate the depressed bone, and, accord- ingly, on the 13th day of July, with the assistance of Drs. D. V. Dean, L. Bremer, O’Reilly, C. Barck, and oth- ers, proceeded to perform the opera- tion. (See Figs. 1 and 2.) 4 CRANIOTOMY raising the depressed bone nearly to its normal position. During the en- tire operation, the field was kept con- stantly irrigated with a solution of boric acid, four per cent. I stitched the flap, which consisted of skin and periosteum, into its place by fourteen fine silk sutures. Four catgut strings were left between the edges in such a manner that they could be drawn out in case there would be any suppura- tion under the flap. The wound was dressed with antiseptic gauze covered with rubber tissue. The wound united completely by first intention, there being no secre- tion of any kind, in six days. There was no elevation ol pulse or of tem- perature. Patient declared that he felt “ lighter,” had lost the feeling of pressure in his head immediately after the operation. Fig. i.—The depression just above the ear, as found in Case i. The left side of the head was shaved, and thoroughly cleansed with five per cent carbolic acid solution. I made an angular incision, lifting the flap in the manner shown in Fig. 2. He was dismissed on the 24th day of July, the strabismus having de- cidedly decreased. The symptom of double vision is not cured, but the double objects are seen closer to- gether than before the operation. The depression in the skull is very slight. On the 30th day of August, patient came to the city again, and we found him much improved, feeling free from the pressure in his head, memory nearly normal, and speaking without difficulty. Strabismus and double vision almost disappeared. Fig. 2 —ln the L shaped groove which has been made by the chisel, is seen the elevator in position for lifting the depressed portions. Case ll.—Mr. E, Z., from Belle- ville, 111., was injured while at work in a coal mine. He struck his head, the right frontal bone from near the glabella to the juncture with the pari- etal bone, lacerating the scalp and scraping the periosteum from the bone. The outer table was probably not fractured, but the inner table was cracked, as we afterwards found at the operation. After this accident he was a constant sufferer from a most dis- The anterior margin of the fractured bone was found completely depressed under the posterior portion, and the fracture was firmly united by com- pletely ossified callus. By means of small dental chisels, I carefully cut out about one-fourth of an inch of the callus and margin of the fracture the entire length of the depression, and by means of an elevator succeeded in BERNAYS 5 tressing pressure in his head,was con- stantly in fear of becoming insane, and was totally unable to do work of any kind. He had no symptoms of paralysis, but a glance at his face clearly proved that he was suffering some distressing agony. He had the peculiar, restless, wild and weird ex- pression of-the countenance which so frequently accompanies certain forms of mental disease. upon the head, exposed the right half of the frontal bone almost in its en- tire extent. There was a black discol- oration of the periosteum and the bone at this place, which was so in- tense that it made a very peculiar im- pression at first sight. This black pig- mentation permeated the bone even into the diploe, and was found also in the soft parts up to the skin, which was of a bluish tint. I have several times, when performing surgical ope- rations on aged coalminers, noticed that whatever part of the system be- comes the seat of disease, particularly of an injury the repair of which is associated with the formation of scar tissue or connective tissue thickening, will be found of a deep black color when the epidermis is removed. It is no rare thing to find the spleen, the lymphatic glands and the lungs of a solid black at post mortems of vete- ran coalminers. The latter condition is called pneumonokoniosis anthra- cotica by pathologists. In my case I can account for the black pigmenta- tion on the supposition that the so- called “wander cells,” which every- where permeate the intercellular spaces of connective tissue, carry par- ticles of pigment, which become sta- tionary when the cells themselves assume a permanent function as spin- dle-shaped or round elements of scar tissue. With a chisel I worked a ditch through the outer table and diploe, of the size and shape which seemed requisite to cover the seat of the in- jury. After this was done, I found a soft place—a defect in the inner table —at a point near the superior median margin of the ditch, and by introduc- ing the end of the elevator, between the dura mater and the inner table, I was enabled to lift the entire piece of bone from the dura mater, the vitre- ous table being very fragile. The lower surface of this rhomboid piece Fig. 3.