THE SPECIAL THERAPEUTICS OF THE NEW REMEDIES. MATERIA MEDICA AND SPECIAL THERAPEUTICS OF THE NEW REMEDIES. BY EDWIN M. HALE, M.D., LATE PROFESSOR OF MATERIA MEDICA AND THERAPEUTICS OF THE NEW REMEDIES IN HAHNEMANN MEDICAL COLLEGE, CHICAGO; PROFESSOR OF MATERIA MEDICA IN THE CHICAGO HOMOEOPATHIC COLLEGE ; AUTHOR OF “ LECTURES ON DISEASES OF THE HEART,” “CHARACTERISTICS OF NEW REMEDIES,” “DISEASES OF WOMEN,” ETC. FIFTH EDITION—REVISED AND ENLARGED. (thirty-seven new remedies.) IN TWO VOLUMES. VOL. II. SPECIAL THERAPEUTICS, WITH ILLUSTRATIVE CLINICAL CASES. BOERICKE & TAFEL: NEW YORK: 145 GRAND STREET. PHILADELPHIA : 635 ARCH STREET. I 880. Entered according to Act of Congress, in the year 1879, By BOERICKE & TAFEL, In the Office of the Librarian of Congress, at Washington, D. C. SHERMAN & CO., PRINTERS AND STKREOTYPERS, PHILADELPHIA. $0 DR. RICHARD HUGHES, OF ENGLAND, AUTHOR OF THE MANUALS OF PHARMACODYNAMICS AND THERAPEUTICS, &l)is bclume / IS RESPECTFULLY DEDICATED BY THE AUTHOR. . . . “ Touching the open questions of medical opinion and practice—while each of us proclaims the opinions he has espoused, and zealously puts them in practice, let us cultivate the catholic and noble spirit of Chillingworth : ‘ I will take no man’s liberty of judgment from him, nor shall any man take mine from me, and what measure I mete out to others, I expect from them again.’ ”—Car- roll Dunham, Address before the American Institute of Homoeopathy, 1870. “ Some people suppose that a physician, professing belief in the homoeopathic law, is obliged to limit his practice strictly to the application of that law. He is not to administer a purgative, or to give an opiate, or to prescribe Quinine, or to recommend a mineral water, under any circumstances, without in some way incurring the suspicion of sailing under false colors, of having deserted his creed and betrayed his principles. To those who cannot rise above the mere partisan spirit of cliques and schools, this may seem to be a righteous judgment. The man, however, who is loyal only to nature and to truth, regards such re- strictions as sheer, impertinence, and claims everything which cures, be the pro- cess explainable or not, as inalienably his own. He is astonished at the blind- ness and bigotry of the old school, who permit the grandest treasures of the curative art to lie unrecognized before them. He sets them a nobler example. He cultivates assiduously his own special field of science, but if he finds any residuum of truth or usefulness in allopathy, or any other system, he asks no man’s permission to use it; but acknowledging its source, appropriates it by divine right as the legitimate property of every healer of the sick.”—Wm. H. Holcombe, Address before the Hahnemann Medical Society of Cincinnati, 1875. PREFACE TO FIFTH EDITION. That a fifth edition of this volume is called for is good proof that the Homoeopathic School is not satisfied to be confined to the old reme- dies, valuable and indispensable as they are. Of the thirty-seven new medicines added to this volume, eighteen are indigenous to the United States, and three to the islands of the Pacific. That many of them have not been proved is no reason why we should not use them, for the clinical experience is sufficient until we have their pathogeneses. In addition to these following named new drugs I have added copiously to many of the medicines included in the previous edition : Alstonia constricta, Antimonium iodatum, Arseniate of antimony, Arseniate of strychnia, Arum dracontium, Arum arseniosum, Auri et sodii chloridum, Benzoate of lithia, Berberis aquifolium, Brachyglottis repens1, Bromide of ethyl, Bromide of nickel, Bromide of zinc, Calcarea iodata, Eryodycton, Eucalyptus, Euonymin, Fucus vesiculosus, Gentiana quinqueflora, Grind elia robusta, Hydrobromic acid, Iridin, Kumyss, Melilotus, Mercurius iod. cum kali iod., Penthorum sedoides, Phoradendron, Pilocarpus primatus, Piper methysticum, Polymnia uvedalia, Picrate of ammonia, Quebracha, Rhus aromatica, Salicylic acid, Salicylate of soda, Sanguinarina, nitrate of, Thymol, Turnera aphrodisiaca, Weythia helenoides. If the medical profession receive this edition with the same cordiality as the previous ones, I shall feel amply repaid for my labors. EDWIN M. HALE. Chicago, January, 1880. PREFACE TO FOURTH EDITION. This volume contains my own personal experience in the therapeutical use of the New Eemedies, together with the clinical experience of phy- sicians belonging to the homoeopathic and other schools of medicine. With some remedies this experience extends over a period of more than twenty years ; with others a briefer time ; a few of the medicines I have not used. In quoting the clinical experience of others I have tried to give all the authorities as far as attainable. I have not intended to show any preferences, for I believe in tolerating the largest liberty of opinion and practice. When the First Volume Avas in course of preparation, a few of my colleagues suggested that I should pursue the plan adopted in the first two editions, namely : giving the day-books of the provers, and the authority for each symptom. After due consideration and consultation it was decided that such a plan was not necessary or desirable. The scope and purpose of the volume did not require it, for it was not in- tended as a general, but a special Symptomatology. In this volume, in my mention of each remedy, I have generally given its pathogenetic history, names of provers, etc. Moreover, Allen’s Encyclopedia of Materia Medica now finished, renders the citing of every authority altogether superfluous. Those who have any desire to ascertain the paternitj'-, or investigate the original sources of my pathogenetic char- acteristic symptoms, are respectfully referred to the above-mentioned work, wherein they are generally given with much accuracy. The few instances where I have appended the names of physicians to symptoms in Vol. I were inadvertencies ; for it was not my intention to give any authority, except for some peculiar curative symptom, or indication, or for some very recent proving. I trust this explanation will serve as sufficient apology for any apparent omission or neglect in acknowledging my indebtedness to the many authorities from whom I have drawn. In this volume I have tried to explain the Law of Dose, based on the primary and secondary action of drugs, and hp.ve given some illustra- tions which appear to prove its truth. I expect it will meet with that persistent opposition and severe criticism, which greets every discovery or new principle ; but my convictions are strong that Avhen accepted and adopted it will prove of incalculable value in the advancement of our school of practice, and to the Art of Healing. Chicago, July, 1875. EDWIN M. HALE. HOW TO USE THESE VOLUMES. It will be seen by the reader that these volumes complement each other. The student or practitioner should have them both before him, and in the study of any particular medicine or disease, constant refer- ence from the Symptomatology of a remedy to its Special Therapeutics will be necessary. The copious Therapeutical Index to this volume, it is to he hoped, will prove a valuable aid. THERAPEUTICS OF THE N EW REMEDIES. ABIES CANADENSIS. The use of the Hemlock Spruce for dyspepsia is empirical, and originated in domestic practice. A tincture of the buds made by maceration in whiskey is said to have cured the following symp- toms : A light-headed feeling, attended with a gnawing, hungry, faint feeling at the epigastrium, craving hunger, which, if gratified, was followed by distension of the stomach and hard beating of the heart. The condition represented by the above symptoms resembles that observed in catarrh of the stomach. Drs. Gatchell and Beck- with claim to have cured many cases having the above symptoms, with the tincture. A tincture of the gum of the Abies nigra has caused and cured somewhat similar symptoms.—See Allen’s “ En- cyclopedia of Materia Medica,” vol. i. ACALYPHA INDICA. Ainslie, in his “ Materia Medica Indiea,” says the Indian (Ta- mool) name for this plant is Koopamanie, and observes that the Hakeems (native physicians) prescribe it in consumption. Dr. Tonnere, of Calcutta, claims to have cured some pulmonary symp- toms, viz.: yon. it.—2 10 A3SCULUS HIPPO OAST A XUM. Dry cough, followed by spitting of blood. He, as well as Drs. Thomas and Plolcombe, asserts that it will arrest haemoptysis after all other remedies fail. It is indicated in expectoration of pure blood in the morning, and dark lumps of clotted blood in the evening. It cures this kind of hemorrhage, but not when caused by tuberculosis of the lungs. iESOULUS HIPP0CASTANUM. Tliis is a veritable polycrest, having a wide range of action, but, like some other polycrests, it lias a central point of action from which radiate a series of reflex symptoms. This central point of action is the liver and the portal system, and nine out of every ten of its symptoms are due to this action. I have found it analogous in its effects to Aloes, Collinsonia, Nux vomica, Sulphur, and Po- dophyllum. It is not as poisonous as the Buckeye, its indigenous relative, for the nut is used in Europe to fatten animals, and they are often eaten with impunity by children ; the meat of the seeds is sweet when boiled, but the rind is bitter. I think the tincture should be prepared from equal parts of the nut-meat, rind of the nut, and the bark of the tree or its root. In this way we shall be sure to get all its active medicinal principles. In my practice I have been most successful with it in the fol- lowing disorders: Congestion of the liver, when accompanied by piles. It is indicated by the symptoms : aching, pinching pains in the right hypochondrium, aggravated by walking. The pain extends up between the shoulders. Constipation, when there is present a hard, knotty, dry condi- tion of the stools, which are white. (If the stools are black, or dark, or brown, knotty, and hard, I prefer Nux vomica.) Haemorrhoids, if the following symptoms are present, are promptly removed by iEseulus. (It will not prove a successful routine remedy, but must be closely affiiliated.) The tumors are protruding, or internal, are usually purple, hard, and very sore (not raw, as in Aloes, but a bruised feeling), with aching, burning, rarely bleeding. The rectal symptoms are characteristic, and con- sist of very disagreeable sensations of dryness, soreness, constric- JESCULUS HIPPOCASTANUM. 11 tion, fulness, and a feeling as if sticks, splinters, gravel, or other foreign, irritating substances had become lodged in the rectum. We find also a feeling of fulness with protrusion, and a desire to strain (tenesmus). A characteristic condition is usually present, which differentiates between this medicine and other pile remedies, namely, the absence of actual constipation. In nearly every case the stools are too frequent, and soft, sometimes quite loose, pale, or dark, and rarely, if ever, large, dry, or scybalous. In this re- spect it resembles Aloes. I do not agree with Dr. Hughes, when he says, “ when the only connected symptoms or appreciable cause is constipation, iEsculus is indicated;” for I believe its action on the portal system is the primary cause of its heemorrhoidal symp- toms; but I do agree with him in his belief that “when there is much pain, but little bleeding, TEsculus seems pretty likely to cure.” My experience with TEsculus has been verified by the majority of physicians, so that it may claim a high position as a remedy in diseases of the rectum. The pains in the back which attend its rectal symptoms are quite notable. They are sometimes shooting or cutting, but usually consist of a lameness as if strained, extend- ing to the hips or legs, or an aching and weakness aggravated by walking, stooping, or any movement. Like Rhus, its pain and stiffness often goes off after continued motion. Dr. Guernsey advises it for a backache occurring during preg- nancy, when the pain is in the sacro-iliac symphysis, and prevents walking, because “that part of her back gives out, compelling her to sit down.” I have prescribed it with good results in slight cases of fissure of the anus, also in incipient stricture of the rectum. In prolapsus ani it compares favorably with Nitric acid, Podo- phyllum, and Mercury, which it resembles in its pathological ac- tion. Nux and Ignatia cause prolapsus in a different way, namely, by a secondary paralysis of the circular fibres of the intes- tinal and sphincter muscles. In some rare instances it will be found useful in headache when attended by constipation or piles. The pain is mostly confined to the occipital region, and is dull and pressing, or a bruised, stupefying aching with a sensation of heat. It has been recommended in influenza, and many of its 12 A3SCULUS HIPPOCASTANUM. symptoms bear a strong resemblance to those caused by a cold af- fecting the nose and throat. Dr. Buchmann says he cured with JEsculus a chronic cough vnth emaciation. The symptoms point to a laryngeal origin of the cough, and it may be found useful in catarrhal laryngitis, and possibly in some cases of cough of hepatic origin. Dr. Meyhoffer, in his “ Chronic Diseases of the Organs of Res- piration,” says: “iEsculus hippocastanum rendered us last win- ter great service in a case of pharyngo-laryngitis follicularis with considerable catarrhal inflammation of the lining of the throat and larynx, complicated with piles and the most obstinate costiveness of long standing ; it not only restored the muscular contraction of the intestinal tube, but also greatly relieved the laryngeal irri- tation; cough and expectoration diminished speedily, and the signs of congestion in the affected parts diminished rapidly.” In several cases of pain about the heart in haemorrhoidal sub- jects it seemed to be of decided benefit. Dr. Neidhard says, “ In a case of curvature of the spine the pains were entirely cured by .ZEsculus.” Its action on the venous system and mucous membranes is un- doubted. If it acts on the spinal cord, it is but slightly, and not as intensely as the Buckeye. The lower attenuations have usually been prescribed. The triturations of the nut-meat (albumen) is generally used, but, as before stated, I prefer a tincture of the va- rious portions. Since writing the above, I observed a paper on this drug by Dr. Hart, of Wyoming, Ohio, who opposes Dr. Hughes’s view of its action, and agrees with my opinion, namely, that the iEsculus h. is primarily homoeopathic to portal and intra- abdominal congestions, and that the constipation is secondary. Dr. Hart claims to have discovered a keynote to the employment of this remedy in a symptom not found in its pathogenesis : “ Throbbing in the abdominal and pelvic cavities ; especially the latter.” Hence, he says, it is especially indicated in all active intra- abdominal and pelvic congestions. I have prescribed it with inva- riable success in all cases of congestion and inflammation of the neck of the uterus, attended with the above-mentioned symptoms. Nor is it necessary to use the remedy very low. One drop of iESCULTJS HIPPOCASTANUM—JESCULUS GLABRA. 13 JEsculus 6X, three or four times a day, has cured, in my hands, the most inveterate cases of inflamed cervix uteri, when not com- plicated with ulceration ; and has greatly relieved, and sometimes cured, similar cases attended with retroversion, prolapsus, ulcera- tion, enlargement, and induration, when characterized by great tenderness, heat, and throbbing, as in the following cases : Mrs. C., aged 22, a small, delicate blonde, had suffered during the last five years with congestive dysmenorrhcea. Eight months ago she was thrown from a carriage, since which time she has been under both allopathic and homoeopathic treatment for retro- version and prolapsus of the uterus. Growing worse under the treatment to which she was subjected at Denver City, she was brought to me for advice with the following result: Sept. 8.—Semi-paralyzed condition of the right lower extrem- ity ; muscles sore and contracted ; has to be carried, being totally unable to walk ; great weakness and emaciation; pulse 110, ir- regular and very weak ; face flushed and eyes sparkling ; bowels obstinately constipated ; occasional nausea and vomiting; skin hot and dry ; patient complains of great weakness and pain in the back, cephalalgia, and constant throbbing behind the pubes. A digital vaginal examination shows retroversion and enlarge- ment of the fundus, with great tenderness, heat, and swelling of the cervix uteri, the vessels of which pulsate with great violence. Ordered the patient to lie constantly on the face and left side; to use cold vaginal injections three times a day, and to take JEs- culus 6% one globule every two hours, until the throbbing ceases, after which it is to be taken only twice a day. Sept. 12.—Throbbing ceased. Continued treatment. Oct. 1.—Patient greatly improved, and able to walk. Nov. 1.—Patient dismissed cured. JESCULUS GLABRA, This relative of the horse-chestnut has been neglected. It is doubtless a more powerful medicine than the latter, for the Buck- eye cannot be eaten with safety by animals or men. From the meagre provings we have, it would seem to resemble Cocculus and Nux vomica. It has been found curative by Drs% Hill, P. H. 14 AILANTUS GLANDULOSA. Hale, Douglass, and myself in haemorrhoids with the following symptoms: Very painful external tumors, dark purple, with constipation and vertigo; weakness of the sacrum and lower extremities. It is said that carrying the nut in the pocket, or wearing it on the body, will cure piles. Many physicians assert this to be a fact. Why not? May not the curative principle be absorbed in sufficient quantity ? I would suggest its use in cerebro-spinal meningitis, when we have: Wry neck, vertigo, vomiting, opisthotonos, tympanitis, with stupor or coma. It has usually been prescribed in the first three triturations of the pulp of the ripe nut. AILANTUS GLANDULOSA. A careful study ot the pathogenetic, and toxical effects of this drug cannot fail to convince one that it is a powerful blood-poison. When we compare drug-effects with diseases, we observe not only a similarity in symptoms, but a marked similarity in pathological effects. For example, the results of poisoning by Arsenic and Veratrum alb. compare closely with the toxic effects of cholera Asiatica. The ultimate effects of Ailantus correspond to that con- dition and type of disease known as scarlatina maligna. Bella- donna does not correspond to this form of the malady, but to the ordinary scarlatina of Sydenham. It is in the putrid, malignant, and typhoid varieties of scarlet fever that Ailantus is indicated, not only by the symptoms, but the pathological state of the blood and secretions. Like the poison of the above disease, its morbific effects involve the brain and cerebro-spinal centres, and destroy life in the same manner. The eruption is peculiar; it is dark, almost livid, irregular, patchy, of a violet hue, even scaly, covering the whole body, or delayed and irregular in its appearance. In some cases there are large maculae or bullae filled with dark-colored serum. It (the eruption) remains livid—it never takes on the genuine scarlet color. It sometimes takes the form of petechiae. The fever is in- AILANTUS GLANDULOSA. 15 tense, with pungent heat, a rapid small pulse, hardly to be counted, great thirst, delirium or coma, and heavy, hurried, irregular breathing. The head is burning hot, with great pain, eyes sparkling, with delirium, or inflamed (conjunctivitis). The nose discharges a co- pious, thin, sanious fluid, which irritates the skin (Arum, Nit. ac., Ars.), or blood and pus; the tongue is of a livid hue, dry, parched, and cracked; the throat livid and swollen; tonsils studded with numerous, deep, angry-looking ulcerations, exuding a scanty fetid discharge; the pain when swallowing extends to the ears, and the teeth are covered with sordes. The urine is scanty, and voided unconsciously. This is certainly a vivid picture of disease, but the Ailantus has in many instances, in my own practice, appeared to dissipate this malignant condition. Drs. P. P. Wells, Small, Chambers, and others have testified in its favor. Other physicians, however, have failed to get curative effects. Besides this disease the Ailantus has proved curative in conges- tion of the brain, purulent ophthalmia, conjunctivitis, ozccna, ma- lignant ulcerated sore throat, tonsillitis with ulceration, and bron- chitis, with asthmatic oppression, cough oppressed, deep and painful, with muco-purulent expectoration, free in the morning, sticky and scanty during the day, excessive tenderness all over the lungs; feeling as if the air-cells were stuck together; inability to completely expand the lungs, crepitant rales; cough constant, dry, with oppressive, burning, and stitching-aching pains in the chest. As these conditions often occur during the progress of measles and small-pox, as well as scarlatina, this remedy wiil meet all the indications, not only in the latter disease, but all the erup- tive fevers, when they are attended by the unfavorable symptoms above mentioned. In one case of cerebro-spinal meningitis I pre- scribed it with excellent results. The special symptom, in addi- tion to the general condition, which led me to its selection, was “ intolerable pain in the back of the neck, upper part of the back, and the right hip-joint.” Some of the symptoms indicate that we shall find it useful in malignant dysentery and some varieties of enteritis. Dr. Robert, a French surgeon, communicates a paper to the 16 ALETRIS FARINOSA. “Archives of Naval Medicine,” relating to the use, by the Chi- nese and Japanese physicians, of the bark of the root of Ailantus in dysentery. They use an infusion of the fresh bark, allowing the patient to drink it until it causes vomiting and fecal stools. Dr. Robert tested its value; he used a tincture of the dried roots and bark in small doses, and found it superior to Mercury, Ipe- cac., or any other drug. He states that the blood began to de- crease in a few days, and improvement soon set in, and continued steadily to convalescence. When we remember that this disease was tropical dysentery, and that dysentery in that hot climate is a far more serious one than in ours, the value of the Ailantus must have been very decidedly shown or Dr. Robert would not have considered it worthy of mention. This is a remedy which has considerable reputation among Western homoeopathists, but as yet no proving has been made of it. The clinical indications for its use were all obtained originally from eclectic practice. It has been a favorite remedy with me for many years for the peculiar ancemic debility of chlorotic girls and pregnant women. Given in the lower dilutions, alone or alternated with Ferrum, it will soon restore appetite, strength, and the waning vitality. If such cases are attended by Dyspepsia, slow digestion and flatulence, the Aletris is very prominently indicated. I believe that certain remedies have such a special affinity for the reproductive organs of women, and that the term “ uterine tonic” is not inaptly applied. Among the old remedies we have Calcarea and Sepia, which act in such a manner. Uterine atony, even to the extent of suspension of the menses or sterility, comes under the curative sphere of this medicine. There are no characteristic symptoms yet known which specially indicate this remedy, but the general condition of the patient has been a sure guide to me in its selection. I have used it successfully for scanty, pale menses, where there was general debility, emaciation, and impoverished blood. In the scanty menses of corpulent and plethoric women it is of no value. ALETRIS FARmOSA. ALNUS RUBRA—ALSTONIA CONSTRICTA. 17 Prolapsus uteri, ante- or retroversion, where the dislocations de- pend on weakness in general, or of the uterine ligaments, can be cured by the lower dilutions of Aletris. Habitual abortion, or sterility, when caused by uterine irritabil- ity and weakness, is a condition for which the Aletris is almost a specific, if it is prescribed properly. It should be given during the few weeks before the expected miscarriage (three or four doses daily), and continued until the dreaded period has passed by sev- eral weeks, and its use resorted to, afterwards, upon the slightest appearance of threatening symptoms. It has been asserted on good authority, that the fresh root has caused abortion ; if so, like Sabina, it is homoeopathic to that accident. Several physicians have informed me that in cases even where pains and a show of blood had appeared, it has succeeded, aided by quiet and the re- cumbent posture, in warding off a miscarriage which seemed im- minent. Dr. Silas Jones, of New York, says it is valuable during the first months of pregnancy, where there is excessive nausea, vomiting, faintness, giddiness, and pain in the hypogastrium. The tincture is intensely bitter and nauseous. In general, I prefer the 2X dil., although in some cases I like the action of the lx dil. best. ALNUS RUBRA. Although a notice of this medicine appeared in all three editions of “New Remedies/’ we know of no provings or clinical reports. I have had no experience with it, but have observed several cures in cases of obstinate chronic eruptions, such as impetigo, prurigo, herpes, etc. It is said to be particularly useful in cases where eruptions on the skin alternate with diseased conditions of mucous membranes. Scrofulous enlargement of the glands, and even hsematuria, have been, it is said, treated successfully with the Alnus. I am in doubt whether it is an “antipsoric” or not. The same may be said of the ALSTONIA CONSTEIOTA. This remedy was introduced to our school by Dr, Augustus Cathcart, of Australia. The Alstonia constricta belongs to the order of Apocynese. It 18 ALSTONIA CONSTRICTA. grows in the form of a tall shrub or tree, and is known by the name of “Bitter Bark.” It is indigenous to the colonies of New South Wales and Queensland, being found in the interior in some of the “scrubs,” and occasionally in the open forests. The por- tion used in medicine is the bark, which is thick, yellow, deeply fissured, and of an intense bitterness. A few of the shepherds in the interior have somehow or other (probably from accidentally finding out its bitterness, or by direction of the natives) discovered its use in fever and ague, and some of them, in addition to calling it the “ Bitter Bark,” call it “Native Quinine Bark,” as they look upon it as possessing properties similar to those of Quinine. As a remedy for fever and ague they use it in decoction, so I was informed by an old up-country shepherd, who first made me acquainted with it. “An esteemed friend in Queensland,” says Dr. Cathcart, “has, at my request, carefully watched the effects of this drug upon ‘ beer topers’—those who had drank large quantities of a certain beer which had been adulterated with this bitter drug as a cheap substitute for the hop. From the effects which he observed, and from those produced in other persons whom I have prevailed upon to take large doses of this drug while in robust health as a 1 proving,’ and those produced in my own person, I have abun- dantly satisfied myself that, in large doses, its action is that of in- variably producing great debility and general prostration, or low fever,—often also with diarrhoea,—and, when pushed sufficiently far, rigors, sweats (usually cold), and other symptoms resembling fever and ague. “Taking the large dose effects as my guide, I have used this remedy with far greater success than China in convalescence from acute diseases of every kind, even to post-diphtheritic and post- scarlatinal debility, and the debility following parturition, under- lactation, diarrhoea, etc. “In the great majority of all those other cases where China is indicated I have found the Alstonia a more efficacious and far more reliable remedy. This use of it would alone stamp it as an invaluable remedy in all countries where patients have already been overdosed with Quinine at some time or other by allopathic practitioners. “ In cases of summer diarrhoea (in this hot climate), where un- ALSTONIA CONSTRICTA. 19 digested food is passed, more especially, and even when tinged with blood, I have found it specific. “ I have used it in cases of dysentery with success, especially where I thought the attack was complicated with symptoms of malarial poisoning, or proceeded from drinking bad water, or swamp-water impregnated with decayed vegetable matter—a fre- quent source of dysentery. Indeed, I have found it such a specific for these cases that I am confident it will prove the best remedy yet introduced for camp diarrhoea and dysentery of soldiers, when proceeding from this cause. “ In simple atonie dyspepsia, with loss of appetite, etc., its ac- tion is very satisfactory. “ In fever and ague, and in low fevers, especially those follow- ing upon attacks of acute disease, its extraordinary powers are manifested. For these it will be found a more reliable remedy than Quinine, Berberinum, or Chinoidin; and, moreover, not being so liable to affect the head, it may be confidently regarded as a perfectly safe antiperiodic and also a preventive of ague. “ In carrying out and confirmatory of the rule of the dose which I have adopted, I find that it takes comparatively large (homoeo- pathic) doses to cure fever and ague, a weak decoction being the most reliable form, perhaps, or even nauseous doses of the mother tincture. Other cases require from the mother tincture to the 2d decimal dilution, in from one to five-drop doses, according to the strength of the disease and the age and susceptibilty of the patient. Being of a very bitter and unpleasant taste to some people, the dose has to be diluted with plenty of water, and sometimes re- duced for those patients who have a great repugnance to bitters of any kind. “ I make my mother tincture from the coarsely-powdered bark, using rectified spirits, in the proportion of one pint of spirits to two ounces of bark, and this tincture I invariably carry in my pocket-case.” Since Dr. Catlicart’s notice was written, several physicians in the United States have used the Alstonia with good results in the class of cases mentioned by him. Dr. Grosvenor, of Chicago, and Dr. K , of St. Louis, report favorably. A fragmentary proving has been made. 20 AMPELOPSIS QUINQUEFOLIA—AMYL NITKITE. The bark of Alstonia constrida, F. v. M., contains an alkaloid, Alstonin, which may be obtained by treating the alcoholic extract with water and a little hydrochloric acid, adding to the filtered solution a small excess of ammonia, dissolving the Separated flocks in ether, evaporating the ethereal solution, and purifying the re- mainder by dissolving again in dilute acid, and repeating the above process. Orange-yellow, brittle, pellucid mass of very bitter taste, melts below 100° C., and is carbonized in higher temperature; dissolves easily in alcohol, ether, and dilute acids, sparingly in water. All its solutions in the dilute state exhibit a strong blue fluorescence, which is not affected by acids or alkalies. Its alco- holic solution has a slightly alkaline reaction. Alstonin combines with acids, but does not completely neutralize them. Hydro- chloric and other strong acids, also alkalies, decompose it partly on evaporation in the water-bath to a dark-colored acid substance. AMPELOPSIS QUINQUEFOLIA, which is said by eclectics to affect the skin, mucous membranes, and glandular system, in nearly the same manner as the Alnus. Its continued use for a long time is said to cure obstinate cases of dropsy. Dr. Lee asserts that it is a stimulant to the glands, and it is said to have cured enlargements of the lymphatics. I have had no personal experience with it, but Dr. P. H. Hale believes that it restored the secretion of milk in a lying-in woman who was very weak, tearful, and despondent. He gave it as a dernier ressort after Calcarea, Pulsatilla, and other remedies had failed to affect the secretion. The Nitrite of amyl is a singular and unique drug, having very little affinity for, and no close resemblance to, any other agent in our Materia Medica. Its oidy similarity to Glonoin is in the arterial relaxation it causes, which simulates congestion. But the arterial turgescence of Glonoin is active and forcible, and always accompanied by 'painful sensations. The congestion of Amyl is not due to any forcible rush of blood AMYL NITRITE, 21 AMYL NITRITE. into the cerebral arteries, but a passive filling up, owing to relax- ation of those vessels. Pain in the head is rarely present during the effects of Amyl, although it sometimes occurs at the height of its effect. It differs from Belladonna in the transient character of the cerebral fulness. Its action is of shorter duration than Glon- oin, lasting but a minute or two in most cases. Its rapidity of action is another peculiarity of this drug. In thirty or forty seconds, whether inhaled, subcutaneously injected, or swallowed, its action begins, and shows itself by flushing the face and start- ing the perspiration from the head, face, and neck. This property makes it more valuable than Ether or Chloroform in cases of se- vere internal spasms with pain, such as angina pectoris, or in ep- ilepsy and asthmatic sufferings. The most prominent symptoms induced when it is inhaled by man in moderate quantities (a few drops) are a sense of fulness and distension of the head, amounting at last to severe pain, and accompanied at last by intense flushing of the face, a deep, labored breathing, and an exceedingly rapid, violent action of the heart. The succession of these phenomena is so rapid that often they seem to be simultaneous ; but it is said that the cardiac disturb- ance is sometimes very distinctly manifest before the other symp- toms. Dr. H. C. Wood, in his “ Materia Medica and Toxicology,” says of its method of action : “ I have found as the results of nu- merous experiments made in the ordinary methods, that the dim- inution of reflex activity and of voluntary motion, which undoubt- edly occurs in toxaemia from this agent, is chiefly spinal in its origin ; since, after death, the nerves and muscles preserve, though in an impaired condition, their functional power. In the motor centres of the cord, the Nitrite is a direct and powerful depressant at the same time that it exerts a similar but much less pronounced action on the nerves and muscles, decreasing but not destroying their functional life. The diminution of reflex activity is never preceded by a stage of functional excitement. In some animals convulsions do occur, especially when the drug is administered by inhalation; but they are in all probability cerebral, not spinal, and due to the asphyxiating influence of the poison. Over the sensory nerves and centres, Nitrite of amyl has but little power. 22 AMYL NITKITE. They are among the last portions of the body to be affected, sen- sation being intact until near death, so that the drug is in no sense an anaesthetic. The cause of death appears to be due to the failure of power in the cord or respiratory centres higher up. The fact that it is not an anaesthetic does not militate against its power to relieve the pain of angina pectoris and similar painful affections. Angina is now supposed to be due to cramp, or a spasmodic contraction of the cardiac muscle. Cramp may cause the most agonizing pain known to man. A remedy that removes the cramp relieves the pain, not by any anaesthetic power, but by relaxing the spasmodically-contracted muscle. Wood proves quite conclusively that its action on the arterial system is not that of a motor-stimulant. Its action is peripheric, not centric. In other words, its apparent stimulating action on the heart is reflex. It paralyzes the arterioles, dilating them to such an extent that the heart gathers up and exerts its force vio- lently for a short time ; but if the inhalation be persisted in, its impulse constantly grows weaker, until its power is become ex- tinguished. After this examination of its physiological and pathological action, the question arises : To what abnormal conditions and symptoms is the Amyl homoeopathic? It is primarily homoeo- pathic to those cases where there is dilatation of the arterioles, and a redness and flushing of the surface of the body, not due to any primary disturbance of cardiac power. The action of Amyl, ac- cording to eminent experimenters, is peripheric. It first exercises a paralyzing influence on the coats of the arterioles. This para- lyzing influence spreads to the centres, and the heart itself is the last to feel its influence. This singular and unique quality of Amyl makes it one of the very few remedies which in their action correspond with the phys- ical effects of the mental emotions. If you study the effects of excessive joy, you will see a remarkable resemblance to the action of Amyl, namely, a sudden flushing of the face, a distension of the peripheral arteries, a quick, bounding pulse, and an increase in the number and frequency of the heart-beats. But during this period of increased action there is really a diminution of arterial pressure at the surface of the body. Sometimes after this 23 AMYL NITRITE. Amyl-flushing has lasted a few moments, the face changes to paleness and coldness, and a faintness supervenes, and the same occurs after the flushings of joy. Other mental emotions have a similar action. Joy is only one example. Amyl is homoeopathic to all such symptoms. It is a singular and suggestive fact, and makes us very hopeful of the final acceptation of the law of Similia by the best men of all schools, that the foremost man in the allopathic ranks in Eng- land, Dr. Sidney Ringer, recommends, from his own actual expe- riences, the Nitrite of amyl for the very symptoms and con- ditions which it primarily causes. I quote from his “Thera- peutics”—a splendid work, which should be in the hands of every homoeopathic physician. (The italics are my own.) He says : Dr. Brunton shows that it relaxes the whole arterial system, probably by par- tially paralyzing the sympathetic ganglia and motor nerves. This paralyzing effect of the arterial system is well shown by the sphygmographic tracings, the flushing of the face, and the increase in the size of visible arteries like the tem- poral, which often becomes notably large, sometimes, indeed, being doubled in size, and branches previously invisible become plainly apparent; and by the interesting fact observed by Talfourd Jones, who, while cupping a patient over the loins and finding that the blood would not flow, administered Nitrite of amyl by inhalation, when the cuts immediately began to bleed freely. After an inhalation the larger arteries are slower in recovering their normal size than the capillaries, a phenomenon well observed in the temporal artery, which remains enlarged half a minute or longer after the blush has quite left the face. Dr. Brunton first employed Nitrite of amyl in angina pectoris with signal success, and found it more effective than any other remedy in this painful and dangerous disease. During an attack, his patient suffered from throbbing of the heart and carotids as high as the ears, with severe prsecordial pain extending to the right arm. The usual characteristic “sense of impending death” was absent. The pulse was slightly quickened and the sphygmographic tracing became modified, for, as Dr. Brunton states, “ as the pain increased the curve became lower, both the ascent and descent more gradual, and dicrotism disap- peared. This form of curve clearly indicates that the arterial tension is much increased, and can, I think, be due only to contraction of the small systemic vessels.” The increased tension first led Dr. Brunton to employ Nitrite of amyl. In the case in question he considers that the attack consisted of spas- modic contraction of some, if not all, of the small systemic and pulmonary vessels, which state of arterial tension gave way on inhaling the Nitrite, and the pain then disappeared. On the recurrence of an attack, the patient inhaled the Ni- trite of amyl, and always obtained instantaneous relief. Dr. Anstie reports a well-marked case of angina greatly relieved by this 24 AMYL NITRITE. treatment. He says: “ The first sniff produced, after an interval of a few seconds, the characteristic flushing of the face and sense of fulness of the head; the heart gave one strong beat, and then he passed from the state of agony to one of perfect repose and peace, and at his usual bedtime slept naturally. This expe- rience has, I am happy to say, been repeated on several occasions, and with this fortunate result, that so confident now is the patient of being able to cut short the paroxysm that he has discarded all use of Ether, and greatly reduced his allowance of stimulants.” Hr. Talfourd Jones also finds it very useful in angina. Since the previous edition of this work, Nitrite of amyl has been largely used in angina, and with considerable success. Indeed, in most cases no other remedy affords so much relief. As might be expected, it is not uniformly suc- cessful. Thus, in one case due, as we discovered after death, to aneurism of the heart immediately below the aortic valve, an inhalation always arrested the pain, but it returned after a few seconds or minutes, even if the administration were several times repeated, and was as severe and lasting as when no Amyl was used. In another case, whilst it gave great relief, always arresting the par- oxysm, it took ten minutes to effect this, and was in no way superior to a full dose of Ether, which the patient preferred, as the Amyl produced so much gid- diness and sensation of fulness in the head. In three other cases, however, it proved strikingly successful. In one desperate case the slightest exertion brought on intense pain; but by the aid of Amyl the patient could always at once cut short the attack, so that now he can walk several miles, though he is obliged during his journey to employ the Amyl several times. It has appeared to me that by at once checking the paroxysm the attacks come on less frequently and less severely, and after a time a much smaller quantity suffices to control the pain; so that Amyl really contributes to the prolonged relief of these un- happy patients. Dr. Talfourd Jones found it remarkably successful in very severe attacks of asthma, removing the dyspnoea immediately and averting its return. Others have found it very useful in asthma. He found it useful also in a case of cardiac dyspnoea, accompanied by extreme anasarca, due to a dilated and hypertrophied heart. Dr. Sanderson suggests that it may be a relaxer of spasm generally, and Dr. Anstie has used it with success in cases of spasm of the stomach. Dr. Talfourd Jones advises inhalation of the Nitrite in syncope, and thinks it should be of service in the paroxysm of whooping-cough. It is useful in neu- ralgia, at least in neuralgia affecting the fifth nerve- It often eases the pain at once, and in some cases a single administration has averted further attacks, but so signal a result as this is probably exceptional. Dr. Richardson finds that Nitrite of amyl arrests in frogs the convulsions due to Strychnia, and in this way he has saved their lives; and he advises a trial of the Nitrite, either by inhalation or subcutaneons injection, in strychnia poisoning and tetanus. In the foregoing diseases it is better to administer this remedy by inhalation, for, according to Brunton, it will not answer with anything like the same certainty when given by the stomach ; for, in the striking case of angina pectoris just cited, he gave ten minims in brandy by the stomach, with the effect of staying the pain for only a short time, but a single inhalation afforded perfect and permanent AMYL NITRITE. 25 relief from the attack. It should be borne in mind that it affects some persons much more than others; one individual being able to inhale five or ten drops from a handkerchief, or to breathe the fumes from the bottle held close to the nose, while another on smelling a whiff from the bottle held at a distance will become affected with great giddiness, much mental confusion, and general weakness. Jones directs five or ten drops poured on a handkerchief, or the fumes from the bottle held close to the nose, to be inhaled till the pulse quickens, when the inhalation should be discontinued; but this plan is far too potent for some persons, especially feeble and sensitive women, who in the first instance should inhale a much weaker dose. As Jones points out, patients become habit- uated to it so that after awhile it must be inhaled several times before it affords relief. This habituation is well exemplified in the internal adminis- tration of the remedy. Jones also finds that by exposure it gets “flat” and loses its efficacy. Nitrite of amyl is generally considered a powerful and even dangerous remedy, whose administration must be watched with great care, and only a measured quantity employed. I am sure it is not nearly so dangerous as is generally imagined, though it is true that nervous, sensitive women are far more powerfully affected by it than men. No doubt its administration at first should be conducted by a doctor, in order to ascertain how far the patient is susceptible to its influence, and that the patient may learn when he ought to discontinue the inhalation. But after one or two inhalations, patients soon learn how to administer it to themselves. I have now five patients with angina pectoris, who always carry with them a small bottle of this medicine, and on the first warning of an attack they at once begin to sniff at the bottle, whether walking or standing. This they have done for months, and one patient for just a year, using the inhalation many times daily, so that he consumes about two drachms a fortnight with still unfailing relief. Except in relieving the angina, the Amyl seems to produce no other effect on the system. Dr. Jones recommends a trial of it in epilepsy. To an epileptic patient, who, in addition to severe and repeated attacks, suffered from much mental confusion, and was haunted many times a day with an indescribable dread and sensation as of an oncoming fit, although it came on only once or twice a week, the author gave it in three-drop doses thrice daily, and an additional dose on the earliest warnings of a fit. Amyl lessened considerably the frequency of the fits, and en- tirely removed the harassing sensations. Dr. Crichton Browne has lately published some valuable observations on the use of Nitrite of amyl in this disease. In two rabbits made artificially epileptic, he prevented the oncoming of the con- vulsions, which otherwise follow the application of the electrodes to the brain, by making them inhale Nitrite of amyl. By the same means he has likewise arrested epileptic attacks on the occurrence of the aura before the onset of the fit, and has even cut short the fit after its commencement. He has, too, ob- tained very satisfactory results in that form of epilepsy called status epilepticus —a condition consisting essentially of a succession of fits, linked together by intervening unconsciousness, the fits recurring with greater frequency till at last no sooner is one fit ended, nay, before it has finished, another fit begins. Fits like these he has arrested, and has rescued several patients out of this desperate VOL. IX.—3 26 AMYL NITRITE. plight. Amongst other successful cases, Dr. Weir Mitchell reports one where the remedy was used immediately the aura was perceived, and other cases where the spasms lasted for hours, one fit following another. These two gentlemen give it by inhalation. Since my last edition I have given this remedy with considerable success to several epileptic out-patients, in whom the attacks have been very frequent. In some it has appeared to be more useful than full doses (20 to 30 gr.) of Bromide of potassium thrice daily; in another case, whilst it decidedly lessened the frequency of the attacks, it was less serviceable than Bromide of potassium. I have given it in two to five minim doses suspended in mucilage, every three hours or three times a day, and have not found these doses produce any unpleasant effects in these epileptics, nay, in some cases they have not even caused flushing, whilst in other cases patients have told me that they flush with each dose, but only whilst swallowing it. The patient should take the medicine whilst lying down ; and as some pa- tients, especially women, are very readily affected by the drug, it is well in the first instance to give it in smaller doses. But until the remedy is pushed to two and in some cases to five minims every three hours, I have failed to obtain con- spicuous results. Dr. Crichton Browne maintains that epileptics are more sensi- tive than others to inhalation of Amyl administered in this way. I imagine that this medicine will be useful only where the attacks are frequent, and that it can- not be given thus, where they occur only at comparatively long intervals of three weeks or a month. Inhalation of Nitrite of amyl has been recommended in sick headache, and one successful case is reported by O. Berger. The author has used this remedy extensively with considerable success in cases of the following kind: A woman, perhaps from the sudden arrest of menstruation, depraved health, or nervous depression, or, more frequently, at the change of life, suffers from frequent attacks of flushings or “heats,” starting from various parts, as the face, epigastrium, etc., thence spreading over the greater part of the body. The face, and even the backs of the hands, are often deeply reddened, the veins of the hands in some cases dilating to double the previous size. Sometimes, although the patient feels deeply flushed, the skin remains natural. The sensation of heat may be so urgent that the patient opens her clothes or removes the greater part of the bed-covering, and even throws open the window in the coldest weather. These heats may last a few minutes only, or an hour or more, and may be repeated many times a day. Sometimes they occur chiefly at night, greatly disturbing sleep. They are generally fol- lowed by perspiration, often very profuse, at other times the skin remains dry ; the attacks are then commonly termed “ dry heats.” The “ heats ” are often accompanied by great throbbing throughout the whole body, and are followed by much prostration, the patient feeling scarcely able to rouse herself. After the heats pass away the skin becomes cold and clammy, and may turn very pale. The least exertion or excitement may bring on these heats, and such a patient generally complains of cold feet and sometimes of cold hands. The flushings are occasionally peculiarly and abruptly limited, reaching to the thighs, knees, or elbows, and while all the parts above these feel burning hot the parts below feel icy cold; sleep, too, is often much broken, the patient waking AMYL NITRITE. 