—The pigmentation of the periosteum is seen on the turned down flap, as well as the size and shape of the defect produced by the operation. About a year after the accident, in September last (1886), the patient came to the Pius Hospital for the purpose of submitting to the opera- tion of craniotomy. I told him that the operation would be explorative, and that I could promise him nothing but that the surgical procedure would not in any way injure him. In the presence of the senior class of the College of Physicians and Sur- geons, and with the assistance of Drs. A. H. Ohmann-Dumesnil and J. B. Clancies, I made a semicircular in- cision around the scar on the patient’s forehead, and turning the flap, which, as in the former case, included the periosteum and all soft parts, back 6 CRANIOTOMY of bone, corresponding to small gran- ulations upon the dura mater, was roughened. I scraped these from the dura with a curette, leaving this mem- brane uninjured. The wound was treated exactly as in Case I. It healed by first intention. The result in this case was not as satisfactory as could be desired, and I do not think now, about eight months after the opera- tion, that the patient was benefited much beyond being slightly relieved of his headache and sleeplessness. Case lll.—George Kohler, aged sixteen, received a compound fracture of the temporal and parietal bones, by the teeth of a cogwheel, while at work in a nail-mill in Belleville, 111. The wound was dressed and attended to in the usual manner by some of the bestphysicians in thatcity. Soon after the accident, the boy, a good steady worker and a favorite with his em- ployers, was seized with maniacal at- tacks, and by very frequent and severe attacks of screaming epilepsy. These attacks were sometimes as many as twenty per day, and he was some- times delirious, or in a state of frenzy, for several days and nights at a time, during which he became almost un- manageable,very violent, and refusing to take food or medicine. Fig. 4.—The flap is turned down covering the ear, and the fistula is seen perforating the flap. The two trephine holes as they were left after the first operation lie just above the small fracture disclosed by the second. The dotted line shows the extent to which I enlarged the opening in the skull before incising the dura mater. tal in November, 1886, and, on exam- ination of the case, I found a fistulous opening remaining, which led down to roughened and diseased bone. There were two linear scars over the trephine openings, a slight swelling of the soft parts in the temporal re- gion, and in that of the external ear. The epileptic accesses which I had occasion to observe were severe, throwing the boy into violent convul- sions. He complained of a constant severe headache, and was troubled with painful cramps in his hands and feet almost every two or three hours. His general health was beginning to be impaired; he became paler and weaker day by day. Before attempt- ing to give relief by a surgical opera- tion, I called in the well-known neu- rologists, Drs. Wm. B. Hazard and Ludwig Bremer, to see the case, and kept the boy under careful supervision for about ten days. The two experts, independently of one another, came to the conclusion that a further and more thorough exploration of the in- jury should be made ; both said that they could see no other hope of curing the case. They also recommended During this condition the boy was trephined, two buttons being re- moved, These buttons were small, not much larger than a silver dime. The operation was performed by Dr. Per- ryman, of Belleville, I am told. The operation of trephining was undoubt- edly justified and indicated by the symptoms. After this operation a slight improvement seems to have taken place for a few hours, but the patient soon relapsed into his former condition, the epileptic seizures being very violent and frequent. He was brought to the Pius Hospi- BERNAYS 7 opening of the dura mater, in case no cause for the trouble could be found in the more external parts, and both thought that there might be a blood- clot or a brain-abscess, which might only be gotten at by opening the dura mater and searching for it. from the dura mater. This being done, the dura was seen to bulge out con- siderably through the opening in the bone, and the bulging portion gave a clear sensation of fluctuation to the fingers. I next made an incision about an inch long through the dura. This was followed by a phenomenon which 1 have never seen before, and which was most alarming. The flow of cerebro-spinal fluid was so copious that for fully ten minutes the entire field of the operation was flooded with this clear liquid. The flow was uncon- trollable by sponges. The brain was seen to be normal; the pia mater not opaque, thickened or hypersemic. After perhaps ten ounces of the cere- bro-spinal liquid had escaped, the brain receded into the cavity, and ac- tually appeared much too small to fill out the skull. The clear liquid still oozed out, and I succeeded in stopping it only after a very careful suture of the dura mater with seven sutures of the finest catgut. Fig. 5.—The flap is replaced and fixed by sutures. Four catgut drains are drawn under the flap and twisted together after they were conducted to the outside through the fistula. I proceeded to perform this opera- tion on November 14th, in the pres- ence of the senior class of the College of Physicians and Surgeons, with the assistance of Drs. Graves and Oster- tog. The incision.was made along the temporal line, beginning near the mastoid process and extending en- tirely around the temporal muscle, and was over six inches long. The periosteum and all the soft parts were pushed down, exposing the planum temporale, which was the seat of the injury. The holes left by the two but- tons which had been removed were now readily seen, and were partially filled up with granulation tissue; the bridge of bone separating the two had been partially removed. Just below these there was a depressed and frac- tured piece of bone, which had been overlooked at the former operation. I chiseled this away, and also enlarged the trephine holes with the chisel, and scraped away the granulations At this time, the patient being deeply chloroformed, his pulse was 120—regular, but weak ; respiration 24. I used a 1-2000 bichloride of mer- cury solution, with which I flooded the whole wound for fully ten minutes after the opening in the dura was su- tured, and while I closed the flap wound. I drained it through the lit- tle fistulous tract, which was thor- oughly curetted, in the manner shown in Fig. 5, by means of four thick strings of catgut. The -wound was dressed with bi- chloride gauze covered with rubber tissue, the whole held in place by a ten-yard gauze bandage. The object of the rubber tissue, which was care- fully adapted and covered the moist gauze on all sides, was to keep out the air, prevent drying of the dressings, and thus insure drainage along the catgut strings into the moist gauze. 8 CRANIOTOMY The external gauze bandage, of course, soon became dry, thus making a very secure and comfortable dressing for the head. This kind of dressing should be employed in all scalp wounds, especially if there is a suspi- cion of an injury to the bones of the skull. can not walk without assistance, nor can he use his upper extremities even sufficiently well to put on a shirt. His right side seems to me slightly more affected than his left. The injury to his scalp healed up well, and a fracture of the skull was not clearly made out at the time of the accident. There is a slight de- pression at the seat of the injury, un- der the scar. Mr. Prescott was de- sirous of having me operate on him, hoping that at the operation we might find a local lesion, which could per- haps be,remedied. This boy made a splendid recovery from the severe surgical operation. There was absolute union by first in- tention. His cramps in the hands and feet were relieved ; his headache much improved ; but, unfortunately, his epilepsy continued at intervals of a few days for several months. On Sunday, June 7th, 1887, I last heard from the boy, and his mother reports that he has been at work for three months without having an at- tack of epilepsy at all. She thinks he is improving in many ways. The fact is undeniable that at the present time the boy is better than at any time since he was injured; but I dare not offer an explanation or try to ac- count for the cure, as this would be mere guesswork, considering the very complicated factors in the case. Case IV.—Mr. Prescott, a highly educated gentleman, teacher of tel- egraphy, fell down a high flight of stairs, while going to his room on a dark night, striking his head on the left side, near the vertex. He was in good health up to that time, some- times a little jovially disposed, fifty years ol age, single, and gives a good family history. Since this fall, symp- toms of progressive muscular atrophy are developing in him in a marked manner. The muscles affected are chiefly the pectoral muscles, the ex- tensors of the hand and fingers, and the interossei, also the extensors of the leg and of the toes, as well as some other muscles of his lower ex- tremities in a less marked degree. He Fig. 6.—The size and location, as well as the shape of the defect in Case IV, are seen above the deflected flap. On Sunday, May 15th, 1887, with the assistance of Dr. Dalton, the superin- tendent, and the staff of the City Hos- pital, and of my private assistant, Dr. W. V. Kingsbury, I removed a portion of bone about an inch and a-quarter square from the skull, at the seat of the injury. The incision of the soft parts •was made as in the former case, but in this instance I used a circular saw, mounted in a dental engine, for the purpose of making the incisions in the bone. This instrument works ad- mirably, and I have used it for tre- phining in cases where there was no traumatism as a cause of brain dis- ease, in several instances, with good BERN AYS 9 effect.