27 with frequent starts, and in the morning feeling unrefreshed. In many cases palpitation or “fluttering at the heart” occur on the slightest excitement, or even without apparent cause. Nitrite of amyl prevents or greatly lessens these flushings or “heats,” and averts the profuse perspiration, throbbing of vessels, and great prostration. Sometimes it warms the feet and hands, and controls the fluttering of the heart, but in most cases it leaves these symptoms unaffected, and for their cure other remedies, as iron, are required. Amyl removes also giddiness, confusion of mind, heaviness in the head, and even headache; it generally produces calm, refreshing sleep. When the flushings and perspiration are slight this remedy is scarcely needed; moreover, the perspirations are generally considered vicarious and beneficial at the change of life. The symptoms, in many cases, form only a minor part of the troubles of the patient, who may complain of great sinking at the epigastrium, or severe pains in different parts of the body, and other suffer- ings incident to this period, over which Nitrite of amyl has little if any influ- ence. But when flushings, etc., constitute the chief part of the patient’s troubles this medicine is most serviceable. The Nitrite of amyl in ten days completely cured the following singular case of a woman who had been horribly tormented, for three years, with attacks, repeated several times daily, of severe burning sensation over the loins, from whence a glow of heat spread over the whole body, followed by perspiration. The burning sensation was so unendurable that she was constrained to open the window at night even in winter, and sometimes to rush out of doors. For the symptoms thus described the author has generally administered this drug by the stomach, though inhalation answers as well. In respect of dose it must be borne in mind that, like Glonoin (Nitroglycerin), its effects vary very greatly with different persons. One, two, or even three minims produce in some only flushing of the face and slight giddiness, while in others even a drop will induce various disagreeable symptoms. Thus one woman immediately after a drop dose turned deadly pale, felt very giddy, and then became partially un- conscious, remaining so for ten minutes. In another patient the same dose produced a sensation as if “a vapor spread from the throat through her head,” and rendered her quite powerless for one or two seconds. A third of a minim dose sometimes excites great nausea or a tickling in the throat; and one delicate woman after one-thirtieth of a drop passed for a few minutes after each dose into a trancelike state, everything to her seeming unreal, and the breathing becoming rather panting. The author began with a minim dose, but was obliged to reduce this quantity, and he ultimately found that, for the most part, those patients can bear one-third of a minim without any disagreeable symp- toms, but that a tenth, nay, even a thirtieth of a minim will in some patients produce the desired effect on flushing. It may be dissolved in rectified spirits, two minims to the drachm, and of this three to five drops should be taken on sugar every three hours, with an additional dose as soon as a flush begins. Re- lief generally ensues immediately, but sometimes not till the medicine has been taken for a week. As the patient grows accustomed to the remedy the dose must be increased. 28 AMYL NITRITE. Dr. H. L. Waldo, of Troy, N. Y., in a paper on the Nitrite of amyl, takes a somewhat different view of its action than I have given. I quote his remarks, and also his clinical observations: Its power over all forms of spasmodic diseases is exerted by virtue of its direct action on the ganglionic centres of the sympathetic system, and not by any stimulating or paralyzing action on the capillaries, or any direct sedative action on muscular tissue, as certain allopathic physicians would have us believe. The vasomotor nerves, which are a part of the great sympathetic system, supply the muscular coat of the arteries, and thereby regulate the expansion and contraction of these tubes, and so determine the amount of blood that shall pass through them. It is well known that all spasmodic diseases, as asthma, chorea, epilepsy, etc., are due to a deficient innervation, and in turn this deficient innervation is due to a deficient supply of blood to the nerve centres ; and this deficient supply is due to an irritation of the cerebral ganglia, which is transmitted by the vaso- motor nerves to the coats of the arteries, causing them to contract. Now, Nitrite of amyl acts directly on the cerebral ganglia of the sympathetic, and produces a commotion in the circulatory system similar to that which occurs in an epileptic fit. “ When it is given rapidly the lungs and brain are found blanched, and the left side of the heart empty, though the right cavities are gorged with blood. If given slowly it leaves a congested state of the brain and lungs, and blood is found in both sides of the heart.”—“ United States Dispensatory.” We see that its action falls almost entirely on the nerves of the arteries, scarcely any at all upon those of the veins, thereby greatly modifying the supply of blood to the brain, but not greatly influencing its return to the heart, and this again is just the state of things found in epilepsy. In chorea and spasmodic asthma the spasm is due to the same cause, though it differs in extent. In syncope, too, we find the same condition of the cerebral circulation to which Nitrite of amyl has just been proved to be so peculiarly homoeopathic, and in this affection it has been found very useful by allopathic physicians. It is a powerful cardiac stimulant. The excitement which it pro- duces is followed by diminished but not extinguished action of the heart. A reduction of the respiration and circulation so extreme as to resemble trance may be induced and maintained for hours. Muscular action is at first “ wildly excited,” and then subdued by its use. I fully believe that if administered just before an epileptic fit is to occur it will prevent the spasm of vessels, and hence prevent the fit every time; and in several cases that have come to my knowledge it has thus far proved perma- nently curative, preventing any recurrence of the fits. In a case of seven years’ standing, brought on by masturbation, now under treatment, the patient carries a vial of it in his pocket, and when the aura occurs takes a few inspirations from it, and thus far has not failed to throw oft’ the fits, a good many of which would certainly have occurred but for this treatment. Two fits have occurred while he was asleep and could not use the remedy. I have used it in several severe cases of eclampsia or fits in children, produced by various causes, and with the invariable result of at once breaking the fit. In a case of meningitis caused by a fall, while the child was kept under its influence the fits were pre- 29 AMYL NITRITE. vented or at once broken, but the child died in a few hours from the severity of the disease. It may be inhaled directly from a small vial, or five or ten drops may be put on a sponge or small cloth, from which it may be inhaled. For children I make the first decimal dilution with alcohol, and put ten or fifteen drops on a hand- kerchief and hold it near the nose.—“American Journal of Materia Medica.” Dr. H. C. Wood, in speaking of its use in angina pectoris, says: “There is now abundant evidence of its value in relieving, almost instantly, agony which has resisted all other treatment, whether valvular disease or merely functional disorder exists.” He adds, however, that “in cases of advanced fatty degeneration, or of very great dilatation of the heart, I think its use would be attended with danger, owing to its effect upon the heart’s muscle.” Here we have the opinion of one who only looks upon its ap- parent antipathic action and the administration of large quanti- ties by inhalation. But we can view it in another light. It is homoeopathic to the very condition of debility alluded to by Wood, and in minute doses it may act promptly as a curative agent. It will be remembered that we are warned against using Chloral in cases of weakened heart, because in large or toxic doses it par- alyzes the heart. But it has been demonstrated many times, by myself and others of our school, that in small doses it actually strengthens failing cardiac power ; as witness the remarkable case reported by Drs. Swan and Helmuth, and quoted under “ Chlo- ral.” Nitrite of Amyl in Ague—Dr. W. E. Saunders, of Indore, calls attention to the value of Amyl nitrite in ague, and records a number of cases in which advan- tage has been derived from its use. The drug itself, he remarks, is inexpensive and goes a long way. He now uses Nitrite of amyl mixed with an equal part of Oil of coriander, to render it less volatile and at the same time to cover its odor. He regards it as the most powerful diaphoretic he has seen, and he uses it in all cases of fever to produce diaphoresis. The following is one of his cases: Mr. F. C. came for treatment about 7 p.m. in the cold stage of ague. Two minims of Nitrite of amyl were administered ; sweating came on in seven minutes. He lay down for half an hour to get cool, and then walked home well. He next morn- ing took a dose of Quinine, and has had but one attack of fever without the cold stage since. Previous to this he had fever every day for one month, during which he took large doses of Quinine. Dr. Saunders observes that he does not mean to say that Quinine should not be used in the cases, for there is ample proof that it tends to check the return of the attacks, and removes to some ex- 30 AMYL NITRITE. tent the septic condition of the blood induced by the malarial poison, and this more especially if small doses of Opium be combined with it. In no case did the Amyl fail to remove the attack in about one-third the usual time, and in most cases the fever did not return. The method of administration he adopts is this: Four drops of the mixture or two of Amyl are poured on a small piece of lint, which is given into the hands of the patient, and he is told to inhale it freely. He soon becomes flushed, and both his pulse and respiration are much accel- erated, and when he feels warm all over the inhalation is discontinued, as the symptoms continue to increase for some time afterwards. A profuse perspiration now sets in, which speedily ends the attack; in some cases, however, the cold stage merely passes off without any hot or sweating stage.-—" Indian Medical Ga- zette ” in “ The Practitioner.” Pathogenesis. The characteristic symptoms of Amyl, so far as we have gained the knowledge of them, have appeared in Allen’s “ Encyclopedia of Materia Medica,” vol. i, from which I quote them, adding a few which I have gleaned from other sources. Through an inadvertence they were omitted in Vol. I, “ Special Symptomatology,” and are, therefore, appended hereunto. Mind. Anxiety, as if something might happen; must have fresh air. Actual fright at the throbbing in the head, and a bursting-out feeling in the ears. Mental confusion and a dreamlike state. She passed for a few minutes, after each dose of one-thirtieth of a drop, into a trancelike state, everything seeming to her un- real . Head. Great confusion of the head, with vertigo. Heat and throbbing in the head, with a feeling of intense fulness, with great heat and flushing of the face. * Beating, throbbing, bursting sensation in the head and ears, with constriction of the throat and heart. Visible pulsating throbbing in the temples, with sense of ten- sion in the temples. Sensation of something rushing upward, and throbbing in the vertex. Heavy, dull aching all through the head. AMYL NITRITE. 31 It causes no severe pain in the head until the acme of its effects is reached. Sensation as if a vapor spread from her, through her head, and rendered her powerless. Face. Flushing of the face, a bright scarlet. It becomes intensely red and hot; on passing off the face became paler than usual. A sensation as if the blood would start through the skin of the face, with lachrymation. The flushing of the face is attended by heat and perspiration of the head, face, and neck, while the hands and feet become very cold, and sometimes continue so for hours. ° Flushing and perspirations of the face and neck of women at the change of life. 0 Neuralgia of fifth nerve. ° Supraorbital neuralgia. Eyes. Protruding, staring eyes, with bloodshot conjunctiva. Pupils dilated. Sight very hazy, the outline of objects indistinct. A spot on the wall appears of a yellowish hue, surrounded by a yellowish circle, and this again surrounded by a violet-blue halo, with undulating edges. Under the ophthalmoscope the veins of the disk were seen to be- come enlarged, varicose, and tortuous; the arteries small, but not abnormally so. It causes a very profuse flow of urine, which contains an abun dance of Sugar (in animals). Urinary Organs. Ears. Much throbbing in ears. ° Tinnitus aurium. Bursting sensation in ears, as if membrani tympani of each ear would be forced out with each beat of the heart. Pressure over the root of the nose. 0 Epistaxis. Nose. 32 AMYL NITRITE. Throat. Choking feeling in the throat on each side of the trachea, along the carotids. Feeling of constriction. The collar seemed too tight, with desire to loosen it. Tickling in the throat. Stomach. Slight nausea, with uncomfortable feeling of the stomach. Constriction and pressure over the region of the praecordia, as though he wants to rub it. ° Spasm of the stomach (Dr. Anstie). 0 Very successful in seasickness (by inhalation or internally). Chest and Respiration. The feeling of constriction in the throat extended to the chest, and produced dyspnoea and asthmatic feeling in the larynx and trachea, with desire te eructate. An indescribable feeling of fulness about the chest, with invol- untary coughing, but the normal respirations are not altered in frequency. It sometimes causes slight dyspnoea, or breathlessness, with in- clination to cough. A desire to sigh convulsively. ° Asthma, it removes the dyspnoea immediately, and prevents its return. Heart and. Circulation. * Prcecordial anxiety. * The heating of thq heart and of the carotids is, in some persons, very marked. * Accelerated heart-action, with increased frequency of cardiac pulsations. * Great cardiac oppression and tumultuous heart-action. * An aching pain and constriction around the heart. (This sen- sation continued, more or less, for three weeks; was relieved by taking Cactus.) AMYL NITRITE ANTIMONIUM IODATUM. 33 It invariably quickens the pulse, but in a variable degree, some- times doubling its pace. While the pulse is always increased in frequency, it is not in force. Pulse irregular and jerking. It relaxes the whole arterial system, probably by partially par- alyzing the sympathetic ganglia and motor nerves. ° Angina pectoris, with throbbing of the heart and carotids as high as the ears. Very severe prsecordial pain, extending to the right arm. (Dr. Sidney Ringer.) * Angina pectoris, with great agony. (Drs. Brunton, Anstie, and Talfourd Jones.) ° Very successful in sun-stroke or heat-stroke. Extremities. Tired feeling of the limbs. Tremulousness of the hand, and stiffness and slight numbness of the fingers. Generalities. General relaxed, weak feeling all over tlie whole body. General sudden perspiration. She turned deadly pale, felt very giddy, then became partially unconscious, remaining so for ten minutes. A feeling of increased warmth and perspiration over the whole body, especially the head, face, and neck, while the hands and feet may become very cold, and remain so for many hours. 0 A severe burning sensation over the loins, from whence a glow of heat spreads over the whole body, followed by perspira- tion. This sensation was so unendurable that she would rush to open a window at night, even in the winter, and sometimes rush outdoors. (This symptom had lasted three years, with several attacks daily, and was cured in ten days.) (Dr. Ringer.) ANTIMONIUM IODATUM. (Teriodide of Antimony.) I have recommended this remedy in my work on Sterility, for uterine areolar hyperplasia, for which Tartar emetic has heretofore been used. 34 APOCYNUM ANDPOSEMIFOLIUM. The remedy has been used with excellent results in bronchitis, humid asthma, and even in cases which simulated pulmonary phthisis. The symptoms present in the cases cured are: Frequent spells of coughing, with expectoration of frothy, white, or thick yellowish mucus; loss of appetite and strength; moderate febrile ac- tion ; coated tongue; yellowish discoloration of the skin and con- junctive. In subacute bronchitis it acts like a charm. In chronic bronchitis with or without asthma it has brought relief when other remedies have failed. The dose is from one grain of the third decimal trituration to five grains of the second. The rem- edy bids fair to rival Tartar emetic (Tartrate of antimony and Potash) in the treatment of bronchial and pulmonary affections. From the nature of the elements of which the new remedy is composed we may expect that it will have a specific action on the skin as well as on the mucous membrane. APOOYNUM ANDROSEMIFOLIUM. Although belonging to the same genus as the A. cannabinum, it certainly differs very much from it in its specific action. The sphere of action of the Dog’s-bane includes the muscular and fibrous tissues, especially those of the smaller extremities. My experience with this remedy has been quite limited. I have used it successfully in two cases of “ rheumatic gout” so called by an English surgeon of eminence. The symptoms cor- responded so nearly that it was given in preference to Bryonia or Benzoic acid. Dr. Williams, of St. Paul, Minn., writes that he considers it the chief remedy for acute rheumatic affections in that region. When the acute pains in the joints are attended by cramps, bilious stools, and flying pains in the teeth, it will be well indicated, according to Dr. Henry’s heroic provings. Its curative power in dropsy is very much inferior to A. can- nabinum, if it' has any such power at all. The tincture in drop doses has been known to expel ascarides and other worms. Its analogues are probably Bryonia, Iris, Colchicum, and a few others, but the drug needs further develop- ment to determine its true place. APOCYNUM CANNABINUM. 35 APOCYNUM CANNABINUM. Th is should not be confounded with the India hemp (Canna- bis indica), a drug which has little or no analogy to this plant, and belongs to another family. This is one of those remedies whose sphere of action is very lim- ited, but in that sphere it is of immense importance. Its patho- genetic and curative action appears to be confined almost wholly to the kidneys—all the other symptoms seem to be the result. This action on the Sidneys does not seem to go beyond passive congestion, with some irritation of the urinary mucous membrane, for even in the most heroic provings no trace of blood, epithelium, or other abnormal sediment is observable in the urine. Primarily it causes profuse discharges, the secretion being very light-colored. Secondarily it causes a peculiar torpid action of the kidneys, very scanty urine, but no pain or renal tenderness. I do not doubt but it could cause vesical and urethral pain, for it has cured such con- ditions. This medicine had a reputation for the cure of dropsy in the early history of this country, and has retained that reputation in all systems of practice. Homoeopathists have made many bril- liant cures where they have used it rationally. Dropsy, in its various forms, is the chief curative sphere of Apocynum c., but renal dropsy is strictly the proper sphere of its action. Other dropsies may be temporarily removed or palliated by its use, but not cured. It is this palliative power which gave it the name, among the early physicians, of the “ vegetable trocar,” meaning that its value was similar to that of tapping. Anasarca, ascites, oedema of the legs, and even hydrothorax, may all proceed from suspended action of the kidneys, as an idio- pathic affection. When this is the case the Indian hemp properly administered will rarely fail to cure if no structural disease of the kidneys exists. I will here repeat the two rules, given by me in “ New Remedies,” as a guide to its administration: (1.) In cases of acute, idiopathic dropsies use the dilutions, beginning with the high, and descending more or less rapidly, according to the progress of the disease. 36 APOCYNUM CANNAPINUM. (2.) In chronic, atonic, or secondary dropsies, use the tincture, or tiie decoction in one or two-drachm doses. The most brilliant cures ever made with the Apoc. c. were made with the infusion or decoction (§j to one quart of hot water) in doses of half a drachm to four drachms. Even in acute dropsies the infusion acts more promptly than the tincture. This infusion can be “ run up” to the third dilution, in water, if that strength is preferred. Like Digitalis, the Apoc. c. is often apparently inert if given in the alcoholic tincture. There is no variety of dropsy but may be amenable to its pal- liative, if not its curative, action. Even in dropsy from organic diseases of the heart it will keep down the effusion and allow the heart a chance to regain much of its former strength. In post-scarlatinal dropsy, or simple, uncomplicated albuminu- ria, it will often prove promptly curative. Bright’s disease cannot be cured by this medicine, and rarely by any other, but the dropsy may be kept in check so long as any considerable portion of the kidney is free from organic changes. Hydrocephalus has doubtless been cured by Apoc. c., if we are to accept the statement of two eminent physicians, one of each school of medicine (see second edition of “ New Remedies ”). The symptoms were : (1) “ Sutures of the head opened ; forehead project - ing, sight of one eye lost, the other almost; child lying in a stupor with constant involuntary motion of one arm and leg;” and, (2) “ Paralysis of left side, one eye motionless, the other rolling, bowels disturbed, pulse slow.” In the first case drachm doses of a weaker infusion cured. In the second, drop doses of the tinc- ture. I think I have cured two cases with it, while it has failed in a great many; but in this respect it is no worse than the Helle- bore, which has been so highly praised, and so unsuccessful. In addition to its value in dropsy the Apoc. c. has been used suc- cessfully in other disorders. Nasal catarrh has been caused and cured by its use. The catarrhal symptoms are : “ Peculiar dryness of the mucous membrane of the nose, with a sensation of stiffness, followed by secretion of thick, yellow mucus, preceded in some cases by a thin, irritating discharge.” APOCYNUM CANNABINUM—APOMOEPHIN. 37 For this species of coryza the 2X trit. of the root is snuffed up the nose. The eyes, throat, and bronchia are affected with the same catarrh, which accounts for its popularity in bronchial and asthmatic coughs, for which it is certainly useful, as I have often proved. Diabetes insipidus is one of the primary conditions caused by this drug, and the characteristic concomitant symptom is : “ A sense of sinking at the pit of the stomach, with great de- bility.” Like all powerful diuretics, the Apoc. c. sometimes proves pow- erfully emetic and cathartic. In dropsy, when the stomach is very irritable, and vomiting of all drinks is a troublesome symp- tom, the Apoc. c. often corrects immediately. Dr. Paine recom- mends it in diarrhoea, intestinal haemorrhage, and cholera infantum, but I have never had any experience with it in such cases. Uterine haemorrhage has been cured by Apoc. c., according to Dr. Marsden, who gives us the only clinical experience we have of its use in that affection. In one case (menorrhagia) the flow was profuse, clotted, and attended by “ great irritability of the stomach,” fainting, etc. In another case the haemorrhage occurred at the change of life, but was checked in a week, after lasting six. Several other cases of long-continued haemorrhage Dr. Marsden reports cured by the Apoc. c. in drop doses of the tincture. In my practice it has appeared to restore the menses when given for dropsical conditions, and Dr. Barnes, of California, reports that he often cures with it amenorrhoea in young girls, when attended with bloating of the abdomen and extremities. Dr. Lindsay reports his own case of severe haemoptysis, which had resisted the use of Aeon., Ham., China, and Frig., but was promptly checked by Apoc. c. lx, repeated every few minutes. Another physician says he has checked pulmonary haemorrhage in consumptives with it. It would seem from the cures of haemor- rhage reported that it acts very similarly to Ipecac, in such cases, and is indicated by very nearly the same symptom, namely, the vomiting, or nausea. APOMOEPHIN. This new alkaloid of Opium was discovered by Dr. Mathieson. 38 APOMORPHIN. It is a snow-white powder, which is permanent when dry, but when moist soon becomes green. A solution suffers this change in a few hours, and in a few weeks the green color turns to black. For homoeopathic use triturations should be made with pure, dry sugar of milk, and kept closely corked. I ought to say that Dr. Dyce Brown says the 3d centesimal dilution does keep its virtues a long time. One of the most remarkable effects of this alkaloid is sudden vomiting. As small a quantity as one-twentieth or one-fifteenth of a grain injected under the skin of an adult man will cause copious vomiting in five or ten minutes. Dr. Blackley (“British Journal of Homoeopathy,” 1873) gives a graphic account of its action. He injected ten minims of a ten per cent, solution of Apomorphin under the skin of his left arm. During the first two minutes no effect was produced. After about ten minutes the pulse began to rise slightly, and the respirations became slightly accelerated. At the end of four minutes he felt a sudden qualmishness, which was almost immediately followed by nausea and profuse vomiting. This continued for several minutes, anti was followed, as soon as the contents of the stomach had been evacuated, by severe retching. On taking a draught of water with a little brandy in it this was immediately rejected ; the same occurred after drinking cold water. JSlo bile, however, came up in the vomited matter. At the end of seven or eight minutes from the commencement of the experiment he began to feel very faint, and was compelled to lie down, and almost immediately on doing so fainted entirely, and remained in a state of syncope for about five minutes. On awaking from this he felt giddy and chilly. He took a little brandy and water, which was retained. He then be- came drowsy, and slept an hour, during which he perspired pro- fusely. On rising, he felt slight giddiness, but no desire to vomit; slept soundly all night; awoke pale and hungry. Dr. Blackley made several experiments on animals, in which it developed more grave symptoms, convulsive and cerebral; but I doubt if they are useful to us. The question arises: What use can we make of such a powerful drug? It will be noted that the vomiting is marked by sudden- ness, completeness, and the absence of pain, or continued nausea. It APOMORPHIN. 39 occurs to me that we shall find it the safest and quickest emetic in cases of poisoning, when the object is to evacuate the poison as soon as possible. In such cases inject hypodermically one-tenth or one- fifth of a grain in a few drops of a recent aqueous solution, or give internally, in solution, one-fifth to one-third grain of the pure drug. Next to the mustard-water emetic it seems preferable to all others. Dr. Blackley says it does not interfere with digestion, as a man to whom he gave it, vomiting at 8 P.M., at 9 P.M. ate a hearty supper and digested it. “This,” says Dr. D. Brown, “coincides with what I find to be its sphere of action on the stomach. The cases where I have used it with success are chiefly those where sickness or vomiting constitute the disease under which the patient is labor- ing. The tongue is clean, the bowels are regular, there are no headaches, the patient has a desire more or less for food, and has no pain after eating, but a feeling of nausea comes on at intervals, especially after taking food, which may or may not be omitted. In other cases, when there is marked dyspepsia, and when Nux or Pulsatilla is indicated, I find Apomorphin very valuable, given at the time of the onset of the sick feeling, and repeated every ten or fifteen minutes until it is relieved. In other cases still, when the vomiting is sympathetic, as in the case of neuralgic headache, gall- stones, a cerebral affection, or uterine disease, Apomorphin is equally useful.” Dr. Cooper states that he had seen it cause im- mediate cessation of vomiting in a distressing case where a tumor pressed on the brain. Dr. Brown thinks it resembles Ipecac. I do not agree with him ; for Ipecac, is useless in vomiting from cerebral and nearly all other remote irritations. Apomorphin will not cause vomiting in ani- mals if the vagus is cut, or if the subject is chloroformed. Some authorities assert that so small a quantity as one-five-hundredth of a grain causes vomiting. This seems to prove, with Dr. Cooper’s case, that the action of Apomorphin is central. If such be the case, it ought to cure or palliate all cases of vomiting from cerebral disease or irritation. I do not see how this can agree with the statement of Brown that it removes vomiting from uterine and he- patic disorder, but such seems to be the case. Dr. Brown reports thirteen cases of nausea or vomiting cured 40 APOMORPHIN—ARCTIUM LAPPA. by Apomorphin (“British Journal of Homoeopathy,” July, 1874), viz.: (1.) Case of nausea, with disgust for food; white tongue. (2.) Case of a child vomiting for three days, bowels slightly loose, stools whitish, tongue white. (3.) A woman of sixty vomits her food about an hour after taking it; nausea all the time. (4.) Frequent vomiting, and almost constant nausea, in a wo- man. (5.) A woman of fifty, constant nausea and vomiting, with pain and tenderness in the region of the liver, which was enlarged. He gave Bryonia and Apomorphin in alternation. He thinks the latter cured the sickness, as it was better after two doses. (6.) A young lady with displacement of the uterus had almost constant feeling of sickness, with frequent attacks of violent retch- ing, followed by intense prostration. This medicine relieved the vomiting after all others failed. (7.) A lady of forty-two, with large ovarian tumor, had per- sistent vomiting; got immediate relief, after a fruitless trial of all other remedies. (8.) Sickness and incessant vomiting in a sailor, tenderness over the liver, but no enlargement. Three doses cured. (9, 10, and 12.) Vomiting of food in children. (11 and 13.) Morning sickness and vomiting (the patients did not report, but he thinks they were cured or they would have re- turned). Dr. Brown further says: “ I have found Apomorphin success- ful in removing nausea which frequently presented between attacks of gallstones, and in a case of long-standing supraorbital neural- gia” I have had no personal experience with this remedy, but would advise a trial of it in seasickness, and in the vomiting from riding in a carriage or in railway cars. Some points of its action remind me of Cocculus. Dr. Brown used the 3d cent. dil. invariably. ARCTIUM LAPPA, From time immemorial this plant has been used as a “ blood ARCTIUM LAPPA—ARALIA RACEMOSA. 41 purifier” in domestic practice. It grows in nearly every country, and its popularity is almost universal. Dr. Burt observed that its continued use in the form of decoc- tion or syrup was quite successful in curing obstinate cutaneous eruptions, and it occurred to him to use it in practice. He claims to have cured several cases of tinea capitis “ when the head was completely covered with a grayish-white crust, and most of the hair gone; the eruption extended to the face.” These cases were cured by the Burdock after Sulphur, Iris, Merc., Graph., and Lyc. had been tried faithfully without benefit. Orusta lactea has also been cured by this remedy. Chronic erysipelas is said to be removed permanently by its persistent use. My observations have been mainly confined to its use in fur- unculi, when crops of boils persistently occur. In such instances I have known its use to be followed by an apparent removal of the furunculous tendency. Hordeolum and ulcerated eyelids are benefited by it, and Old Culpepper recommends it in fetid sweat of the axillfe. Abscesses of the axillary glands have been cured by it. It appears to me to be an analogue of Hepar sulphur, Graph- ites, Phytolacca, and Sulphur. A proving may show this affinity ; also its real value in dropsy, dysuria, and other disorders of the urinary organs, for which it has been recommended. Although attention was called to this plant, so extensively used by the people in domestic practice, in the first and second editions of “ New Remedies,” it attracted but little attention, until Dr. Samuel A. Jones, of New York, made his graphic and unique proving, which was published in the appendix to my third edition. It always seemed to me that a remedy so popular with the masses as a curative agent in coughs of all kinds ought to have some specific affinities for the respiratory organs. Dr. Jones thought he had discovered its true sphere of action. Prescribing it for the symptoms which he elicited in his provings, he claims to have succeeded in curing some very severe cases of “ hay fever ,” humid asthma, and some cases of suffocating cough. As it may be interesting to the class, the most characteristic symptoms are here given : ARABIA RACEMOSA. YOL II.—4 42 ARALIA RACEMOSA. Dry, wheezing respiration, with sense of impending suffocation, and rapidly increasing dyspnoea. Very loud musical whistlings, during both inspiration and ex- piration, but louder during inspiration. Could not possibly lie down; felt as if he would suffocate if he did not sit up. The oppression first appeared to be all in the right lung; it then attacked the left lung, and the right became entirely relieved. All the obstruction seemed to be in inspiration. When the attack reached its acme expectoration set in; at first scanty, then increased in quantity, warm and salt. A constant desire to clear the chest of something, so that I could inspire better. On making a forcible expiration, in the attempt to clear the chest, had a raw, burning, sore feeling behind the whole length of the sternum, and in each lung. Although Dr. Jones was “ inclined to asthma,” as he says, this attack was very different from his usual attacks. The question arises—would the Aralia originate an attack in a person not in- clined to asthma? When we consider that it is drank in large quantities of the decoction without causing any such effects—so far as we know,—its power of causing such attacks sui generis is more than doubtful. But this will not prevent its being useful and homceopathic to asthma, especially in persons subject to at- tacks. Dr. Jones took ten drops of the mother tincture. I have greatly relieved asthmatics with the same doses, repeated every hour. For children the 2X dilution acts well. The tincture to be potent must be made from the fresh root. Dr. Jones relates a ease of hay asthma, cured by Aralia, in which the characteristic symptoms were : Yearly attacks of suffocative catarrh, with “ extreme sensitive- ness to a draught, the least current of air causing sneezing, with copious watery, acrid discharge from nostrils and posterior nares, of a salty, acrid taste, excoriating all the passages.” Waking at midnight, with suffocative breathing, inability to lie down, and the copious discharge above mentioned. Relief of the asthma by bending forward, elbows on knees. In- spiration more difficult than expiration. When the corvza ceased the trouble went to the lungs, with * o y ARALIA RACEMOSA ARANEA DIADEMA. 43 dry, wheezing cough, ejecting yellow, threadlike pieces of tough mucus. Aralia, ten drops, three times a day ; cured in three days. It has been used with apparent benefit in dysmenorrhoea, leucor- rhoea, and suppressed lochia, but in these cases the home infusion was given. ARANEA DIADEMA. This remedy, heretofore rarely used except for haemorrhages from punctured wounds, has lately been brought into notice by Grauvogl. The pathogenesis, as will be seen by reference to Vol. I, is very meagre, being made up of fragmentary provings. But Grauvogl, like many of his countrymen, has the power, apparently, of evolv- ing unfailing indications for a remedy out of his “ inner conscious- ness” rather than from extended provings. Grauvogl (page 354) first mentions Aranea in the following way—after giving a clinical case illustrating the hydrogenoid constitution. He says : “ As I had found in my practice that Aranea diadema, still more than Nux and Ipecac., diminishes the influence of hydrogen on the system, and since it was also indicated, according to the laws of similarity, by the constant chilliness, I directed,” etc. The case he narrates is of a woman subject to catalepsy, periodi- cal headache, etc. Her sufferings were always aggravated by damp weather, the use of baths. She was constantly chilly, with cold hands and feet, even in a warm room. The Aranea cured this case in a short time. In another case of enlarged spleen, in a man subject to ague, who was constantly chilly, who lived in a damp location, and was worse when it rained, the 2X of Aranea cured. Grauvogl more than intimates that in certain cases this remedy would be a specific for chlorosis. He narrates a case of protracted pneumonia, when the patient was “ one day better, the next decid- edly worse, and then at 8 p.m. he was worse than ever .... he felt chilly, notwithstanding a constant sweat, and in spite of hot cloths to the abdomen.” Nux and Ipecac, ameliorated the symp- toms, but “ after eight days he still was chilly in the upper parts of the body.” Aranea 3X was given alternately with Nux, under which he soon recovered. 44 ARANEA DIADEMA. It does not matter with Grauvogl what the nature of the dis- ease is, or where it is located, if the patient is constantly chilly he cures him with Aranea or some hydrogenoid remedy. Thus, an old man had an abscess on his heel, due to “ chronic inflammation of the periosteum of the os calcis.” The ulcer was gangrenous, very painful. Aranea relieved the pains, but the ulcer deepened. Silica and Calc. carb. aggravated. Because the patient was con- stantly chilly, and the pains increased and decreased periodically, he gave Aranea, and says he effected a “ rapid cure,” although the time was five months before the “ cure ” was complete. On page 205 he gives a graphic description of a case of ague, in which the chill came on at 7 p.m. and lasted till 8 a.m. (no fever or sweat was present). lie gave this patient 80 grains of Quinine, in three days, with no effect. Then he cured him with Aranea 2X, five drops every hour. An immediate improvement was observed. Additional eases, as follows, are reported in the u Allg. Horn. Zeit.,” 55, 166. (1.) A case of chronic headache, preceded by flickering before the eyes and vertigo, which forces her to lie down. The head- ache is attended with dulness, great heat in the face, weariness, loss of strength, and lasts one day. Cured by Aranea 6th. 2. Toothache ; pinching, pressing pain in upper incisors, regularly from 9 a.m. to 7 p.m., leaving a sensitiveness and cold feeling on drawing in air. Nux was taken without result. The patient was bitten by a spider (Aranea), and “ from that instant the pains gradually went off.” This physician says he has often cured such toothaches, with sensation as if the gum or cheek was swol- len, by means of Aranea 6th. (3.) Pain in the temples, with vertigo on rising, and a disa- greeable feeling, as if the hands and head were swollen. Cured by Aranea. Dr. Chapman, in the “ Annals of the British Horn. Soc.,” vol. ii, cured a similar case in a very nervous woman, who, for sev- eral years, was nightly distressed with the sensation that her hands and arms were enormously sivollen. She was speedily cured by this remedy. In Europe, ever since Dioscorides, the spider’s web has been used for ague. In this country it is used in domestic practice for AESENIATE OF ANTIMONY—AESENITE OF COFFEE. 45 the same disease. Old physicians used it in epilepsy, palpitation from hypertrophy, spasms, neuralgia, sleeplessness, etc. It was given in pills about the size of a small pea. I have never given Aranea but once, viz., when I thought it decidedly cabled for by Grauvogl’s indication, but I saw no benefit from its use. I use a great deal in cardiac debility, with concomitant dyspnoea, asthma, cough, and emaciation. It acts well in the 2X trit. given three times daily. ARSENIATE OF ANTIMONY. ARSENITE OF COPPER This heroic- remedy has always been a favorite one with me. Many years before it was proven by Dr. Blakey I had used it in many cases, and with uniformly good results. I selected it according to the indications afforded by the well-known provings of both drugs, and from the recorded cases of poisoning found in the standard works on toxicology. The reports of poisoning by sleeping in rooms which had paper colored with Scheele’s green upon the walls afforded me many excellent indications. I first used it in some severe cases of cholera which occurred in the years 1866 and 1867. These cases were marked by the usual intestinal disorder, to which was added severe and painful cramps in the abdomen and extremities. The alternation of Arsenicum and Cuprum did not prove as satisfactory as I expected, but the use of Cupric arsenite, in the 6* trituration, in water for chil- dren, and dry on the tongue in adults, generally acted promptly. I can recommend it in cholera infantum, spasmodic and neurcdgic pains in the bowels, accompanied by screams, and cramps in the fingers and toes, attended with great debility and threatened col- lapse. I have also used it with good effect in chorea, dependent on a profound affection of the nervous centres, and presenting the well-known characteristic symptoms of Cuprum, united to the dyscrasia which always indicates Arsenic. In the treatment of some anomalous disorders of the heart, which may be designated as cardiac chorea, it is eminently suc- cessful. These cardiac disorders have not until lately been suf- 46 ARSENIATE OF IRON. ficiently understood. They are marked by singular aberrations in the rhythm of the heart’s action ; at one time the beats are very irregular and feeble, at another violent and irregular. The attacks appear in paroxysms, with intermissions, during which neither auscultation or percussion reveals anything abnormal in the action of that organ. In some cases the irregular cardiac action is changed to choreic movements in other parts of the body. In several cases of this character which have come under my care, the 3X trituration several times a day for weeks has succeeded in permanently curing a malady which is very distressing, if not serious. ARSENIATE OF IRON. I do not know if this remedy has been used in our school by any one but myself. I came to use it in this wise: I had a case of chorea in a pale ansemic girl. She had been dosed on the Tine, ferr. mur., Citrate of iron and Quinine, Fowler’s Solution, and other drugs; but I felt that Ferrum was indicated. Arsenic was also indicated, and as a matter of convenience I had prepared the 2* trituration of the Arseniate of iron. This patient, who had been dosed with massive doses of both medicines without good effect, recovered rapidly under the use of minute doses of this compound drug. We have no provings of this drug, nor do I know that any are necessary. If we take the well-known effects of both as a basis for our indications, we shall succeed very well and avoid alterna- tion. There are very few drugs, if we except the bromide salts, which are changed by a true chemical union. I have used the Arseniate of iron a good deal, and its effects have rarely disap- pointed me. My selection has been based on the Ferrum blood- impoverishment, and the well-known effects of Arsenicum on the nervous system. I have never used it in any gastric or intestinal disease, because I have an idea that the Arsenicum alone, or the Arsenite of cop- per, is a better remedy for such cases. But if I had to treat cuta- neous diseases in which Arsenic was indicated, and the patient was decidedly chlorotic or anaemic, I should prescribe the Arseniate of iron with a great amount of confidence. AESENIATE OF QUINIA. 47 ARSENIATE OF QUINIA. This is another unproven drug, which I think ought to be used more than it is by our school. My experience with it in a certain class of malarious diseases has been quite satisfactory. While en- gaged in practice in a miasmatic district I frequently had to treat mismanaged intermittents of an obstinate character. They were generally of a mixed type; sometimes tertian, then quotidian, and often changing to a mashed form, such as periodical neuralgia and various obscure neuroses. To treat such cases was like chasing a 11 will-o’-wisp ” through a dark swamp, especially if I tried to treat them symptomatically. In fact, I can assure you that it is useless to treat the symptoms of such cases, for you will have to change your remedy every day, and then fail to cure the disease, which will constantly elude you. You must strike at the root of the malady ; you must select the remedy for the genius of the dis- ease, first; afterwards characteristic symptoms may be taken into account. In the majority of these obstinate and masked intermittents both Arsenicum and Cinchona are indicated, and instead of using them in alternation I hit upon the plan of prescribing this com- pound or . chemical union of the two drugs. Some cases required the lx trituration, but rarely did I have to use it below the 2X. It was usually ordered in doses of one or two grains every two or four hours, and the patient was urged to persist in its use for sev- eral weeks. This plan, aided sometimes by a temporary removal to a non-malarious region, was generally very successful in eradi- cating the disorder. Dr. George A. Hall, and several other physicians of Chicago, are enthusiastic in their praises of this remedy. ITe values it very highly in all diseases where Arsenic and China are indicated. In diseases of children, characterized by chronic intestinal derange- ments, combined with debility from loss of fluids and poor nutrition, he prescribes the 3X trituration with good results. I have never given it higher than the 6th dilution. Pellets sat- urated with this attenuation often act kindly in children of sensi- tive nervous systems. I believe it will prove a valuable addition to our Materia Medica. 48 ARSENIATE OF STRYCHNIA. Dr. W. IT. Plolcombe, in a clinical lecture on “Primary Chronic Malarial Poisoning/’ says: “ It is only by prolonged treatment that we can effectually cure these insidious and complicated chronic diseases. If the remedy now chosen fails to make an im- pression in a fortnight, I shall probably remind you of two others which I have found exceedingly valuable in these cases of chronic malarial poisoning. These are the Arseniate of quinine and Ar- seniate of iron. I use them in the first centesimal trituration, not the decimal, for there is too much Arsenic in them for that. I prefer the former when the nervous system is more deeply impli- cated than the organic; and the latter when the anaemia seems to be the preponderating element in the pathological state.” ARSENIATE OF STRYCHNIA, Several months ago the Liebig Manufacturing Company of New York sent me, among several new and unique drugs, a small quantity of the Arseniate of Strychnia, from which I had prepared triturations up to the 6th centesimal. It occurred to me that cases might occur in which both remedies might be so strongly indicated that I would feel justified in giving this combination. These powerful remedies affect the human organism in a very different manner. Arsenic affects profoundly the fluids of the body, the glandular organs, and the mucous system. Strychnia has as great an affinity for the nervous system, especially the spinal cord—the motor and trophic nerves. My first case was one of chronic diarrhoea in a child. The diarrhoea choradentes were all covered by Arsenicum. But there were many symptoms which called for Nux, or its alkaloid, Strychnia, namely, paralytic conditions of the bladder, rectum, and lower extremities. I might have given Arsenicum until its symptoms were cured, then followed it by Nux to cure the remainder. This would be following the strict Hahnemannian doctrine as taught by some of our school. But I doubt if Hahnemann himself would have done so in this case, for the condition of the patient was such as to cause serious anxiety, and it would not answer to lose time in treating him secundum artem. Therefore, I prescribed Ars. Strych. 4th, ARSENIATE OF STRYCHNIA—ARUM TRIPHYLLUM. 49 one grain every three hours. The result wras all that could be desired—a rapid recovery followed. This case will afford an example of the class of diseases for which this remedy is indicated. I cannot imagine a bigotry so narrow as to deprive one of using a drug because it has not been proven, especially when we are well acquainted with the patho- genetic action of its constituents, as in this case. Some of our remedies, which have made the best cures and have served most to make Homoeopathy popular, have not been proven. I recommend a trial of this remedy in complicated disorders, when the mucous, glandular, and nutritive system is deranged, and the nervous system is seriously implicated ; in the various forms of paresis, paralysis, chronic ulceration, wasting diseases, and even cholera, typhus, and malignant dysentery. AEUM TRIPHYLLUM. This Northern representative of a family which, in the tropics, attain great size and intense virulence, has been used in the dried state, ever since the settlement of the United States, for coughs of various kinds. The dry bulb is almost tasteless, the acrid volatile principle having escaped. The homoeopathists were the first to use any preparation of the fresh bulb. It is very difficult to pro- cure a permanent tincture of the fresh root. Alcohol does not preserve it. Glycerin with alcohol is some better. A distilled water, to which sufficient alcohol is added, may be a successful method of preparation. The virtues of the drug doubtless reside in the acrid, volatile principle, and it is probably the minute quantity retained in the dry bulb which gives it some of its curative power. Its sphere of action appears to include the mucous membrane of the mouth, fauces, larynx, and bronchi, and it probably exerts some disorganizing effect on the blood. It has been used success- fully in Malignant scarlatina, with “ delirium; nose discharges much watery, thin, ichorous fiuid, making the nose, lips, and corners of the mouth cracked, sore, and bleeding; excoriation of the inside of the mouth ; tongue red, papillae swollen and prominent; sore, 50 ARUM TRIPHYLLUM ARUM DRACONTIUM. moist places in the bends of the thighs and knees; submaxillary glands swollen; voice hoarse; pulse 140, full; urine very abun- dant and pale; eruptions all over the body, with much itching and restlessness.” Another symptom, which is an important “ key- note” for this remedy, is “ the children pick the nose and lips and chin persistently, until they are raw and bleeding.” In a few cases where this symptom was very prominent the Arum has appeared to act promptly. In its relation to scarlet fever it is analogous to Arsenic, Nitric acid, Ailantus, and Phosphorus. It is used from the 6th to the 200th. Sudden hoarseness and loss of voice, in public speakers and others, is promptly cured by Arum. Tonsillitis, sudden and painful, oedema of the glottis, catarrhal angina, glossitis, and similar inflammatory affections of the mouth and throat, should be cured by this remedy. In all these diseases the symptoms indicating the Arum are the pricking, stinging pains and the sudden swelling of the tissues, as well as the subsequent burning, excoriating discharge. The British species, Arum maculatum, is nearly identical, and may be used for the same symptoms as the A. triphyllum. Its value in coughs and asthmatic affections has not been fully tested; further experience and provings are needed. AKUM DKACOMTUM. This drug was proven by Dr. C. P. Hart, of Wyoming, Ohio, and was published in the “American Homoeopathic Observer ” of the year 1875. Dr. Hart was forty-six years of age, and seemed quite susceptible to the effects of the drug, although he states that he “ never before had any laryngeal, bronchial, or pulmonary dis- orders.” This proving was not incorporated into Allen’s “ Ency- clopedia of Materia Medica,” because tlie first volume of that work was published the year before the proving was published. Dr. Hart’s proving of this species of Arum is an excellent one. It brings out some of the finer, as well as the general character- istics of the remedy. The Arum dracontium is the only other species besides the Arum triphyllum and Arum quinatum in the United States. All the family of Aracece possess similar acrid, ARUM DRACONTIUM. 