* The instrument can not be used to finish the removal of the piece of skull, but after sawing through the diploe the fine chisels must be used to finish the division of the bone down to the dura mater. We found some few little granulations on the dura mater, over the ascending parietal convolution, which are said by Hors- ley, Ferrier and others to represent the pectoral and shoulder muscles and the muscles of the thumb in the mo- tor sphere of the cortex. These were scraped off, the wound closed as in the previous cases, after the sharp edges of the bone were smoothed. We had the pleasure also in this case of seeing an instance of perfect union by first intention, with the formation of only a linear scar. There is scarcely any change perceptible in the mobil- ity of the patient’s limbs, although he himself fancies a slight improvement. Only five weeks have passed since the operation, and it is too early to judge of the effect of the operation. view, the question of the influence of the “Antiseptic Method” very natu- rally comes up. During the past ten years I have been practicing surgery with the especial intention of testing and comparing, in my practice in chosen cases, the results to be ob- tained by following conscientiously two different methods. In one set of cases I employed as a dressing and as a wash during the operation only wa- ter and such substances as had been thoroughly cleansed by the use of hoi water, the instruments being cleansed by means of steaming hot water, and my hands also being purified by wa- ter only, such as can be drawn from any hydrant in this city. The other set of cases were operated upon with perfect antiseptic precautions, the in- struments, sponges and dressings, as well as my hands, being thoroughly cleansed before the operation in the carbolic acid or the bichloride solu- tions. The operating room was also subjected to the strictest kind of anti- septic processes of purification, using the most approved methods and the most powerful disinfectants. While studying in Europe, from 1872 to 1878, I had ample opportunities of learning the antiseptic methods in their minu- test details, and I often employed the original Lister dressing, having been taught its application in Heidelberg by Mr. Lister himself, who visited the surgical wards of my teacher, Prof. Simon, during the spring term of 1875. The experiments of Pasteur, and, in fact, all that was known about putre- faction and the spreading of disease by means of germs, were studied and practically demonstrated by me in such a thorough manner that I may say I had the qualifications which are necessary to properly conduct the practical series of experiments indi- cated above. The four* cases above briefly re- lated are instances of what the old surgeons called capital operations. These operations were considered to be very dangerous, and, indeed, from the statistics and mortality tables of trephining in civil cases in European hospitals, it is found to be quite for- midable. In a list of sixty cases of trephining, on account of epilepsy, done between 1858 and 1868, I find- that ten died from the- effects of the operation, either pyaemia, phlegmon- ous inflammation or erysipelas being given as the causes of death. In commenting upon the result of my own cases from a surgical point of * Besides the four cases here related, I have per- formed craniotomy four more times in cases of ob- scure cerebral diseases not due to traumatism. In all of these the operation was successful, the wound healing up in every instance. In one ease, only, death followed within a month, and was due to the original cerebral disease. 10 CRANIOTOMY Without entering into details, I will state the conclusions to which I have arrived: These tablets* are so arranged that by dissolving them in a given quantity of water they make a solution of a cer- tain strength. For general use, 1-4000 is the proper strength, and large quantities of this should be prepared before beginning the operation. Three basinsful, each containing a gallon or more,will usually suffice. The sponges should be immersed in one, the in- struments and silk or catgut in an- other, the third being kept for use during the dressing after the operation has been finished. It is a good plan to keep the whole wound constantly irrigated with the bichloride solution during the operation, the object being to let the fluid penetrate into all the recesses of the wound and fill up the spaces between the muscles and the sheaths of the tendons, etc. After the flaps have been united by sutures and a drainage tube introduced in a proper manner, the stump should again be thoroughly washed with the bichlo- ride, No matter what may be the method of treating the hemorrhage during the operation, let the whole stump or wound, before and. after the bleeding has been controlled, be con- stantly irrigated with the bichloride solution. This irrigation is best ac- complished by letting the solution constantly flow out of a fountain syr- inge (irrigator), or by constantly squeezing it out of sponges into the wound. 1. By the use of the antiseptic method an open wound can he made to resemble a subcutaneous one, in several respects; especially can it be made to behave like a subcutaneous wound during the process of repair. 2. The advantage of the use of anti- septics in surgery is in exact proportion to our ability to make wounds subcuta- neous, or like unto subcutaneous lesions, by this means. 