51 poisonous principles, but it is one of the mysterious works of the Great Designer that this virulent poison is enveloped in one of the purest and most innocuous vehicles known, namely, arrowroot. Much of the arrowroot of commerce is made by separating it from the acrid principle in the roots of members of this family. It is interesting to note the resemblance in pathogenetic effect be- tween the various species of Araoece. The symptoms of the three Arums are very similar. Dr. Hart’s proving has developed also a marked resemblance between the Arum dracontium and Caladium (Arum sequinium). Both cause pruritus of the sexual organs and incompetency. Both cause urticaria and other eruptions, proba- bly neurotic, as Dr. Hart suggests. Both cause laryngitis of an aggravated character, and both have cured all the above condi- tions. A near relative of the Arum, the Symplocarpus (Skunk cab- bage), ought to be proven; also the Alisma plantago. Dr. Streeter uses Symploearpus in nausea and vomiting of pregnancy, and it lias been found useful in hysteria and chorea. Dr. Hart theoretically recommended it for laryngeal diseases, especially for those of a subacute or chronic character. He gave but a few clinical verifications, but they were very suggestive. One case was “asthmatic attacks at night, from a cold, which had resisted Lobelia and Tart. em. A few doses of the Arum d. lx trit. arrested the paroxysm.” Another case: “A child three years old; hoarse, croupy cough, with sore throat, rattling, laryngeal respira- tion, and considerable swelling of the air-passages, threatening suffocation. A dose of the 3* ameliorated in twenty minutes, and after three doses the child slept quietly till morning.” Since these cases were published, Dr. Hart and others, with myself, have frequently verified these clinical observations. Dr. Hart says it cured him of a “ chronic pruritus scroti of twelve years’ standing.” This reminds us of the action, both pathogenetic and curative, of Caladium. It may prove a very valuable ear remedy. symptomatology op arum dracontium. (Green Dragon.) Analogues. Arum triphyllum, Arum maculatum, Arum italicum, Ailantus, Argentum nit., Belladonna, Causticum, Carbo veg., Eryngium, 52 ARUM DRACONTIUM. IJepar sulph., Iodine, Kali Inch., Nitric acid, Merc, iod., Phos- phorus, Phytolacca, Rhus vernix, Sticta, Sulphur, Sanguinaria, Spongia, Wyethia. Head and Neck Shooting pains in the left anterior inferior triangle of the neck near the clavicle. Head feels heavy and aches slightly in occipital and right parietal regions. Eyes. Aching pain over the left eye; pain transient; conjunctiva highly injected. Eyelids dry, stiff, and slightly agglutinated at their edges, which burn and smart. Heat, dryness, and smarting of the eyelids. Ears. At 8 A.M. shooting pains in the right ear. They are transient but frequent, and leave a feeling of fulness and slight aching in middle ear (next day changed to left ear, same symptoms except no shooting pains; feeling of warmth and fulness in left middle ear); next day is again in right ear; left ear normal. A feeling of warmth and fulness in the ears, sometimes in one and sometimes in the other; seldom in both at once ; aching pain behind right ear; shooting pains in the right ear, sometimes very severe; deep shooting pains in the right ear, occurring frequently and continu- ing sometimes for ten or fifteen minutes; the ear-pains are still more persistent; occasional shooting pains in left ear; accumula- tion of mucus in the left Eustachian tube. (See Throat Symptoms.) Nose. Eruption of pimples; a species of lichen on the nose. Mouth and Fauces. In five minutes felt a peculiar acrid sensation in mouth and throat. Disposition to swallow arising from excess of mucus in throat; a slight uneasiness in throat and disposition to cough; slight soreness of muscles of throat; excess of mucus in throat; loose cough with dry soreness of the throat closely simulating a mild attack of catarrhal angina—most marked during the act of ARUM DRACONTIUM. 53 deglutition. *There is a feeling of dryness and smarting in the throat, a feeling of rawness, with a sense of fulness, not really painful, but sufficiently annoying to attract constant attention. * Hawking; ; expectorated a quantity of thick mucus; produce a continual disposition to clear the throat by swallowing and coughing. * Throat raw and tender. Aphthous ulcer appeared on the tongue, and on the following day (seventeenth of proving) the mouth and throat became so sore that the proving had to be discontinued. For the week following was troubled with an annoying cough and rattling of mucus; worse at night lying down. One week later recommenced the proving, causing * constant rawness of the throat, constant coughing, with mucus in the morning; bad taste in the mouth; tongue and mouth coated with a foul, slimy mucus having a putnid taste. Expectoration consisting of thick, heavy, yellowish white pus (?); continuation of violent cough; rawness of throat and purulent expectoration. Rattling of mucus in the larynx at every full expiration, which disappears in the morning. Accumulation of mucus in throat, the raising of which by coughing produces a rattling of mucus in larynx. Excess of mucus in larynx (see Throat); increased *sore- ness of the larynx, and great disposition to cough. * About mid- night great oppression of breathing, soon passing off, leaving con- siderable rattling of mucus in the larynx and upper part of the trachea. Rattling of mucus in the larynx during expiration, but which ceased on rising except when the expirations were prolonged by voluntary effort. *Paroxysms of dyspnoea would sometimes occur with much aching in the chest, always associated with a con- siderable secretion of mucus in the larynx and trachea. Much rattling of mucus in the larynx and an annoying cough. Cough from laryngeal irritation, worse at night and when lying down. Expectoration of thick, heavy, yellowish-white pus from larynx in large quantities. Very much annoyed by the gravity and persist- ence of laryngeal symptoms; its influence is deepseated and per- manent on the larynx. (Hart.) Oroupy cough, with hoarseness and rawness of the throat—during an epidemic influenza. (Hale.) Larynx. 54 ARUM DRACONTIUM. Stomach. Eructation of flatus from the stomach, tasting of the medicine. Pain in the bowels, caused by incarceration of flatus; escape of flatus from stomach and bowels; sinking feeling at the pit of the stomach; copious semi-liquid stool, with much flatus; bilious passages from the bowels, attended with aching in the abdomen and burning in the rectum ; twenty-four hours later, a bilious diarrhoea, borborygmus, and the escape of much flatus from the bowels. Urinary. Irresistible desire to pass urine, which is diminished in quantity, very high-colored, and has a burning or smarting effect on the urethra. (Primary.) Second day, frequent, copious emissions of limpid urine; inclination to urinate every hour or so during the day; urine increased to four or five times the normal amount; tenderness and slight smarting or burning of the orifice of the urethra, especially during micturition. (Secondary.) Sexual. During the proving a great diminution, and most of the time an entire absence of the sexual desire; penis flaccid and relaxed. This condition of generative organs continued for a long time afterwards. Fine shooting pains in the course of the left sper- matic cord. °Chronic pruritus scroti. Respiratory Organs. Retired to bed and slept well the first part of the night, but *awoke about midnight with great oppression of breathing, a kind of asthmatic attack, which, however, soon passed off. Great lan- guor and depression of spirits; dull, heavy aching in head and chest. *Paroxysms of dyspnoea would sometimes occur, with much aching in the chest, and always associated with a consider- able secretion of mucus in the larynx and trachea. On the nineteenth day of proving, a full dose produced a vio- lent asthmatic attack at night, and lighter ones on each succeeding night, for about a week, when they left me altogether. ARUM DRACONTIUM. 55 Pulse. 80, full, hard, and somewhat jerking, which soon becomes small and irregular; artery seems to roll under the finger, and requires considerable pressure in order to be correctly counted. Later, the pulse becomes moderately full and more regular. The pulse continues full, soft, and regular. On third day after taking a large dose, pulse became feeble, 84—small, and somewhat irreg- ular. Heart. Five minutes after taking a dose the heart beat so violently as to shake the walls of the chest (reflex symptom—Hale), slight aching pain in prsecordial region and down the left arm, flushing of hands and face, and increased heart’s action. Aching along the spine, particularly between the shoulder- blades and the lumbar region; great weakness across the loins; feeling of extreme prostration. The last-mentioned symptoms continued to increase until the exhaustion became so great that I had to retire early. Back. Extremities. Tingling, or slight stinging sensation in the fingers, as when circulation is impeded ; fine tingling sensation all over the right hand, which is warmer and redder than the left, and appears somewhat swollen ; aching pain in the left forearm, left hand, and right humerus; tingling or slight stinging sensation in the toes, as when circulation is impeded; sharp, shooting pains at the sty- loid process of the right ulna; right hand remains somewhat red and swollen. Fine tingling or pricking sensation in the hands and feet, especially the right. Shooting pain down the right thigh. Fine pricking or tingling sensation in the feet and hands, beginning in right foot, and afterwards affecting in regular succession the right hand, left foot, and left hand. Occasional shooting pains have occurred during the same time, in the follow- ing order: right malar region, right external malleolus, thenar eminence of right thumb, left malar region ; occasional shooting 56 ASARUM CANADENSE—ASCLEPIAS INCARNATA. and aching pains along the right humerus and right thumb. Slight aching pain in the pnecordial region and down the left arm. Aching pain along the outer aspect of the left foot, imme- diately followed by a similar pain in the corresponding part of left hand; shooting and aching pains in the left brachial plexus of nerves. Sharp shooting pains at the styloid process of right ulna. Preternatural heat in the palms of the hands; burning of the soles of the feet. ASARUM CANADENSE. This plant only differs from the Asarum Europceum in degree. Its effects are similar to the foreign root, but less irritating and potent. The same qualities, however, have been ascribed to both. The indigenous species has the reputation of being an “em- menagogue and abortivant” in domestic practice. In Europe and England the foreign species has the same reputation, and is even credited with the power of causing miscarriage. That the foreign plant possesses an irritant action on the uterus is proved by its pathogenesis and the testimony of the old physi- cians. Our species may have the same action, but in a minor degree. I have never used it but once, and then in a case of pain in sacrum following miscarriage. It seemed to relieve. It was prescribed as a substitute for the A. Europoeum. Theoretically I should place it as an analogue of such new reme- dies as Senecio and Trillium. ASCLEPIAS INCARNATA, When this remedy was mentioned in the second edition of “ Hew Remedies/’ I supposed it would be used and proven, but no clinical experience has been reported. I have tried it several times in gonorrhoea, on the recommendation of Dr. Hauser, but without good results. Dr. Fowler recommended it in amenor- rlioea, but no verifications have been reported. Only a systematic proving will show its real value as a medicine. ASCLEPIAS SYRIACA. 57 ASOLEPIAS SYRIAOA, (A, Oornuti.) This is really a potent plant, and one that ought to prove useful if prescribed with judgment. The proving by Dr. Cler- borne was a singularly careful physiological experiment for a member of the allopathic school to make. The head-symptoms were quite notable, and the following symptoms are especially valuable : (1.) “When the drug did not cause sweating or profuse urina- tion, it caused violent headache with vertigo, pulse quick, full, 92.” (2.) “A feeling as if some sharp instrument was thrust through from one temple to the other, with feeble pulse and cold skin.” (3.) “Violent headache between the eyes; a sense of constric- tion across the forehead.” I would particularly recommend it in Congestive headaches from suppression of sweat or urine and fever. Also Nervous headaches, which are attended by dry skin and scanty urine, cool skin and feeble pulse, and followed by sweating or pro- fuse urination. In the latter cases it may rival Ignatia, Pulsatilla, or Gelseminum. Diarrhoea, brown or yellow, with nausea and vomiting, and the headache above described in the second symptom. Constipation has been cured by the administration of 10 to 30 drops of the tincture three times a day. I predict that its chief curative value will be confined to those cases in which the organic and inorganic solids, which should be eliminated by the urine, are not excreted fully. Like Colchicum it causes the amount of solids excreted to greatly increase (from 565 grs. to 700 grs.), or an increase of 132 grs. in six days. This power would make it the best remedy in the uraemia of pregnant women, or for any cause; also in post-scarlatinal dropsy, when it would rapidly eliminate the poison of the disease, and prevent the unpleasant sequelte. Dropsy, especially when caused by renal diseases of an obstruc- tive character, ought to be cured as readily by Asclepias s. as by YOL. IX.—5 58 ASCLEPIAS SYRIACA—ASCLEPIAS TUBEROSA. Apocynura, and perhaps more promptly. In the provings it caused the urine to increase from the normal quantity of 35 ounces to 135 ounces in six days. This shows its immense power over the secretory power of the kidneys, and that it is secondarily ho- moeopathic to dropsy, for the secondary effect of such hyperstim- ulation must be an almost complete arrest of secretion and excre- tion. It has cured many cases of renal dropsy when given in the tincture and infusion. I have palliated many cases of cardiac dropsy by its use, and with many of my colleagues it has a high reputation in acute cases of anasarca from sudden check of perspi- ration. Since the last edition of this work was issued, clinical experience has verified its great value in all forms of dropsy. It is homoeopathic to dysmenorrhoea and threatened abortion, when the pains are intermittent, and pressing from the sacrum to the hypogastrium, with scanty flow. Rheumatism has been successfully treated by many physicians by the use of this species. Dr. Lee says it rivals Cimicifuga. Dr. Pattee states that in six cases of acute rheumatism it caused the average duration to be confined to eight days. The inflammation was confined to the large joints, with considerable pain and swell- ing. It had a remarkable effect in relieving the pain. The low- est dilutions will probably be found most useful. ASCLEPIAS TUBEROSA. This plant, commonly called Pleurisy root, is one of the oldest in use, and one of the most popular of all our indigenous reme- dies. The popular name given to the root indicates the estima- tion with which it is held. The early physicians incorporated it into the Pharmacopoeia, and its use by eclectic practitioners is va- ried and extensive. Their principal use of this Asclepias is in disorders of the respiratory organs, and in nearly the same con- ditions as we use Bryonia. We have only two provings of this remedy, one by Dr. Savery, of France, the other by Dr. Niehol, of Montreal. The former I consider untrustworthy in the main, because only two drops of the tincture were taken, and all the symptoms for forty days recorded ! Dr. Niehol took every day ASCLEPIAS TUBEROSA. 59 twenty to forty drops of the 1* dil. and 0, and got symptoms which were characteristic. I believe this Asclepias acts chiefly on the mucous surfaces, es- pecially those of the respiratory organs, and the serous tissues, especially the pleura and synovial membranes. It is common in the country for the people to treat pleurisy and pleurodynia with an infusion of the root. When sweating oc- curs, the pain subsides. Bronchitis is also treated successfully in the same manner. Our provings testify to the fact that it is ho- moeopathic to these atfections. The chest symptoms of Nichol’s provings are : “Cough dry and spasmodic, with constriction of the throat; harsh, dry cough, causing pain in the forehead and abdomen. “ Dull pain at base of both lungs, with a feeling of tightness. “Sharp pains shooting from left nipple downward. “Sharp, cutting pain behind the sternum,aggravated by breath- ing, moving the arms, singing, or loud talking. “Acute, darting pains in left side, shooting over to the right, and up to left shoulder, with tenderness of the spaces between the ribs. “The pains left the left side and attacked the right side, and extended to right shoulder. “The pains werq relieved by bending forward.” These symptoms give us a fair picture of a case of subacute pleuritis. The fever was slight (pulse 88). I have used it successfully in mild cases of pleurisy and inter- costal rheumatism, giving the 1* frequently repeated. Dr. Nichol had many rheumatic symptoms. The pains were stitching and aggravated by motion. The Asclepias is especially adapted to the diseases of children, not only the thoracic but the intestinal. It resembles Ipecac, in this respect. It is also useful in asthmatic complaints and catar- rhal atfections of old people. It is useful in the coughs and colds of children, in “snuffles,” in catarrhal croupy coughs, and suffocative catarrh. The fever attendant is not very severe, the skin is hot, but at the same time moist. It is indicated in those cases of catarrhal fever in which the intestinal mucous membrane 60 ASCLEPIAS TUBEROSA—ATROPIA. is affected simultaneously with the bronchial, and as having slimy, green alvine evacuations. I have prescribed it with benefit in subacute rheumatic peri- carditis, when there was pinching pain in the region of the heart, extending to left shoulder, palpitation, feeling of contraction in the cardiac region, tenderness over that region, fever, with hot, moist skin. Catarrhal dysentery, with rheumatic pains all over, yields read- ily to this medicine. I usually use the mother tincture or lx, 20 drops in half a glass of water, a spoonful as often as seems neces- sary. If oftener used, instead of Bryonia, I think it would gain in favor with our school. ATROPIA, It may seem out of place to call this drug a new remedy, when Belladonna is so old, but Atropia was not used in homoeopathic practice until about the year 1860, or about the time the new remedies began to appear in our school. No complete provings of Atropia have been made, but the symptoms which have been obtained, both from provings and cases of poisoning, are identical with many of the symptoms of Bella- donna. Atropia cannot cause all the symptoms of Belladonna, any more than Quinia can cause all the symptoms belonging to China, for the reason that it does not contain all the medicinal forces re- siding in the plant. To the mere chemist, or the crude experi- menter, there seems nothing of value left in the plant after the extraction of its active principle. But they do not appreciate the fact that there are intangible or atomic forces in plants which do not reside in any alkaloid or resinoid, and will escape the subtlest analysis of the chemist. These medicinal forces can only be evolved by careful physiological provings on the healthy. Atropia, therefore, cannot represent the Belladonna in the treatment of disease, except in its own limited sphere. I cannot advise the use of Atropia in the febrile diseases, in acute or chronic exanthemata, inflammations of organs and tis- sues, or certain cerebral disorders, for which we have in Bella- donna such an admirable remedy. 61 ATEOPIA. Its sphere of action appears to me to include the nervous system, affecting alike the nerves of sensation, motion, and the sympa- thetic. In functional disorders of these nerves, especially when hyper cesthesia and irritation obtain, Atropia will prove a valua- ble remedial agent. In neuralgia., certain acute congestions of a nervous origin, painful spasmodic affections, especially of the sphincters, and ner- vous jactitations, hypersesthesia, spinal irritation, etc., Atropia will often do better service than Belladonna. Its action is analogous to Solanum, Stramonium, Agaricus, and many of the analogues of Belladonna. I cannot accept the assertion of allopathic experimenters that Atropia contracts the bloodvessels of the brain and spinal cord. We have abundant evidence that it causes death by acute conges- tion of the brain. As to its action on the bloodvessels of the spinal cord, I am not prepared to dispute the statement of Brown-S6quard, who says that “ it is a powerful excitant of bloodvessels, and espe- cially those of the spinal cord and its membranes. In consequence of this influence, it diminishes the amount of blood in the vertebral canal, and in so doing produces a relative diminution of the vital properties of the spinal cord and its nerves.” But granted that this is its primary action in toxical doses, its secondary action is directly opposite. In death from poisonous doses, the surface of the body is pale and cold, and the internal organs all congested. But death must in such cases occur from its secondary action. Death rarely occurs from its primary action. In homoeopathic practice, we usually prescribe Atropia for symptoms similar to its secondary effects, for all the morbid con- ditions which I mentioned as indicating Atropia are due to such secondary action, or for symptoms of irritation of the motor, sensi- tive, and vasomotor or nutritive nerve fibres of the spinal cord, or of the roots of its nerves; or, in other words, in cases of conges- tion, meningitis, myelitis, and cerebro-spinal meningitis. Pain anywhere in the body is not properly a primary effect of Belladonna (Atropia) any more than of Opium (Morphine.) Contraction of the bloodvessels of the spinal cord and brain correspond to painlessness in the parts supplied by the nerves hav- ing their origin in such locations. 62 ATROPIA. Atropia causes primarily such conditions, but secondarily it causes congestion, and even inflammation, bringing with it pain, spasm, hyperaesthesia, etc.,—all the consequences of irritation of nerve-tissue. In diseases of the brain I rarely find Atropia of service. If we use it at all, it must be used cautiously, and Belladonna is to be preferred in all but purely functional disturbances. Certain it is that in hemicrania, facial neuralgia, neuralgic cephalalgia, and other very painful affections of the nerves of the head, the 2d c. trit. of Atropia is one of our most successful remedies. In acute congestion, however, when the face is red, temples throbbing, eyes bloodshot, ears ringing, and wild delirium, who would dare to give any but the high attenuations of this drug or of Belladonna? In typhoid fever, particularly typhus-cerebralis, when nightly delirium, spectral illusions, wild, uncontrollable laughter, obsti- nate insomnia, and often furious delirium and redness of the face occurs, the 6th of Atropia will often dissipate the troublesome symptoms, due in this case to irritation of the brain from conges- tion. On the other hand, we meet with cases of advanced typhoid, where, with the general prostration, there is insomnia, with ram- bling, incoherent muttering, coma vigil, with picking at the clothes, very dry tongue, pale, cool face, 'etc., due to cerebral anaemia with irritation. Here we find Atropia' 2d c. trit. an admirable remedy. I will briefly enumerate the disorders in which Atropia has been found efficacious in our practice, when used in the 2d or 3d centesimal triturations : Neuralgia, especially of the head, face, and eyes. Gastralgia, purely neuralgic. Enteralgia, a neuralgia of the abdominal nerves. Nephralgia, neuralgic, or owing to passage of calculi. Violent, irresistible, and ineffectual urging to urinate, with agonizing tenesmus, both vesical and rectal. Nocturnal enuresis, from paralysis of the sphincter. Ovarian neuralgia, and uterine colic. ATROPIA—AURUM ARSENIOSUM. 63 Vaginismus, when purely spasmodic and neuralgic (internally in the 6X trit., and apply a cerate of gr. i to 5j of simple cerate). Whooping-cough, with violent paroxysms very frequent, and ex- pectoration of very tough mucus. Chorea, tetanus, and even convulsions. I would advise you to carefully study not only the symptoms I have collated in “New Remedies,” but the careful experiments recorded in the best allopathic works on toxicology. In Wood and Stille you will find most of value. AURUM ARSENIOSUM. This new salt, combining as it does two most potent remedies, ought to become one of our most powerful agents against many destructive diseases and mental disorders. I would recommend it for the following affections: Suicidal mania, accompanied with great fear of death, i. e., a powerful impulse to commit suicide owing to deep melancholy, but at the same time great fear and anxiety relating to'death. Chronic headaches due to syphilis, necrosis, periostitis, and ozoena, presenting a combination of the agonizing bone-pains of Gold with the intense neuralgic pains of Arsenic, especially after Iodide of potassa has failed. Cancer of the face, nose, and uterus ought to come under its curative sphere. Also malignant diseases of the intestinal tract. There is a large class of chronic diseases which seem to indicate both of these constituents, and we hesitate which to select. Here is a field for the application of this remedy. It is best administered in the triturations from the 3X to 6\ To Hr. Chrestien is due the credit of being the first to use a combination of Gold and Arsenic Chrestien having treated phthisical patients with the Chloride of gold and Arsenic alternately, immediately discovered the similarity of their action. The first applications in France were made by Hr. Massart, who administered the Arseniate of gold in cancer and in phthisis, and who had the honor of seeing his remarkable work approved by the Societes de Medecine of Lyons and Toulouse. Italian and American observations have established beyond a 64 AURI ET SODII CHLORIDUM. doubt that diseases, such as lupus, depending upon scrofula, are rapidly ameliorated and ultimately cured by the Arseniate of gold. The first effect of the Arseniate of gold is a rapid increase of ap- petite. As Harless, Biet, and Cazenave have already remarked, the peristaltic contractions of the stomach and intestine are ex- cited, and absorption occurs with greater rapidity. The Arseniate of gold then directly involves the nutrition of the anatomical ele- ments, and consequently exercises a direct effect upon the different varieties of anaemia and chlorosis. AUEI ET SODII CHLOBIDUM, The proving of the Chloride of Gold and Sodium by Lembke, in Allen’s “ Encyclopedia,” is very incomplete and unsatisfactory. It is the most active of all the preparations of Gold. In toxic doses it causes violent gastro-enteritis, accompanied by cramps, convulsive trembling, insomnia, priapism,, insensibility, and other serious symp- toms. In pathogenetic doses it causes epigastric pain, nausea, loss of appetite, and constipation. The constipation is peculiar, in that it is accompanied by an increased secretion of mucus from the in- testinal glands. It is, therefore, homoeopathic to constipation with intestinal catarrh, resembling in this respect Hydrastia. I have found this preparation useful in the following: Nervous dyspepsia, with melancholy, desire for death, a red, glazed tongue, pain in the stomach (left side) of a burning, drawing, press- ing character, after eating, with tendency to diarrhoea after eating. Gastric and duodenal catarrh, and in some cases of jaundice from catarrh of the gall-ducts, when the peculiar suicidal melancholy is present. Syphilis, after abuse of Mercury, or when, during secondary or tertiary stages, the bones of the nose are affected, or the throat is ulcerated. The action of Gold on the organs of generation is deepseated and prolonged. Its primary effect is to cause congestive irritation of the uterus and ovaries, resulting in subacute metritis, ovaritis, profuse and premature menses, habitual abortion, nymphomania, and even ulceration of the uterus and endo-cervicitis. It is, there- AURI ET SODII CHLORIDUM—BADIAGA FLUVIATILIS. 65 fore, indicated in those affections in the sixth trituration and up- ward. The secondary effects of Gold are to cause atonic amenorrhcea, scanty and delaying menses, deficient sexual desire, sterility from ovarian torpor, ovarian dropsy, etc. In ray practice it has been successful in removing these conditions when given in the lowest triturations, lc to 3C. I would recommend a trial of it in cases of puerperal mania with sexual excitement, ovaritis, gastro-intestinal irritation, and suicidal impulses. In men Gold causes corresponding conditions, and is useful pri- marily (in the smallest doses) in sexual erethism from plethora, sem- inal emissions with vivid dreams, strong erections, etc.; and, second- arily, in larger doses (2* to 3X, three times a day), in decline of the sexual power, diurnal seminal losses or nightly emissions ivith feeble erections and no dreams, impotence from weak, inefficient erections, irritability of the sexual organs, and premature emission of semen. Its action is just the opposite of Bromide of potassium, and it is useful in minute doses when the former is indicated in large, and vice versa. An efficient formula for its administration is gr. j of the Gold to Sj aqua dest. Dose 5 drops. The melancholy, suicidal mania and hypochondria of Gold is probably due to cerebral anaemia, as the vertigo, and should be treated with low triturations, for they are secondary effects. Gold causes primarily excessive intracranial blood-pressure (hyperoemia), and aggravation will follow the use of any potency below the third. In some cases of dropsy froni chronic Bright's disease Muriate of gold will act promptly in removing the oedema, by causing profuse flow of urine. (See Burnett’s recent Monograph on Gold, Horn. Pub. Co., London, 1879.) BADIAGA FLUVIATILIS, The provings of this medicine appeared in the “ Ilahnemannian Monthly,” and also in Ilering’s “ Materia Medica,” but no clinical use of it has since been reported. I am not able, therefore, to give any additional information relative to its curative value. I have never used it myself. Many of its symptoms closely resemble those of the marine sponge which we use in practice. 66 BADIAGA FLUVIATILIS—BALSAMUM PERUVIANUM. The head symptoms would indicate its probable value in some cases of headache, and “ tetterlike eruptions on the scalp.” It causes painfulness of the left eyeball, especially the posterior portion, and Dr. Bedford says he has had very good results from its use in “ scrofulous inflammation of the eyes, with hardening and induration of the Meibomian glands.” Hahnemann considered it an antipsoric, but never published any account of it. It contains Carbonate of lime, Silicea, Phos- phate of lime, and a trace of Alumina, which would make it an antipsoric in the sense Hahnemann used the word. Hering says of it: “ A comparison with Spongia, its nearest of kin in the ani- mal kingdom, will show striking similarities and remarkable dif- ferences.” He also compares it with Silicea and Clematis. Rosenstein considers it complementary to Sulph., Iodine, and Mercurius. This last writer reported a complete cure of a chronic syphilitic bubo with Badiaga, after Sulph., Carbo, Clemat., Sil., Iod., and Ars. had been given in vain. Among the new indigenous remedies its analogues are Phyto- lacca, Corydalis, and Stillingia. Hering thinks the Badiaga will be useful for the complaints of adults who had scrofulous complaints in childhood, and which showed again in after life. He adds that it had a reputation in Russia for the cure of haemorrhoids. lie thinks it follows well after Lachesis. I doubt if it will be used much, for we have many similar and more active remedies. It may, however, meet special cases when its analogues fail. Its heart-symptoms are peculiar, and are worthy of attention. EALSAMUM PERUVIARUM. The scientific name of this tree is Myrospermum Peruiferum ; the substance used is the resinous juice which exudes from the tree when cut. It is strange that this agent should be now nearly obsolete with the allopathic school, for when it was first intro- BALSAMUM PEBUVIANUM. 67 duced into Europe by the Spanish Jesuits it was lauded as highly for the cure of consumption and kindred complaints as is now the cod-liver oil. It remains for homoeopathy to take up these neg- lected medicines and make of them valuable curative agents. Although no systematic provings have been made of it, we know enough of it to assert that it is an analogue of Copaiva, Cu- beba, Chimaphila, Stannum, Thuja, and Uva ursi. Its sphere of action is upon the mucous membranes, especially those of the respiratory tract. Its special indication is for muco- purulent discharges—yellow, green, and fetid. The pathological condition calling for its use is doubtless torpid indolent ulceration, or purulent catarrh. For many years I have made extensive use of this balsam, and have seen most gratifying results in the following affections : Chronic, purulent, fetid anterior or posterior nasal catarrh, with or without ulceration. Coughs, with copious expectoration of thick, yellow, green, and fetid pus. This condition occurs commonly in old people, and scrofulous subjects, and may arise from laryngitis or bronchitis, or neglected catarrh of those organs. It will not cure tubercular phthisis, but may act as a useful palliative. My usual dose is the 1st or 2X dilution, or trituration of the crude balsam. (It seems to act best in trituration.) But I do not confine myself to its internal administration. The most bril- liant results are obtained from its inhalation by means of the steam atomizer. By this means the finely divided atoms come in di- rect contact with the diseased surface. If triturated with equal parts of Carbonate of magnesia and sugar, or pulverized Glycyrrhiza, it will mix with water, otherwise it clogs the instrument. Make of the lx trit., thus prepared, a solution representing in strength the 2X dil., and have its spray inhaled three times a day, each in- halation lasting for five minutes. Dr. Hoffman, in some French homoeopathic journal, reports as to his use of the balsam. He praises it highly in cases of Cough after pneumonia, when it is loose, thick, yellow, and fetid (one-tenth dil.); also in 68 BALSAMUM PERUVIANUM—BAPTISIA TINCTORIA. Suppression of the accustomed expectoration in bronchial af- fections. (6th dil.) (In very large doses the Bal. Peru, lias been known to check copious expectoration, but with resulting fever, dry cough, and oppression, a primary effect of the drug.) Hoffman says : “ I have seen persons laboring under perfectly formed phthisis, and seriously affected for several years, happily restored by the use of the balsam.” I doubt if these persons had tuberculous phthisis. They may have had vomicae, for there are many authenticated cases of vomicce, with offensive expectoration, cured by this balsam. It formerly had a high reputation for Hectic fever, which it doubtless cured by removing the suppu- ration upon which it depended. Not only in purulent discharges from the bronchia is it useful, but I have cured cases of gastric catarrh with obstinate vomiting of food mixed with mucus, chronic mucous catarrh of the bowels (sometimes called chronic dysentery), catarrh of the bladder, and even obstinate leucorrhoea, uterine and vaginal, in which last dis- ease I advise injections of the Aqua bal. Peru., such as above recommended for inhalation. A cerate of the balsam is the best application, next to Glycerole de aloes, for indolent ulcers, cracked nipples, cracks in the fingers and palmar surfaces of the hands, or fissured and chapped lips. It is said that the most inveterate case of itch is cured promptly by one application of the pure balsam, warmed and rubbed all over the surface of the affected skin. BAPTISIA TINOTORIA. This indigenous plant has proved to be one of the most valua- ble additions to our Materia Medica. It has become an indispen- sable agent in the treatment of adynamic fevers and similar dis- orders. There are thirteen species in the United States, and all of them probably have similar medicinal action. I have used—besides the officinal species—the B. australis (blue-flowered), B. leuco- plioea (cream-colored flowers), and B. leucantha (white-flowered), 69 BAPTISIA TINCTOEIA. and can see no difference in medicinal effects and but little in smell or taste. All the above grow in the Northern States. In the Southern States some very large species grow, which ought to be equally if not more potent. Although this remedy covers many grave and important mor- bid conditions, it has not a very wide range of action. It seems to affect principally the blood, impairing its integrity, the nervous system, which it deprives of its normal tonicity, and the mucous surface, which under its influence ulcerates and takes on inflam- matory action, with a decided tendency to unhealthy, fetid dis- charge. It was first used empirically in typhoid and typhus fever, in which its popularity is still very wide,and well deserved. It was for a time supposed that its use was called for in all stages of the malady, but more recent observations seem to prove that its pe- riod of greatest usefulness is during the premonitory and first stage of all fevers of an adynamic type. The testimony is too large and authoritative to be set aside that it possesses a real abortive or preventive power over such fevers, if given at the proper time. Numerous observations and exper- iments, both in England and this country, have shown conclu- sively that if prescribed for the following characteristic conditions and symptoms it will arrest the disease which, but for its influence, would end in the typhoid state: A condition of great prostration, when typhous epidemics abound, at any season of the year. General malaise, with a feeling as if one had been bruised all over; cannot lie on either side long because the part on which he is lying becomes sore; pressure on any part of the body soon causes soreness. The extremities feel too large, tremulous, with “thrilling” sensations in them. General fetid odor from the body, the breath, and all the ex- cretions. General heat, with very dry, red, or brown, parched tongue, and dry throat. Head heavy, confused, internally sore, with a feeling like that preceding delirium. “An illusion, as if he was several persons, 70 BAPTISIA TINCTORIA. and lie tries to get himself together.” (Bell.) Stupor, incoherent raving. The Baptisia is infinitely superior to Aconite, Gelserninum, or Verat. viride in all fevers having a typhoid tendency, while it is nearly useless in the so-called “synochal” fever. The condition is one of erethism rather than inflammation, the pulse rarely goes above 100, and the skin is not as hot and dry as in true febrile conditions. The lowest dilutions, or mother tincture, have generally been most successful in the treatment of typhoids. I prefer the tincture made from the fresh root, one part to nine of alcohol, by weight. Ten or fifteen drops of this preparation in four ounces of water, a spoonful every one, two, or three hours, until a decidedly favor- able change occurs or the symptoms call for Bryonia, Rhus, Ar- senicum, Phosphoric acid, or Terebinth. Not only in the beginning of typhoid fever is the Baptisia in- dicated, but in all similar conditions, whether occurring idiopathi- cally or during the progress of any other disease. For example: If, during the progress of scarlatina, small-pox, pneumonia, bilious fever, dysentery, or puerperal fever, the above symptoms, charac- teristic of this remedy, appear, a few doses will generally dissipate them, and either restore the patient to convalescence or allow the original disease to pursue its normal course. Its action on the cerebro-spinal nervous system is of such a de- pressing character that it led me to suggest it as a probable remedy for “spotted fever” as far back as 1864. Recent observations of its good effects in cerebro-spinal meningitis, by Dr. Searle and others, as well as myself, have proven that in the typhoid variety of the disease it is nearly a specific. It is useful when a condition of general paralysis threatens, the excretions all become offensive, and the blood rapidly tends to disorganization. It may have to be alternated with Gelserninum, Secale, or Calabar, as it rarely suc- ceeds alone in averting that terrible malady. Taking the one symptom, “ putrid odor of the discharges, with dark red or ulcerated mucous membrane,” I have used it exten- sively in chronic sore mouth, whether mercurial or cachectic, in malignant, dysentery or diarrhoea, offensive leucorrhcea or lochia, and even offensive ulcers on the skin. I prescribe it as a topical ap- BAPTISIA TINCTORIA. 71 plication as well as internally. It appears to resemble, in its top- ical effect, Chlorate of potassa and Carbolic acid. In putrid angina and diphtheria it aids the action of Ars. iod., Phyto., and Merc, cyanate. One drachm of the tincture to four ounces of water makes an efficient gargle in such cases. One peculiar symptom indicates Baptisia in some sore throats. The throat may look dark purple, livid, and as if very painful, but it is not. Dr. Miner cured an inveterate sore throat which was not painful (with the 30th). There are two gastric symptoms of Baptisia which are worthy of notice, namely : (1.) “ Gone, empty feeling at the stomach.” This symptom is readily removed by Baptisia when it is the result of anxiety, grief, night-watching, or fasting, provided the breath is fetid and the tongue dry. If not, then Iguatia or Caladium is more appropriate. Dr. reports a case of “ dyspepsia after typhus,” presenting “sinking at the stomach, frequent fainting, brown, dry tongue,” etc., cured promptly by Baptisia. (2.) “ Nausea, with want of appetite, and constant desire for water.” In the beginning of fever this is often a prominent symptom, and may be removed, with all of its concomitants, by this remedy. The abdominal symptoms are not peculiar, but Dr. Hart reports a case which he believes to be abdominal neuralgia, which he cured with Baptisia. The symptoms were : “ Extreme uneasiness rather than pain; a sensation as of something crawling about in the ab- domen. The paroxysms occurred after midnight, with throbbing and congestion of the bowels, vomiting, purging, and great pros- tration. The pulse, at first accelerated, became slow, weak, and often imperceptible.” My experience with Baptisia in bowel affections leads me to es- teem it highly in all cases of adynamic or typhoid diarrhoea and dysentery, when dependent on an epidemic typhoid miasm, or the result of local septic conditions. If the miasm be malarial (ague poison) it is of small value as compared with Arsenicum, China, Eucalyptus, or Gelseminum. The evacuations indicating Baptisia are usually dark, black, or brown, watery, murky, slimy, bloody, and always particularly 72 BAPTISIA TINOTOKIA. offensive. If, with these appearances, you find a dry tongue, fetid breath, sinking at the stomach, and other characteristic symptoms of this medicine, it will prove a prompt remedy. I prefer the lx or 2X dilution. It has rarely been recommended in diseases of the urinary and genital organs, but there is one condition in which it is specific, namely, in threatened miscarriage from mental depression, shock of bad news, watching and fasting, or from low fever. I have often prevented miscarriage by its timely use. In case of death of the foetus in utero, the mother often falls into a condition in which the “ dreadful sinking at the stomach,” fetid breath, dry, brown tongue, and great prostration, with or without fetid vaginal dis- charge, are the prominent symptoms. Here the Baptisia acts well, preventing blood-poisoning, and aiding Caulophyllum or Ergot in expelling the decaying substance. As an important addenda to my lecture on Baptisia I will give the following excellent comparisons of that drug with Rhus, Ar- nica, and Muriatic acid, by Dr. E. A. Farrington, of Philadel- phia : BAPTISIA. Anxious, certain of death. Delirium constant, low; thinks her head is scattered over the bed, and that she must toss about to get the pieces together. While answering a question, goes to sleep. Mentally restless, yet too lifeless to move; confused as if drunk. Feels as if the top of the head would fly off. Expression besotted; cheeks yellow, with a deep central flush. Teeth covered with sordes ; mouth full of ulcers, fetid breath, aphthae. Jaws rigid; pain. Tongue white, dry, yellow centre (early stages typhus). Tongue dry, dark red, shining, cracked, ulcerated ; or, dry, with a brown streak down the centre, edges clean, red. Saliva viscid, thick. RHUS TOX. Faint, timid, fear of death. Delirium mild, low; thinks that he is roaming over fields, swimming, or en- gaged in some other physical work. Answers correctly, but in a hasty man- ner. Mentally restless; slow flow of ideas; better moving. Feels as if a board were bound across the forehead. Expression listless; or anxious appear- ance ; cheeks dark red. Teeth and mouth covered with thick, hard, brown mucus ; vesicles. Jaws crack; feel stiff. Tongue white on one side, dry (early stages typhus). Tongue dry, hard as a board, hardened, dirty phlegm; or, red triangular tip, cracked, shows imprints of teeth. Saliva bloody, runs out in sleep. BAPTISIA TINCTOEIA. 73 BAPTISIA. Dry mouth, great thirst; spits out the liquid put into his mouth. TJvula long; mucus in the throat, can- not raise or swallow it; can only swallow liquids. Putrid, painless, dark ulcers.* Stool yellow, involuntary, horribly fetid ; sour belchings. Dysentery, great tenesmus with dis- charge of pure blood, no mucus. Urine alkaline, offensive, dark red. Cannot draw a full breath, gasping; tightness across the chest. Heart throbs audibly; seems to fill the chest. Pulse full, whether hard, slow, or quick; variable, threadlike. Cannot lie long anywhere; yet motion is painful. Must change position, the bed feels so hard. Feels as if sinking away; lies with the head thrown back; jaw dropped; sliding down in bed; puti'id breath. RHUS TOX. Dry mouth, unquenchable thirst; re- pugnance to either food or drink. Throat sore as if strained; swallow- ing difficult from paralyzed epiglot- tis, oesophagitis, cannot swallow solid food. Stool yellow, slimy, involuntary at night, almost no fetor; empty belch- ings. Dysentery, tenesmus, discharge of transparent lumps of mucus. Urine albuminous; involuntary at night. Difficult breathing referred to the lower chest and pit of stomach. Heart beats feebly; trembling about the heart. Pulse small, weak and quick, weak and small, threadlike. Cannot remain quiet; motion of the limbs improves.f Must change to relieve the pains in the limbs. Feels as if paralysis were coming on; mouth open; lies as if intoxicated ; involuntary stool and urine. J * The painlessness may decide for Baptisia not only in typhus, but in scarlatina, putrid sore throat, etc., when the suspicious odor and general weak- ness offer a dangerous reason for the absence of pain. The ability to swallow only liquids distinguishes it from Lach., Apis, Canth. Rhus tox. has not so marked a tendency towards putrid ulcers. In oesophageal spasm both can only swallow liquids; but with Baptisia solids simply cause gagging; with Rhus vomiting. f Rhus, in the beginning of typhus during profound weakness, has an ex- ceptional symptom: wants to lie still in one spot. | It would be prematux-e to characterize Baptisia while so imperfectly proved. But in general it shows a heavy besotted face; fetid breath, stool, and urine; dyspnoea from weakness; in the beginning, nervous restlessness. Rhus shows a bland expression, pale waxy skin ; hepatization of lower lobes (hence dyspnoea is referred to the stomach and hypochondria); in the beginning, erethism (hence the nose bleeds, which relieves). YOL. II.—6 74 BAPTISIA TINCTORIA. BAPTISIA. Anxious, certain of death. Falls asleep in the midst of his answer. Lies with head thrown back, lower jaw dropped; slides down in bed. Vertigo, worse stooping. Gasping; breathing as if he could not draw a long breath. Can swallow only liquids; spits out the water taken. Stool involuntary, fetid. Pulse full and slow; variable. Nervous symptoms predominant. BAPTISIA. Goes to sleep while answering. Delirium; cannot sleep, because she must toss about to get the pieces of her head together. Soreness as if in the frontal brain ; wild feeling. Senses generally blunt; besotted, heavy expression. Dull hearing during and after typhus. Cheeks dark red, yellow ground. Aphthae putrid, dark, ulcerating; thick, viscid saliva. Tongue dry, brown down the centre; feels numb or scalded. Goneness; sinking at the stomach. Stool involuntary, putrid; occasional diarrhoea or costive (beginning). Urine offensive, alkaline. Heart-beats seem to fill the chest. Pulse full and slow; variable; thread- like. Slides down in bed ; lower jaw dropped ; putrid breath. ARNICA.* Indifference. Falls asleep, forgetting the words for his answer. Lies quiet, no complaints ; says he is well ; lower lip trembles. Vertigo raising the head. Loud, blowing inspiration and expira- tion in sleep. Pharynx seems “ lame; ” a gurgling noise when swallowing. Stool and urine involuntary. Pulse frequeftt, sunken. Stupefaction from the very beginning. MURIATIC ACID. Forgets what he has said. Delirium; would sleep but cannot; vivid hallucinations of changing im- ages from past to present. Brain feels sore, as if it was tom or had been beaten. Senses generally too acute; distant talk- ing gives headache. Dull hearing, with dryness of ears, or dark wax. Circumscribed glowing red cheeks. Aphthae putrif, small, bluish, deep. Tongue small, bluish or rattling like leather; heavy, as if paralyzed. Emptiness all over the abdomen. Involuntary while urinating; putrid; during crisis, papescent stool relieves. Urine acid; difficult to expel. Heart-beats seem to be felt in the face. Pulse irritated, but without energy; omits every third beat. Slides down in bed; lower jaw hanging; moaning. * Arnica has but little resemblance in the beginning of typhus; but when stupor and petechife appear we find in common such symptoms as: must move, the bed feels so hard ; brown tongue; putrid breath ; goes to sleep while answer- ing, stupid, heavy look, etc. BAROSMA CRENATA. 75 BAPTISIA. Scarlatina with dark, fetid ulcers in the throat; great prostration; petechise; stupor. Stupor resembling that of Arnica and Opium. MURIATIC ACID. Scarlatina with blue feet; dark bluish fauces; scanty eruption; sudden red face; petechia,; stupor. Stupor and nervous weakness after Rhus and Bry. fail. BAROSMA ORENATA It often happens that a drug suffers in reputation from the com- pany it keeps. So with the Buchu. It was taken up by an un- principled adventurer and its fair fame prostituted to the vilest purposes. Previously it had been quite largely and successfully used by the allopathic school as a remedy in abnormal discharges from the urinary organs. Its sphere of action seems to include the kidneys and mucous surfaces of the urinary organs principally. It has also a specific action on all mucous membranes, especially when brought in con- tact with them topically. We should not reject it because it lacks a proving, or because it has been improperly used. It is in chronic diseases of the urino-genital organs, when char- acterized by muco-purulent discharges, that the Buchu seems to act best. I have made some notable cures of such cases when the urinary deposit showed an abundance of epithelium mixed with pus- and mucus-corpuscles. “ Chronic inflammation of the pelvis of the kidneys and mu- cous membrane of the bladder, with copious discharge of mucus,” is mentioned by several authors as curative by this remedy. Irritable bladder, with vesical catarrh, or gravel (Lithic acid calculi), complicated with spasmodic stricture of the urethra or sphincter, has, in my practice, rapidly disappeared under the use of the Barosma. Prostatic disorders have been cured by this remedy when the general conditions coincided (compare Populus, Copaiva, and Thuja). Certain varieties of dropsy have been cured by Buchu, but the cases reported have not been characterized by any peculiar symp- toms. 76 BELLIS PERENNIS—BENZOATE OF AMMONIA. I have cured several cases of vaginal leucorrhoea with this medicine, prescribing it by enema (fl. 5j to §iv) as well as inter- nally. Dr. Stille, in his “Materia Medica,” recommends it as a specific for “undue secretion from the mucous follicles of the urethra, the vesiculse seminales, or prostate, produced by excessive venery or self-pollution.” (I have verified this several times.) It seems to act best in the lowest dilutions, and in some cases a weak infusion cures with surprising promptness. BELLIS PERENNIS. In Dr. Thomas’s additions to “ Homoeopathic Materia Medica” (London, 1868) is a proving of this plant. He recommends it as a substitute for Arnica. He thinks it will prove a specific for boils, bruises, sprains, whitlows, etc., used topically and internally. We have a Daisy (B. integrifolia) indigenous to the United States. It probably has the same properties. I have had no personal expe- rience with either. BENZOATE OF AMMONIA. This preparation was first recommended by Dr. Todd as the best remedy in dropsy after scarlet fever. The symptoms indicating its use do not differ from those laid down by Hering and Kitchen as calling for Benzoic acid, namely : “ Very scanty, dark-red, bloody-looking urine, with strong, pun- gent odor, and red, thick sediment.” It is indicated, also, by “ scanty, dark, smoky-looking urine,” such as we find in albuminuria dropsy in children. If this kind of urine occurs in rheumatic or gouty affections, this drug is just as well indicated, and will promptly remove the disease. Dr. Seymour recommends it highly in gout, when the small joints are red and swollen, or when fluid is deposited in the joints of the great toe; also in cases when the Lithate of soda existed in the joints of the fingers (gouty concretions). I have had excellent success with it in rheumatism. (The Ben- zoate of potassa will act more satisfactorily in some cases.) BENZOATE OF LITHIA—BERBERIS AQUIFOLIUM. 77 In that form of jaundice arising from arrest of secretion of bile, and not from obstruction, the Benzoates or Benzoic acid is often a specific, especially when the urine is similar to that above mentioned. I believe these preparations are preferable to the Benzoic acid, because of their ready solubility. The 1* triturations for adults, and 2X for children, have succeeded best in my practice. Dr. McAffee, of Mt. Carroll, 111., writes me he has used this preparation successfully in many cases of dropsy from disease of the liver. BENZOATE OF LITHIA, Dr. T. O. Summers says : “ In our hands Benzoate of lithia has often a most magical effect in diminishing the uric acid deposits, and increasing the free hippuric acid of the urine. It will thus be seen that this agent acts in a manner entirely different from the alkalies in the cure of uric acid deposits. Benzoate of lithia acts upon the urine before it leaves the blood, converting the uric acid which would otherwise be deposited into hippuric acid, a harmless agent, which passes off in solution, leaving no ill effects. The al- kalies do not act in this way. They dissolve the uric acid directly after it has left the blood. Hence, while they are clearly indicated in those cases in which the acidity of the urine is so great as.to pro- duce irritability of the bladder, or any part of the genito-urinary apparatus, it is clear that they cannot change the lithic acid dia- thesis—an end which we may hope to attain according to the ra- tionale of the Benzoate of lithia action.”—u Nashville Journal of Medicine and Surgery.” BEBBERIS AQUIFOLIUM. This unproven remedy is being used a good deal on the Pacific Slope, and latterly in the East. I doubt if it comes up to the ex- pectations of its friends. Dr. Bundy, of California, writes of it: “ In the introduction of this new drug to the profession I must say that, as a shrub, it is one of considerable beauty, and is on this account cultivated in our California gardens, and can be found at most of our florists, who find a large sale for it as a flowering 78 BERBERIS AQUIFOLIUM. shrub. It belongs to the natural order Berber idaceae, an order which, on this coast, is made up of three genera—Berberis, Vau- couveria, and Achlys. The genus under consideration is the Ber- beris. Of this genus there are four species—Berberis repens, Aqui- folium, Pinnata, and ISTervosa. The species Aquifolium inhabits the Coast Range Mountains, and is found to delight in a high alti- tude, being more plenty there than lower down. “ It was first brought to my notice by a gentleman who had been suffering for years from syphilis, and who, himself, was a 1 walking drug store,’ as he expressed it, and had made the mountains a re- sort that he might live through summer ; and, while there, when very weak and low, just able to wait upon himself, he picked some of the berries, ate them, relishing them because they were sour, and they finally acted as a cathartic, and, having been much consti- pated, he received immediate relief. He tasted the leaves, bark, and also dug the root, which he found to be an intense bitter, steeped it, and began to take it. In three months he found him- self wonderfully restored, and came home to this place (Colusa). He continued the use of the drug by steeping in whiskey, as he called it, and in eight months every vestige of the syphilis was gone, and he was certainly (to use a vulgar term) almost rotten with it, and that was his cure. Having treated him myself more or less fora year before he commenced its use, and being intimate friends, he gave the above statements regarding the remedy as he used it, but not until lately have I been able to obtain its botanical name, though I have used it months without knowing what it was, or I should have presented it before. Its power as an altera- tive is certainly marvellous, and not only as an alterative but a tonic also. The root is the part used, and it is extremely hard and tough, and of a bright, golden yellow color, an intense but pleas- ant bitter, and makes a very handsome preparation. As a tonic, and a general tonic, I know of nothing that can excel it, and I find it also to be an effective antiperiodic. Combining, as it does, its great alterative properties with its fine tonic power, its great value as an alterative is increased ; for where an alterative is desirable a tonic is always needed. Since learning of this drug’s great anti- syphilitic power, I prescribe but very little of the iodides, from the fact of this so far outdoing them in syphilis. I do not care what BERBERIS AQUIFOLIUM. 79 the disordered state of the blood may be, requiring an alterative or tonic, you will find in this the power of renovation and inner- vation that will give perfect satisfaction, as it will bring the an- swer faithfully. I have just commenced its use in a case of salt rheum, and as the patient has only been taking it two weeks I do not know what the result will be, but it does renovate the system so thoroughly in syphilis and other blood diseases that I believe it will succeed in this case. I will report further in this case after trial. I might report very many cases of syphilis, together with other blood difficulties, which are ordinarily met with, that I have cured, and I don’t think of using much else.” There is considerable enthusiastic testimony for its value in syphilis, but unfortunately it was nearly always combined with Iodide of potassa, which renders such testimony very doubtful. The following cases of psoriasis, where it was used alone, are of more value: Case 1.—In October last a Mr. Hall, native of London, Eng- land, about aged thirty, and body well nourished, presented him- self to me with typical psoriasis diffusa, involving the entire in- tegument excepting that of parts of the face, hands, and feet. It was his second attack, and had then troubled him three or four months, growing gradually worse in that time. During his first attack some years ago, being unsuccessful with any treatment in Canada, where he then lived, he went to Lon- don, England, and under the treatment of Balmanno Squire, Sur- geon to the British Hospital for Diseases of the Skin, which he says consisted of baths, and ointments, and internal treatment, the composition of which he does not very well remember, he pretty soon got well, and so remained until the present recurrence. After calling on me in October last, and pending his efforts to get into some hospital where he could avail himself of, what I sup- posed to be necessary, baths and treatment, he met with Mr. Hig- gins, of this city, and was induced by him to try Berberis aquifo- lium, which he did in teaspoonful doses of the tincture four times a day. Improving remarkably in a short time, he and Mr. Higgins 80 BERBERIS AQUIFOLIUM. called at my office and wished me, if I felt any interest in it, to superintend the treatment and watch the progress. Struck with so much change without any external macerations or anointings I was glad to watch it still further. Soon after commencing the treatment he frequently felt a warm tingling sensation in the skin, and while exfoliation of scales went on, the production of them gradually ceased. The psoriatic patches left the trunk first, the head next, and next the arms. There are a few scales yet in front of the knees, but excepting those he is entirely well. The red discoloration which remained for some time on the trunk has lately entirely disappeared. I have allowed myself to report the case, not from any special interest that the affection possessed, but from its disappearance during the administration of this medicine. I exercised particu- lar care on every hand to ascertain if any other medication was had, and believe it to be the only remedy used. The patient has also told me, from time to time, that he made no change in diet or any of his habits of life. He says the medicine may have in- creased the action of the bowels somewhat, but not very percepti- bly. In conjecturing as to its modus operandi, I have thought sometimes that it may act upon the bowels and other emunctories, and from its bitter principle, as a tonic, and in that way correct defective elimination and mal-assimilation, upon which this affec- tion with many others may probably enough depend.—Dr. T. 1ST. Reynolds, in the “ Michigan Medical News.” As there has been some little questioning of the authenticity of the above case, reported in our April issue, of the wonderful ef- fects of Berberis aquifolium, we took the liberty to ask for a brief statement from the patient, Mr. Hall. This is what he writes us: “Sir,—I think that I am in duty bound to bear testimony to the virtues of Berberis aquifolium, having received almost mirac- ulous benefits from it in psoriasis. I have been troubled for the past six or seven years, and believe there could not be found in Michigan a finer developed specimen than mine, being completely covered from head to foot with those charming incrustations. “ The only ill effect that I felt was my inability to work at my trade as a machinist. It never was irritable, but the fact of its being there almost drove me crazy. I went to England, and at- BERBERIS AQUIFOLIUM. 81 tended the Royal Hospital for Skin Diseases about three months. The chief thing administered was Fowler’s Solution, and in about six months got better. Was well for about one year, when again it made its appearance in a worse form, and I was induced to try Berberis aquifolium. I had an 8-ounce bottle, and at the outset I experienced a tingling sensation of the skin, which lasted for some time, and then found the exfoliation gradually getting less and less. After taking the Berberis about six weeks in teaspoon- ful doses, four times a day, it ceased to form, and the red discol- oration gradually disappeared. There is only one obstinate patch, about the size of a 2-cent piece, on my knee, but that does not form any scales, and gives me no inconvenience. If you think proper you can publish this statement. I can produce half a dozen medical gentlemen that saw me before taking the Berberis, and I was indeed a picture of misery. I never deviated from my regu- lar course of diet and cannot ascribe the cure to anything else but Berberis.”—“ New Preparations.” Case 2.—On the first of November, 1877, Mr. W. D., of this place, called me to see his two little daughters, aged respectively ten and twelve years, whom I found suffering from a terrible eruption covering the scalp and extending downwards over the face and chest. I was told by the mother that, in spite of all she could do, the disease had existed over two years, and the mother, by the way, is a very neat housewife. She said she had used all the domestic remedies she could procure, but the disease had now become so bad and the odor so offensive that she was compelled to take them from school. To make the story short, I diagnosed the disease scrofula, and prescribed the following: R. Fluid extract berberis, Syrup simplex, aa, M. S. Teaspoonful every four hours. The first effect was to increase the eruption, but in four weeks from the time they commenced the use of the medicine the erup- tion had entirely disappeared, leaving the skin smooth and healthy. My third case was a young lady whose family had all shown scrofulous symptoms, some of whom had died of the disease. The lady referred to had been troubled with an eruption confined to 82 BISMUTH. the ears and back of the head and neck of six months’ standing. One eight ounce bottle of Fluid extract of berberis aquifolium, prepared according to the above-mentioned formula, and taken in teaspoonful doses, effected the cure.—Dr. Mallory, Ohio. Dr. Buisly makes the following emphatic remarks concerning its use in skin diseases: “ If you wish to smooth the skin of a lady’s face, which has be- come rough and unsightly, give her Berberis and she will give you many a puff, together with thanks,” etc. If experience of our school confirms the above, by means of its use alone and in smaller doses, it will prove that it is an analogue of Phytolacca, Stillingia, Corydalis, and the Mercurial iodides, and Arsenic. BISMUTH. This is a very old remedy in one sense, but very new in another. Teste introduced it into his “ Materia Medica ” with the remark that it “ is very little known to homoeopathic physicians.” The same remark applies almost equally well now, for the great majority of our school rarely use it; only those who have been allopaths, or have gained some knowledge of its value from allopathic text- books. Bismuth is a very important remedy in its sphere of action, but that sphere is narrow, and confined to the nerves of the stomach and those organs in special sympathy with it. Hahnemann published a few symptoms of the Oxide of bis- muth in his “ Materia Medica Pura,” but they have attracted little attention. Teste tried to call attention to it, but he absurdly linked it with a group of medicines to which it has but slight re- semblance. His clinical observations were from allopathic ex- perience mainly, and his own personal experience with it was quite fanciful and unreliable. My experience with it has been large enough to warrant me in speaking decidedly as to its value. I have found it of the greatest use in painful digestion, or a kind of gastralgia which comes on soon after eating. The pain is peculiar; it is a remittent pressure, as from a stone or some heavy substance in the stomach. Some describe it as a crampy pain, others BISMUTH, 83 a griping. It differs from the gastralgia of Nux, which comes on later after eating; from Carbo veg., which is still later, as well as burning. The only medicines which closely resemble it, in the nature of the pain, are Dioscorea and Calabar. This gastralgia of Bismuth is often attended with eructations, tasting of undigested roast meat, frontal headache, vomiting of un- digested food; but these are not necessary concomitants. In vomiting from gastric irritation it is an excellent remedy. The vomiting is not attended by fever, is generally chronic, or has followed acute gastritis, or has been caused by irritating drugs. It is not useful in vomiting of sour, ropy fluids, or when inflam- mation is present. It will often palliate the vomiting from can- cer, or ulcer of the stomach; also the vomiting of pregnancy, when the reflex has caused local irritation of the stomach. Of Teste’s observations the only trustworthy one is, that Bis- muth is indicated in “absence of fever, nidorous (roasted-meat smelling) eructations, mucous or brownish, foul-smelling vomit- ing ; small, serous, intermittent diarrhoea, stools of a light color and foul odor, preceded by crampy pains at the stomach, and pinching in the abdomen.” In the diarrhoea of infants, when teething, if they have the above symptoms the Bismuth is a specific. If the diarrhoea occurs in poorly nourished adults, or feeble persons with slow digestion, it will act admirably. In headache it is an excellent remedy when it alternates with or is attended by the gastralgia, or when it comes on immediately after eating, and is relieved by vomiting of the ingesta. The pain is gen erally/rcmfoZ. In the treatment of dyspepsia or painful digestion, not compli- cated with any liver affection, it is almost indispensable. I have been very successful with it aided by Pepsin, which is peculiarly adapted to assist Bismuth in its curative action. I do not approve of those quackish combinations of “ Bismuth, Iron, Strychnine, and Pepsin,” with which the country is flooded. Pepsin will not combine properly, in solution, with any drug. It should be given uncombined. My plan is to give the Bismuth, if indicated, just before eating, and the Pepsin with the last portion of the food 84 BISMUTH BISULPHIDE OF CAKBON. taken at meals, followed by the Bismuth again in half an hour, if the pain and distress come on. I usually use in all cases the first decimal trituration of thesw&- nitrate of bismuth, giving to adults ten to twenty grains, to chil- dren five or ten grains. Ido not hesitate to give the same quantity of the crude medicine in obstinate cases. If the preparation is chemically pure no aggravation can possibly accrue from its use. When it is given for the vomiting and diarrhoea of children, the same plan, namely, a dose just before nursing or taking the bottle, with or without the Pepsin after. You will find recorded in Hempel’s “Materia Medica,” also in Orfila “ On Poisons,” some cases of alleged poisoning from Bis- muth, but it is now ascertained beyond a doubt that it is only when Arsenic is combined with Bismuth that it has unpleasant effects. “Notwithstanding all the care of modern pharmacy,” says Wood, “ Bismuth even yet contains Arsenic, and I have seen it from this cause produce bloody purging.” You should be careful, then, that you procure a pure article. I do not mean to infer that the chemically pure Bismuth will not cause diseased conditions similar to those it will cure, for such an assertion would contravene our law of cure. I do say, however, that only its long-continued use, in large doses, could produce such effects by slowly deranging the gastric nerves. Its primary effect is, doubtless, to benumb and abolish the nor- mal sensitiveness of the nerves of the stomach and intestines, while its secondary effects would be to cure just that hypersensi- tiveness which results in the gastralgia, which it is so successful in curing. BISULPHIDE OF CARBON. This drug was once used to some extent by the allopathic school, and was found quite useful in many diseases, but it has gradually fallen into disuse, more on account of its intolerably fetid odor, probably, than from any deficiency of curative power. It was employed in obstinate rheumatic and arthritic affections, paralysis and cutaneous eruptions, and as a resolvent in indolent tumors. In the latter case a few drops were applied to the tumor several times a day. A Dr. Otto claims to have reduced a stran- BISULPHIDE OF CARBON. 85 gulated hernia by applying a few drops. The vapor was said to cause the disappearance of indurated lymphatic glands, also in deaf- ness from want of nervous energy. It was recommended to be rubbed on the face in neuralgia, toothache, etc. Workmen exposed to its fumes are affected with headache, ver- tigo, and overexcitement of the nervous system, as evinced by voluble talking, incoherent singing, immoderate laughter, or weep- ing. A long continuance of exposure causes a kind of cachexia, char- acterized by general weakness, loss of sexual appetite, dulness of sight and hearing, and loss of memory. It does not seem to cause any lesion of the brain (in rabbits killed by its fumes), but only congestion of the lungs. From the symptoms caused by it in workmen I would suggest its use, by inhalation, in some cases of hysteria. Its odor, if noth- ing else, would help to dissipate the peculiar abnormal condition of the nervous system which occurs in some of the victims of hys- teria. I have had no personal experience with this agent. It is recom- mended in Ilering’s pathogenesis for several ailments. He men- tions among the clinical cases : ° Intoxication, to entire loss of consciousness, from drinking whiskey. I cannot recommend this to you as a good report. People “dead drunk” generally recover after a time, and it is doubtful if the medicine had anything to do with the recovery. Hering recommends it in “ asphyxia from alcohol or coal gas.” It is evident he thinks the victim would recover sooner with than without this remedy. The head symptoms are quite prominent, and it is reported to have cured the following kinds of headache: °“ Violent pain in the head, increasing until it causes confusion of mind, writh fever- ish attacks, cold extremities, and spasmodic (?) pulse.” It is recommended for facial neuralgia, and “ toothache brought on by warm food.” It causes quite severe intestinal irritation, and among the cura- tive symptoms you will find ° “ chronic diarrhoea, every four or six weeks, lasting one or two days, stools yellowish, frothy, sour- 86 BRACH YGLOTTIS REPENS. smelling, fluid, with tenesmus and colic in umbilical region at night. It is said to cure °constipation with sour-smelling flatus.” Its administration to rabbits is said to cause “congestion of the upper lobes of the lungs, hepatization of the lower and posterior lobes, deposit of tubercles in the lungs, some ecchymosis, and in- filtration.” Tiering therefore recommends it “ in the first stages of tuberculosis of the lungs, before any or only slight fever has set in, flying, burning, and stitches in the chest, flushing of the face, dry cough, and difficult breathing when moving.” Also for “con- striction, stitching, pressing pains in the chest.” By referring to the provings you will see that it is recommended for rheumatism of the upper and lower extremities, for sciatica, very severe, of both the left and right thigh. The rheumatism seems to be attended with much “ cracking of the joints.” It is further recommended for “ itch, tetter, impetigo, herpes, and other cutaneous eruptions.” The dilutions may be made by adding to 10 grains of the drug 100 drops of alcohol. It should be kept in a glass or rubber- stoppered bottle. I)o not try to make triturations. BE ACHYGLOTTIS REPENS, (.Puke-Puke, New Zealand.) The cattle which eat the leaves of the Brachyglottis repens ap- pear to get paralyzed in the lower extremities and fall on the hind quarter; after a few days they seem to sink; sometimes they recover, but regain their strength very slowly. The natives of New Zeal- and use it as a medicine to produce perspiration. In its effects (see provings) it certainly produces symptoms of albuminuria and disturbances of the urinary organs. It has been a very reliable remedy in Bright’s disease, and rarely failed to produce a satisfactory result. PROVING. lsi day, Sept. 7th.—C. F. F., 46 years old, with no illness, took, 10 a.m., 10 drops Tincture puke-puke in water. Pulse 60, pleasant taste. Immediately after taking it, soreness in the stomach. One hour afterwards, pain in the right (,September 7th to September 25th, 1868.) BE ACHY GLOTTIS EEPENS. 87 knee, a soreness and throbbing sensation, pain in the back and in the right side, cold and chilly for 1} hours; slight soreness in the throat and soreness on the nos- trils exteriorly; pain in the arm—as if full, pressing pain in the forehead. 1 p.m. Heavy pain in the occiput and forehead; isolated sore throbbing in the right side, back, and left side ; isolated sore throbs under the right armpit and in left groin ; chilly; pulse 50. Pain in the thigh by walking. 2d day, Sept. 8th, 11 A.M.—20 drops. 12 noon. Weary pain in the upper arm, transitory pain in the left side of the head, weariness in the arms; faceache—left side, zygomatic process of the face, also lower jaw, submaxillory glands ; pressure and soreness in the neck of the bladder, transitory pains in the thighs, similar to those felt yesterday; transitory throbs in the thighs; heat in the mouth ; soreness in left wrist. 1 p.m. Severe pain around the loins, tingling itching in the cheeks and nose, with much sneezing repeatedly. Evening. Nausea, with eruc- tations tasting of the food taken. 3d day, Sept. 9th, Morning.—Soreness in the groins, left groin especially; throb- bing pain in the left elbow, weariness in the limbs. 4th day, Sept. 10th, 10 a.m.—40 drops. Eructations soon after taking it, flutter- ing in the stomach, soreness in the zygomatic process of the right side, shivering and chilliness immediately after taking the dose; frequent eructations of the taste of the medicine; excitement in the nostrils, more particularly left nostril, like yesterday, as if the air was too sharp. 10.30 a.m. Urine clear, but mucous streaks and filaments—(microscopic examination yielded numerous cells and epithelium); some time after voiding the urine the same soreness and pain in the neck of the bladder and anterior base of the penis as yesterday; sensation as if the urine could not he retained ; rawness of the throat. 12 noon. Toothache in right side, extending to the ear; irritation as if the urine could not he retained, and slight soreness in the urethra; specific gravity of urine passed at 11 a.m., 1008 ; passed urine again 12.30 p.m., specific gravity 1004; urine acid, eructations. 1.30. Inclination to pass urine almost constant, soreness in the groin, weariness in the limbs, soreness in the kidneys, pressure in the chest, nausea, eructations, weariness in the arms, scraping sensation in the throat, painful throbs in left shoulder about the region of the collar-bone, soreness in the fingers and lower joint of the left thumb, Aveariness in the fingers by writing. 2.30 p.m. Passed a great quantity of colorless urine. 9 p.m. Evacuation of the bowels with severe constrictive and sore pain in the arms, weakness in the legs and groin by walk- ing. All symptoms seem to last only three or four hours. A reaction seems to set in ; passed no urine all the evening and night, then passed urine the next 24 hours 58 ounces, of specific gravity 1020, with mucous sediment. 5th day, Sept. 11th, 11 a.m.—80 drops. The effects on the urinary organs are decidedly exciting. Soon after taking the dose eructations, soreness under the shoulders, neck, and arms; prick in the ear, pain in the forehead, urine contains albumen and spermatozoa. 1 p.m. Weariness and weakness in the back, region of the coccyx, and dull pain in the kidneys; confusion in the head ; all the morn- ing excited in mind; a kind of cold tightness about the scalp, weakness in the limbs; toothache, heat in the mouth and soreness in the tongue, pain in the neck, and by rocking the head from one side to the other soreness in the attachment of the sterno-mastoid muscle to the neck ; soreness in the right Avrist, extending up- 88 BE ACHY GLOTTIS REPENS. ward; pressive pain in the left side of the forehead, soreness in the throat, weak- ness and soreness in the biceps and isolated thrills about the wrists; by walking weakness in the lower extremities, and pain like last night in the groin, left side particularly. No appetite; after dinner heat and itching in the nose. Passed urine of a dark-amber color, and containing several long threads, which by mi- croscopic examination indicated waxy easts ; acute stinging pains in the groins ; the prostration in the extremities is more prominent, isolated throbs, pain in the forehead (it rained heavily all the day) ; driving during the afternoon felt slight headache; soreness and stinging on the tongue, pain in the back, and weariness in the extremities; a few stinging pains in the urethra. Soon after tea desire to urinate, rather a pressure in the neck of the bladder and stinging in the glans penis. The urine has been much less in quantity to-day than yesterday. 7 p.m. The urine specific gravity 1024, darker in color, and long threads float- ing in it. 9 p.m. Stool of papescent evacuation, attended with severe pain in the anus, pain also in the neck of the bladder; since the stool constant smarting and burning in the urethra and the glans penis. 10 p.m. Aching weariness in both arms, aching in the nape of the neck, muscles feel sore to touch, pressure under the sternum, the cervical muscles are sore by moving and bending the head, soreness in the left groin by walking, also in both calves; microscopic ex- amination of the urine—threads, tubes, or casts, consisting of a regular mass of epithelic cells adhering to each other, which, on account of their length, come probably from the urethra and bladder; a feeling of rawness and soreness is clearly perceptible, and especially in the glans penis; passed urine again and feel great soreness in the urethra; the dull pain in the back and region of the kid- neys is increasing, pain in the neck continues, soreness and rawness about the pharynx ; the soreness extends from the neck to the shoulder and shoulderblade, attended with muscular prostration; passed 48 ounces of urine in 24 hours ; ex- amination yielded triple phosphate, oxalate of lime, and (cystine?); during the night slept heavily. Was awoke very early to go to a patient; pain and great weakness in the limbs. 6Ik day, Sept. 11th.—Took 80 drops. Half an hour afterwards headache; passed a large quantity of urine, not so painfully as yesterday, but after passing it desire to pass more and irritation in the neck of the bladder as if the bladder was not emptied ; pain in the kidneys as yesterday; flushed face and headache around the forehead, pain in the back, continued all the afternoon, with soreness and weakness in the thighs and lower extremities, also prostration in the arm; was obliged to void urine three times, with pain in the urethra. 3 p.m. An inclination for an evacuation of the bowels, which, after long sitting and pressing, proved ineffective. Evening. Pain and soreness in the groins, both sides, as if in the spermatic cords, and a thrilling sensation, by sitting, through the penis and testes; an acute throbbing in the right hypochondriacal region; soreness under the shoulderblades. 1th day, Sept. 12th.—This morning, by walking, excessive prostration in the legs and soreness in the lower part of the spine; the weakness and the pain are more perceptible in the left thigh than in the right. The action of the drug influences evidently the sciatic nerve. The effect of the drug is decidedly on the spinal nerves; the pains are transitory, scarcely shooting, but short, sore throb- BEACHYGLOTTIS EEPENS. 89 bings, influencing the motor power more than the nerves of sensation. Except in the lumbar region of the spine, where the pain is more constant, aching and sore to pressure. The loss of appetite was great yesterday, but to-day a sinking sensation in the stomach. Although I felt a few times desire to evacuate the bowels, when attempting to do so no effect after long straining. 8th day, Sept. 13th.—Was well, comparatively; could walk a distance of six miles. The only perceptible effect of the medicine still remaining was the sore- ness in the urethra, and an excoriation internally at the corners of the mouth. 9th day, Sept. 14th.—Mixed 20 drops of the tincture in 20 spoonfuls of water. Took 4 spoonfuls at 12. Immediately after taking the medicine gnawing pain in the spine, region of the kidneys, the same isolated throbs or shootings in arms, dryness and rawness in the throat, severe pain in left jaw, submaxillary glands (of very short duration), tingling sensation In the ears. The soreness in the lower part of the spine, which had left me entirely, in the course of the sciatic nerve; throbbing in the left temple and headache, prostration and weakness in the right arm by writing, weakness in left arm, cracking of the joints of left arm, rigor, and chills. During the afternoon the symptoms subsided except weakness in the extremities. Urine, specific gravity 1023. 10th day, Sept. 15th.—The sleep during the night was good ; no particular un- easiness during the day except constipation. 11th day, Sept. 16th.—A very restless and sleepless night, but whether attrib- utable to the medicine is doubtful, having been much engaged during the day; the meals were irregular, and I could only take dinner late at night. However, after my ride this evening the severe pain in the lumbar region returned with great violence and is continuing. A great deal of pain in the upper arm, aching and severe pain in chest and back. 12th day, Sept. VIth.—Sleep during the night good and undisturbed. Took 4 spoonfuls of solution containing 4 drops. 10 A.M., after breakfast, pain and weariness in the back, headache ; very sleepy and heavy; during the day constant yawning. Depressed in spirit and vexed mood. 13th day, Sept. 18th.—Since taking the medicine, from the commencement, ting- ling in the ear, and secretion in and from the ear increased, with which I have never been troubled. Very sleepy and heavy, yawning all day. 14th day, Sept. 19th.—Healthy sleep. Took, at 10 A.M., 1 spoonful of the so- lution. After breakfast immediate eructations. The sense of general lassitude predominates. Shooting, short, isolated throbs in the arms. Sensation of pain in the dorsum of right foot; confusion in the head ; a degree of nausea. 11 a.m. One spoonful. Immediately sharp throbs in both knees at the internal and in- ferior attachment of the triceps; internal pain in the back returns, with great intensity in the lumbar region; the confusion in the head and pain in the fore- head worse, the same throbs as in the knees are now in the sternum ; with the pain in the sternum increasing nausea, pains flying about the chest and under the right shoulder; the headache concentrates itself more on left eye; stiffness of neck, as on former occasion, with pain. 12 noon. The weakness about the lower extremities is increasing in the same positions as before (in left leg more promi- nent), extending from the hip to the knee. In urinating flattening sensation in the bladder; pain in the neck as if I could not hold the head erect; weakness YOL. II.—7 90 BRACHYGLOTTIS REPENS. and prostration in the arms, also right wrist; confusion of the head, great depres- sion of spirits, soreness in the zygomatic process, left side ; pain and soreness in the forehead, soreness in the neck anteriorly, sterno-mastoid process ; pain in back continues, 8 p.m. During the afternoon, by walking, great weariness ; when re- turning from my visits violent headache, pressing and throbbing about the fore- head, beating, throbbing, and pressing; a painful twitch about the left side of the face; the evacuations of the bowels were small and knotty, and unsatisfactory ever since taking the medicine; the form of the faeces has been like balls—some- times soft, as if diarrhoeic, but always required a certain amount of effort to expel the faeces. This evening, with the evacuation, returned the soreness in the penis, as experienced by former provings, and a feeling as if the bladder had not been emptied. The headache lasted till midnight, with great intensity; felt very heavy, but no inclination to sleep; reading till 2 a.m., when retired to bed. 15th day, Sept. 20th.—Slept very heavy ; coffee for breakfast; great lassitude and confusion this morning; stretching in the limbs, pain running in the kid- neys and lower part of spine, transitory pains in the neck and left upper arm. At 12 noon, 20 drops in 8 spoonfuls of water, 1 spoonful of this solution; soon after taking the dose confusion, pain in the left side, lower maxillary ; pricking in the ears ; a sensation of pain gradually running down the left upper arm ; the same sen- sation in right arm; the pain is remaining stationary in the left arm; a slight sensa- tion of pain under the right axilla, extending to the sterno-mastoideus and great pectoral muscle. Sudden short pain right side (teeth), sudden but severe pain in the left temple; pain, as formerly, repeated in the left groin ; muddled confusion in the head increasing, light rawness in the, throat, severe aching in the lumbar region, nauseatic sensation in the stomach, cracking in the left shoulder. This has never been experienced before the proving. Greater inclination to stretch the limbs, and particularly the arms, as to give relief to an uneasiness between the shoulder- blades, evidently in the trapezius and clavicular muscles, also increased desire to stretch the head downward, as if the whole back would contract backwards; the desire for stretching the muscles and limbs is rapidly increasing in intensity; in- creased painful sensation in the neck. This muscular influence is proved by pain felt when the face is turned sideways ; colic and inclination to stool; a slight ner- vous rigor all over the frame. All these symptoms occurred in succession during the first fifteen minutes. Hands feel cold and rigor is increasing, pain in left jaw, headache across the forehead, pain in right forearm and upper arm, soreness under the submaxillary glands. The evacuation of the bowels was small and ineffective, although the stools were neither hard nor knotty. 1.15 p.m. A sore throbbing in the glans penis. This is the same kind of pain as experienced all throughout the proving of the drug. Pain in the ears, both sides ; chilliness) heat in the face and flushed; oppression in breathing, as if a deep inspiration would afford relief; pain in the dorsal muscles, particularly under the right thigh; shoulderhlade; eructations and yawning. 2 p.m. Itching of the skin; itching and soreness of right buttock, near the course of the anus, which is tender and sore as if an eruption would appear; itching of right forearm; soreness now felt in both interior corners of the mouth, which has relieved itself externally by a swelling of the lips. These are the first symptoms of the skin since the com- mencement of the medicine. Painful itching; burning, by walking, under the BE ACHY GLOTTIS EEPENS. 91 big toes; itching in the dorsum of the right foot; sensation as if the ears were stopped up, lasting for a short time; pain and soreness in the upper arm; severe sore pain in the left wrist; the same kind of pain also in the knees, not exteri- orly. All pains are throbbing or sore throbs ; cracking in the joints of the lower extremities when walking; great inclination to stretch. Was told by Mr. B. that the cattle and horses which eat the poison fall to the ground, as if the back was affected, and appear to suffer across the loins. Just now, while writing, feel a severe pain in the spine, first dorsal vertebra, which is painful and sore to the touch; pains in the calf from the knee downwards, exterior side of leg. 7.15 p.m. About one hour after tea same kind of sore throbs in the region of the stomach and liver, position of the duodenum. Took 1 spoonful, containing 5 drops. Bawness in the throat, right side, same as in the morning; pricking in the ears, frontal headache, nauseatic sensation in the stomach, pain of greater in- tensity than usual in the upper arm, near the insertion of the deltoid muscle. 8.30 p.m. Pricking and numbness of the tongue, pain in left ear, sensation as if the ears are discharging, slight twitches in the left side of the face; first time pain in chest, left side prominently, about the region of the heart; oppressed breathing, deep breath seems to give relief; great fatigue in the arms; more nau- sea ; headache not so severe as last night; sudden pain in the spine about fourth to fifth dorsal vertebra, extending to right side of chest and shoulders. Passed 48 ounces of water on the 20th. 16th day, Sept. 21st.—The sleep was disturbed; awoke in the middle of the night twice and had difficulty to go to sleep again ; dreams confused and wild; during the night itching and burning in the nostrils, with urinating burning in the urethra. Two spoonfuls. Immediately afterwards pain in left lower maxil- lary and face; throbbing in chest, region of the heart; pain under the right arm, rawness of the throat, giddiness, flushed face, itching and pricking in the ears; pain in the neck very prominent, affecting the upper or cervical part of the tra- pezius muscle and the splenius, lower jaw, right side ; when moving tingling in right ear; again great prostration in the arms; forehead painful, and some prick- ing sensation in the skin of the forehead. During the afternoon when visiting my patients, great weakness ; at one time, while sitting, a very severe pain in the bladder; pains of short duration in the region of the heart; soreness rather under the soles of the feet. All pains and sensations are worse when at rest (like Rhus tox.). Stiff soreness still in the neck. I am told by people that I do not look so well as prior to taking the drug. Certainly I am much thinner than I was a fortnight ago. By sitting the lumbar pain is more intense; soreness and stiffness in the neck; pain is flying about, now in the hands, fingers, then in the forearm and feet. At the commencement of the proving the symptoms appeared to have the character of nervous pains, while now they are decidedly muscular. Took one dose late, at 12, before going to bed. 11th day, Sept. 22d.—Sleep full of dreams, but was told that I talked in my sleep almost the whole night, which has never happened before, nor have I been subject to it. The urine passed during the 24 hours and saved amounts to 48 ounces; that which was secreted in twice voiding may be calculated at 8 ounces m<*>re; the urine is of specific gravity 1020, mucous sediment, white, fiocky, more than any previous secretion. Bowels costive. Pains in the various parts were 92 THE BROMIDES. felt all day; by walking great prostration ; in the evening a settled, lasting rheu- matic pain; moving, aching about the left knee, very soft diarrhoeic stool this evening; pain in the arm.—C. F. Fischek, M.D., Sydney, N. S. W. THE BROMIDES. The introduction of the Bromine salts into allopathic practice marked an era of improvement in the therapeutics of that school. It occurred just about the time that the influence of homoeopathy, acting through public opinion, obliged the relinquishment of blood- letting. The Bromides took the place of the lancet, and were an incalculable improvement upon that instrument of destruction, for, notwithstanding the very general abuse of these salts, they rarely caused notable injury to the patient, and never, I believe, caused death. On the contrary, they have been of vast benefit in the treatment of disorders of the brain and nerve-centres. The amelioration of one disease, epilepsy, by their use, is enough to give them claim to a high place in the Materia Medica of any school. Before taking up each salt I propose to make some general re- marks relative to their mode of action, and explain how such ac- tion may be made to agree with our law of cure, and how our school may use them as homoeopathic remedies. I. The primary effect of the usual medicinal doses of any of the Bromides is to contract all the bloodvessels, notably those of the brain and spinal cord. Under their primary influence all the or- gans sleep, or are placed in that condition of quietude which leads to sleep. They arrest reflex action and diminish muscular irrita- bility. II. The secondary effect of the Bromides, which may occur dur- ing their prolonged use, or after their suspension, is just the oppo- site, namely: the contracted arteries dilate, congestion occurs, either passive or active; sleeplessness, nervous erethism, hyperses- thesia of the reflex nervous system, and abnormal muscular irrita- bility results. These pathogenetic effects are those which occur when the Bro- mides are administered to healthy animals or men. Uow in choosing a homoeopathic remedy we cannot ignore, but BROMIDE OF AMMONIUM. 93 must take into account both actions of a drug. Herein we differ from the allopathic school, which, until very lately, made use of the primary effects of drugs only. The latter prescribes a drug to cause its primary action (the Bromides in fulness of the cerebral bloodvessels), and usually give unnecessarily large doses, wdiich are apt to lead to secondary symptoms. In homoeopathy we can prescribe the Bromides for cerebral and spinal aneemia, etc. (prim- ary effects), using very minute doses, and thus aid in restoring the normal equilibrium of the circulation. In congestion, spasm, erethism, etc., we can prescribe the Bromides, for the latter belong to their secondary effects. According to the only rational law of dose we give appreciable doses, but not enough to lead to an aggra- vation of the malady. The homoeopathic physician, using the Bromides according to these rules, becomes possessed of a class of valuable remedies, with- out which his success in the treatment of many severe and dan- gerous disorders wrnuld be greatly diminished. BROMIDE OF AMMONIUM. This is the only one of the Bromides which has been subjected to a physiological proving by a member of our school. Dr. Cush- ing has published an excellent pathogenesis, made up chiefly from provings upon his own person. Its action appears to be principally upon the brain, the cervical and dorsal portion of the spinal cord, the eyes and nose. Its action upon the brain is similar to that of all the Bromides. According to Brown-Sequard it is preferable to Bromide of am- monia “ when there is a suspicion of the existence of congestion of the base of the brain or of the spinal cord and its meninges.” In accordance with this view of its special action I have usually selected this salt in the treatment of the first stages of cerebro- spinal meningitis, basilar meningitis, and certain severe occipital headaches. It is well known that certain cerebro-spinal congestions are at- tended by a peculiar spasmodic cough. In such cases I consider this salt specifically indicated. It has not been as much used in 94 BROMIDE OF AMMONIUM. epilepsy as the potash salt, but in those cases where the predomi- nant symptom is basilar congestion, I give it the precedence. In the above affections the dose must be graduated to suit the age and idiosyncrasies of the patient. My experience leads me to the belief that the maximum dose is one grain for each year up to twenty years. For instance, a child of three years requires in se- vere cases three grains, repeated every two or three hours. A strong man of twenty or thirty requires twenty grains every three or six hours, until improvement sets in. In cases of less severity half or one-fourth the quantity may cure. Cases may occur where we may select this remedy from the symptoms of its primary action, namely, in conditions of anaemia of the base of the brain and upper portion of the cord, when such anaemia is due to a dimin- ished calibre of its bloodvessels. It is evident that it would not be indicated in cerebral anaemia due to feebleness of the heart’s action, or a deficiency in the amount of blood. Such cases must be met by other remedies, as China, Ferrum, etc., aided by Digitalis and a bloodmaking diet. Hammond (“ Diseases of Nervous System ”) says: “ It cannot be doubted that spasm of the bloodvessels, produced through the sympathetic and vasomotor nerves, explains the origin and con- tinuance of many cases of cerebral anaemia. It is in this way that mental emotions act, and sometimes with such rapidity as to cause instant death. This spasm may be kept up for a considerable time, with the effect of developing the ordinary symptoms of cere- bral anaemia even after the emotion which originated it has long disappeared.” It is in just such cases that the Bromides are primarily homoeo- pathic. If the reader will consult the symptoms of these salts, he will find a perfect picture of brain anaemia. Especially do the mental symptoms point to that condition. The dose in such cases must be very minute. I have seen prompt curative action from the 3* and 6X dilution, frequently repeated until improvement sets in. The eyes are specially affected by the Bromide of ammonium. Dr. Cushing experienced “redness and soreness of both eyes, with sticking together of the lids in the morning ; the eyes were full of stringy mucus, the eyeballs felt unnaturally large, and pain around BliOMIDE OF AMMONIUM. 