3. The results of different operators with the antiseptic method will depend on the greater or less ability and inge- nuity, ivhich each surgeon can bring to bear, towards fulfilling the desideratum expressed in the previous propositions. 4. The use of antiseptics in the prac- tice of surgery is not an essential ele- ment of success, since success can be achieved without their use. 5. The use of antiseptics in the treat- ment of surgical cases, by general prac- titioners of medicine, is to be commend- ed, since there is greater danger of infectioyi of a woilnd by the general practitioner than by a person devoting himself exclusively to a specialty. The following simple directions, if followed carefully, will be sufficient as a guide for the application of an antiseptic dressing to any ordinary wound, such as, for instance, an am- putation of the leg. The cheapest and best antiseptic fluid is a solution of bichloride of mercury. This should be used pro- fusely on the limb before the opera- tion, in order to cleanse the skin and hair of all dirt and blood or other ex- traneous material which may be pres- ent. The simplest way to prepare a solution is by using the antiseptic tab- lets which have been prepared by some of the manufacturing chemists. The dressing is begun by applying an eight-fold layer of moist gauze over the wound, so as to entirely cover *Parke, Davis & Co., of Detroit, have prepared some tablets, which, for ready solubility in ordi- nary well or hydrant water, are the best known to me. They are prepared by triturating the bichlo- ride of mercury with citric acid, the object being to make the solutions permanent, so that the bi- chloride will not be precipitated by the salts of lime usually contained in the water BERNAYS 11 it up.* I have dispensed with the use of the protective silk strip, as being useless, and can not recommend it at all. The whole wound, which is cov- ered by the gauze, is now to be care- fully covered by a piece of rubber tissue which has been thoroughly im- mersed in and disinfected by the bi- chloride solution. This rubber may be supplanted by oiled silk or Mac- intosh cloth, but in all cases the es- sential point is that the impermeable tissue be larger than the gauze and overlaps it several inches on all sides. The whole is held in place by band- ages so applied as to hold the rubber tissue down upon the healthy integu- ment all around the parts covered by the gauze. (Fig. 7.) This acts so as After a surgical operation I find my thermometer the most indispensable instrument, and I rely entirely upon it to guide me as to the time when a change of the dressings becomes nec- essary. A rise of temperature above 101$°, in my estimation, is an impera- tive indication to change the dressing, whether the patient complains of pain or not. The pulse is not a reliable guide in this respect, and is only of importance when it rises simultane- ously with the temperature. After the first dressing has been re- moved, an exactly similar one should be reapplied, the wound having been thoroughly irrigated with bichloride solution. The tablets above mentioned will be found most convenient and time-saving for making the necessary solution, especially in private prac- tice. The four cases above described, all of which healed by first intention, without fever or pain, were treated according to the method given, and I feel sure that no better results could have been attained by any other. All of the four patients are living, and those that were not greatly benefited directly by the operation, were at least not injured. From my own ex- perience, I am led to the conclusion that: The operation of explorative craniotomy by means of chisel and saw,with antiseptic precautions, ought to be recognized as a perfectly justifi- able procedure, where a diagnosis can not be made without it, in many cases of obscure brain disease. This opera- tion will most assuredly be the source of saving life, and is certainly not more dangerous than explorative lap- arotomy. Fig. 7.—This shows a simple antiseptic dressing as recommended by the author lor general use. 1: the skin. 2 : the layers of gauze. 3: the rubber tissue. 4 : external bandage. 5 : stitches in the skin. to exclude the air and keep the wound in an aseptic moist chamber, thus se- curing perfect drainage and an equal temperature all the time. The dress- ing may be left untouched for several days ; in fact, I have, upon several occasions, applied plaster of Paris splints over this kind of dressing, in compound fractures, and have waited six days before cutting a fenestrum into the splint. * I take pleasure in recommending to the profes- sion, for this purpose, the gauze prepared by the Myron E. Meyer Manfg. Co., of Milwaukee, Wis. All the antiseptic goods made by this firm are of supe- rior excellence. Their antiseptic gauze is superior to any now on the market, both in the quality of the gauze itself, which is white and absorbent, and because it is put up in sealed cans, so that it is always moist, and the antiseptic qualities of the chemical used are sure to be active in their full strength. 903 Olive Street, St. Louis,