95 both eyes into the head; in the evening the eyelids droop, and it is painful and difficult to raise them.” Dr. Gibbs, an English surgeon, recommends it very highly in “strumous ophthalmia, conjunctivitis, corneitis, and leucoma.” Dr. Woodyatt, of Chicago, an oculist (homoeopathic), esteems it very highly in similar affections, and also in swelling of the edges of the lids and inflammation of the Meibomian glands. I know of no more efficient remedy in that common affection, catarrh of the 'posterior nares and fauces, especially when the dis- charge is a thick, stringy mucus. A few grains of the lx tritura- tion, three times a day, used persistently for a few weeks, will effectually remove that condition. It was once lauded very highly by allopathic physicians in the treatment of whooping-cough. It was used successfully in many cases, but did not cure all, and as a consequence of its failure it has fallen into disuse. Too much was expected of it, but to the homoeopathists it will prove a valuable aid in the treatment of that malady and many other coughs of a spasmodic character. The characteristic indications are : “Sudden, deep,spasmodic cough, causing a pain in the stomach. “ Cough, deep, spasmodic, severe, at intervals of a few moments, almost continuous for hours, especially when lying down at night, with sensations of tickling irritation in the larynx, sometimes with a distinct ivhoop.” The expectoration, if any, consists of a stringy, tough mucus. The provings of Cushing and Okie demonstrate that this Bro- mide is capable of causing a spasmodic cough resembling whoop- ing cough. Another proof that all drugs capable of curing a disease are capable of causing a similar one. The curative dose I have found to lie between the lx and 3X dilutions. Dr. Griffiths considers that it acts upon the uterine bloodves- sels as does Ergot, namely, causing contraction. He claims to have used it successfully in uterine haemorrhage from any cause; also in amenorrhoea and dysmenorrhoea from congestion (?). I have had no experience with it in this direction, except in dysmen- orrhoea; in a few cases, obstinate and obscure, it seemed to alle- viate the suffering. In the treatment of epilepsy, convulsions, and sleeplessness, this 96 BROMIDE OF CALCIUM. salt is not as useful as some other Bromide. But it may be sub- stituted if necessary. To ward off a threatened attack of epilepsy or convulsions from congestion of the brain 20 grains is as small a dose as will prove effectual in an adult. In children the dose has been stated. In the obstinate sleeplessness preceding an at- tack of cerebro-spinal meningitis the dose (20 grains) must be given at bedtime, and when the house and street are quiet. BROMIDE OF CALCIUM. “This salt is said, by Dr. Hammond, to have effects which re- semble both Bromide of potassium and Chloral hydrate. It is asserted to be preferable to either when there is congestion of the brain with delirium and sleeplessness, or in sleeplessness alone with great nervous irritability.” This paragraph was written nearly two years ago. Since that time I have had frequent opportunities of testing its value, and do not hesitate to assert that it is the most valuable of all the Bro- mides in the treatment of diseases of children. Hahnemann rightly considered the preparations of Calcarea almost indispensable in the treatment of diseases of children, especially during the period of dentition. Calc, carb., Calc, phos., Calc, arseniosum, and Calc. iod. are a most valuable group, and if we add the Calc. brom. we have five medicines with which I am almost ready to assert we can treat suc- cessfully a large proportion of the ailments of children from birth to puberty. Given in the lower triturations, or even 1 to 10 grains of the crude salt, we can control the cerebral congestions and irritations of children, whether direct or reflex. The children for whom Calc. brom. is most useful are the lax- lymphatic, nervous, and irritable. They grow fast, but the flesh is not solid ; they learn to walk with difficult)7, the teeth come tar- dily, and are attended with gastric, intestinal, and cerebral irrita- tion. It is useful in the vomiting and diarrhoea as well as for the sleeplessness, fretfulness, and tendency to brain disease. My experience with this medicine has given me greater confi- dence in it in the incipient and first stages of cerebral diseases, in BROMIDE OP CALCIUM—BROMIDE OF CAMPHOR. 97 such children as I have described, than in the much-vaunted Bel- ladonna, Hyoscyamus, Aconite, and Bryonia. (Before I learned the value of Calc. brom. I had better success with Solanum and AEthusa than the remedies I have named.) But to be successful with Calc. brom. it must be used boldly. No danger need be feared from its use. It is not a narcotic like Opium and its preparations. It simply contracts the cerebral ves- sels, preventing congestion, and at the same time it diminishes or prevents the dangers of reflex irritation. One grain of the crude drug can be given for each year of the child's age) and this dose can be repeated every hour in urgent cases with perfect safety until the dangerous symptoms subside. In milder cases of erethism or irritation the lx to 3X trituration may be relied on. I have often prescribed it for children fed by the bottle or other- wise, by dissolving two or three grains in their regular allowance of food for the day. I never saw any bad effects from it, but on the contrary the happiest results in the general improvement of the physical and mental condition. I will here add that in thin, bilious, nervous children, with black hair and eyes, I have found the Bromides of soda or potassa to act the best. I hope this earnest recommendation will have the effect of in- ducing physicians to pay more attention to the value of this truly beneficent remedy. BROMIDE OF CAMPHOR. This bromide would seem to be a combination of medicines pos- sessing directly opposite effects. All the bromides, except the Bromide of quinine, cause primarily cerebral anaemia. Camphor causes cerebral congestion, and may cause epileptiform convulsions primarily. It would seem that a union of the two elements would counteract each other. My observations of the use of this drug in allopathic practice leads me to believe that the Camphor-effects predominate in most cases when it is given in large doses. I have known doses of from 6 to 10 grains cause congestion of the brain, with delirium and threatened convulsions. So commonly have 98 BROMIDE OF CAMPHOR. these unpleasant effects resulted from such doses that allopathic physicians are shy of prescribing it much of late. Dr. Hammond, however, is quite successful with the drug, but he gives it in moderate doses. Its sphere of action is doubtless nearly that of Camphor, modified somewhat by the Bromine. It is primarily homoeopathic to cerebral congestion, with great ner- vous erethism, especially when it assumes the form of hysteria. I should consider it secondarily indicated in cerebral anaemia, from previous overstimulation, and attended by sleeplessness, cold ex- tremities, feeble circulation, and nervous headache. Dr. Hammond published several cases in which he found it use- ful. I condense them as illustrative of its use in his hands. Infantile convulsions due to irritation of teething, with the effect in each instance (two) of preventing the further occurrence of the paroxysms, which previous to its administration had been very frequent. Dose: in each case, one grain an hour, rubbed up in a little mucilage of Acacia. Three doses were sufficient in one, and two in the other case. The ages of the children were respectively 15 and 18 months. A very obstinate case of hysteria, occurring in a young married lady, in the form of paroxysms of weeping and laughter alter- nately, with epileptiform and choreiform convulsions. Dose: four grains every hour. Improvement commenced after two doses were taken, but ten were necessary to entirely break up the attack. All previous seizures had lasted from five to eleven days, unin- fluenced by medication or moral suasion. Headache in women and young girls, due to mental excitement and excessive study. One dose of four grains was generally suf- ficient to cut short the attack. Delirium tremens, in a large man of plethoric habits. Symp- toms : great cerebral congestion, tremulousness, and great jactita- tion of the limbs ; conversation muttering and incoherent; pulse full and soft; no sleep for several nights. 100 grains Bromide of sodium did not cause sleep; 5 grains Monobromide camphor caused sleep within half an hour. He slept over 12 hours ; after- wards the same dose at night caused good sleep and relief of all the other symptoms. In this case there may have been congestion of the brain in the BROMIDE OF CAMPHOR BROMIDE OF ETHYL. 99 beginning, but it could not very well have been present after the patient had swallowed 100 grains of Bromide of soda. In fact, the symptoms which existed when the Camphor bromide was given were those of cerebral aruemia, a condition in which 5 grains of the drug would be likely to have a good effect. The Belgian physicians who first used it recommended it for delirium tremens. I think it will prove useful in the delirium of low typhoids, when anaemia of the brain and erethism are both present. Owing to the powerful depressing influence which both constit- uents of this drug have over the generative organs of both sexes, I predict that it will form a useful remedy in the opposite con- ditions of excitement and debility. It must be primarily homoeo- pathic to impotence, torpor, and passive spermatorrhoea, and I should expect it would cure such conditions when prescribed in the -3X or 6X triturations. It is secondarily indicated in nympho- mania, chordee, active spermatorrhoea, with nocturnal emissions and amorous dreams. Dr. Hamilton says it is far superior to any remedy he has ever tried in chordee. lean testify to the same, and I have found that two or three grains at bedtime will effec- tually control nocturnal chordee, emissions, and erotic dreams. In a case of obstinate neuralgia of the testicles and prostate gland, which were both indurated and enlarged, the patient having lost his sleep for weeks, two grains at night not only caused sleep, but greatly relieved the other symptoms. In my third edition of “New Remedies” I predicted that it would prove useful in cholera infantum with impending or actual spasms. Its use in many cases since that time has justified that prediction. The 2* trituration, a grain or two every half hour, acts very favorably in the collapse with cerebral symptoms. It may prove as useful in cholera morbus and cholera Asiatica. BROMIDE OF ETHYL. (A New Ancesthetic.) Ethyl bromide, Bromide of ethyl, or Bromethane, C2H5Br, is a colorless liquid, of pleasant ethereal odor, biting taste, has a spe- cific gravity of 1.470, boils at 41° C. (= 106° F.), and takes fire 100 BROMIDE OF ETHYL—BROMIDE OF IRON. only with difficulty. It is formed during the action of Bromine and Phosphorus upon alcohol, or by causing Olefiant gas to come into contact with ITydrobromic gas, or by heating alcohol with Amyl bromide. It is best prepared by pouring upon 1 part of white or red Phosphorus, in a retort, 40 parts of alcohol of 0.840, adding | parts of bromine in rapid drops, distilling, washing the distillate with water, drying it with Calcium chloride, and rectify- ing it. It is but little soluble in water and is miscible with Ether and alcohol. When heated with water it splits into Ether, Ethene (Olefiant gas), Oil of wine, and Hydrobromic acid. With Potash it yields Ether and Potassium bromide, and with Aqueous ammonia it forms Hydrobromate of ethylamine. When inhaled it produces, according to Rabuteau, a complete anaesthesia, as rapidly or more so even than Chloroform. This has been shown by experiments upon animals. Dogs are com- pletely anaesthetized by inhaling it from a sponge for two to five minutes, and they rally from it quicker than after the administra- tion of Chloroform. On injecting subcutaneously a solution of Muriate of narceia or morphia, before anaesthetizing with Ethyl bromide, similar appearances are noticed as when these substances are administered previous to Chloroform, namely, consciousness is partly retained, while insensibility to pain is complete. Compared with Chloroform, Ethyl bromide cannot be called caustic, nor even irritating. It may be applied without danger, subcutaneously, upon mucous membranes, and even in the meatus of the ear. In this case it has an advantage over Chloroform and Ether, as the former is too irritating and the latter is too volatile. In doses of one to two grammes, administered to man, it does not interfere with the appetite, does not produce anaesthesia, but alle- viates pain. In whatever way it may be ingested into the organ- ism, it is entirely, or almost entirely, eliminated by the lungs. Only traces of it can be detected in the urine. This medicine has been recommended very highly by several physicians for spermatorrhoea, with anaemia, great debility, and de- pression of spirits. It has been used in the 2X trituration. My experience is limited and not very satisfactory. BROMIDE OF IRON, BROMIDE OF LITHIUM—BROMIDE OF NICKEL. 101 BROMIDE OF LITHIUM. Dr. S. Weir Mitchell prefers this salt to the other Bromides, in that it does not cause eruptions, and that its action is far more speedy. He gives a case of a gentleman threatened with apoplexy, who had had one attack and was hemiplegic. He was taken with numbness, vertigo, headache, and thickness of speech ; one dose of 30 grains removed the symptoms in less than half an hour. He also records a case of epilepsy, when a fit occurred every morning, on rising. Cured by 10 grains twice a day. When the other Bromides lose their effect in epilepsy this salt will arrest the fits. It relieved a case presenting the following symptoms: after any prolonged mental exertion, flushed face, insomnia, and intense pain between the shoulders. If I was to prescribe any Bromide in rheumatism and gout, I should prefer this on account of the Lithia which it contains. BROMIDE OF MERCURY. I have used this preparation in a few cases of diphtheria, with great painfulness of the inner throat, white deposit, and a dusky redness of the fauces and tonsils. It acts very satisfactory in the 3X trituration. Dr. Hildreth (an oculist) was enthusiastic in its praises in iritis and intense congestion of the tissues of the eye. BROMIDE OF NICKEL, The only mention of the preparations of Nickel in our Materia Medina is the pathogenesis of Niccolum carb. in the “Symptomen Codex,” but I am not aware that it has ever been used much by our school, no clinical record having come under my notice. By referring to the head symptoms, however, it will be seen that it causes a peculiar headache—a bruised aching, as if the head were being dashed in pieces, with heaviness, vertigo when rising, also tearing, stitches, hammering, boring, etc. These headaches resemble those of Nux, Ferrum, China, and Arsenicum. The Sulphate of nickel, which I mention in the “ Therapeutics 102 BROMIDE OF POTASSIUM. of New Remedies,” was introduced into use by Dr. J. Y. Simpson, of Edinburgh. Pie prescribed it successfully in periodical head- aches, and more lately some American physicians have found it successful in neuralgic headaches. I have cured periodical head- aches resembling the cephalalgia described in the provings of the Carbonate of nickel. It occurred to me that the Bromide of nickel, on account of its greater solubility, and the addition of the bromic influence, would be a better preparation than the Carbon- ate or Sulphate. I presented this to the profession through the Wisconsin State Society for trial in headaches. Until we have separate provings of this salt the symptomatology of the Carbon- ate can be used whereby to select it. I would advise the 2X or 4* trituration or attenuation. BROMIDE OF POTASSIUM, This was the first preparation of the Bromides which was pre- sented to the profession. It lias been most extensively used and its effects recorded with greater minuteness than any other. Of late, however, the Bromide of sodium, owing to its less irritating effects on mucous surfaces, its pleasanter taste, and some other qualities, is considered preferable. In fact, I think for the most purposes the Sodium salt may be used as a substitute for the Po- tassium. The pathogenetic and physiological action of the latter has been so well studied that we may safely allow it a place among our best proven medicines. Already it lias been prescribed success- fully for its direct primary effects by several physicians of our practice. No physician can read of its effect upon the mind without being convinced of its great power in causing abnormal conditions of the brain and mind. It is supposed that the uniform pathological condition caused by its direct effects in large doses is cerebral anccmia. If this con- dition is kept up, we have deficient nutrition. If the brain has been already diseased, structural or functional disease may become permanent—fixed by its primary or secondary action. BROMIDE OF POTASSIUM. 103 The most prominent, unvarying symptoms of the brain and mind caused by this drug are: (1.) Profound melancholic, delusions, either a religious depression or a feeling of moral deficiency. (2.) Loss of memory, absent-mindedness, he forgets howto talk, slowness of ideas. (3.) Delusions of conspiracies against him. (4.) Illusions, as that of seeing her brother fall overboard. (5.) Amnesic aphasia; he could pronounce any word he was told to, but could not speak otherwise. It does not cause melancholy with belief in approaching poverty and want, but the contrary; a belief that “ thousands of dollars are sewed up in his clothing,” or that “gold was concealed in the lining of his coat.” These profound melancholic and other illusions were all caused by massive doses. If, therefore, this medicine is prescribed for the symptoms enumerated as primarily pathogenetic—e. g., mental de- pression from cerebral anaemia or exhaustion—it must be given in minute doses, 3* to 6*. Dr. Wesselhceft, of Boston, and myself have prescribed it suc- cessfully in such cases after Cimicifuga, Sulphur, and Veratrum failed. The secondary pathogenetic effects of large doses are sometimes quite serious. It has been observed that when doses of 40 to 60 grains, several times a day, have been suddenly suspended, one of two conditions sets in: (1) a condition of cerebral irritation, (2) cerebral congestion. In cases of post-mortem of animals to which the Bromide had been given in massive doses, intense congestion of the brain and its meninges were found. This proves that the secondary action of the Bromides is to cause that condition for which it is given successfully. It is, therefore, homoeopathic in rational doses (1 to 20 grains) in cases of cerebral irritation and congestion. I have collected numerous cures of such cases and recorded them in “New Remedies,” 4th edition, but will here briefly enu- merate them, and will add that I have verified nearly all of them in my own practice. The first or irritative stage of delirium tremens is ordinarily 104 BROMIDE OF POTASSIUM. treated by 5 to 10 grains of Bromide repeated every two or three hours; but the face must be flushed, eyes red, pulse quick and hard, with delirium of active type and horrid illusions. If the face is cold and pale, pulse weak and thready, Digitalis is the proper remedy. I have found these two medicines, aided by Cimi- cifuga 3*, or Hyoscyamus lx, to control all cases of that fearful malady. No remedy compares in efficacy with this in the treatment of night terrors of children, from any cause. A few grains, according to the age of the child, given at bedtime, banishes these attacks at once, and often for a long time. If worms are present, a few doses of Santonin lx, during the day, is a valuable adjunct. Frightful imaginings in pregnant women, usually caused by an engorged condition of the brain, are speedily dissipated by a few doses. Somnambulism has been cured by it. Puerperal mania, when attended by ferocious or erotic delirium, is always relieved and often cured by the free administration of this medicine. Spasms and convulsions from fright, anger, and other emotional causes, occurring in plethoric, nervous people, or in women at the time of the menses. I prefer it to any other medicine. Epilepsy, when the attacks are attended or caused by unmistaka- ble congestion of the brain, are always alleviated. It has been asserted by our school that it never cures. I know that it has cured many cases of epilepsy of a recent character, and not de- pendent on constitutional causes. I admit that it will not cure congenital epilepsy, or the syphilitic, but it will modify such cases greatly; and it is only common humanity to give it for that pur- pose, even when a cure is not expected. I must mention one other condition of the brain and mind in which I have often found it useful, namely, in that condition of nervous irritability caused by the severe illness or death of some dear friend, or loss of property, or reputation. The patient is con- stantly fretting, will not eat, cannot sleep, is very irritable to all around; the pulse is quick, tongue coated, and breath fetid. In these cases give every hour or two a teaspoonful of a solution of BROMIDE OF POTASSIUM. 105 20 or 30 grains in half a glass of water. You will be gratified with the result. In acute congestions or inflammatory diseases of the brain I con- fess to a great liking for this medicine. It ranks with Aconite, Gelseminum, Veratrum viride, and Solanum. (I regret to say that I have nearly always been disappointed in Belladonna and Glonoin.) In active congestion or the first stage of inflammation, before ef- fusion has occurred, I verily believe the Bromides, if promptly and properly given, will arrest the disease. I did not at one time believe this, but repeated failures with our best remedies prompted me to give this a fair trial. I had hundreds of times been mor- tified and angry at the failure of Aconite, Belladonna, Bryonia, Gelseminum, Glonoin, and Veratrum, aided by hot foot-baths and cold water to the head. The patients would grow worse, and either run into fatal cerebral disease or into the hands of allo- paths. I once resolved that the next case that occurred Twould treat boldly with some Bromide. Two severe cases soon came under my care—a child aged 3, and an adult woman of 30. To the former I gave 3 grains, and to the latter lb grains, every hour for four hours, when I had the satisfaction of seeing a decided im- provement, followed by a recovery under smaller doses and less often repeated. Since that time, unless I see very prominent characteristic in- dications for some other medicines, I give the Bromide (of sodi- um) generally, and have been perfectly satisfied with the results. In the reflex cerebral irritations and congestions of children during teething, cholera infantum, or in scarlet fever, it is almost specific. Also in incipient basilar meningitis, many cases of which I have arrested before serious disease fixed itself on the child. The eye and ear symptoms are important as designating local disorder. The amaurosis, strabismus, squinting, photophobia, etc., the ringing in the ears, and sensitiveness to noise, all point to cerebral irritation. It causes, and will cure, a peculiar state of the throat, in which the patient is choked every time he tries to drink fluids, although he can swallow solids with impunity. I have often verified Dr. Caro’s recommendation and practice VOL II.—8 106 BROMIDE OF POTASSIUM. in treating difficult and painful dentition of children by its local application. Dissolve a few grains in an ounce of milk or water, and bathe the gums. From being turgid, swollen, and red, they assume their natural color. If the salivation is difficult, it restores it; and the sleeplessness, jactitation, vomiting, and diarrhoea are all relieved. In the vomiting of drunkards and of pregnant women it often acts magically. It quiets that reflex action, whether arisingfrom the brain or uterus. Give a dose, say 10 grains, at night, and the same amount in the morning before rising. A few days’ trial will suffice to test its value. One of the worst cases I ever saw was cured by enemas of 20 grains, night and morning. Hysterical women often vomit their food after each meal, es- pecially if they are subject to exciting emotions. A few grains given just before eating will often prevent the recurrence of the vomiting. Several years ago one Dr. Caro, of New York, made a report on cholera infantum, in which he claimed to have cured one hun- dred and fifty-seven out of one hundred and sixty cases by the administration of Bromide of potassium, in doses varying from one-fiftieth to two grains every hour. This report created quite a sensation, and allopathic physicians all over the United States tested its value in that disease. Many homoeopaths, attracted by the “ glittering generalities ” of Caro, gave it a trial, but the results failed to verify Caro’s experience, and the medicine fell into disuse. Such is too often the case with new remedies in allopathic hands. How shall we explain this discrepancy ? Bromide of potassium does not cause this disease by its primary action, and its secondary action has not been sufficiently studied to show that cholera infantum belongs to the secondary effects. I believe, however, that it would appear if children were the subjects exper- imented upon. What is cholera infantum? A disease of the bowels? I be- lieve that true cholera infantum, that kind which comes on sud- denly, attended by great prostration, cold hands and feet, hot head, dilated pupils, rolling of the eyes and head, starts, jactitation, spasms, watery, very offensive stools, vomiting of all drinks, and, intense thirst, 107 BROMIDE OF POTASSIUM. is nearly always a disease of cerebral origin, or an overexcitement of the nervous and vascular systems. Probably Caro’s cases were all of that character, or nearly all. Certain it is, that when I meet with cases such as above described, I find one of the Bro- mides to be almost specific in removing those symptoms. I do not rely on it in all cases alone, but alternate Camphor, Veratrum alb., Carbolic acid, or Solarium, as the case seems to indicate. But in the majority of cases I rely on the Bromide alone. Asiatic cholera has been successfully treated by twenty-grain doses of Bromide every hour. Dr. Begbie says: “ In the first stage it arrests the vomiting, the cramps and the rice-water dis- charges, restores the secretion of urine ; the warmth and color re- turns to the previously cold and livid skin.” He suspends its use when reaction sets in. I have never had oppurtunity to treat cholera with this remeday, but from my happy experience in cer- tain cases of cholera infantum I should prescribe it with every hope of success. Colic in young children of a peculiar character, according to Sidney Ringer, is readily cured by it. I have often verified his recommendation. The special symptoms are: “ The walls of the belly are retracted and hard, while the intestines can be seen at one spot contracted into a hard lump, of the size of a small orange, and the lump can be seen to travel from one part of the belly to the other. These attacks are frequent and excruciating, are un- connected with diarrhoea or constipation, but are often associated with an aphthous condition of the mouth.” I have often observed that the attacks were periodic, coming on in the evening at a reg- ular hour. I give a grain or two of the 1* trituration in water every two hours during the interval, and every fifteen minutes during the attack. Constipation of years’standing has often been cured unexpectedly while giving this remedy continuously for other disorders. I cannot pretend to give a rationale of its curative action in such cases ; but the fact is worth noting. Some anomalous disorders of the rectum have been benefited by the Bromides. Dr. He!muth cured “ polypoid tumors.” I have relieved spasms of the sphincter ani. Dr. Caro records a cure of a child three days’ old who had re- 108 BROMIDE OF POTASSIUM. tention of the meconium. The infant vomited all food; no action of the bowels. One half grain of the lx trituration every hour rapidly removed these conditions. If this medicine was useful in no other sphere, its prompt and beneficent action in Morbid affections of the organs of generation would give it a high rank as a curative agent. In massive doses it causes a diminution, sometimes absolute, of all sexual desire and power. In this respect it resembles Gelseminum, Conium, Camphor, Ba- ryta, and Caladium ; but, unlike these drugs, it does not cause this impotent condition in all cases. It does, however, often give rise to secondary effects just the opposite. Pel vet says it causes contraction of the minute afferent vessels of the corpus cavernosum (primarily). The reaction against this contraction is, therefore, congestion or fulness, thence erections, etc. It is (primarily) ho- mceopathic to impotence, with loss of desire or power, or both, with or without atonic spermatorrhoea, and in such cases should be used in the 3d or 6th attenuation. It is (secondarily) indicated in satyriasis, nymphomania, erotomonia (hysterical, with spasms), sensual, amorous, and disgustingly lascivious dreams, nocturnal emissions, with erections and dreams, chordee, etc. I have made frequent and very successful use of it in all these latter conditions, giving 5 to 20 grains once, twice, or thrice a day, and have never seen other than good effects from its use. In some of the menstrual ailments it is specific, namely, when they are preceded or attended by epileptic spasms, catalepsy, headache, and congestive heat, burning and irritation of the genitals, nymphomania, erotic fancies, lascivious dreams, sleep- lessness, spasms of the uterus, pains in the ovaries, menorrhagia, and many disagreeable reflex symptoms. I have records of many cases cured promptly by giving a few grains daily through the mouth, and every hour or two during the menses. Ovarian disorders, such as irritation, neuralgia, swelling, and even tumors, have been cured by the Bromide. It has a specific influence on those glands, and ought to be used more in the reflex disorders caused by ovarian diseases. Enlargement of the uterus, especially that kind called by Simp- BROMIDE OF POTASSIUM. 109 son “subinvolution,” or a failure to return to its normal size after labor or miscarriage, speedily resolves under the use of this medi- cine. It has even relieved the pain and diminished the size of fibrous tumors of the uterus. This, with the Iodide of baryta and Ergotin, will, I believe, prove to be the best treatment for all tumors. Among the few pathogenetic symptoms recorded by homoeo- pathic provers, we find “ profuse urination, with thirst, copious, yellowish-white, thin urine, having a peculiar fetid smell; the urine sometimes contains albumen.” These symptoms would ap- pear to indicate it in diabetes, and Begbie reports two cases of diabetes mellitus which he cured in six weeks by giving 20 grains three times a day. The symptoms were pronounced and unmis- takable. The inquiry may arise, Why did such large doses cure? When it is remembered that if a man with the ague takes 20 grains daily of Quinine, the urine will contain the 20 grains, yet the man is cured of his ague (see Grauvogl), we can say the same of the Bromides. It is all, apparently, eliminated by the urine, yet the patient is cured. Maybe one grain or less would have cured the two cases, but if the 20 grains cured without injury, where is the harm ? Nocturnal enuresis has been cured by the Bromides. I cured several children of this troublesome disorder when giving them this medicine for “ night terrors,” which sometimes has some con- nection with the bladder difficulty. In whooping-cough it often acts as well as the Bromide of am- monium. Spasmodic croup is often relieved promptly, especially when it occurs suddenly in the night, and is the result of reflex irritation from teething or worms, rather than a catarrhal irritation. Dr. Snelling once treated many cases of diphtheritic angina and membranous croup successfully with this Bromide; but for some reason his use of it was not adopted extensively. (The Bromide of mercury will probably prove a better remedy.) Dr. Carson relates an obstinate case of nervous cough during pregnancy, threatening abortion. The cough was dry, hard, and incessant. No disease of lungs or throat. Opium and Belladonna were tried for two months uselessly. A few doses of the Bromide 110 BROMIDE OF POTASSIUM. of potassium cured. I have cured several similar cases, even when occurring in children ; a peculiar barking, brassy, incessant cough, which Kali bich. ought to have cured, but did not. It ought to cure in high potencies, loss of sensation in the glottis and larynx, but I have had no experience with it in such cases. * /Spasmodic asthma in children (asthma of Millar), according to Hebra and Londahl, has been cured promptly by this Bromide, even when suppression of urine, oedema, lividity of the body, and great dyspnoea had set in. Cardiac neuroses are often among the most obstinate and diffi- cult of all the maladies the physician is called upon to treat. Medicines which have a special affinity for the heart, such as Digi- talis and Cactus, exercise but little influence in these affections, unless the disorder has its origin in the ganglia of the heart itself. The majority of cardiac neuroses have their origin remote from that organ, namely, in some irritation or atony of the brain, spinal cord, liver, or reproductive organs. They are kept up by reflex irritation, or nerve enervation. The Bromides, if judiciously prescribed, will act curatively in that class due to irritation of a reflex character, especially when that irritation is in the uterus, ovaries, brain, or spinal cord. If the disorder is due to nerve enervation, the most useful remedies are Phosphorus, Zinc, Ferrum, Ignatia, Nux vomica, Lilium, etc. I can give no characteristic symptoms. The best guide for its use is in the general indications above given. All kinds of excited action, irregularity, palpitation, etc., when unattended by local lesion, come under the sphere of its usefulness. In sleeplessness, no medicine has been more abused. It is not useful in all cases. In fact there is but one pathological state in which it is useful, namely, an overfulness of the cerebral blood- vessels. When we have this condition, the Bromide, in doses of 10 to 20 grains, restores the normal calibre of the bloodvessels, and sleep comes of itself, i. e., it is not forced. The remedy acts in a physiological (homoeopathic) manner. Sleeplessness from this cause may arise from various causes, namely, mental anxiety, excessive intellectual labor, hysteria, pregnancy, teething, the exanthemata, typhoid fever, erysipelas, BROMIDE OF POTASSIUM BROMIDE OF SODIUM. 111 and a general “nervous irritability;” also anger and various ex- citing emotions. Sleeplessness may arise from an anaemic state of the brain, and then demands Opium, Hyoscyamus, Ignatia, or Digitalis, aided by food and a low position of the head. The action of Bromide of potassa on the shin is quite decided and specific. It seems to cause, invariably, after it has been taken some time in large doses, (a) an eruption of small boils, in succes- sive crops, chiefly over the face and trunk, with troublesome itch- ing ; (b) a papular rash on the face, with heat and itching; (c) acne, chiefly on face, scalp, and shoulders, not very painful, vary- ing in size from a millet-seed to a large pea; (cl) pustular erup- tions of malignant aspect, much resembling varioloid; (e) corrod- ing ulcers. Nursing children have had the characteristic acne, from the taking of a Bromide by the mother, showing that it is taken up into the milk. It ought, therefore, to be homoeopathic to these cutaneous affec- tions. My clinical use of the Bromides in skin diseases has been confined to the treatment of acne in young people of gross habits of eating, in which disorder it has seemed to act beneficially in the 3d trituration. I have used it successfully in the following general nervous affections: 'paralysis agitans, tetanus, chorea. In that condition known as hysterical spinal irritation, and in anomalous disorders of the vasomotor nerves, it is worthy a thorough trial. BROMIDE OF QUININE. Dr. Richardson, of England, introduced this medicine, and used it with favorable results. I have had no experience with it, but should I have much ague to treat, I think I should give it a fair trial. It ought to prove very useful, and in some respects supe- rior to the Sulphate. The unpleasant congestion of the head might be avoided, as the two constituents are antagonistic. BROMIDE OF SODIUM. I have already mentioned this salt. It is to be preferred in nearly all cases to the Bromide of potassium. It can be mixed 112 BROMIDE OF ZINC BUFO. with the food of patients, with the milk of children, as its taste is almost identical with common salt. BROMIDE OF ZINC. This combination has been but little used except by its origi- nator, Dr. Hammond, of New York, and by Dr. Delamater, of Chicago, who estimate it very highly in certain cerebral affections. As homoeopathists we value Zincum as a great remedy in dis- eases of the brain and nervous system. We know that Zinc, by its ultimate primary action, causes and cures cerebral depression, anaemia, and even paralysis. It is our sheet-anchor in cases of senile atrophy, softening, and brain fag. It has saved thousands of children from the fatal effects of hydrocephalus and hydro- cephaloid conditions. In my opinion the Bromide will prove more useful than Zinc alone, for it has a quicker action and is absorbed more readily. It is but a few months since I procured this drug, but I have already learned to value it highly. I prescribe it for the known effects of both Bromine and Zinc. Teething children often suffer intensely from pain in the nerves of the head and face. These pains often throw the children into an exhausted condition, marked by stupor alternating with wake- fulness, until they are so worn out that symptoms simulating hydrocephalus appear. In such cases the 3d or 6th attenuations act promptly. In the brain fag of business men I prefer the Phosphide of zinc. But if this condition is attended by violent pain in the head—periodical—the Bromide is superior. In chronic congestion of the brain, attended by a tendency to dementia or melancholy, the Bromide is also useful. In some respects it is an analogue of Picric acid or Cimicifuga. BUFO. I have seen no reason to change the opinion I expressed in the third edition of “New Remedies/’ relative to the trustworthiness of the provings of this and other medicines of which Houat has BUFO—CACTUS GRANDIFLORUS. 113 given pathogeneses. It would be better for our school had they never seen the light. I have tried the Bufo in several cases of epilepsy when it seemed indicated, but I never saw any such brilliant results as have been recorded by Dr. Holcombe and others. CACTUS GRANDIFLORUS. I doubt if this medicine has come up to the expectations of some members of our school of practice. It was heralded by the most fulsome laudations of its great value, not only in diseases of the heart, but in all other acute inflammations. I do not remember, however, to have seen any record of diseases other than disorders of the heart cured by the Cactus. It is my opinion, from careful observation and study of its ac- tion, that all the symptoms and conditions caused and cured by Cactus are due to its affinity for the heart, and its pathogenetic action thereon. It appears to me that its action on the heart is that of an intense irritant of the ganglia of that organ. It may thereby cause the several conditions of hypercesthesia, irritability, neuralgia, spasm, irregular action, and, finally, inflammation. It differs from Digi- talis in this, that it seems to have an action on the circular fibres of the muscular tissue of the heart, while Digitalis acts on all the muscular fibres alike. Cactus is capable of causing carditis and pericarditis ; Digitalis is not. Cactus resembles Bryonia, Aconite, and Spigelia more than it does Digitalis. In only one condition does it resemble Digitalis, namely, cardiac failure, and in both the failure is a secondary effect. If you will carefully study the symptomatology of Cactus, you will see that the mental, cerebral, ocular, aural, nasal, pharyngeal, gastric, hepatic, urinary, ovarian, uterine, and thoracic symptoms can all be traced back to a profound cardiac disturbance. It will be useless, therefore, for you to prescribe Cactus in dis- orders of the above-mentioned organs, unless the great central organ of circulation is at fault. I wish to call your attention particularly to the haemoptysis of Cactus. It is not indicated in spitting of blood, unless it is caused 114 CACTUS GTtANDIFLORUS. by an excited action of the heart, acting on pulmonary vessels weakened by disease of the lung-tissue. In haemoptysis, with weak, small pulse, it is not indicated ; but if the heart’s action is hard, tumultuous, and the pulse similar, then Cactus will arrest it. The blood must be bright and fluid (arterial). It is recommended in pneumonia and pleuritis, but has not at- tained any popularity in those diseases. In the few cases reported the pulse was hard, vibrating, 120. I suspect, in all cases when it is useful, some cardiac inflammation or abnormal excitement must be present, as a complication, or as a cause. The bronchitis and asthma. in which it is indicated is, without doubt, always a cardiac complication. The characteristic symptom of Cactus heart-trouble is “a sensa- tion as if the heart was constricted as by an iron band.” This sen- sation is very distressing, and whenever felt is a pretty sure indication for this remedy, or for Iberis, Arnica, and sometimes Digitalis, but in a less degree. Valvular diseases of the heart may be palliated by Cactus in a large proportion of cases, unless the disorganization is too far ad- vanced, when Digitalis will be of greater service. Hypertrophy with enlargement is more under the control of Cac- tus than is hypertrophy with dilatation, which is just the reverse of Digitalis, Iberis, or Lycopus. For the numerous cases cured or relieved by Cactus, see the extended collection made in the fourth edition of “Symptoma- tology of New Remedies,” which I copy. * Sensation of constriction in the heart, as if an iron band pre- vented its normal movement. * Palpitation of the heart, continues day and night, worse when walking, and at night when lying on left side. ° Functional disorder of the heart from mental emotion, aggra- vated at the menstrual period. ° Angina pectoris. 0 Palpitation, acute and chronic, even in organic diseases of the heart. ° Acute inflammatory affections of the heart, idiopathic, and even from rheumatism. 115 CACTUS GRANDIFLORUS. ° Acute carditis, with'blueness of the face; oppression of breath- ing; dry cough; pricking pain in the head; cannot lie on the left side; pulse quick, throbbing, tense, and hard. ° Chronic carditis, with oederaatous and cyanotic face, suffocating respiration, continued dull pain in the heart, dropsical effusion throughout the body; cannot drink or speak; hands and feet cold, pulse intermittent. ° Hypertrophy with dilatation ; patient is pulseless, extremely exhausted, panting, and sad; cannot lie down or speak; has scarcely slept for fifteen days; forgetful; feet cedematous. (Is soon relieved, lies down, and sleeps twelve hours.) 0 Organic diseases of the heart; valvular diseases (an invalua- ble palliative for many distressing symptoms). 0 Heart disease, with oedema of left hand only (no other rem- edy has this symptom). ° A constant fluttering sensation in the stomach over the location of the coeliac axis, in a spot about the size of a dollar; a burning line extends down from it to the lower ribs on either side; a hot flash shoots downwards frequently (cured by a few doses). ° Rheumatic inflammation of the heart with severe pain in the apex of the heart, and pain shooting down the left arm to the ends of the fingers; dyspnoea, pulse feeble, 120, etc. ° Palpitation of the heart from any exertion, with excessive pain over the left side between the scapulse and sacral region. ° A whizzing to-and-fro sound, or bruit de soufflet. ° Endocardial bruit, increased prsecordial dulness, excessive im- pulse of the heart’s action, and evident enlargement of the right ventricle. ° Great iregularity of the heart’s action—intermittent at times and of varying character—great frequency of action alternating with slowness. (Enlargement of left ventricle, with great irrita- tion of the cardiac nerves.—Sandford.) ° Irregularity of the heart’s action, from reflex irritation. ° Palpitation, with vertigo, dyspnoea, loss of consciousness. Indications for Cactus in cerebro-spinal meningitis: Melancholic and hypochondriac mood. Vertigo from congestion to the head. 116 CACTUS GRANDIFLORUS—CALABAR BEAN. Heavy pains, like a weight on the vertex, worse from sounds, even talking. Pulsative pains in the temples, intolerable at night. Dimness of sight, circles of red light before the eyes. Pulsations and buzzing in the ears. Contraction in the throat and oesophagus, preventing swallowing. Oppression on the chest, like a great weight, or as if the chest were compressed, with fainting, cold perspiration, and loss of pulse. Sensation of constriction around the heart, as if an iron band was around it. Very acute pain, and such fearful stitches in the heart as to cause him to cry aloud, with distressing palpitation, faintness, dyspnoea, etc. (Pains everywhere—head, arms, legs, back, chest, heart; dart- ing, springing like chain-lightning, terminating with a sharp, vise- like grip, only to commence again a moment afterward, with rest- lessness and groaning.) This last symptom is a curative one, observed by Dr. Lilienthal, and doubtless would be found pathogenetic in a full proving. This sense of constriction seems to affect all portions of the body. Dr. Farrington writes me that “a very intelligent lady, who for years has used homoeopathy, took many doses of Cactus30. She complained of irresistible inclinations to cry. She felt as if her whole body was in a wire cage, and that each several wire was being twisted tighter and tighter.” Dr. F. also sends me a case of rheumatism of the diaphragm, cured by Cactus 30th and 200th. The symptoms were “constric- tion around the lower part of the chest as from a cord, the con- striction marking the periphery of the diaphragm; jerking breathing; sharp pains shooting through the body, towards the back and upwards into the chest, with sensation of rush of blood to the chest.” The C. Bonplanti and another species have lately been used successfully in place of C. grand. CALABAR BEAN, This powerful and unique medieine has not been sufficiently proven by our school to enable us to arrive at any definite conclu- CALABAR BEAN. 117 sion as to its special symptomatic indications. There are certain pathological conditions which it has been known to cause, and these afford 11s trustworthy data for its use in some peculiar cases. According to the best observers of its effects in large and poison- ous doses, its operation is spinal, not cerebral ; it acts on the an- terior or motor column, so as to suspend or deaden its energy, or reduce the activity of its functions. The powerless parts are those which receive their nervous supply from the spinal cord and its nerves. The muscles of the extremities and of respiration are most enfeebled ; the paralysis is primary and always seated in the shaped muscles; there is no failure of volition ; the will is strong, but a difficulty lies in the way of carrying out its purpose. The paralysis is commonly preceded by twitching or trembling of the muscles (in animals convulsions). In rare cases the unstriped muscles and brain are involved (sec- ondarily). Death occurs from paralysis of the heart, or fatal syncope. (Digitalis from the opposite, or tetanic contraction.) To sum up its effects, as I conceive them : (1) General paralysis of motor nerves, or voluntary muscles (primary); (2) paralysis of involuntary muscles (secondarily). Viewing its action in this light, you will see that it is primarily homoeopathic to such maladies as : Chorea, of which there are several cases reported as cured by ten to eighteen drops a day. (a) A boy of fourteen, the disease had lasted several months; had resisted Ferrum, Arsenicum, and Zinc; cured in nine weeks. (6) A girl of twenty, cured rapidly, (c) Chorea of right side, the tongue seemed too large (paralyzed). The symptoms are not fully recorded, as they should have been. Paralysis agitans, if no structural lesion, as softening of nervous tissue, exists. Several observers (allopathic) mention that it did no service in such cases. Hammond (“ Diseases of Nervous Sys- tem”) says: “Under the term paralysis agitans several affections have been included, which are very different in character.” He classes them : (1) multiple cerebral sclerosis; (2) cerebro-spinal sclerosis. “These two are usually met with in old persons and depend on organic wasting changes in the nervous centres, are incur- able, and known as ‘ shaking palsy.’ ” (3) A form of tremors occur- 118 CALABAR BEAN". ring in younger persons, is more curable, and therefore is presum- ably not dependent on organic change. The causes of this variety are emotional disturbance, continuous or severe muscular exertion, exhausting diseases, rheumatism, blows, falls, etc. The Calabar bean in small doses (lower dilutions, possibly the high) will doubtless prove curative in this form of tremors. It may have to be preceded or followed by Arnica, Ignatia, Scutel- laria, Cocculus, and Phosphorus. The “ constant primary electri- cal current,” according to Hammond, is very useful in all cases. The heart may partake of this variety of tremors. I have met with several cases due to emotional disturbance. In one case I used Calabar 3X with good results. It is certainly homoeopathic to cardiac debility, and ought to be useful in that peculiar condi- tion I have named cardiac chorea. I recently cured with Calabar a case of tetanic spasms, where the heart was affected by the disease. (See “N. A. Jour. Horn.,” May, 1875.) Cerebrospinal meningitis. It was first used in that terrible dis- ease by some eminent allopathic physicians of Chicago. Their successful use of it coming to my knowledge, I ascertained that they used it, as they thought, antipathically, or for the tetanic con- tractions of the spinal, cervical, and other voluntary muscles, which commonly occur during the progress of that malady. This condition, however, is only apparently tetanic in many cases; it is really a paralysis of the opposing or antagonistic muscles. In such cases the Calabar is primarily homoeopathic to the condition. If, however, the condition is really tetanic, it is secondarily indicated, for I believe a primary paralysis is often followed by a secondary tetanus. In the former condition the attenuations (2X to 3X) would prove most useful; in the latter five to ten drops of the mother tincture every three or four hours, either in alternation with or followed by Secale 0 in similar doses. I speak from my own experience, for I have the records of several cases, pronounced incurable, which recovered under the use of Calabar. A primary symptom indicating Calabar is contraction of the pupils; a secondary, dilated pupils. The heart’s action is tumultuous, feeble, and irregular. Idiopathic tetanus has been successfully treated with Calabar in CALABAR CAFFEIN. 119 large closes. Many severe cases have been reported. It has also been efficient in tetanic spasm from Strychnia poisoning. Certain epileptiform spasms have been cured by this medicine, but the details of the cases were given with that peculiar indefi- niteness which belongs to allopathic reports, and I cannot give you the specific indications. The action of Calabar on the eye is specific and unvarying. It is the opposite of Belladonna. It causes contraction of the pupils to the size of a pin’s head, attended at first by a “ twilight gloom,” which wears off before the pupils dilate. It causes short-sightedness in healthy eyes, and restores, tempo- rarily, normal vision in long-sighted persons. Astigmatism is a condition caused by Calabar. It has proved curative in several cases of paralysis of the circular fibres of the iris and ciliary muscles of one or both eyes. In prolapsus of the iris from injuries, its topical application caused the retraction of the prolapsed portion and contraction of the pupil. Oculists make extensive use of it locally when it is desirable to cause contraction of the pupil. The provings of Beckwith, Chase, and Wesselhoeft give some peculiar symptoms, but they did not use sufficient quantities to cause those distinctive characteristic symptoms which we require. Beckwith found it to cause and cure a form of dyspepsia marked by great pain (pressure) immediately after eating. In this it is analogous to Dios., Arg. nit., and Bismuth. I have cured many obstinate cases of constipation with Calabar. Also the trouble flatulence which so greatly annoys women at the “change of life.” It resembles somewhat, in its action, Agaricus, Gelseminum, Solanum, Conium, and Arnica, but no remedy is very closely analogous to it. It is one of those medicines which you will find have a narrow but decided action, and when indicated will act promptly and profoundly. CAFFEIN. This substance is the alkaloid of the Coffee bean. It is said that a cup of coffee, forming an infusion of 16.75 grams of dry 120 CAFFEIX. coffee, contains about 0.1 to 0.12 gram of Caffein; and an infu- sion of 5 grams of very good tea contains the same quantity of Caffein. The chemists have decreed Caffein and Thein are identical, but we cannot always accept the dictum of the chemist, for two substances may appear chemically identical, yet may pos- sess different physiological properties. It was once supposed that Caffein represented the principal qualities of tea, coffee, guarana, and some other substances used as beverages by various nations. But it is doubtful if such is the fact, for they all differ in effect, while the action of the Caffein is uniform. It is probable that coffee contains several other constit- uents in smaller quantities than Caffein, so that Caffein cannot be made a complete substitute for the “ Coffea ” which we have used in practice. Dr. Aubert (“Pfluger’s Archiv ”), who has studied the effects of this substance on the nerves, muscles, respiratory movements, heart, and circulation, says it increases the reflex excitability and may produce tetanus. He considers this “ a medullary tetanus, for it is produced in the frog if the ischiatic nerves are cut, and it takes place in a limb the circulation in which has been stopped by a ligature before the subcutaneous injection into the skin of the back.” Caffein has been used in the practice of European and English physicians, and also in this country, much as the Guarana (Paul- liana) is now used, namely, for nervous and sick headaches. Its pathogenetic power of causing excessive reflex excitability accounts for the virtues of Coffea, even in high potencies, in the nervous erethism of children and women, and shows that it may homoeopathically prevent the accession of tetanoid spasms during intestinal irritation, or even the irritation of dentition. It is therefore an analogue of Hux and Ignatia, but antago- nistic to Scutellaria, Cypripedium, Calabar, and the Bromides (also Chloral). But it has other curative powers which may be utilized. It has been found curative in cardialgia, spasmodic asthma, hemicrania, and nervous palpitations. Coffee-drinkers are notoriously subject to crampy pains in the stomach, palpitation of the heart, and severe headache. A proof CAFFEIN. 121 that tea is not identical with coffee, is the fact that after the sus- pension of the use of coffee, and a resort to tea as a beverage, these symptoms disappear. Tea symptoms subside after substituting coffee. I have used Caffein a good deal during the last few years, especially in sleeplessness; nervous agitation after excessive pleas- urable emotions; nervousness in teething children, and in women suffering from uterine diseases. I usually prescribe the 3X trituration, nor have I ever observed any aggravations from it. On the contrary, it generally relieves, when Scutellaria or Ignatia fails. Sometimes Coffea 200 will act better than Caffein. This is probably due to some idiosyncrasy or extreme susceptibility. One of the pathogenetic symptoms of Caffein is “flushing of the face.” You will find it palliative of that symptom when occurring in women at the climacteric. The Bromo-hydrate of Caffein exceeds Caffein in some of its sedative effects on the system. I have been pleased with the effects of the 2X trituration, in sleeplessness, especially when there was frequent and watery urine. Citrate of Cajfein as Diuretic in Cardiac Dropsy.—Professor Gubler called atten- tion some time since to the property of the Citrate or the Bromo-hydrate of caf- fein, given in doses of four to eight grains, in producing abundant and instantaneous diuresis in cases of cardiac dropsy, either when given hypodermically or by the mouth. Dr. Lewis Shapter (“ Practitioner,” January) adds to this his experience with the Citrate alone. The dose given by Dr. S. has not exceeded three grains in any case, on account of the nausea and vomiting produced by larger amounts. This has been sufficient, however, to establish copious diuresis as a general thing even in the most advanced stages of cardiac dropsy. In one of Dr. S.’s cases a pill of Citrate of caffein, three grains, was given at night. The urine previously passed had been to the amount of a pint to a pint and a half in twenty-four hours. During the first night after taking the pill, and the next morning, the patient, passed two and half pints of urine. Subsequently Citrate of caffein in three- grain doses was ordered in solution with Glycerin and water, and for six weeks, while this was continued, the amount of urine passed during each twenty-four hours amounted to from two to three pints. Other cases are detailed by Dr. Shapter, in which the Citrate of caffein acted equally well. His observations lead him to the opinion that Citrate of caffein occupies a “ special ” place as a therapeutic agent in cardiac disorder, its position being limited as a cardiac diu- retic to advanced cases of cardiac disorders, or such advancing cases of cardiac disorders where muscular embarrassment and neurosal incoordinate cardiac ac- YOL. II.—9 122 CAFFEIN—CALCAREA IODATA—CANCHALAGUA. tion (the indicators of progressive mural decay) exist. The existence of these symptoms appears clinically to forbid the administration of “tonic” doses of Digitalis so long as an outlet has not been effected from the venous system which shall coincidently, with more powerful cardiac contraction, relieve the stagnating pressure of venous blood on the right side of the heart. Citrate of caffein is (1) a diuretic. (2) It increases the heart’s action, either (a) directly by stimulating the organ itself, or (b) indirectly by means of the arteries, which it also excites to further contraction. After discussing its physiological action at some length, Dr. S. concludes that, whatever may be the true theory of the action of Citrate of caf- fein, the opinion is forced upon him from observation, that in doses of gr. iii to to gr. vi it is a diuretic and cardiac stimulant of great value in cases of cardiac dropsy, where a dilated, feeble, and irregularly contracting heart, undergoing progressive mural decay, is the main clinical and pathological element to be con- tended against.—“ Philadelphia Medical Times.” A recent German writer praises theBromo-hydrate of caffein in doses of and T X01J grain (lx and 2* triturations) in dropsy from heart disease, especially when due to dilatation or failure of the circulation from cardiac debility. It seems to act better than the simple Caffein or the Citrate. CALCAREA IODATA. (Iodide of Calcium.) This is a crystalline salt, soluble in water, but readily decom- posed in the liquid state. It has been used mostly in scrofula and tuberculosis. Admin- istered in phthisis, it improves the appetite and digestion, and diminishes the cough and nightsweats. It has been used with considerable success in goitre and other glandular enlargements. The first decimal trituration is the best form for ordinary use. CANCHALAGUA. This plant was introduced as a remedy for ague, but its use was never attended with such success as to warrant its continu- ance. While practicing in a malarious district many years ago, I tried it in many cases, but it proved useless. I do not believe it is now used, as it is rarely, if ever, ordered from our pharmacies. Its botanical identity is in doubt. The name above given is the vulgar name given it in California. CANNABIS INDICA. 123 CANNABIS INDICA. The marked and peculiar influence of the Hashish upon the brain and mind, has always given it a high rank as a supposed remedy in mania, insanity, and other disorders of the mind, but the experience of both schools has not realized the hopes of phy- sicians. It stands almost alone as a medicine that seems to possess the power of acting on the soul. It seems to give us some idea of the vast capabilities of emotion, comprehension and capacity for hap- piness and sorrow, which the soul of man possesses, but which lie latent while the body incloses it. As a homoeopathic remedy, it is indicated in all degrees and varieties of insanity, from profound depression to the highest ex- hilaration. I can find recorded, however, but few cases of insanity where it has been of much service. Dr. Gray reports its successful use in “spectral illusions, not accompanied by terror, caused by nervous fevers, puerperal mania, or religious excesses.” It ought to be useful in puerperal mania, with nymphomania (in a high dilution), but in two cases in which I used it, no cura- tive results were obtained. It is my opinion, that in order that it shall prove curative in mental diseases, they must be purely psychical in their origin, and not depend on any bodily ailment. In this respect it differs from Belladonna and Stramonium. In some affections of the brain and nerves of the head, the Cannabis takes a high rank. It is one of my favorite remedies in nervous vertigo, so called, which comes on after mental excitement, or remains after acute congestion of the brain. (Dose 2X to 6th.) Hemicrania, in its severest form, is often cured by the hemp, when all the usual medicines have been used in vain. The symp- toms of the provings do not give us any characteristic indications, but the published experience shows that it is indicated when the attacks occur periodically, every week or two, and are very agonizing, rendering the patients delirious or unconscious, leaving them pros- 124 CANNABIS INDICA. trated and nervous. The face is generally pale, the head cool, noise and light aggravate, but no vomiting occurs. In such cases it is analogous in some respects to Sepia, Spigelia, Arsenic, and Zinc, val. The dose most successful has been the mother tincture, 5 drops three times a day, as a preventive, and every hour during the paroxysm. This variety of neuralgia generally occurs in thin, delicate women, and has lasted for years. I am cognizant of some cases permanently cured by this plan of treatment. Dr. Marcy claims for it great value in subacute inflammation of the brain, delirium tremens, and hypochondria in females advanced in life. A prominent symptom in its provings is “involuntary shaking of the head,” such as we see in some cases of palsy. (See Calabar.) Since the third edition of “ New Remedies” was published, the India hemp has been used successfully in many cases of cerebro- spinal meningitis. Both schools of medicine claim its use. It is undoubtedly homoeopathic to that disease, as the pathological effects of poisonous and fatal doses on the spinal cord and brain, as well as the recorded symptoms, are very similar to those observed in that disease. My observation and experience lead me to restrict its value to the first stages of the malady, or the stages of irritation and congestion. After effusion or structural lesion has taken place, its action is not strictly curative, although it may prove a valuable palliative, and thereby aid indirectly in bringing about recovery. The following indications were published in a paper on that disease contributed by me to the “ U. S. Medical and Surgical Journal,” 1873: Delirium, generally gay; laughter, hallucinations, ecstasy, with or without loss of consciousness. On regaining consciousness, violent shocks are felt passing through the brain. Vertigo on rising, with stunning pain in the back part of the head, and he falls. Fulness and throbbing in the forehead, as if it would burst, with sensation like a heavy blow on back part of head and neck. Involuntary shaking of the head. CANNABIS INDICA. 125 Fixed gaze; dilated pupils; redness of the eyes; throbbing, ringing and buzzing in the ears; sensitive to sounds. Cold face, with drowsy and stupid look. Stinging, burning, and scalding, before, during, and after urina- tion. Amorous paroxysms. Anguish in the chest, with great oppression. Pain across the shoulders and spine, forcing him to stoop, and preventing him from walking erect. Entire paralysis of both lower extremities and the right arm. Convulsions; emprosthotonos, with loss of consciousness; cata- lepsy. Collapse; stupor; insensible pupils; pale, clammy and insen- sible skin; extreme debility; feeble, irregular pulse. In that dreadful disease, hydrophobia, it is highly recommended as the surest palliative when death is imminent. The dose should be large and frequently repeated (gtts. xx to xl every hour, until quiet is obtained). In cases due to imagination, pseudo-hydro- phobia, it will doubtless act as a curative agent in smaller doses. Hysterical spasms and a host of hysterical manifestations ought to be controlled by Cannabis, for its symptoms are more closely allied to the hysterical malady than any drug in our Materia Medica. A healthy lady once took 10 drops—probably more— to see if it wmuld cure mental excitement. It caused decided hys- terical paroxysms, although she had never before had anything of the kind. It causes hypercesthesia of the auditory nerves, also the optic. Hearing and vision are curiously perverted. I have cured several cases of tinnitus aurium with the 3X dilution. It causes canine hunger, but differs from China and other medi- cines causing that condition in this, that digestion is equal to the emergency. One person records that “ pastry and fat food, which previously he never ate without suffering from rancid risings and headache, are now digested regularly.” The urinary symptoms are very similar to those of Cannabis sativa. It is well known to botanists that the two are merely va- rieties, the Cannabis indica being the original and stronger spe- cies. If there is any difference in the symptoms, it is in the greater 126 CANNABIS INDICA. effect the Cannabis indica has on the nerves of the urinary organs, as witness the symptoms of paralysis of the bladder and spasmodic action. On the other hand, the blennorrhagic symptoms are not so well marked, nor are the inflammatory. Its primary action on the organs of generation of both sexes is that of an aphrodisiac, for which purpose it is largely used in the East. It causes satyriasis, erotomania, nymphomania, priapism, chordee, involuntary erections and emissions,—always with amor- ous dreams. Its secondary effects are just the opposite, and the Hashish-eaters of the East all become prematurely impotent. The homoeopathic indications are evident. I often substitute it with good effect for Cannabis sativa. Dr. Hirschel recommends it very highly in profuse menstrua- tion, menorrhagia, and haemorrhage from the uterus of pregnant women. In the treatment of dysmenorrhoea it rivals Viburnum, Caulo- phyllum and Xanthoxyllum. It appears to control the neuralgic and spasmodic varieties, but is more particularly indicated when the patient is hysterical, emotional, and the menses are preceded, attended, or followed by unusual sexual desires. In allopathic practice it has effected some wonderful cures of dysmenorrhoea in women subject to neuralgia, and in my own practice it has relieved and cured patients who had been treated, ineffectually, for years, by uterine specialists, and with electricity. I use the lx tincture trituration, or the mother tincture, giving a few grains of the former, or a few drops of the latter, three times a day during the month, and every hour or oftener in severe cases, during the pain. My experience is, that it is useless to expect a radical cure by giving the remedy only during the paroxysms of pain. The sys- tem must be brought under the influence of the medicine, and kept under it, before the period of suffering arrives. It has been claimed that as a parturient or uterine-motor remedy it is analogous to Secale and Caulophyllum. In a few cases where I have given it to accelerate lingering labor, it has seemed to have the desired effect. It is decidedly beneficial in the 1* in after-pains. Spasmodic asthma has often been promptly relieved by India hemp. One of its most prominent symptoms, which I have often witnessed from one dose, is : 127 CANNABIS INDICA—CARBOLIC ACID. u A feeling of suffocation, wants to be fanned ; oppression of the chest, with deep, labored breathing; anguish, accompanied by great oppression, ameliorated in the open air.” When these symptoms are present, a few drops of the lx, every half hour, will give prompt relief. Cardiac asthma will also be relieved by it, as the following symptoms show: “Pressing pain in the heart, with dyspnoea the whole night; anguish at the heart; stitches in the heart, accompanied by great oppression, the latter relieved by deep breathings.” It has two other prominent heart-symptoms which may be remembered with benefit: “ Pain (stitches) in the heart, with palpitation, when lying on the left side.” “ Palpitation of the heart, awakening him from sleep.” Dr. Gray reports as cured a case of “ paralysis of the lower extremities,” but he alternated it with Nux vom., which spoils the value of the report. Cannabis has, however, many symptoms of paraplegia, and may prove curative in some cases, not caused by any grave lesion of the cord, but functional in its character. It ought to be an excellent remedy in sleeplessness from mental excitement, for nightmare, and for the night-terrors of children; also for a sleep disturbed by vivid dreams, which weary the patient. I regret to say that you will find many “ Hashish-eaters ” in your practice. Its seductive influence is little less fascinating than Opium, and men and women are both driven by care and trouble to its use. CARBOLIC ACID. This powerful agent, introduced into medicine as a disinfectant is worthy a high rank as an internal remedy. The provings in- stituted by Drs. Hoyne and Mitchell develop the fact that its true analogues are Arsenicum, Baptisia, the Bromides, Cimicifuga, Creasote, Lachesis, Belladonna, Solanum, Sulphur, etc. Many of its symptoms remind us of the acro-narcotics; others of the corrosive poisons. It is feared that it will meet the fate that Arnica meets at the 128 CARBOLIC ACID. hands of the majority of our school. Hahnemann had a high opinion of Arnica as an internal remedy, and he gave us an ex- cellent pathogenesis, but somehow the idea takes possession of the average homoeopathist, that it is to be used solely as an external application, or if given internally at all, only in case of injuries. The fact is that Arnica is nearly as valuable as Bryonia or Nux vomica in a variety of internal diseases. So with Carbolic acid. It will prove far more useful as an internal remedy than it ever has as a topical application. As a disinfectant even it has lately been deposed from the high rank once assigned to it. My present estimate of Carbolic acid is, that its sphere of action is the cerebrospinal centres, and that the disorders of the mucous surfaces, of the blood and secretions, of digestion, etc., are but the consequences of this primary action on the central nervous sys- tem. Its pathological action, when applied locally to any tissue, is that of a caustic, disorganizing the surfaces when it is applied in a peculiar manner. It causes an ulceration and sloughing, with tendency to putrescence. It is in this class of local lesions that its use, in very dilute solutions, will cure by its homoeopathic rela- tions. It has been supposed by some that this acid cures diseases, ex- ternal and internal, by its power of destroying certain germs which permeate the blood and secretions. It is true that this substance destroys the life of animal and vegetable growths, such as infusoria, bacteria, vibriones, micro- scopic fungi, etc., quicker than any known substance, unless it be the Sulphite of soda. But this does not prove that it cures or can cure all diseases where these organisms abound in the fluids and solids. In a majority of diseases these organisms are a result and not a. cause of disease. Just in proportion as the nervous life of the body becomes weak- ened, comes the tendency to deterioration of the solids and fluids, and finally the presence in them of animal and vegetable organ- isms. Now, it is my belief that Carbolic acid has the same effect on 129 CARBOLIC ACID. the human as on the lowest organisms, namely, the destruction of the vitality of the nerve-centres. We will now take up the most characteristic symptoms of the drug, and compare them with the cures made with it, and see if the above speculations are borne out: The head symptoms are quite prominent, thus : “ Feels as if a band was around the forehead.” (Bell.) “ Dull pain, running from forehead to occiput.” “ Burning in top of the head.” (Sulph.) “ Constant dull pressure and pain in the occiput and muscles of the back of the neck, especially just behind the ears.” “ A very great sense of weight on the neck, with a tenderness, even to the touch, on the seventh cervical vertebrae.” “Constant vertigo, not relieved by shutting the eyes; better when walking fast in the open air; much worse when sitting down.” “ Constant humming, buzzing noise in the ears, with the head- ache, but without dulness of hearing.” “ A full, dull, but constricted feeling in the head.” All the symptoms closely resemble the headache and abnormal sensations from cerebro-spinal irritation, and resemble the symp- toms of Silica, Gelseminum, Calabar, Cannabis indica, and other irritants of the cerebro-spinal centres. It has been used successfully, by myself and a few others, in the headaches following meningitis, and “ spotted fever ;” or the head symptoms occurring after sunstroke ; for sick-headache, periodical, generally just before or after the menses. The eye-symptoms are notable—they point to failing vitality of the optic nerve. I would call the attention of our oculists to these symptoms. In fetid, purulent discharges from the nose, from any cause, its topical application, not too strong, will be attended by the best re- sults (10 grains of the crystals to a pint of ’water). It may be in- jected with a sponge, or thrown up by an atomizer, or simply snuffed up. If it is done thoroughly, two or three times a day, the unhealthy nature of the discharge will soon disappear. In cases of ulceration it may have to be aided by Aurum, Silica, or Mercurius. If the infusorial origin of hay fever, u catarrhus cestivus,” is 130 CARBOLIC ACID. proven, or even if it is caused by the pollen of plants, the injec- tion of a dilute solution ought to cure that disorder. Helmholtz says Quinine cures it, and Carbolic acid has the same action, only more rapid, on such organisms. In aphthous conditions of the mouth and fauces, if the odor is very offensive or cadaverous Carbolic acid washes are useful; if not, the Sulphite of soda or Borax are better. In diphtheria, with fetor, the same observation will apply, but if fetor is not decided, I prefer Phytolacca or Guaiacum. In ulcer- ation of the throat, syphilitic or not, the acid may be used as a gargle. It is said to have cured “ spasmodic stricture of the oesophagus,” but the authority is not known to me. In caries of the teeth, a plug of cotton, moistened with the officinal solution, and crowded into the cavity, destroys the sensi- tiveness of the dentine and abolishes the fetor. As might be expected it has cured vomiting of sarcince, but Sod® sulphite is just as effectual and much more safe; for, in order to be effectual, enough must be given to destroy the fungi, and prevent their propagation. One of the most persistent of the symptoms in all the provings, was morning nausea and vomiting, and it has been very successful in the practice of both schools, in the treatment of the morning nausea of pregnancy. It cures vomiting of ingesta during preg- nancy, and in children. You may find it very useful in some of the many forms of dyspepsia, and flatulence. Dr. Ployne considers it indicated in attacks of11 diarrhoea from had drainage.” It may be useful in diarrhoea from drinking impure water. I have found it very efficacious in cholera infantum, attended with great prostration, hot head, fetor of the breath and all the excretions; the discharges from the bowels were putrid and like rice-water, or like the odor of spoiled eggs. In true cholera infantum, when the head is implicated, and the disease runs a rapid, malignant course, I have had the best success with Cam- phor, Bromide of soda, and Carbolic acid. I now rarely use Arsenicum, Veratrum, or other of the routine remedies usually recommended. CARBOLIC ACID. 131 All the provers had increased urine. It is known to be diuretic, as is Creasote. I predict it will be useful in some of the varieties of Bright’s diseases, and possibly in diabetes. It is a favorite remedy in pruritus of the organs of generation, and of the perinseum and anus. Pruritus is often caused by ulcer- ation of the os uteri, chronic vaginitis, aphthous conditions of the vagina and vulva. When these conditions are present, a weak solution should be used as an enema, and the same wash applied topically. One of its pathogenetic symptoms is, “ itching of the scrotum and inside of the thighs ; intense burning itching of the genitals.” As an application in ulceration, or granulation, of the os uteri, it is equal to Chromic acid. Carbolic acid is, par excellence, the remedy for the unhealthy discharges from the uterus and vagina following miscarriage and natural labor. In the best-managed cases some small portions of membrane or scraps of placenta will remain and give rise to fetid discharges. I am in the habit of ordering the nurse to use enemas of Carbolic acid, of the strength of ten grains to a quart of water, twice a day, so soon as fetor shows itself. I believe by its use we may prevent the occurrence of pyaemic poisoning, or phlebitis, in the majority of cases. It may be alternated with Sulphite of soda. In uterine cancer, its use is indispensable, either alone or alter- nated with the Sulphite of soda, or Bromo-chloralum. I may as well state in this place, as in any other, that the pretensions claimed for Carbolic acid, as a curative agent (when internally adminis- tered, in the attenuations), in the treatment of cancer, are without foundation. These claims were trumpeted forth by a once no- torious surgeon belonging to our school of practice. The idea that infinitesimal quantities of this acid will exert any destructive action on the cancer-cells or germs in the blood or tissues of the body, is absurd in the extreme. I have carefully watched the progress and termination of the cases of alleged cures, and assert that in no single instance can I learn that the disease has been eradicated. The cough and laryngeal symptoms are important. It causes “short hacking cough, with tickling in the throat. The cough is constant, irritating, and generally dry, or may end in expectora- 132 CARBOLIC ACID. tion of thick white mucus.” This resembles the cough of Rumex, but without the excoriation in the chest. It is an excellent pal- liative in this kind of cough, when occurring in chronic laryngitis, bronchitis and consumption. It may also act as a curative agent in these diseases in the early stages, if it is administered in a proper manner. It should be prescribed internally, in the 3X or 6X, and used in a spray or steam atomizer, in about the same strength. It has one symptom similar to Lachesis, Hepar, and Stillingia, namely : “ Left side of larynx very sore when pressed upon—not the right side.” It is a favorite remedy with many of our school in whooping- cough. Some prefer it in the middle attenuations, others in the lowest, and a few claim brilliant results for its use when inhaled from an atomizer. If the infusorial cause of this disorder be true it ought to be the specific. It is said to be of great value in malignant scarlatina, even when coma is present. Dr. Middleton* reports several cases of confluent variola treated with Carbolic acid. He says: “The pocks began to dry up on the eighth day, tongue cleaned off, no secondary fever ; the pocks were dry all over the body on the twelfth day.” Dose: a few drops of the 2* ever two hours. It is an excellent plan to put a small quantity of the acid into the water with which patients sick with malignant fevers, etc., are bathed. It is enough if the water has a faint odor of the acid. In diseases of the shin it has been found curative, when given internally and applied externally in the form of a lotion or un- guent. It caused, in the provers, “ itching of the skin all over the body; vesicular eruptions, itching excessively, better after rubbing, but leaving a burning pain.” It is said to have cured leprosy, prurigo, pityriasis, lupus, car- buncles, indolent and irritable ulcers, acne, impetigo, scabies, and psoriasis. I have italicized those in which I have used it success- fully. * Hahnemannian Monthly, April, 1872. CARBOLIC ACID. 133 Since the pathogenesis in the first volume of this work was printed I have found the following case of poisoning by Carbolic acid. The symptoms of the heart are so important that I quote the case: “ A man of thirty years, suffering from stricture of the urethra, took by mistake a teaspoonful of a solution of Carbolic acid,” containing, perhaps, twenty-five to thirty centigrams of the acid (two and one-half grains). He felt a burning in the throat and oesophagus, and took some milk and water and a dose of Castor oil. After ten or fifteen minutes a slight tremor set in over the whole body, steadily in- creasing, followed by delirium, irritability and rage, with copious perspiration. Ilis breath smelled slightly of the acid. At the attempt to examine his throat he closed his teeth tightly. The beat of the heart as well as the pulse could not be felt. Pupils were normal and reacted to light. The abdomen was bloated, especially in the epigastric region, but neither hard, nor tense, nor sensitive to pressure. He could not take medicine. After about two hours he became more quiet, the sweating de- creased, pulse and beat of the heart could not yet be counted. Instead of the tremors a somnolent state set in, the sweating ceased, the pupils dilated, but showed reaction to light. He swal- lowed now the most part of a tablespoonful of Magnesia. The pulse was irregular and intermitting, the veins appeared swollen and raised. Three hours after taking the poison the pulse became more regular and stronger, but frequent (120 to the minute), the pupils began to contract, the patient more quiet, answered ration- ally, and only complained of feeling languid. The pupils were now normal, the pulse full, and 100 to the minute. The oil showed now its action, but the faeces showed no smell of Carbolic acid. Later, he vomited twice a watery, thin fluid, not smelling of the acid. Ho pains in the stomach. He slept good, and when awakened complained only of some burning in the throat; fauces were slightly red, and showed some small gray spots, which soon passed off. The urine showed at first large quantities of albumen, after awhile it was clear, but of a dirty brown color; it never smelled of Carbolic acid. The dark color passed off gradually, but it re- mained albuminous for four days. Chemical analysis showed the acid in the dark-colored urine. 134 CARBOLIC ACID. The most pregnant symptom in this case is the relaxation of the activity of the heart; if death had occurred at the beginning of the stage of the depression, following the primary stage of excita- tion, the paralysis of the heart would have to be considered as the causa morbis.—Schmidt’s “ Jalirb.” 10, 1874. Dr. Adams, Professor of Surgery, in Chicago Homoeopathic College, writes of its uses in Surgery : “ Carbolic acid has been most extensively used, and so far has been rivalled in general utility only by Thymol. We can best illustrate the use of the method by describing, e.g., an amputa- tion. The surface of the part to be operated upon is thoroughly cleaned by sponging or irrigation with an aqueous solution of the acid of the strength of 5 per cent. (1-20). All sponges, instru- ments, etc., are carefully cleansed in a solution of the same strength. “ During the operation a weaker solution (1 per cent.), is used for washing sponges, and also in the form of spray, which by means of a suitable atomizer is thrown directly upon the field of operation so as to completely envelop the wound and its surround- ings in an antiseptic mist. The amputation made, the vessels are secured by torsion, acupressure, or the carbolized catgut ligature* firmly tied in a square knot and both ends cut short. A drain- age-tube is inserted, the edges of the wound brought into apposi- tion by carbolized gut or silk sutures,f and the projecting end of the tube cut off flush with the level of the integument. The ex- ternal dressing consists, first, of oiled silk, carbolized, known as “ protective,”:}: its object being to protect the wound from any stimulant effects of the acid in the next application, consisting of eight layers of carbolized gauze,* under the top layer of which a piece of thin rubber cloth is placed to prevent the too rapid washing away of the antiseptic material from the gauze, by the * Catgut Ligature.—Soak catgut of required thickness in carbolized olive oil, one part acid to five of oil, with a small quantity of water diffused through it to keep the gut supple. t Sutures.—Silk may be rendered thoroughly aseptic by steeping in a mixture of beeswax 10 parts, Carbolic acid one part, the superfluous wax being wiped off the silk as it is drawn from the mass. t Protective.—Oiled silk, lightly brushed with copal varnish on both sides. After drying again brush with a solution of starch and dextrin, so that it may re- tain a watery solution of the acid when dipped in it before application. CARBOLIC ACID—CARDUUS MARINE. 135 serous discharge from the womb. The spray is kept up contin- ually from the beginning of the operation until the dressing is completed, and is used at all changes of the dressing until the wound is healed. It will be seen that the method depends for its success upon the principle of allowing nothing to come near the wound except it be first rendered aseptic. The drainage-tube should be of pure rubber, and is essential whenever the wound is of any considerable extent, as a free flow of serum follows the use of the spray. In most cases not more than from two to five dress- ings will be required, and may be made, in the absence of com- plications, at intervals of one, two, and three days, respectively. If suppuration occurs in a case under treatment after this plan, carried out in detail, it will be such as is not due to putrefaction, and the pus will be perfectly innocuous. Frequent meddling with wounds is to be avoided. As long as they do well they are better let alone. All materials needed now can be obtained at the surgical instrument stores ready for use, or may be prepared according to the above-mentioned formulae. CARDUUS MARIE. This medicine, with an odd contradiction of terms, I should call the oldest of the new remedies. I found a pathogenesis of it in one of the early numbers of the “ British Journal of Homoeop- athy,” and if one-half its alleged powers are possessed by it, we should test its value thoroughly. Its sphere of action seems to begin and end in the liver and portal system, and, so far as we can judge, from our present knowledge of its effects, all symptoms are the result, direct or indirect, of such action. It is a close analogue of Bryonia, Chelidonium, Nux vomica, Podophyllum, Benzoic acid, Chionanthus, and Ammonium muri- aticum. It causes hypochondriacal depression of mind, vertigo, dull heavy pain in the forehead, over the eyes and in the temples, confusion of thought, bitter taste, nausea, pyrosis, eructations, distension, retching, vomiting of sour, green fluid, and many other unmistak- * Gauze.—Mix paraffin sixteen parts, resin four parts, and Carbolic acid one part. Dip cheap muslin gauze in the mass and wring or press out while hot. 136 CARDUUS MARIAS. able “bilious” symptoms. Dr. Leidbeck asserts that no remedy more surely removes such symptoms. The same author has col- lected a number of clinical cases illustrating its powers, namely: Morning vomiting of pregnant women ; the food remains undi- gested all day. Swelling and painfulness of the liver. Jaundice (many cases). It is a very popular and successful remedy in domestic practice in Europe. “ Tenderness and hardness of the right hypochondria, especially in the left hepatic lobe; pressure there caused oppressed breathing and cough; stools brown, urine yellow, respiration asthmatic, expectoration thick and tough.” These symptoms indicate en- largement of the liver, with sympathetic bronchial irritation, a con- dition in which Chelidonium and Muriate of ammonia are both now used very successfully. It is capable of curing a more serious condition of the liver, for a case is reported of “ Pain in the liver, with oedema of the feet; scanty, bright urine, and asthma.” It may prove useful in dropsy from hepatic disease. Like Chelidonium, it has a great popularity in Europe for the cure of “ Gallstones, with jaundice, pain in the stomach, vomiting of bile, etc. Dr. L. cured two cases with half an ounce of the tinc- ture in a pint of water, a tablespoonful every two hours. He does not say whether the calculi were expelled or dissolved, but the patients got well, and that was quite as satisfactory.” A case is also reported of “ painful tenderness and sivelling of the gall-bladder,” probably from obstruction of the ductus chole- doch us communis, and which was promptly removed by the Carduus. Among other clinical cases he mentioned “ Hepatic affections with haemoptysis and croup. “ Portal congestion and obstruction, with its consequences. ° “ Hypertrophy of the left hepatic lobe, with tenderness of the cervical and dorsal vertebrae. ° “ Pain in the whole abdomen, near the caecum, cramps, urine normal, complexion smutty, yellowish; sleeplessness, great ema- ciation, and hectic fever.” An affection of the liver, primarily. CARDUUS MAEIiE. 137 It causes tardy, knotted, and hard brown stool, followed by “stool soft, yellowish, thin, loamy, chocolate-colored, pappy, or without bilious tinge.” The urine at first is normal, but as the bile disappears in the stools, it appears in the urine, which becomes scanty, yellow, and finally brown. This gives a complete picture of ordinary cases of jaundice. Dr. Reil recommends it highly for “affections of the climacteric period in women, viz., megrim, metrorrhagia, leucorrhcea, asthma, with consensual disorder of the liver.” This is similar to the action of Aloes, which is so useful at the change of life, when the liver is the suffering organ. Dr. Reil narrates his experience with Carduus in an epidemic of influenza with, hepatic symptoms, namely, a peculiar brown, dirty-gray complexion of the patient, sometimes a real jaundiced tint; sensitiveness of the left hepatic lobes to pressure; bright, pale-yellow, seldom dark-green stools; dark-brown urine, oppres- sion of the chest, stitches in the side, debility, fever, frontal head- ache. Nux, Chelid., and Puls, did no good; only Carduus promptly cured. Here in Chicago, during the months of March and April, we have similar epidemics. In several such epidemics I have found the Carduus indispensable for removing the hepatic difficulties. It is one of the few remedies which is capable of controlling serious pulmonary symptoms resulting from disordered liver. It has cured “painful cough at night, obliging him to sit up in bed;” “ expectoration of pure blood, or blood and mucus, generally con- nected with liver troubles;” “ is palliative in the cough of con- sumptives and asthmatics.” It has an extensive popular reputation in Europe for “ stitches in the side,” generally the right, and nearly always connected with so-called bilious conditions. You will observe in your practice that severe stiches in the sides and chest often precede a “ bilious attack.” These “ stitches ” are said by Dr. Inman to be generally sympathetic, and are in the muscles oftener than in the liver. In pleurisy it has some reputation, but it is not probable that Carduus is indicated in idiopathic pleurisy, but rather in pleuro- dynia (thoracic myalgia). YOL. II.—10 138 CARDUUS MARIAS—CASTANEA YESCA. All the observers of the action of Carduus make this remark: “ It relieves, but does not appear to remove the fever and oppres- sion (in pleurisy) as well as Aconite;” which confirms the opinion I have just expressed. CASTANEA YESCA, It is a little singular that an infusion of the leaves of the common edible chestnut should prove a remedy for ichooping-cough ; but a Dr. Unzicker seems to have been very successful with it, if we can believe his report. He says : “I have found in all cases that it would, in from four to ten days, relieve the spasms of pertussis, and in about two weeks cure it. The little sufferers would whoop no more, but go on to a speedy recovery, to the great delight of myself and their friends.” He uses one-half an ounce of the leaves in a quart of water. This infusion was given in tablespoonful doses, every few hours. Later, he publishes further experience with the fiuid extract in five to ten drop doses. No experience has been published in the literature of our school since my first mention of it, nor have I had any good opportunity to test it. I would suggest a trial of the tincture in some obstinate spas- modic coughs, for which it may prove useful. Since writing the above, I have seen a report of Dr. Davis, in the “ Philadelphia Medical Times/’ of a careful study of the effects of Castanea in whooping-cough, made in the Philadelphia Hospital. Fifteen children were selected, all with severe paroxysms and the characteristic whoop. They had been taking other drugs, but were left without medicines two days, during which time the paroxysms increased in frequency and severity. After being put on FI. ext. castanea, in doses of thirty to sixty drops every three hours, the paroxysms decreased rapidly, so that on the fifth day none occurred except in three cases. The nurse in charge, who had witnessed many epidemics of the disease, declared she had never seen a medicine act like it. CASTANEA VESCA—CAULOPHYLLUM. 139 Since the last edition of this work, not much clinical experi- ence relating to the use of Castanea has been published in the journals of either school. At the March meeting of the Obstet- rical Society of the State of New York, Dr. Rodenstein reported eight cases of whooping-cough treated with Castanea. The aver- age duration of these cases was three weeks, during which time the children took from two to five ounces of the fluid extract (30 drops four times a day was the usual dose). Several other phy- sicians at the meeting stated that they had used it in smaller quantities with good results ; all, however, testified to the superior curative influence of the Bromide of ammonium in severe cases. Such is my own experience. CAULOPHYLLUM. This is one of a class of remedies whose virtues seem to have been well known to the aborigines of this country. They called it “squaw-root,” by which name it is known to the common people. Early pioneers, lay as well as professional, all bear witness to the high estimate placed on it by the Indians for the relief of the suf- ferings and weaknesses of the women of that race. It has another name, “blue cohosh,” the origin of which I have not been able to ascertain. Its sphere of action, as near as can at present be stated, is not extensive, but confined to the small muscles and joints, the muscular tissues of the generative organs, and possibly the motor nerves and mucous membranes. The provings made do not throw much light on its general powers. Its clinical uses afford us almost all the data upon which we base our knowledge. Its most prominent value seems to be its power of causing intermittent contractions of the gravid uterus, and possibly of the unimpregnated. In this it differs from Ergot, which causes, or tends to cause, persistent contractions. The remedies which most resemble it in this respect are Viburnum, Cannabis indica, and Cimicifuga. It has become very popular with a portion of our school, for the following conditions : (1.) Deficient labor pains: (a) When they do not appear with sufficient vigor and regularity, at full term, and during labor. 140 CA TJLOPIIYLLUM. (b) When the pains have disappeared from exhaustion, (c) When they are too severe and too painful, or are spasmodic. In the two first instances it should be given in doses varying from one-fourth grain of the Caulophyllin., crude, to a grain of the 1* or 2X, frequently repeated ; but in the last instance, to which condition it is primarily homceopathic, the dose should be from the 3d to the 6th, or higher. I mention the active principle, because it seems to possess the desired powers of the medicine in a pleasanter form than the tinc- ture, which, in its crude state, is quite irritating to the fauces. But the tincture can be used in about the same proportions, if nec- essary, substituting ten drops for each grain of Caulophyllin. The same directions will answer for the dose in other conditions in which it is specific, namely: (2.) Spasmodic dysmenorrlioea, when the flow is natural in quan- tity and quality. This distressing condition is often cured by Caulophyllin, but to be successful the medicine must be given several times daily during the week or two preceding the menses, as well as during the painful period. (3.) Spasmodic after-pains, in which it is indispensable. (4.) Spasmodic pains in the uterus, broad ligaments, etc., occur- ring at any time, from a cold, rheumatism, during pregnancy (false pains); also general as well as local spasms, from the suppression of the menses or lochia. As might be expected from its powers, which I have just enu- merated, it is a powerful agent for the prevention of premature labor and of miscarriage, provided the premonitions are pains of a spasmodic character. The aborigines and earlier settlers claimed for it the power of preventing tedious and painful labors. This testimony has been substantiated by many prominent and trustworthy physicians of the eclectic school, as well as of the homoeopathic. A few of our school have denied it such power, but the weight of the evidence is against them. Dr. A. E. Small is sure, from the observation of many years, that it actually prevents the unusual sufferings which many women undergo. He also testifies to the singular fact that many women who have taken it for such purposes have over- run their time to the extent, in some cases, of ten or twelve days. CAULOPHYLLUM. 141 The cases referred to, however, all had very easy labors and a good recovery. My experience has been so uniform and conclusive on this point, that I do not hesitate to assert that it prevents not only a too pain- ful labor, but it prevents those premature labors which are so com- mon among the weakly women of this age. You must not expect it to prevent painful labors (dystocia) in women who become advanced in life before they bear children, or in whom there exists any deformity of the pelvic cavity. Such cases are mechanical obstacles to easy, natural labors, Caulophyllum re- moves only abnormal functional causes. The method of giving it in such cases is to prescribe a few grains of the 21 or 3X trit., or a few drops of the 0 or lx dil., three times a day, for the last two weeks previous to the expiration of the term. If, however, a premature labor is feared at the seventh or eighth month, it should be taken during the two weeks preceding those periods. Caulophyllum has been recommended for rigid os uteri, but I believe the rigidity is overcome, not from any specific power on the circular muscles of the os, but from its general action on the uterus. Gelseminum and Belladonna are better for this condition. If uterine displacements are attended by periodic, spasmodic pains, Caulophyllum will form a valuable auxiliary to Sepia, Lilium, Nux, or Belladonna. In my second edition of “New Remedies” was recorded a case of paraplegia from retroversion, which the Caulophyllum was supposed to have cured. We need further confirmation, however, before we accept it as a remedy for such condition. It seems to be homoeopathic to rheumatism of the short muscles and small joints of the extremities, and a few cases of that charac- ter have been reported. It is said to be indicated when spasmodic pains occur in the stomach, intestines, and other organs, in sympathy with the same kind of pains in the uterus. There is no particular reason why they should always be in sympathy with that organ in order to render this remedy curative. 142 CEANOTHUS VIRGINIA NA. This shrub, called Jersey tea, derives its common name from the fact that during the Revolution, when Chinese tea could not be procured, it was used as a substitute, as were many other plants. It is said that the infusion possesses slightly exhilarating effects. It would probably repay a good proving. I found in the “ Atlanta Medical and Surgical Journal ” a com- munication in which it was stated that the Ceanothus possessed the power of curing splenitis and enlargement of the spleen. Dr. savs : “ During the late civil war I used this plant for splenitis, and so well satisfied have I been with the results that for six years I do not remember using anything else for enlarged spleen. I have used it in the worst cases I ever saw, from infancy to old age. I have yet to see or hear of its failure in a single case, however in- veterate.” This is pretty strong and positive testimony, and the author fully confirms my idea that a remedy which cures is homoeopathic always, for he further says : “ In chronic cases, when the organ is no longer tender, under the use of the tincture, even without friction, it soon becomes pain- ful and tender, then sinks rapidly to its normal size, and so re- mains, the patient no longer being conscious of its presence.” We see here a true homoeopathic aggravation, showing that the drug has a specific affinity for that organ. I would advise you to make use of it when you meet with cases of “ ague cake,” so common in malarious districts. The tincture is made from the leaves, and is given in drop doses of the 0 or lx dilution and applied to the region of the spleen. Dr. Carroll Dunham informs me that a physician of his acquaint- ance cured an enormous enlargement of the spleen by the use of this remedy. It is not a little singular that since the first mention of Ceano- thus in the third edition of this work, no clinical reports of its use in disease have been reported in American journals. It remained for an English physician, Dr. J. C. Burnett, to discover its affin- ity for splenic disorders. In an article in the “Monthly Homoe- opathic Review,” of March, 1879. entitled “Ceanothus Ameri- canus in its Relation to Diseases of the Spleen,” he says: CEANOTHUS VIRGINIANA. 143 CEANOTHUS VIRGINIANA. For several years past I have been in the habit of using this drug in true Eademacherian fashion as an organ remedy. The perusal of Eademacher’s “ Magnum Opus ” is one of the greatest literary treats that ever fell to my lot; based on Hohenheimian bizarries, avowedly and obviously merely an attempt at reducing his genial, erratic, pretended mysticism to the concrete form of a practice of medicine, by depolarizing it, if I may so speak, it is nevertheless the most genial and most original production it is possible to find in medical literature. It is one of the most hareboned lawless empiricisms that one can conceive, and yet there are two leading ideas running through the entire work, and these are the genius epidemicus morborum and organopathy; and considered from the pharmacological side, the other two ideas of universal (general) and particular medicines. For Paracelsus there were only three universal remedies, and so also for Eademacher and for their followers. Hahnemann has but three fundamental morbid states, psora, syphilis, and sycosis. Von Grauvogl has but three consti- tutions of the body—they might have all been working out the fatherlandish proverb, Alter guten Dinge sind drei ! The genius epidemicus morborum is beyond question a fact in nature, but it is dreadfully eel-like, hard to get a grip of. The same may be said of Hahne- mann’s tripartite pathology and of Grauvogl’s three constitutional states. Eademacher’s organopathy (that an otherwise able modern writer appropriates with childlike naivete) is no more and no less than the homoeopathic specificity of seat, with just a dash of a mystic psychic something in the several organs; if we set aside this little particular soul for each organ, it is only local affinity, or elective affinity. And it is quite true in nature, and the mind that cannot, or will not, recognize it, is wanting in catholicity of perception; and in practice will often go a mile when three paces would have reached the goal. Whatever else Can- tharis may be, it is first and foremost a kidney medicine ; whatever else Digitalis may be, it is primarily a heart medicine; and let Belladonna be what it may, it is before all other things an artery medicine, and just in this sense Ceanothus Americanus is a spleen medicine. The spleen constitutes a dark corner in the human economy, whether consid- ered physiologically or therapeutically. I have heard it professorially very ably argued that the spleen is the principal manufactory of our blood-corpuscles. I have heard that theory equally, ably, and professorially refuted, and in its stead the thesis set up that the spleen is, as it were, the ultimum refugium of the old and effete blood-corpuscles, wherein they are broken up and their debris sent off again into the circulating medium. A third argued that all this was veritable nonsense, as the spleen had nothing whatever to do with either making leuco- cytes or breaking up their reddened descendants, that in fact the spleen had no other function than to act as a reservoir for the blood, being, indeed, a kind of living sac in the side, to swell or shrink, according as the circulation required more or less of the circulating fluid. I fondle this latter theory myself, and like to call it mine. Whose it really is, I do not know. Perhaps the erudite editors will kindly add a footnote and say what they think the spleen is good for beyond serving as the anatomical wherea- bouts of that enigmatical something that supposedly sends my dear fellow- countrymen in shoals off London Bridge into the Thames on a rainy or foggy 144 CEANOTHUS VIRGINIANA. day—I mean, of course, le spleen ! This great bugbear of our Gallic and Germanic brethren—as applied to ourselves bien entendu ! for they consider it essentially a morbus Anglicus, just as we like to think it is principally those naughty French who commit suicide—is really only another name for being “ hipped,” or suffer- ing from an attack of hypochondriasis, and there cannot be any sound reason for refusing it a habitat under the left ribs, since so many have welcomed it under the right ones. My first and only literary acquaintance with Ceanothus Americanus is the very short empirical account of it in Hale’s “ New Remedies,” which I read some five or six years ago. Previously I had frequently felt a difficulty in treating a pain in the left side, having its seat, apparently, in the spleen. Myrtis communis has a pain in the left side, but that is high up under the clavicle; the pain that is a little lower is the property of Sumbul; still lower of Acidum fluoricum; a little further to the left of Acidum oxalicum; more to the right of Aurum; right under the left breast of Cimicifuga rac. These remedies promptly do their work when these left-sided pains are a part of the diseased picture, but they will not touch the pain that is deep in behind the ribs of the left side; more superficially Bryonia has it; a little deeper than Bryonia, Pulsatilla nuttal. will touch it; and so will Juglans regia, which poor Clo- tliar Muller proved as a student. But the real splenitic stitch requires China, Che- lidonium, Berberis, Chininum sulfuricum, or Conium, or Ceanothus Americanus. Some years since I treated a lady in Chester for “ violent vomiting, pain all up the left side, cough, with expectoration, profuse perspirations, and fever.” She was not a Cestrian, but came only for a short visit, and took lodgings in a small house facing a meadow on the banks of the Dee ; the locality was at one time a part of the port of Chester, but was many years ago reclaimed. At my first visit she told me she often got inflammation on the chest with cough, and finding con- siderable fever, cough, pain in the left side, and dulness on percussion of the same side, I quickly ticketed it pleuropneumonia sinistra, and gave Acidum oxalicum, which seemed to cover all the symptoms, and to correspond also to the supposed pathological state within. Oxalic acid somewhat relieved the vomiting, but noth- ing more, and I then gave various remedies, such as Aconite, Bryonia, Phos., Ipec., and thus elapsed about three weeks, but patient remained as ill as ever. Then I went into the case with very great care, and examined my patient very thoroughly, and, see, there was inflammation of the spleen. I gave her Ceanothus Americanus in a low dilution, and all the symptoms, subjective and objective, disappeared right off, and my previously ill-treated patient was sitting up in a week, and quite well in a few more days. I had never before met with splenitis in the acute form, and have never since met with it. A few cases of Aironic pains in the spleen occurred subsequently in my Chester practice, and they rapidly yielded to Ceanothus, one of which I well remember ; it is this: Chronic Splenitis.—A young lady of about 26 consulted me for a chronic swell- ing in the left side under the ribs, with considerable cutting pain in it. She stated that it was worse in cold damp weather and she always felt chilly; the chilliness was so severe and long lasting that she had spent the greater part of her time during the previous winter sitting at the fireside, and now she was look- ing forward to the winter with perfect dread. In the summer she had felt nearly CEANOTHUS VIKGINIANA. 145 well, but the lump and the chilliness and pain nevertheless persisted, but it be- ing warm she did not heed it much, it being quite bearable. Ceanothus Americanus quite cured her of all her symptoms, and subsequent ob- servation proved its permanency. Often during the following winter she called my attention to the fact that she was not chilly and felt well. One of the first cases I treated at the Wirral Homoeopathic Dispensary in Birkenhead was that of a young man somewhat similarly suffering. Chronic Splenitis.—This young man was sent to the dispensary by the then manager of Messrs. Thompson and Capper’s Birkenhead establishment, and was occupied in the Liverpool post-office in some light but ill-paid employment. His whole trouble consisted in severe pain in the left side in the region of the spleen, and he had long vainly sought relief of many, probably at dispensaries. He there- fore put in an early appearance at my new dispensary to try the new doctor, probably on the well-known principle of the new broom. He had become quite low-spirited and began to fear he would become totally unfit for work, and natu- rally that was a very serious matter for a young married man. He told me he had formerly helped his wife in her household matters, doing the heavy rough work, but the pain in his side had now become so bad that he could not carry a bucket of water into the house or even sweep up their little yard, as handling the broom pained him so dreadfully. I was pressed for time, and prescribed Ceanothus Americanus in pilules of a low dilution, and promised to go into his case that day week, meaning to percuss the part and ascertain whether the spleen was enlarged. He returned that day week almost well, and the following week was quite well. At my request he again reported himself some time afterwards, and he still con- tinued well. I resolved to begin my next case with the physical examination. My next case was this— Chronic Hypertrophy of the Spleen.—A middle-aged lady consulted me shortly after the above case, for a severe pain in the left side and a large swelling in the same position. Bemembering the last case I said I must examine the side. She ob- jected, so I declined to treat her; then she said she would think about it and con- sult with her husband on the subject. In a fortnight or so she returned (driven by the severe pain in the side), and I examined the side and found an enormous spleen occupying the entire left hypochondrium, and reaching interiorly to about an inch above the crest of the ilium; it bulged towards the median line and ran off to an angle literally. It was of long standing. Gave Ceanothus Americanus in a low dilution. This lady being very intelligent I begged she would allow me to examine the side again after I had finished the treatment. She promised to comply. Fourteen days after this she came full of gratitude and reported that the swell- ing was smaller and the pain considerably less. To continue the medicine. She never consulted me again, but as she was a near neighbor of mine I often saw her, and somewhat six months afterwards she called to pay my fee, and then informed me that she had soon got rid of the pain entirely and the swelling was much smaller, so she had discontinued the medi- cine altogether, and did not deem it needful to trouble me again. This is the usual thing. People will not be at the trouble of seeing the doc- tor as soon as they are better; they seem not to understand any interest one feels 146 CEANOTHUS VIItGINIANA. in the case. We can only make periodical reliable examinations of patients in a hospital; in private practice it is extremely difficult, as all practitioners know to their chagrin. Still, faute de mieux, we must put up with those fragments. This patient had had no children, and had a very fresh complexion. My next case is also one of chronic hypertrophy of the spleen, though only about half the size of the one just narrated. Subject, a poor woman of about thirty or thirty-two years of age, whom I was requested to see by a very kindhearted benevolent lay minister well known in Birkenhead and the neighborhood. She is the mother of several children, very poor, ill-fed and overworked, but withal a good respectable woman and very clean. She had a considerable and very painful swelling in the left side under the ribs, that had been there for some time, and latterly she could not get up on account of the severe pain. I carefully examined the tumor and satisfied myself that it was a very much swelled spleen, and the pain seemed to me to be due to its pressing against the ribs. I marked its size on the skin with ink, made her engage not to wash off the ink-mark, and promised her I would call in a week, having first prescribed Ceanothus as in the other cases. But the fates were against my laudable plan, for I received a mes- sage, the day before my next visit was due, to the effect that Mrs. felt her- self so much better that she was up at her housework, and begged me not to call again, as she thought it unnecessary. Since then I have at times had cases of deepseated pain in the left side to treat, and have mostly found it yield to Ceanothus, though not always. In one case in which it failed the pain was cured with Berberis vulgaris. In one case of jaundice, characterized by very severe pain in the left side, I gave Ceanothus, with very prompt relief of the pain only ; Myrica cerifera then finished the icterus. Before giving the Ceanothus I had given Chelidonium majus. In one case of severe metrorrhagia, characterized by pain in the left hypo- chondrium, Ceanothus gave instant relief to the pain, and checked the haemor- rhage. It failed me in a subsequent similar attack in the same person, when Conium was effective, and was suggested by Dr. Thomas of Llandudno. Chronic Splenitis, Chills and Leucorrhoea.—Some four years since, perhaps a little more, I treated a lady of about 55. She complained of rigors at frequent inter- vals, and pain in the left side, both of long standing. The leucorrhoea had lasted some twenty years, and was profuse, thick, and yellow. She had been for years under the best allopathic physicians of Chester, and finally given up as beyond the reach of medical art, evidently on Moliere’s principle that “ nul n’aura de Vesprit que nous et nos amis.” Nevertheless, the patient bethought her of homoeopathy, and came under my care. Her last phy- sician had finally suspected cerebro-spinal mischief, and hinted at incipient paralysis. The pain in the side was the most prominent and distressing symptom, and for this I prescribed Ceanothus: In a month the pain was entirely cured, and also the leucorrhoea, while the cold feeling was very much diminished, but not quite cured. I have also never succeeded in quite curing it with any subsequent treatment. I watched the case for nearly four years, and am thus enabled to state that the pain in the side and the leucorrhoea never returned, and the chilli- 147 CEANOTHUS VIKGINIANA. ness never again became very bad, but still she had it a little when I saw her last. Cases calling for this remedy are not very common with me, but every few weeks I meet with one. Thus, since coming to London, I have met with one such, viz., a girl, Ada, set. 14, who came under observation on Nov. 29, 1878, with pain in the left side for some months, and right-sided headache. She received Ceanothus 1 in pilules. Dec. 13. Cured of pain in left side, head better. Pergat. Did not return. Ceanothus Americanus never having been proved, at any rate as far as I know, I have always used it about 1* or 1, and sometimes in the mother tincture. Most of the persons with these splenitic disturbances, were in fair condition, and many complained of nothing else; many were women, and two of these were drunkards; many had “ chills,” but not all; none had ever had ague. As a first contribution to a proving, I will add two or three data. PATHOGENESIS OE CEANOTHUS AMERICANUS. 1. It very frequently relaxes the bowels, and I have known this even amount to diarrhoea. 2. Ceanothus Americanus 1, four drops in water three times a day was once given by me to a young lady (26) for severe pain and fulness in left side, with in- ability (for years) of lying on left side. In a few days she could lie comfortably on either side, and the pain in the side was said to be nearly well. This was my second visit, and I said go on with the medicine. She did, and I took these notes at my next visit: “ Had been taking it for about a fortnight, when one day I felt great nervous excitement, with chilliness, loss of appetite; felt as if the nerves were shaken, and one day at dinner could scarcely hold knife and fork.” The chilliness was chiefly down the back; she shivered with cold chills (i. e., rigors). Thinking these symptoms were due to the medicine, she left it off for two days, and the symptoms entirely passed off. Then she resumed the medicine for one day, and the same symptoms again appeared; she again discontinued the medi- cine, and again the symptoms ceased. Her bowels were relaxed. Subsequently her menses appeared ten days too early, and very profusely, a thing that had never happened before in her life, as her mamma informed me. I mentioned this medicine to Dr. K,. Hughes at the Manchester Congress, and Dr. Edward Madden and I partly agreed to prove it; I am not aware whether this gentleman has ever done it; if so, he has done more than I have in the matter ; still it is obviously worth proving, for our good spleen medicines are not very plentiful. I have several times had the honor of calling attention to Ceanothus Ameri- canus at the various meetings of the Liverpool Homoeopathic Medico-Chirurgical Society, but do not remember ever hearing any of the members mention having used it; they probably never need it, or very properly object to using an unproved drug as a remedy. Also as no notice of it ever appears in our journals it is probable that it is not a usual remedy with the profession. We are overwhelmed with new remedies, and certainly need rather a better knowledge of what we have than the addition of any fresh ones. I therefore 148 CERASUS VIRGINIANA. think it would be a useful undertaking for some one to prove the needlessness of Ceanothus by showing how deepsealed pain in the left hypochondrium, acute and chronic splenitis, hypertrophy of the spleen, etc., can be more promptly cured than I here show. Some one living in a malarious district would have a good oppor- tunity of showing its worthlessness in ague cases also. CERASUS VIRGINIANA. This tree, the inner bark of which is officinal, is also known as Prunus virginiana. There is another species known to botanists as Cerasus serotina (Prunus serotina). The latter is the common black wild cherry; the former a red wild cherry, known as “ choke cherry.” The plum and cherry family, as well as the peach and apricot, the bitter almond, and laurocerasus, all contain the elements from which hydrocyanic acid is evolved. When properly prepared the infusions or tinctures of these agents all contain that acid, upon the presence of which nearly all of their peculiar effects on the heart depend. But the cherry family also contains Tannin, and a peculiar bitter principle, which resembles Cinchona somewhat. A cold infusion of the inner bark is the best preparation. If prepared by heat the acid is not formed. A tincture may be made which contains all its active principles; but the fluid extracts and the so-called prunin and cerasin are frauds. They contain only the tannin and bitter principle. From time immemorial the cold infusion has been in use for irregular and intermittent action of the heart, with deficient impulse. For this condition Hydrocyanic acid, Laurocerasus, Iberis and Amygdala are primarily homoeopathic; and Digitalis, Lycopus and Collinsonia are secondarily homoeopathic. With the cold infusion in tablespoonful doses I have frequently removed the above abnormal condition of the heart’s action; also the cough sympathetic with functional or organic disease of the heart. It is a valuable palliative in quick, weak pulse, during conva- lescence from disease; during phthisis; and in hypertrophy of the heart with dilatation. The tincture made with dilute alcohol has been useful in my practice for dyspepsia with tendency to acidity of the stomach; in CERASUS VIRGINIANA—CEDRON. 149 slow digestion with pyrosis ; loss of appetite, etc. It is all the more indicated in these affections if they are attended by weak, irritable heart. I have found it much more efficacious when Pepsin (the saccharated powder) is given before each meal, followed by the Cerasus after meals. I have known cases where excessive quantities of the infusion have caused a fulness, and a dull, heavy feeling in the head. This may have been due to the cardiac tonicity which it caused, and implies that we should not give the lower dilutions in con- centric hypertrophy of the heart, or when real fever is present. In the higher dilutions it might prove useful for the symptoms mentioned. CEDRON, Cedron is the seed of the fruit of the Simaruba Cedron,—accord- ing to Hooker’s London Journal of Botany. Teste’s “Materia Medica,” p. 577. “North American Journal of Homoeopathy,” vol. viii, p. 120. “Monthly Homoeopathic Review” (London), vol. v, pp. 164, 208, 251; vol. vi, pp. 71, 136, 203. “New Remedies, Symptomatology of,” 4th edition. According to Dr. S. A. Jones, in the latter work: The earliest mention of the Cedron is found in the “ History of the Buccaneers,” A. D. 1699. The native Indians first offered the seeds for sale in Carthagena in 1828. Analogues. Arnica, Cinchona, Cornus, Cimicifuga, Eucalyptus, Eupatorium perf., Gelseminum, Nux vom., Sepia, Sanguinaria. It has some analogous relations to Pulsatilla, Chelidonium, Lachesis, and other polychrests. The sphere of action of Cedron appears to include both the cerebro-spinal and sympathetic systems, and is a decided “anti- periodic” remedy. “Its chief characteristic is a periodicity, which is often clock-like in its regularity.” (Dr. S. A. Jones.) The clinical uses of Cedron have been mainly confined to obsti- nate intermittents, which resist the usual ague remedies. After the ap- pearance of Teste’s “ Materia Medica,” the demand for it was very 150 CEDRON. large, especially from Western and Southern physicians. At that time a few clinical reports were published favorable to its efficacy in ague; but very many failures were also reported. It did not give general satisfaction. But now that we have a fuller patho- genesis, it will probably be selected with greater certainty. The general opinion, with which I coincide, is that cerebral congestion is one of the keynotes for its use in ague. To illustrate this, I copy some of the head symptoms collected by Dr. Jones, and published in the 4th edition of “New Remedies.” “Head dull and heavy in the morning; distensive headache, increased during the night; temporal arteries enlarged ; bending the head backward, with pressure on the occiput and parietal re- gions, as if these parts were going to burst; forehead cold, as if it were empty, in the morning.” All these symptoms were more marked in the women than in the men. “ Pressure at the right temple, causing a dull pain in the whole right side of the head, disappears wholly toward noon ; heaviness in the head ; headache increases in the open air (toward 9 A.M.); pressive pain over the eyes, as if a band were tied round the parts; pressure at the top of the head, slight in the daytime, some- what violent just at the moment when the shivering begins; it never wholly ceased during the whole proving; towards 6p.m. shuddering, soon followed by a dull and heavy frontal headache, spreading to both parietal regions; pulsating sensation in the temple, and a twisting pain behind the right ear, changing to a dull pain and extending to the temples; head felt as if swollen; whole head feels swollen and heavy, most on the right side; pressure on the occiput in the morning; in the forenoon, occa- sional sharp jerking pains in the occiput; successive sharp pains in the occiput, abdomen, and lower limbs. These pains in the head are dull, except those in the occiput, which are acute. At 10 p.m. dull pain in the top of the head, with sharp flying pains in all the joints of the extremities, worse in the feet, particularly the first joint of the great toe; awoke late A.M., after a sound sleep, with dull pain in the vertex; awoke with dull pain in the whole upper head; throbbing in the temples; throbbing in the temples increasing to pain; pain across the forehead, over the eyes, from temple to temple; beating in the temples, increasing CEDKON. 151 to pain and extending over the ears; throbbing in the temples, increasing to pain, and extending over the eyes ; throbbing pain in the head, commencing in the temples and extending around the forehead; sharp pain in the occiput; dull pain in the vertex ; pain over the ears; headache, especially in the bottom of the orbits (compelling him to close the eyes), and extending to the occiput.” The resemblance to the China headache is very marked. These headaches are decidedly periodic, and the following clini- cal cases illustrate its efficacy in this direction : 1. Tearing, shooting pain on the left orbit, extending to the inner canthi and to the superciliary ridge of the os frontis. This pain came only post coitu, and when the circumstance had occurred which gave rise to it, his sufferings were so intense on waking in the morning that he was compelled to keep his room for several days, and was unable to eat or drink during the greater part of that time. 2. A similar pain over the left eye followed involun- tary nocturnal spermaperthy in the case of a woman ; pain came on when waking in the morning, and was very severe until noon. 3. Chronic intermittent headaches, with shooting and pressing pains in different parts of the head, recurring at certain periods of the day or night. The eye-symptoms somewhat resemble those of Gelseminum ; also Pulsatilla and Cimicifuga. “ Eyes protruding and red, with pressive pain extending to the forehead; pupils fixed and dilated ; objects appear red at night and yellow in the daytime; eyelids injected bright red, and pain- ful when pressed ; enlargement of the meibomian glands and con- junctiva ; smarting in the eyes, especially w'hen closing them ; sensation in the eyes as if one had wrept a good deal; itching of the eyes ; dimness of the sight; the left eyelid seemed dried to the ball; conjunctiva inflamed and dry ; when exposed to the air the eyes feel dry ; eyes felt swollen ; misty vision, as from thick smoke ; dizzy, could not see to light a candle, and could not tell when it was lighted.” It has cured ° flashes of light before the eyes; 0 dull appear- ance of the eyes; 0 tumid face, with pupils much dilated ; ° a pe- 152 CEDRON. culiar, unsteady, glistening appearance of the eyes, and intoler- ance of light. It has many of the ear-symptoms of China : Singing in the ears as of crickets; buzzing of the ears toward noon ; hardness of hearing at night; it antidotes the effects of Sul- phate of quinine on the auditory nerves. Its value in facial neuralgia is substantiated by the following clinical cases: ° Prosopalgia, more frequently in women than in men, generally on the right side, recurring in regular paroxysms of indefinite duration, with spasmodic distortion of the muscles corresponding to the affected region (the zygomatic process almost always). ° Chronic intermittent prosopalgia always coming on at 7 or 8 p.m., and lasting from two to four hours. “ In facial, especially supraorbital neuralgia, in more than one instance a single dose was sufficient where the periodicity was well marked.” Dr. Liebold, “ New York Journal of Homoeopathy,” vol. i, p. 362. Its action on the throat is quite specific. The following case contains its peculiar symptoms: ° Mouth and tongue very dry; difficulty of speech ; great thirst all the time; painful pricking of the tongue, with a sensation of heat; she felt at times as if the tongue was paralyzed; face pale ; deep-sunken eyes; odontalgia every night; fetid breath; lips cold, bluish, dry; now and then slight bleeding of the gums. These symptoms appeared only with the catamenia, and lasted as long as that discharge, at the termination of which she had a profuse ptyalism and leucorrhoeal flow. The gastric symptoms remind one of Arnica, especially in the amelioration by eating, thus : Eructations of bitter wind from the stomach before rising in A.M., with dull pain in the temples; sensation as of a stone on the stomach ; rolling pain in the stomach ; sensation of heat and fulness in the stomach ; distension of the stomach and disposition to nausea, generally aggravated by rest, but relieved by walking, and by eating; ° uncomfortable feeling of the stomach, which obliged him to lie down; great sensitiveness of the prsecordial region ; pulse small and hard; dryness of the mouth and fauces; CEDRON. 153 depressed spirits and inquietude relieved by food and drink. These symptoms appeared every day from 10 to 11 a.m., lasted from one to two hours, after which there was prostration of body and mind for an hour or two. The following cases illustrate its curative power over abnormal stools and urine; it ought to be useful in cholera infantum, with tendency to brain trouble: ° Semiliquid, whit sh feces, somewhat like starch; white, frothy, and papescent evacuat’ons immediately after meals, accompanied with slight colic and discharge of inodorous wind; ° involuntary discharge of urine and fseces. ° Scanty urine; profuse emissions of watery urine; frequent emission of large quantities of pale urine; frequent ineffectual urging to urinate ; dark urine with sediment; urine of a dark-red color; scanty urine and deep yellow color; frequent desire to urinate; ° urine very high-colored ; ° urine precipitates a branlike sediment; 0 involuntary emission of urine; ° a great deal of pain in the kidney. . The genital symptoms are not as prominent as the cures alleged to be made, namely : ° A tic-like pain over the left eye, for more than thirteen years, with the singular circumstance that such a pain never came on except postcoitu (radically cured in 3 days); ° involuntary noc- turnal spermaperthy (in a woman). ° Post coitum, irregular and uncontrollable movements of the left upper and lower extremities, and of some portions of the face, manifested by grimaces and con- tortions of different kinds; these symptoms lasted from fifteen to twenty minutes. She could not speak without stammering, and her respiration was very much affected. She also had involuntary discharge of urine and feces at times during the attack [choreic). ° Leucorrhoea regularly every month, five or six days previous to the appearance of the catamenia, with pain in the uterus and enlargement of the vulva; ° leucorrhoeal discharge appearing in the place of the catamenia. Menstrual epilepsy (epileptoid con- vulsions), precursory symptoms of which were manifested pre- cisely the same day that the catamenia commenced ; vertigo, tin- nitus aurium, and irregularity in the action of the heart; then the aura epileptiea, followed with loss of consciousness and falling; a VOL. II.—11 154 CEDEON. distressing cry, now and then alternated with risus sardonicus and slight foaming at the mouth during the attack. ° Epileptiform eclampsia (hysteria); attacks came on regularly twice a day, morn- ing and evening, at the same hours, with these symptoms : intense pain in the forehead ; tumid face, with pupils much dilated ; then a feeling of giddiness, resulting in her falling down in the most distressing convulsions ; insensibility, closed teeth, and frothy se- cretions from the mouth ; difficult respiration, irregular pulse, and palpitation of the heart—the whole lasting for six or eight min- utes. On recovering consciousness she felt very weak, and dis- charged a large quantity of inodorous urine as clear as pure water (primipara, in seventh month of utero-gestation). The nerves of the larynx are evidently irritated by the drug, re- minding us of the action of Lachesis and other serpent poisons. (It is considered almost a panacea for the bites of serpents in the countries where it grows.) ° Larynx constricted and tender; difficuly of swallowing; diffi- cult respiration with partial loss of voice recurring at inters’als ; ° breath cold; ° hurried respiration and feeling of suffocation in the throat; 0 chronic intermittent laryngitis, the attack comes on every evening, with shivering chills, lasts about two hours, termi- nates with a profuse perspiration ; 0 suffocating fits regularly every day from 10 to 12 o’clock; there are sensations of choking or stifling; difficulty of breathing, obliging her to stand in an erect position; enlargement of the tonsils during the attack, with red- ness of the velum palati, and constant need of swallowing—all these symptoms were aggravated after sleeping, and mitigated by eating; ° troublesome cough, coming on regularly every morn- ing at about 6 o’clock, and lasting from two to three hours; the patient was perfectly free from it during the rest of the day. We see the similarity to Lachesis again in its effects on the cardiac nerves, especially on the accelerators and regulating nerves. Oppression of the chest and throbbing of the heart; oppres- sive pain in the chest every now and then, extending to the back, with frequent desire to moan and take a long breath ; palpitation of the heart and hurried breathing, with headache; pulse increased from 12 to 15 impulses per minute, in from twenty to thirty minutes after the dose. (This was a constant phenomenon in all CEDEON. 155 the American provers—three women and two men. The doses were from one to three drops of the matrix.) ° It has cured irregularity in the action of the heart; 0 irregu- lar pulse and palpitation of the heart; ° rapid intermittent pulse, impossible to reckon the strokes; also, palpitation of the heart, rapid and intermittent. The oppression of the chest and throbbing of the heart occurred in nearly all the provers in whom febrile paroxysms were developed. Many of the symptoms of the spinal region, such as “stiff-neck,” “ pain all along the spine,” verified by cures, point to its hornoeo- pathicity and possible usefulness in cerebrospinal meningitis, es- pecially when the cerebral, laryngeal, febrile, and spasmodic symp- toms correspond. I quote the fever symptoms in full, as a guide to its future ad- ministration in ague: 1. Feverish paroxysms every day in some provers, every other day in others, toward 8 p.m., preceded by depressed spirits, dul- lness of the senses, and pressive headache at noon; cramps, then contracting and tearing pains in the upper and lower extremities, with a cold sensation in the hands and feet; mouth dry, great thirst,and desire for cold water; chills and shivering; sometimes very strong shuddering of the whole body; palpitation of the heart and hurried respiration ; pulse weak and oppressed. These symptoms lasted from one to two hours, varied much in intensity, and were followed by a sensation of dry heat, and then of profuse perspiration, full and quick pulse, with animated red face; cold and pale in the apyrexia; thirst and desire for warm drinks. 2. At 3 o’clock, p.m., shuddering all over the body, with ma- laise and desire to lie down ; the shuddering is renewed by motion; hands, feet, and nose are cold; flying heat in the face several times; lastly, toward 6 o’clock in the morning, constant heat in the face, which looks animated, with smarting in the eyes, es- pecially when closing them; lips dry, with desire to moisten them often; headache, especially in the bottom of the orbits, compelling him to close the eyes, and extending to the occiput. While this congestion of the head lasts, the shuddering continues all the time; the hands, feet, and nose remain cold ; urine of a dark-red color. 156 CEDRON. 3. Toward 6 o’clock in the evening (immediately after dinner) cold all over; shuddering in the back, icy coldness in the feet; the hands are burning; sensation in the eyes as if one had wept a good deal. In the evening toward half past six, half an hour after dinner, shuddering in the back and legs; unusual paleness of the hands; red face; heaviness of the head; stretching toward seven in the evening; general coldness all evening; increase of the head- ache in the open air (toward 9 o’clock); pressive pain over the eyes as of a band of iron tied round the parts; no thirst dur- ing the shuddering; dry heat at night. At 6.30 P.M., feverish paroxysms with itching in the eyes, which is only stopped for a moment by rubbing; laming and weary pains in the shoulders; profuse emission of watery urine. Toward 5.30 P.M., prick- ings in the tongue; itching of the eyes; half an hour later shiverings, with heat of the face, hands pale, feet and tip of the nose cold. Towards 6 P.M., shuddering, soon followed by a dull and heavy frontal headache, spreading to both parietal regions with redness of the eyes, itching of the internal and external sur- faces of the eyelids; icy coldness of the hands and tip of the nose, even in the midst of the febrile reaction (the pulse is 80), the rest of the face is red and burning; lastly, dimness of sight, dilatation of the pupils; objects look red; mouth dry, with thick, viscous saliva; constriction of the throat, which scarcely allows her to swallow the saliva; anxiety, restlessness, general malaise. The medicine being taken by healthy provers, was generally followed by— 1st. A certain state of mental excitement, and augmentation of vital energy; florid face, and a sensation of heat throughout the body; full and strong pulse; more or less perspiration, and no thirst. This group lasted from twenty to forty minutes in some, and disappeared after that time to return no more, without any other abnormal manifestation in their health ; whilst in others the symp- toms were prolonged from one to two hours, and were followed by— 2d. Depressed spirits; dulness of the senses, and torpor of the mental faeulties; general debility, languor, and faintings in some. When these symptoms are followed by those of the first group, 157 CEDRON CHELIDONIUM. the phenomena of both sets are often repeated, and at certain in- tervals of time; but neither of the two occur periodically, unless when they are together. Nor are they absolutely concomitant to pyrexia; for the paroxysms generally take place without them, as in the natural disease. It is for this reason that such phenomena were disconnected from the category of the physical group; but whenever pyrexia occurs, or follows that condition, the symptoms, after weakness of the body and mind, are as follows: 3d. Great thirst; yawning; cramps and painful feelings of contraction in the lower extremities; cold sensation in hands and feet; chills and shivering of the whole body; palpitation of the heart; pulse weak and oppressed; hurried respiration; chattering of the teeth and shaking of the whole body; scanty and highly- colored urine; slight nausea in some, with yellow color of the skin and face in others; great debility; dilated pupils and confused sight. These symptoms lasted from one to two hours, and varied much in their intensity; after which— 4th. Dry heat follows, with full and quick pulse; animated face; profuse perspiration ; longing for cold in some, and for warm drinks in others; and discharge of pale urine in large quantities. These symptoms lasted from two to three hours, and were gener- ally followed by a desire to sleep. The provers felt as if they were contused ; sound sleep in some, and somewhat agitated in others during the night. The apyrexia generally lasted from fifteen to seventeen hours, after which, and in about the same time as the previous day, the paroxysms were repeated as per group third, and continued almost quotidian. CHELIDONIUM. This plant—the Great Celandine—belongs to the family of Papaveracece, to which also belongs Papaver (Opium), Sanguina- ria (Blood-root), Argemone, Stytophorum, and Glaucium—all members of the above family, and growing wild in the United States. When the critics reviewed the third edition of my “New Reme- dies,” they disputed my statement that no complete pathogenesis had ever before been published. But I was right. In the “ Symp- 158 CHELIDONIUM. tomen Codex ” was a brief pathogenesis which had been partially- copied by Lippe; while my pathogenesis was made up from Bachman’s splendid provings, found in the twenty-third volume of the “British Journal of Homoeopathy,” together with pre- vious provings and clinical cases scattered through our journals. Teste’s provings and observations were referred to, although I consider them of but little value. The chemical analysis of Chelidonium is of some interest. It contains Chelidonic acid, which with Malic acid is combined with the organic bases and lime in the plant itself. It contains a principle called Chelerythrin, which is also found in Sanguinaria and Glaueium. I believe we can trace pathogenetic affinities between all the plants of this (Poppy) family, especially between the Chelidonium and Sanguinaria. The sphere of action of Chelidonium includes the liver, portal system, lungs, and kidneys. Voigt, in “Lehrbuch der Pharmacodynamik,” 1838, gives, in the language of that day7, a good idea of its action: “ It causes an increased secretion from the outer skin and kidneys, especially a more active circulation of the fluids of the portal system, and in the lymphatic vessels, and the abdominal glands ; and, in gen- eral, a more active metamorphosis of the vegetative organs of the abdomen.” Rademacher, a close observer, says it acts on the internal struc- ture of the liver, and he believes that all its general effects are due to this specific action. It was proven by7 Buchman and others, with the mother tinc- ture in massive doses, and in the 6th dilution. In Buchman’s summing up of its physiological effects, he says: “The power of exciting the whole arterial and capillary sy7stem is possessed by Chelid., in common with Aconite, as appears from the great similarity of the febrile symptoms, but it does not agree with the transient character of the action of Aconite on the vascu- lar system. This is especially evident from its effects on the vena porta and its functions, inasmuch as it calls forth all the phenom- ena of fully developed abdominal plethora. This effect is al- ways, for the most part, produced by defective circulation in the CHELIDONIUM. 159 liver, and continual catarrhal excitement of the mucous membrane of the abdominal viscera. There is no room to doubt that the at- tacks of palpitation, slowness of the pulse (50), the distension of the veins of the hands, the paralysis, weight, and stiffness of the limbs, and the coldness of the extremities, the oedematous swelling of the legs, dull pains in the head, vertigo, pressure in the occiput, pains in the back and sacrum ; weakness, indolence, irritability, ill- humor, alternation of diarrhoea with costiveness, fits of colic, yel- low-gray color of the skin, renewal of the symptoms on change of weather, etc., are to be referred to a congestive retention of blood in the portal system, and the hyperaemia thereby determined in the abdominal organs. In the cutaneous system it is primarily the mucous membranes upon which this medicine acts, by exciting catarrhal inflammation. We have accordingly observed catarrhal inflammation of the eyes, nostrils, larynx, and bronchial tubes. Even the stomach and ali- mentary canal, and mucous membranes of the female sexual organs, partake of this catarrhal inflammation. It extends also to the mucous lining of the canals through which flow the gall and urine. We find three different conditions of the secretion of bile caused by the Chelidonium. (1.) Diminished secretion. We find, e. g., light, gray, or yel- lowish-white stools, without deposit.of biliary coloring-matter in the skin, and without separation by the urine. (2.) Suppressed secretion, with resorption into the blood. (3.) Absorption, without stopping its escape into the intestinal canal. The urine in most cases was sour to the smell, and reddened litmus-paper like a powerful acid. In intimate connection with the increased acidity of the urine we find a diminution of the acid of the stomach. Analogues.—Buchman says : “ Its symptoms combine a great part of those of Bryonia and Arsenic. It is allied to Arnica, Nux vomica, Ledum, Thuja, Nitric acid, and Sulph. acid ; ” to which I shall add Agaricus, .iEsculus, Benzoic acid, Carduus, Lycopodium, Leptandra, Mercurius, Podophyllum, Phosphorus, and Sanguin- aria (Chionanthus) ? 160 CHELIDONIUM. Clinical Observations.—Buchman gives a list of what might be termed pathological keynotes, for the use of Chelid., namely: Vertigo, stumbling, dizzy confusion of the head ; trembling and twitching in the limbs; grayish-yellow (sallow) amber counte- nance; increased secretion of the meibomian glands; inflamed sebaceous glands; so-called worms in the face; heat in the face; fits of rigor in the evening; cold extremities; restless sleep before midnight; dreams about corpses and funerals; sweat in morning; being terrified out of sleep by the urinal sufferings ; cessation of the sufferings after dinner ; drowsiness during the day ; shortness of breath and anxiety, relieved by eructation ; a feeling of con- striction, tension, and sensitiveness in the region of stomach and right hypochondria; dryness in the throat; nausea, and dislike for flesh-meat; bright-colored (yellow) slimy stools; sour-smelling, reddish, and turbid urine. Buchman thinks it especially indicated in spare subjects, where there exists a disposition to abdominal plethora, cutaneous disease, catarrh, and neuralgia. He agrees with Teste, that it acts with special effect upon persons of blonde complexion. (Bry. for dark complexion.) Chelidonium is certainly not used by homoeopathists as much as its merits demand. Its pathogenesis, as recorded in the “ British Journal/’ vol. xxiv, 18G6, contains many very important symp- toms, which point to very decided pathological conditions. It could be prescribed successfully (perhaps more successfully) in many cases where we think Nux vomica, Bryonia, Mercurius, and Iris are indicated. In certain forms of headache it is indispensable. It is indicated particularly in bilious headache, or those which arise from a defi- ciency in the eliminating function of the liver. The characteristic symptoms are: “ Tension of the head as from a bandage close over the eye- brows, as if the head was compressed ; or, “ Weight on the head, as if bound or compressed in a vise. “ Violent 'pulsating pains from the nape and occiput to temples and forehead (Sanguinaria also). “Great pain in the head, pressing from within outwards, espe- 161 CHELIDONIUM. dally towards the forehead, as if everything was falling out (like Bryonia). “ Pressure and weight in the occiput, with painful throbbing there ; this weight is so great that the head can hardly be lifted from the pillow (Silica, Eupat. perf., Bromides).” The headaches are generally increased by fresh air (contra by cough, blowing the nose, stooping (Bry., Ferr.); relieved by eat- ing (contra Nux). Concomitants.— Vertigo, feeling of congestion, flickering, and bright or dark spots before the eyes ; white or gray coated tongue ; nausea, retching and vomiting of tough mucus. “ In some sick headaches,” or “neuralgic headaches’’ it is very useful. In periodic neuralgic headache located in the region of the eye- brow and temple, especially of the right side, it has effected some brilliant cures. In vol. xx, “British Journal of Homoeopathy,” page 47, Dr. Ferivat, of Madrid, reports Jive cases of neuralgia of the eyebrow and temple (four in the right, one in the left), marked by the following symptoms : “ Shivering, followed by pulsating pains in the eyebrow and temple, occurring at the same hour every day (on getting out of bed at 9 a.m., 11 a.m., 3 p.m.). “The pain, at first slight, increases gradually, until it becomes almost insupportable, driving the patient to distraction. There is a bruised sensation in the eye from the front to the back. The eye becomes red and watery, and very sensitive to the light. Aggravated by fresh air, moving, and holding down the head. Ameliorated a little by pressure. The attacks end with slight perspiration (often sour). Nux was used ineffectually, but Cheli- donium in the 2d and 3d dilution, every two hours, promptly arrested the paroxysms.” I have cured several cases similar to the above, but only when the neuralgia was won-malarial. If it is a form of masked ague Chelidonium will rarely cure, but generally Gelseminum, Quinia, Cedron, or Nux will have to be used. In diseases of the eye Chelidonium always had a reputation, even in the time of Dioscorides and Aristotle. Dr. Ferivat, above quoted, says: “I have often proved its effi- 162 CHELIDONIUM. cacv in acute inflammations of the eyes, where they are swollen, in- jected, with a sensation of burning, as if from the presence of a foreign body. When there is excessive photophobia, lachrymation, abundant sebaceous secretion, agglutination of the eyelids in the morning; shiverings from time to time; pain, which generally ex- tern!*, not only to the forehead, but sometimes all over the head ; this pain, beginning to be felt towards 2 or 3 P.M., is at its height about 8 or 9, and prevents sleep, or even lying down, till nearly daybreak.” Amaurosis, in some of its varieties, may come under the cura- tive sphere of this medicine; also tinnitus aurium and other ner- vous affections of the ear. It is the value of Chelidonium as a remedy for diseases of the liver to which I wish particularly to call your attention. Its action on the liver is strongly marked in all the provings. It causes pain, both acute and dull, and tenderness of that organ; pain in the right shoulder (“ under the right scapula” is a key- symptom); stools either soft or bright yellow, or whitish and cos- tive ; deeply-tinged urine. In three the skin became yellow or dark, and in one regular jaundice was set up. Rademacher, who was a kind of embryo homoeopathist, declares Chelidonium to be a specific; in “ affections of the internal structure of the liver,” the symptoms of which he enumerates as follows: “ The perfect form of the internal hepatic disease is distin- guished by white, quite colorless faeces, as in jaundice, and by the complete absence of all the other symptoms of jaundice. The skin is, and continues white, and has not even a dirty appearance, and the urine is nearly straw-colored as in healthy persons.” (lie ad- mits that this disease is very rare. He only saw five cases in his practice.) “The unknown organ (in this disease) whereby the bile is formed from the blood is itself diseased ; no bile is present, none is therefore absorbed, none therefore deposited in the skin, or urine, consequently no jaundice.” I have never seen but one case of this peculiar disease. The patient died. Rademacher implies that he has cured cases of this nature with Chelidonium. But Chelidonium certainly cures cases of acute and chronic hepatitis, jaundice from absorption of bile, jaundice caused by CHELIDONIUM. 163 catarrh of the biliary ducts, jaundice from gallstones, jaundice com- plicated with pneumonia, and many other common and anomalous hepatic disorders. Rademacher, after using and observing the use of Chelidonium in massive doses, became afraid of it in such quantities (as did Hahnemann of other medicines), and reduced his doses to a few drops or fractions of a drop. He mentions one case of a jaun- diced patient who had previously taken a thimbleful of the juice four times a day, and the disease was thereby so much aggravated that the bright yellow of the skin had turned dark yellow, and the tension of the upper abdominal region was greatly increased. Fifteen drops of the tincture, three times a day, restored him with- out further trouble. In the “British Journal of Homoeopathy,” 1867, are recorded several cases of biliary calculi cured by large doses of Chelidonium. These cases were not ordinary ones, but obstinate, severe, and with dangerous symptoms. In every case the prompt curative action of the medicine was unmistakable. In my own practice, in 1869, one of the most protracted cases of gallstones on record (so far as my reading extends) came under my care. The patient was a gen- tleman, an old resident of Chicago. He had been jaundiced nearly two years, and during that time had suffered intolerably with “congestive chills,” terrible cardialgia, periodic; intense hepatic pains, and his appearance when I first saw him was frightful. He was bronze-yellow; emaciated in the extreme; urine scanty and nearly black; stool hard and white; total inability to retain food; pulse intermittent and almost imperceptible. Like the case above alluded to, he had been drugged constantly for the two years, without the slightest benefit, I began with two drops Tinc- ture of chelidonium every three hours, increasing it a drop each dose every day, until he took ten drops, when he was seized with intense pains in the gall-bladder, followed by the expulsion from the bowels of a stone, dumb-bell shaped, nearly an inch long and half an inch in diameter. He rapidly recovered. Induration of the liver was cured by Dr. Benedix with the Ex- tract of chelidonium, after the disease had lasted a year and a half, and had been (mal)treated by a host of drugs. 164 CHELIDONIUM. Dr. Neidhard considers it an excellent remedy in hepatic dis- eases, and has reported several cores. You will find no better remedy, and none oftener indicated in the disorders of the liver met with in general practice. Study your cases carefully, and select the medicine with equal care, and avoid the routine treatment, so common, of giving Podophyllum or Mercurius in every case. In my opinion Chelidonium is oftener indicated than either of them. A disorder of the secretory functions of the liver, described by Flint under the name of Cholestercemia, may be successfully treated with Chelidonium. One case came under my care which closely resembled that disorder. Chelidonium lx removed the symptoms (like acute rheumatism) in a week. Buchman says he “ cured the fatty liver of a scrofulous girl, aged 4,—the border of the organ extended as far as the navel, with ac- companying icterus,—in six weeks, by three doses of the 6th of Chelidonium.”(!) It is just possible the cure was one of nature’s making. The gastro-intestinal disorders in which Chelidonium may be used to advantage are comprised under two classes, namely, intestinal catarrh and bilious diarrhoea. Buchman gives several cases illus- trative of its action in the former disorder. It was not usually attended by pains in the abdomen; it occurred at night; was yellow-slimy or whitish-yellow; the face was pale or sallow; and there was much debility. The bilious diarrhoea was attended with much debility, but not much pain. My studies and experience with Chelidonium convince me that the action of Chelidonium on the liver and intestinal tract is as follows: Primary.—Irritation of the secretory function of the liver, with yellow fecal discharge, debility, etc., followed by yellow mucous diarrhoea, showing irritation of the intestinal mucous membrane- (6th.) Secondary.—Arrest of secretory function from overstimulation (reaction), or obstruction of hepatic ducts, with white stools, or brown, watery—with jaundice; urine brown or yellow, and sour (loaded with bile). (3d to 0.) It is important to understand this dual action, for thereupon CHELIDONIUM. 165 hinges the selection of the proper dose, which I have designated above. Bell, in his admirable monograph on diarrhoea, says “ theOhelido- nium diarrhoea is aggravated at night, ameliorated from (colic) wine, and attended by rumbling in the abdomen, both before, during, and after stool, with slimy, white-coated tongue, disgusting or bitter taste, desire for wine, milk, which agrees; for hot drinks, which agree; aversion to cheese and boiled meat.” I am of the opinion that the pain is not sufficiently mentioned, for it is not possible for a bilious diarrhoea or intestinal catarrh to be attended with only rumbling, and no pain. In the summer diarrhoea of children, I have found it at certain seasons one of the best of remedies. It is especially indicated in the diarrhoea which attends infantile pneumonia or capillary bron- chitis. Sanguinaria is also indicated here, although it has been but little used. Buchman was quite enthusiastic thatChelidonuim would prove a valuable renal remedy. He based his hopes on one proving,— his wife’s. Her symptoms were “ pressive pains in renal region, not confined to the kidneys, but extending to the ureters and bladder—accompanied by turbid urine.” He says he discovered “renal cylinders” in the urine, from which he divines a condition of “croupose inflammation, and consequent degeneration of the glandular epithelium.” “Just as in this proving, so in morbus Brightii, we found increased uric acid, diminished chloride of so- dium, and dissolved hcematin in pale-yellow, slightly turbid urine, which, when albumen is abundant, is colored reddish.” His wife had, also, other symptoms of Bright’s disease : “ (Edematous swell- ing of the extremeties, neuralgia in the region of the trigeminus and supraorbitalis.” Ho subsequent experience has been published in relation to Chelidonium in diseases of the kidneys. Buchman, however, gives one case with the following symptoms, which he removed with the 6th: “Pain in the region of the kidneys, and in the head, with sparks before the eyes; urine reddish, turbid, containing fibrin, flakes, and sand.” I doubt if Chelidonium will prove a very valuable renal remedy. It certainly needs further proving in that direction. I am of the 166 CHELIDONIUM. opinion that its renal symptoms mostly depend on the hepatic derangement it causes. Chelidonium is recommended by both Buchman and Teste in laryngitis, bronchitis, pneumonia, influenza, whooping-cough, asthma, spasm of the glottis, endocarditis, pericarditis, pleurisy, typhoid fever, hcemorrhoids, worms, chorea, acute rheumatism, measles, erysipelas of the face, acne, eczema rubra, ulcers, and, finally, injuries (instead of Arnica). I do not propose to go into detail and examine the homoeopath- icity of the drug in these diseases. If you would investigate the extensive history of this medicine, I refer you to vols. xxiv and xxv of the “British Journal.” I will only say that the therapeutics of Chelidonium has been almost too elaborately worked up. It has a pathological keynote, which should be the guide, next to the totality of the symptoms, for its selection. That keynote I believe to be derangement of the hepatic system. I do not believe that Chelidonium is capable of causing idio- pathically all of the diseases mentioned above; but they may appear in some forms during the provings, if heroic enough, as concomitants of the central hepatic irritation. With this expla- nation, you will have no difficulty in adapting it to any of the diseases for which it is recommended. My experience with it in pneumonia is, that when the liver is implicated, and the right lung is affected, it will prove useful, if a yellow, slimy diarrhoea is found. In cardiac affections, consequent on hepatic derangements, it is a good remedy (on the contrary, if the hepatic trouble is caused by cardiac disorder, Digitalis). I have found it useful in haemorrhoids, in some phases of typhoid fever, and in influenza. I have not used it enough in whooping-cough to give any favor- able opinion of its virtues. It is highly praised by some. Dr. Clifton, of England, writing of his experience in dyspepsia, speaks highly of Chelidonium. He recommends it for the follow- ing conditions: 1. Tongue dry and white. 2. Appetite. (Desires and dislikes.) 167 CHELIDONIUM. a. Desire for milk which produces comfort, though it formerly caused flatulence. b. Great longing for wine, which does not as before produce congestion and heat in the head. .c. Prefers hot things, dislikes those which are cold. d. Dislikes boiled flesh. e. Must eat more breakfast than usual, in order not to get faint before dinner. /. Disgusting taste; food tastes naturally. 3. Eructations relieve nausea. 4. Stomach, aching and gnawing pain in; constrictive feeling over, aggravated by pressure, but relieved by eating or during the early hours of digestion. 5. Sensation of constriction and sensitiveness in the scrobiculus cordis and right hypochondrium. 1. The first of these symptoms or “ characteristics ” relates to the tongue. All that is said of it is, that “ it is dry and white.” The description I would give of the Chelidonium tongue is, that it is moderately dry or moist, of a good natural color, but slightly coated white, and sometimes streaky, the shape of it being narrow and pointed. It has been, in cases of dyspepsia, where there are other symptoms indicating Chelidonium, that I have found the tongue to answer to this description. Where the liver is more affected, there is often a yellowish fur. 2. Appetite, desires, dislikes to food. a. “Desire for milk, which does not cause flatulence as it used to do, but produces comfort.” In several cases of dyspepsia, where Chelidonium has been otherwise indicated, this symptom has been very marked. In all cases of dyspepsia where the appearance of the tongue answers to that indicating Chelidonium, I generally find that when such persons are in health milk gives rise to flatulence. One such case was a man, 64 years of age, suffering from hyper- trophy of the heart, with gastric dyspepsia, giving rise to loud, tasteless, or bitter eructations. He had suffered from gallstones, and I had successfully treated him with Berberis. To relieve his dyspepsia, I unavailingly gave him Carbo v., Argentum nit., and Bismuth, as well as other medicines; Chelidonium greatly relieved the dyspepsia, though it failed to check the eructations. 168 CHELIDONIUM. I kept him on a milk diet (not skim milk) for a month with benefit. Previously he had had the desire for milk, but was un- able to digest it. Another patient, who suffered frightfully from spasmodic pains in the stomach, followed by bitter and bilious vomitings, had noticed that when well she could not take milk, but was able to do so when ill, provided it was warm. She obtained rapid relief from Chelidoniurn (1st dec.) in two attacks, and the dyspeptic symptoms which ordinarily preceded and followed an attack were quite cured by the same remedy. b. “ Great longing for wine, which does not cause congestion or heat in the head as before.” I have occasionally noticed these symptoms in cases of dyspepsia indicating Chelidoniurn, though not to so marked an extent as the incapacity to digest milk just referred to. In one case—to be noticed presently—there was a longing for beer, which I did not gratify, as it manifestly disagreed with the patient, but I permitted him to take wine with advan- tage. e. “ Prefers hot things.” This I have often noticed in dyspep- tics cured by Chelidoniurn. d. The dislike to boiled flesh, said to be a characteristic of the Chelidoniurn dyspepsia, I have not noticed. e. The feeling a necessity to eat a larger breakfast than usual in order to prevent faintness before the next meal, I have seen something like in the desire for food to prevent stomach pains. 3. Eructation relieving nausea I have occasionally observed to occur in dyspeptics relieved by Chelidoniurn. 4. Stomach.—“ Aching-gnawing pain in the stomach, with a sense of constriction, aggravated by pressure, but relieved by eating or during the early hours of digestion,” is, I believe, a very marked characteristic of Chelidoniurn dyspepsia. 5. “Sensation of constriction and sensitiveness in the scrobiculus cordis and right hypochondrium,” are often associated with the foregoing; or rather, whilst in the former, the aching gnawing is relieved, during the early hours of digestion, this is often aggravated slightly, and in my experience is more frequently indicative of Kux vomica, if other symptoms correspond, than of Chelidoniurn. CHELIDONIUM. 169 As an illustration of symptoms 4 and 5, I will adduce the fol- lowing case: A gentleman, aged fifty-two, of spare habit, accustomed to a moderate amount of exercise by day, but poring over his books and plans till one or two in the morning, had frequently suffered from indigestion. On one occasion he had jaundice, and once had had intermittent fever. When he consulted me he had been suffering for two months, and had taken from his own medicine case Bryonia, Nux, Chamomilla, Sulphur, etc., without benefit. He complained of giddiness in the morning, and of headache on waking. His sleep was unrefreshing from vivid dreams of busi- ness matters. He disliked his usual mental studies. The appe- tite was diminished, but when he had eaten a little he could eat more, because he then felt better. An aching pain in the stomach was nearly constant, but was better after food. Constrictive feel- ing across the stomach from right to left hypochondrium, so much so as to oblige him to loosen his clothes two hours after a meal. Slight eructations; bad taste in mouth ; desire for beer, which, though he relished it, caused heartburn and headache; his stools were pappy and light-colored ; urine normal; his tongue was only slightly coated white, and rather moist, thin, and narrow in shape, like that in persons of a nervous temperament, or where there is nervous irritability; his face was pale, and of a yellowish tint. For a month I gave him Nux, China, and Ignatia of various dilu- tions, but without benefit. I therefore turned to a record I keep of characteristics, where, under “Stomach and Appetite,” I found No. 4 characteristic of Chelidonium. I next consulted the Re- pertory of the Hahnemann Publishing Society (a work it is dis- graceful to us as a body not to have completed long since). In this I found that, under Petroleum and Nitric acid, there is “aching pain when fasting, relieved by food ;” under Pulsatilla, “gnawing pain when fasting, relieved by food ;” under Nux vom- ica, “contusive pain when fasting, relieved by food.” None of these corresponded so well, especially in the mental sphere, in the to- tality of their symptoms to the case under consideration, as did Chelidonium. One drop of Chelidonium, 3d dilution, taken four times a day, gave relief in three days, and in a fortnight my pa- YOL. II.—12 170 CHELIDONIUM CHELONE GLABRA. tient was well. He has had a similar attack since, when a few doses of the same medicine soon cured him. Such are the chief characteristics of the Chelidonium dyspepsia I have been able to verify clinically. I have in addition seen one case of mental distress cured by this medicine. Without much dyspepsia, there was a dry, white, narrow, and pointed tongue ; with a desire for wine and but little appetite. The mental symp- toms were restlessness and uneasiness of conscience. She felt that she had committed the unpardonable sin, and that she would be eternally lost—a condition very similar to one described by Dr. Buchman in his proving of Chelidonium.—“Horn. Review.” CHELONE GLABRA. The Chelone is one of those bitter indigenous plants which has always had a popular reputation as a tonic, or strength-restorer. The same may be said of Gentian, Frazera, the foreign Columbo, and others. But the Chelone seems to possess some specific powers aside front its general action. No provings have been made, but the clinical experience of a few homoeopathists, and my own, show that it must affect the liver. It has been found very beneficial in weak digestion, especially when due to want of tone in the stomach. Jaundice, with loss of appetite, disgust for food, constipation and debility, has been removed promptly by drop doses of the tincture. Dr. Ball, of Marshall, Mich., has had much experience with Chelone in intermittent fever after abuse of Quinine. In such cases the Chelone cures, not by possessing any anti-malarial virtue like Quinine, but by its power of removing the Quinine cachexia. That troublesome condition, which follows severe attacks of ma- larial fever, known as “dumb ague,” consisting of ill-defined paroxysms of aching, with fever and distress, may be removed by this medicine if its use is patiently continued a few weeks. Dr. E. C. Price, of Baltimore, verifies Dr. Ball’s experience. He gave it to a man broken down with ague, and who, notwith- standing the use of Quinine, Iron, and Strychnia, became so CHLORAL, 171 weak as to be unable to sit up. “ The tincture of Chelone, five drops three times a day, brought him right up, and he has re- mained well ever since.” CHLORAL. The Hydrate of Chloral was discovered by M. Liebreich, and introduced by him as a therapeutic agent, before the Medical So- ciety of Berlin, in June, 1869. It was a white solid, made up of needle-form crystals having the appearance of snow. It has an odor similar to ripe muskmelons. On exposure to the air it rapidly deliquesces, and after a time wholly disappears. It is soluble in water, alcohol, and ether. The lower animals are readily affected by very small doses, two to five grains causing profound sleep. It is certain and rapid in its action. For an adult man twenty grains is the average dose. This generally causes the semblance of a normal, profound slum- ber, commencing in fifteen to twenty minutes after the drug is taken into the stomach, and lasting from six to ten hours. Certain persons, however, are so constituted that they require double this quantity to produce the same degree of somnolence. As a rule, the quantity may be safely graduated for a single soporific (sleep- causing) dose. Two grains can be given for each year of age until the patient is twenty. This dose may be repeated in an hour (or even thirty minutes if intense pain is present). If you give the Chloral hydrate to cause sleep and alleviate pain, you must admin- ister the definite quantity known to cause the desired result. You can no more produce aneesthesia with the attenuations than you can with the attenuations of Chloroform or Ether. It is only for symptoms and conditions simulating its primary effects, that you can give attenuated doses; nor will it bear much attenuation, all theorists to the contrary notwithstanding. Under a heavy dose the breathing is imperceptible; after a moderate one the breathing is soft and gentle. There is no sensi- bility during this sleep, not even upon the external applications of stimulants. They sleep on, while all the functions of life are apparently at rest, except one, the circulation. On a microscopic examination of the web of a frog’s foot, while under Chloral, the 172 CHLORAL. circulation is found most perfect, confirming the theory of Lieb- reich, that the heart is the last to die. One prominent and persistent effect is the decrease of animal temperature with contracted pupils. No excitement precedes the sleep. Patients can be aroused at any time to full consciousness, the natural functions are performed, there is no disturbance of the secretions, and waking is not attended by disagreeable symptoms. In fatal cases the following symptoms occur : Stertorous respi- ration ; eyes set and glassy, pupils contracted and insensible to light; conjunctiva congested ; motion of the heart quite rapid and so feeble as to be scarcely felt; blood settles under the finger nails ; purple spots are on the side on which they lie; extremities cold, and frothy mucus flows from the mouth ; insensibility of the skin, with occasional moments of hypersesthesia. The functions are destroyed in the following order: (1) The cerebral; (2) the involuntary muscles; (3) the respiratory ; lastly, the heart. It paralyzes the ganglionic cells of (1) the brain, (2) the spinal cord, (3) and last, the heart. Its mode of action is quite analogous to Chloroform, but large doses should be avoided when the heart is weakened. Its therapeutical uses in homoeopathic practice are similar, in one respect, to its use by the opposite school, viz., for the necessary alleviation of pain and the production of sleep. I do not hesitate to resort to it, after a fair trial of our most approved homoeopathic remedies; nor should any of you, after you have decided in your best judgment that your patient will be in better condition from its use than without it. It is to the public one of the most fascinating of narcotics, if its taste is tolerated; but its habitual use is attended by all the evils which follow the abuse of such agents. Attempts to break off the habit have resulted in a condition similar to delirium tremens, and other depressed and irritable mental states. Its immediate effects on the mental sphere are always calming, soothing, and quieting. Its remote (secondary) effects, depressing and irritating. It is, therefore, secondarily homoeopathic to many forms of insanity, idiocy, and dementia. CHLOKAL, 173 The records of insane asylums give the following pretty uniform results, the average dose being from 20 to 30 grs.: “ When pa- tients are destructive and violent, it acts as an excellent hypnotic by night, and a soothing agent by day; they become free from destructive habits, and gain in weight and strength; the action of the bowels and bladder improves; the appetite is increased; it relieves abnormal sensations and hallucinations; it checks the desire for self-inj ury; and melancholic patients become more cheerful.” It has been observed that “ the greater the disorganization of the brain and cord, the sooner does the system come under its action.” I have used it successfully in many cases of delirium tremens and 'puerperal mania, when the symptoms were like those I have just described. The pathological condition which it induces in the brain in fatal cases is said to be ancemia. This I suppose to be thc ■primary, direct result of a single fatal dose. But cases are on record which go to show that an opposite con- dition results from longer use—of massive doses ending in death. In other words, secondary effects supervene. Thus Hammond relates a fatal case, where he gave it for a disease of the brain, and found congestion of the brain post-mortem. In other cases, the brain, cerebellum, and their membranes, showed an increased vas- cularity ; but these I believe were secondary effects. Its purely homoeopathic applications in brain disorders are as follows: In cerebral ancemia, suddenly appearing, simulating the usual effects of a dangerous single dose, you may prescribe it in the 3* or 6X dilution. In such cases it is analogous to the Bromides and Conium. In cerebral congestion, occurring as a reaction from previous anaemia, the Chloral is one of the best remedies you can use, if you select it judiciously. It here rivals the Bromides. This condition of the brain is that which is found in patients whose insanity takes the form I mentioned at the beginning of this lecture. There is sometimes excruciating pain in the occiput and tem- 174 CHLORAL. pies; great heaviness of the head, and a feeling of compression of the head, as if in a vice; also aching and redness of the eyes, illu- sions of vision, and photophobia. I have cured congestion of the brain in children after cholera in- fantum, with the l1 dilution. It is useful for the night terrors of children when arising from worms, teething, and the result of cerebral irritation after colli- quative discharges. Here it rivals Cuprum aceticum and the bromides, either of which are superior to Belladonna, which is so absurdly used in a routine way. I can hardly give you the differential diagnosis between the Chloral and the Bromides in such cases; the line of distinction is very intangible. You will have to learn it by experience, or rely upon your intuitions, or wait until we have complete provings of these important drugs. I believe it will prove useful in some cases of cerebrospinal congestion, but doubt its usefulness after inflammation has taken place. The pains in the occiput and head seem to indicate its relation to this disease. When inhaled it causes intense irritation of the nasal and other surfaces of the respiratory mucous membrane. You may find it useful in cases of hay fever (catarrhus sestivus) if inhaled at the very outset of the malady, in a very dilute form. In my own case 10 grains taken at the outset of an influenza always arrests it. Its effects on the eye and sense of vision are unique and pecu- liar. (You will find many hay-fever symptoms among its eye symptoms.) It causes aching in the eyeballs, which feel too large. (Spig.) The lids feel so heavy he can hardly lift them. (Gels.) Intense itching of the inner canthi and edges of the lids; the lids are puffy and swollen; red, injected, and bloodshot eyes; burning in the eye and eyelids; profuse irritating lachrymation. You will find some interesting contributions to the therapeutics of Chloral in the “ British Journal,” for July, 1874, by Dr. D. Dyce Brown. Taking the above symptoms of the eye as the indi- cations, he treated twelve cases of conjunctivitis with Chloral, and with uniform success. His doses were—“one grain of the pure salt, in water, three times a day, for adults, and fractional doses CHLORAL. 175 for children.” In two cases, in my own practice, its curative effects were simply magical. In addition to the symptoms already given, his cases presented others, namely, small ulcers on the cornea ; phlyctcence; severe cir- cumorbital pain ; chemosis ; loss of appetite, and sleeplessness. It ought to be useful in abnormal conditions of the sense of vision, such as asthenopia, color-blindness, ocular hypercesthesia, photophobia,- and perhaps, threatened paralysis of the optic nerve. Many of its eye-symptoms resemble those of Gelseminum, Coca, Calabar, and Cannabis indica. Spasm of the glottis is imitated by the symptoms of the tongue and throat (primary). I have made some very gratifying cures of traumatic odontalgia by means of Chloral, several of which have been reported in our journals. If the toothache is from the pressure of a tilling, give the usual anodyne dose internally; if from substances which have gotten into a cavity, clean it out, and till it with the crude salt, or cotton saturated with the mother tincture (one grain to each drop of water or alcohol). It may be useful in the attenuations, in the severe flushings which occur at the critical age, for it has caused a “dark scarlet flushing and heat of the head and face, from roots of the hair to ramus of the lower jaw, including the eyes; it was persistent under pressure; was blotchy in places, and extended to the neck and chest. There was excited circulation and slight contraction of the pupils.” Similar paroxysms occur premonitory to, and during tubercular meningitis, and I observed them last summer, after attacks of cholera infantum. In the latter it came on in the evening, and pre- vented sleep from the heat and itching. I have used it in a few instances in the severe pains, vomiting and retching from passage of biliary or renal calculi ; but you must avoid its use in large doses in jaundice from arrest of secretion, for it has caused “ jaundice, with coma and stupefaction,” and aggra- vated many cases. It has also caused atrophy of the liver, but these facts need not deter you from trying it in just such cases, if you prescribe the 176 CHLORAL. attenuations (1* to 3X). The law of Sirnilia ought to hold good in relation to Chloral as well as to Mercury. Chloral does not cause diarrhoea, nor do the Bromides, yet in those cases where the diarrhoea is the result of morbid nervous depression with irritation, it will remove the cause, thus indirectly curing that symptom. For example, in cases of cholera infantum, where there is in- tense nervous erethism, severe pain, and threatening spasms, I have not hesitated to give Chloral in doses of 1 to 5 grains. The Bromides and some other remedies may be equally well indicated by the symptoms; but no other drug acts as quickly, and in some cases a few minutes lost is fatal to the patient. It has been suggested in cholera. It causes all the symptoms of cholera, except the purging and vomiting. But in some cases of cholera (cholera sicca) no discharges occur. The patient is stricken down suddenly, and dies from syncope induced by cere- bral and cardiac paralysis. Chloral is homoeopathic to such cases. No special observations have been made as to its pathogenetic action on the kidneys and bladder. It has been used with good results in incontinence of urine. Dr. Leonards considers it the only reliable remedy to remove the spasmodic action of the detrusor vesiese, which overbalances the contraction of the sphincter. He gives children from 6 to 10 grains dissolved in water, just before going to bed; allows only small quantities of fluids at supper, which should be taken several hours before going to bed. He adds: “We must, in enuresis nocturna, strictly differentiate between spasm and atony of the vesical muscles, as in the latter case Iron and Quinine are indi- cated.” (Ferr. mur., Nux.) It appears to have some diuretic action, either direct or indirect. In the case of anasarca where it was given by Dr. Swan, in 5, 10, and finally in 15 grains, every 2 or 3 hours, it alleviated the terrible sufferings ; and the action of the kidneys, which had been almost suspended for days, became active again under its use. Chloral-eaters are said to lose their sexual desires and become impotent. I have not observed any such phenomena. I have used it in many cases of painful and persistent chordee CHLORAL. 177 during gonorrhoea. Ten or fifteen grains taken at bedtime, not only causes sleep, but actually prevents the painful erections. In the diseases peculiar to women, Chloral is a useful pallia- tive. In dysmenorrhcea of unusual severity, it will give relief when specific remedies fail. It may require 5, 10, or 15 grains every hour, according to the intensity of the symptoms and the idiosyn- crasy of the patient. In a paper read before the Edinburgh Obstetrical Society, E. Lambert claimed that while Chloral could not supplant Chloro- form, it can be used to advantage in the first stage of labor. He also claimed that it could be given “ under favorable circumstan- ces ” all through labor, and that the woman could go through from commencement to termination without consciousness. I suppose he means by “ favorable circumstances,” that the patient has no tendency to haemorrhage, for if such exists, Chloral is not considered a safe remedy. American accoucheurs rarely give Chloroform during labor, and then for a few moments only at the very termination. If the patient requires it for an hour, or for hours, Ether is the best and safest anaesthetic. I should hesitate to administer Chloral in large doses to a person with weak heart, or in whom I suspected a tendency to haemorrhage. I have, however, used Chloral in several cases of labor, when the intense nervous irritability led me to fear con- vulsions, and when Veratrum viride was not admissible. In all these cases it had the happiest effects. I agree with Dr. Lambert, that “it does not suspend, but rather promotes uterine contraction, by suspending all reflex actions which tend to counteract the ex- citability of the centres of organic motion.” The dose of Chloral required will depend on many circumstances. I have given 10 to 15 grains every hour. Lambert advises gr. xv every quarter of an hour until the desired results are produced. I have alluded to its power of preventing puerperal convulsions.' I believe it has such power. The late Dr. F. A. Lord reported two cases where 20 grains arrested such convulsions promptly. It causes pulmonary oedema, yet it has been found a valuable palliative in that condition, as well as in emphysema. In very 178 CHLORAL. small doses it ought to cure the former, if the general state of the patient is not too much depressed. It weakens the heart; it paralyzes the ganglionic life of that organ, yet true to the law of Similia, it has been found to restore force and motion to the heart when life was rapidly ebbing away. In Drs. Swan and Helmuth’s case there was organic disease of the heart. The Chloral almost restored normal action to the seri- ously disorganized organ. The symptoms it causes are: “Great dyspnoea, a sense of suf- focation, oppression at the base of the chest, in front; tendency to fainting, intolerable sinking at the stomach, livid lips, cold extremities, respirations as low as four per minute, pulse imper- ceptible.” I have given it in the threatened 'paralysis of the heart during pericarditis. The dyspnoea and distress were fearful, yet 5 grains every 15 minutes restored the action of the heart, and the patient made a good recovery. The pulse of Chloral is frequent, weak, irregular, in both force and rhythm, frequently intermittent; but the heart at the same time acts regularly, but with increased frequency and diminished force. I predict that in cardiac neuroses Chloral in properly gradu- ated doses will prove one of our best remedies, not only pallia- tive, but curative. I am not as sanguine as Dr. Swan, who claims to have got heart-symptoms by taking the 200th di 1., and that the 40th will cure cardiac neuroses. Such assumptions need be put to the test of positive experience before we accept them. When brought in contact with blood, it stops the process of coagulation. It destroys the blood-corpuscles, and produces a general destruction of that fluid. Its continued use internally has caused purpura hwmorrhagica, preceded by a “ bright red blush, erythematous in aspect, but permanent under pressure,” followed in two days by “deep red spots, mixed with mottled livid patches.” The buccal mucous membrane becomes red, raw, ulcerated, and blistered, breath fetid, pulse 120 and feeble. A desquamation ensued, but with bed-sores 179 CHLORAL. in some places. In other cases it caused peteehim, vibices, and ecchymoses. If this action of Chloral is dynamic, it may prove a homoeopathic remedy in purpura and scurvy. If chemical, we need not expect curative effects from it. Reference has been made to the peculiar flushings of the face and neck caused by Chloral. It causes another species of eruption, namely, of blotches of different shapes, raised above the surface, and of a deep-red color. These blotches nearly coalesced, nearly resembling measles. This was attended with high fever, thirst, coated tongue, loss of appetite, and intense irritation of the skin, preventing sleep at night. It has caused an eruption on the arms and legs exactly like nettlerash, in large raised wheals, with intense irritative itching. Another case so imitated scarlet fever that the person was supposed to be laboring under that disease. In this same case, “ A number of large, pale elevations, or wheals, showed themselves on the legs, shoulders, and waist, while similar ones could be produced on other parts by scratching. At the same time, burning and stinging sensations, and a feeling of tightness and hardness over the whole surface, with lassitude, headache, sharp pain in the eyeballs, wheezing respiration, etc.” It is not improbable to suppose that it affects the mucous mem- brane in a similar manner. These symptoms make Chloral an analogue of Apis, and this analogy may be closer than we now imagine; it is also a congener of Urtica urens, Copaiva, and Arsenic. Dr. Dyce Brown, believing that Chloral might be used with ad- vantage, tried it in nine cases of urticaria, and with complete suc- cess. He gave from one to one-quarter grain every three hours. In another six cases the patients did not return and report, and he thinks they, too, were cured. In one case of pruritus vulva it relieved after Collinsonia failed. It will be a lucky thing for us if we have found a specific for nettlerash, for it has been a difficult matter to affiliate a remedy Some of the freaks of nettlerash resemble Chloral effects, namely, the sudden stupefaction, asthma, and cramp of internal organs, not to mention vomiting and purging, which latter is supposed to be due to its retrocession upon mucous surfaces. I have only had 180 CHLORAL. the opportunity to try it in a few cases, one of which was quite satisfactory. A child, a year old, had suffered from severe sum- mer complaint for several weeks, had become pale and weak, when a new symptom set in which deprived it of all rest and sleep—an urticarious eruption, red, blotchy, and itching, on the face, neck, and shoulders, worse in the evening. Apis, Arsenicum, and Cro- ton were tried unsuccessfully. Chloral, 5 grains in half a glass of water, a spoonful every hour, removed the trouble in two days. There is a kind of nervous itching, a species of pruritus, affecting the whole body, coming on after undressing, especially at night; there is no visible eruption until the skin is scratched, and some- times not then. Ignatia is recommended, and will sometimes re- lieve, but Chloral may prove a better remedy. In certain spasmodic diseases Chloral has been of infinite ser- vice to the physicians and surgeons of all schools. I have already alluded to its use in puerperal convulsions. In tetanus it has made some very brilliant cures. It is indicated for tetanic spasms from Strychnia poisoning; trismus from traumatic causes; from cerebro-spinal meningitis; and also in infantile tetanus. You must not expect to cure such a terrible disease as tetanus with any but massive doses. You might as well attempt to pro- pel a five-pound shot with ten grains of gunpowder. The dose in cases of tetanus in strong adults ranges from 10 grains to 3 drachms, repeated every one, two, or three hours, as the case demands. One patient, with traumatic tetanus, reported by Dr. Vernuil, took the enormous quantity of 200 grams (3000 grains) in twenty-eight days, and made a good recovery. Dr. AEs- chenthal cured a case of trismus in a child seven days old. It had twenty-seven spasms, and took in all 25 grains. In trismus and tetanic convulsions of very young infants, or in teething children, I have given it in many cases. I prefer it to any other remedy because it acts so quickly (in ten to fifteen min- utes), as in some cases a few moments lost is a life lost. In tetanus it rivals Calabar, Atropia, Gelseminum, Bromide of potassa, and Curare, all of which cure by virtue of their sec- ondary action. I do not assert that remedies primarily indicated in tetanus, like Yux vomica, Strychnia, and Ignatia, will not cure, 181 CHLORAL. for I know that cases have been cured by the latter class. I would advise you to use the latter in cases of less intensity, or when you think you have time to test their power. I need not inform you that primarily indicated remedies must be used in minute doses (from the 6th to the 30th attenuations). Chorea in its severest forms has been treated by Chloral with success. A severe case, in which the little child could neither lie nor stand, the head, limbs, and body being in constant motion, and each muscle apparently partaking of irregular action. She could not utter a syllable, and swallowed with difficulty. She would wake from disturbed rest, cry out, and scream until perfectly exhausted and in danger of general convulsions. She became anaemic and emaciated. Two grains of chloral put her to sleep. Its use was continued every night for a week. After that time improvement was so rapid that it was abandoned. M. Bouchet says: “ Chloral is a most prompt and efficacious remedy in those cases of intense chorea where the constancy and severity of the spasmodic movements threaten the life of the pa- tient.” Dr. Bussell relates a case of severe chorea during the fifth month of pregnancy cured by Chloral. Dr. Strange cured an obstinate and long-continued case of chorea in nine days, with eight grains repeated every three hours. No remedy, in my experience, will so quickly and permanently remove the uncontrollable nervous agitation of hysteria. A dose of 15 or 20 grains will quiet a fit of hysterics so suddenly as to astonish the patient and her friends. It is quite homoeopathic to a hysterico-cataleptic state, when the patient is conscious of all that transpires but cannot rouse herself. A word as to the proper treatment of a case of Chloral poison- ing. Nux vomica lx, Strychnia 3X, and Atropia 2X are the best antidotes, aided by Digitalis when the heart is failing; elec- tricity applied to the spinal cord ; and Ammonia by inhalation and internally. The sleep caused by Chloral is not always calm. Some patients seem to suffer from and complain of horrible dreams, frightful visions ; they scream and cry out, sit up in bed, and cannot be quieted. An adult who was taking it for rheumatism, after 182 CHLORAL. sleeping a few hours, would jump out of bed trembling with fear, bathed in a cold, clammy sweat, and scream frightfully as if in mortal terror. Here we have a good picture of those conditions known as nightmare, night-terrors, and similar morbid conditions occurring premonitory of or during meningitis. I usually give in such cases very small doses, T\th to 1 or 2 grains, according to age, and have been very successful in removing these abnormal symptoms. In the 6th or 30th it may prove curative in “ comatose condi- tions lasting for days, ending in cerebral congestion.” The pleasantest vehicle in which to administer this drug, when given in appreciable doses, is the Syrup of tolu, to which you can add from 1 to 20 grains to each teaspoonful. The dilutions from the mother tincture (1 grain to 1 drop) are made with water, alcohol, or syrup. On the Use of Chloral-hydrate Enemata.—Dr. Starcke, of Berlin, has a paper on the employment of Chloral-hydrate enemata in the “ Berliner Klinische Wochenschrift” (August 19th). lie observes that there are great prejudices, es- pecially in England, against the continued use of Chloral, occasioned, probably, by the not unfrequent misadventures occurring in connection with its use in ha- bitual drunkards. Last year Dr. Starcke himself fell ill of a chronic gastric catarrh, with great acidity of the contents of the stomach, and considerable emaciation and prostration. The principal and most distressing symptom, however, was persistent insomnia, only half an hour to an hour’s sleep being obtained at night. At the suggestion of his colleagues Dr. Starcke resorted to the use of Chloral, but the irritable state of the stomach forbade its use by the mouth, and hence he deter- mined to take it per rectum. An aqueous five per cent, solution of Chloral was warmed to about 95° Fahr., of which he first injected 10 grams, and after a quar- ter of an hour a further quantity of 10 grams, so that in all 1 gram (151 grains) of Chloral were thus taken. This was in a few minutes followed by a feeling of warmth, comfort, and repose, and lastly by sound sleep, which lasted uninter- ruptedly for five hours. In this manner Dr. Starcke continued the injection of Chloral for five months, taking in all 120 grams of the drug. Decided conva- lescence set in after almost the very first dose, which was followed every morn- ing by a sense of vigor and a desire for food, without any headache or other dis- comfort. Nor did the efficacy of the dose of Chloral diminish, and latterly even half the quantity, i. e., .5 gram was sufficient. Frequently the attempt was made to obtain sleep without resorting to Chloral, but in vain, until within the last month, when Dr. Starcke found he could discontinue it altogether. This em- ployment of Chloral per rectum has decided advantages in cases of gastric irrita- bility. Dr. Starcke tried twice to take it by the mouth, and each time it was, after a lapse of a few minutes, completely rejected, and no sleep ensued. The ab- sence of all unpleasant results when administered by the rectum is doubtless due to its undergoing no decomposition, as is generally the case when it comes into CHLORAL—CROTON CHLORAL. 183 contact with the contents of the stomach. Of course, the drug should be abso- lutely pure. The sensation of burning and tenesmus which at first follows an injection may be materially obviated by well oiling the nozzle of the syringe. And since the site of the tenesmus is chiefly in the region of the sphincter, con- tact of the chloral solution with this part of the gut should be avoided by passing the injection pipe as high up as possible. And if the injection is made by one’s self, the position on knees and elbows will be found the most convenient. It is also of consequence that the solution should be complete, and that it should be warmed to the temperature of the body ; also that the dose required is a mode- rate and even small one, as compared with that usually given by the mouth. Dr. Starcke has subsequently used Chloral in the same way in various cases and with the same uniformly safe and favorable results. It seems specially applica- ble in the case of aged people, and in no case need the dose exceed one gram (15J grains).—“ London Medical Becord,” October 15th. Enemata of Chloral in Sick Headache.—Dr. J. Seure (“Bull. Gdn. de Tberap.” 1878, p. 365) recommends this treatment very highly. lie says that a patient of his, a lady, who is subject to severe attacks of migraine after shopping, etc., is accustomed, on her return home, to take an enema consisting of a glass of warm water, with a tablespoonful of the following mixture: K. Chloral, gr. xlv; Aq. destillat., fgx.—M. She then reclines upon a sofa, with closed eyes. Within a few seconds she begins to taste the Chloral in her mouth, and at the same time she experiences a sensation of numbness. Little by little the headache disap- pears, nausea is allayed, and half an hour later nothing remains but a slight discomfort in the head, with a little torpor. Within an hour and a half this lady finds herself able to sit down to dinner, and by the time the meal is over she has forgotten all about her headache and is able to entertain visitors during the evening. In this case twenty grains of the Chloral are enough, but in the case of men thirty to forty grains are required. Dr. Seure has noticed that the relief gained is more prompt if a tablespoonful of brandy or whiskey is added to the enema. The enema has one disadvantage, that is, the slight burning pain which it causes in the rectum. This may be avoided by the use of a glass of warm milk instead of water, or better by beating up the yolk of an egg in the water. In the case of individuals who retain enemata only with difficulty, a smaller amount may be injected, and a drop or two of Lauda- num may be added. Dr. Seure regards this treatment as almost infallible for the arrest of an attack of sick headache, and as decidedly preferable to the ad- ministration of remedies by the mouth. It has the advantage of not disturbing the stomach. Chloral also acts very promptly, its absorption by the rectum being almost instantaneous, as is proved by the effects on the general system, and also by the exhalation of Chloroform by the lungs within a few seconds after the enema has been taken.—“ Philadelphia Medical Times.” CROTON CHLORAL. This drag is said to possess the singular property of producing ancesthesia of the brain and nerves of the head, leaving all the body 184 CROTON CHLORAL—CHIMAPHILA. below in a natural condition. It is highly recommended for neu- ralgia of the head and face, and other very painful affections of the head. In the “British Journal of Homoeopathy ” for 1873, page 188, Dr. J. W. Legg is quoted as reporting this medicine as useful in the principal affections of the fifth nerve. The drug was given to about twenty persons, all suffering pains in the regions sup- plied by the fifth nerve, i. e., the upper and lower jaw, the face, and supraorbital region of the forehead ; pains paroxysmal, in- creased at night mostly. In nearly all the patients there was caries of the teeth, and in about one-half signs of anaemia. Five, ten, and twenty grains were given at a dose, dissolved in water. In all the patients except two great relief from pain followed the dose. In the two cases the pains were aggravated. Some slept, others were eased but did not sleep. I have never used it, and it does not seem to have become pop- ular with physicians. You will do well to watch its history and use, for it may prove homoeopathic to some serious conditions, paralysis of the brain, for instance. CHIMAPHILA. This pretty little plant, a native of the Northern and Middle States, belongs to the class of popular renal remedies. That it pos- sesses undoubted affinity for the genito-urinary mucous membrane is now admitted. It is called by allopathic authorities an “as- tringent diuretic”—a curious and apparently incongruous name, which is doubtless meant to imply that, while it increases the watery portions of the urine, it decreases its solid constituents. This it does do, especially when such constituents are abnormal. It is probable that massive doses, long continued, would provoke inflammatory action, but such effects have not come under my observation. Its principal curative indications are : Scanty urine, containing a large quantity of muco-purulent sedi- ment. Excessive itching and painful irritation of the urethra from the end of the penis to the neck of the bladder. 185 CHIMAPHILA—CHIONANTHUS VIEGINICA. Sensation of swelling in the perinseum, as if, in sitting down, a ball was pressing up against it. It has proved curative in the following: Dropsy after scarlatina, or during Bright’s disease. Chronic catarrh of the bladder, with hectic fever. Chronic disease of the prostate gland. Hcematuria, passive, symptomatic, in local disease. Dysuria, in plethoric, hysterical women; scanty, frequent uri- nation, with pressing, scalding and smarting pain ; also tenesmus of the bladder; urine filled with mucus. Urine thick, ropy, brick-colored, with bloody sediment. It has some reputation in scrofula with glandular enlargements, and is said to have cured, in the practice of various physicians, tumors of the mammce, enlargements of lymphatic glands, scrofu- lous eruptions, and even scirrhus and cancer. Success is claimed by use of the 30th, as well as the tincture and infusion. I prefer the infusion in diseases of the bladder. CHIONANTHUS VIRGINICA, This is a singular-looking shrub, growing from Pennsylvania to Georgia, on river-banks and sandy plains. It presents clusters of snow-white flowers in May and June. The common names are “ old man’s beard ” and “ fringe tree.” I call your attention to this medicine, which may fill a place in your armcimentorium which no other can fill. It seems to be very similar in its action on the liver to the Chelidonium, upon which I lately lectured. I get my knowledge of it from Dr. Goss, a well-known physician. He says: “The most important thera- peutic property that it possesses is its specific power over morbid conditions of the liver. “I have tried it in hypertrophy of that organ, and with uniform success ; and also in obstruction of the liver, in malarious districts, with like success. “ Some years ago I called the attention of the profession to its specific effects in jaundice, and gave several cases in proof of the fact. “Since then I have used the Chionanthus in a great many cases TOL. II.—13 186 CHIONANTHUS VIRGINICA—CIMICIFUGA RACEMOSA. of jaundice, and have never failed to remove it in but a single in- stance, and that one I think was a case of obstruction of the gall- ducts by calculi; in that case I tried all the reputed cholagogues without success. It removes jaundice of years’ standing in from eight to ten days. I have treated several persons who had been subject to jaundice annually, in summer, for several years, and had been dosed with blue pill, calomel, and other articles without any benefit, and I have not failed in a single instance to remove the dis- ease entirely. And when it is removed by the Chionanthus, it does not return—at least it has not in any instance to my knowledge.” This is very positive testimony. lie adds that it is not a pur- gative—which would go to prove that it was a true hepatic remedy. The tincture of the bark should be made with strong alcohol, and given in ten or fifteen drops every three hours. CIMICIFUGA RACEMOSA. We now come to speak of one of the most important of all the new remedies. It is to the new, what Ignatia was, and is, to the Materia Medica of Hahnemann. Its range of action is quite ex- tensive; it has been quite thoroughly proven; the clinical expe- rience with it is already large; and it has large possibilities for future development. It is known under the common names of black snake-root, black cohosh, and rattleweed. Its former botanical names were Actsea and Macrotys, from which latter came the name of its active prin- ciple Macrotin. (Now Oimicifugin.) Sphere of action.—It is essentially a cerebro-spinal remedy. The braiu and spinal cord are directly under its influence, and upon which it acts primarily as a depressing irritant. Its action on the muscular system is probably not direct, but a result of its effect upon the spinal cord. It differs from Nux and Ignatia, in that they are exciting irritants of the spinal cord. Cimi- cifuga indirectly affects the vegetative system—the functions of digestion and assimilation. It has but few symptoms of gastric or intestinal derangement not due to reflex irritation. It has become one of our most potent remedies in disorders of the mental sphere, namely, in melancholy and aberration of mind. CIMICIFUGA RACEMOSA. 187 The characteristic symptoms indicating its nse are: “Great melancholy; she feels grieved ; troubled with sighing ; sensation as if a heavy black cloud had settled all over her, and enveloped her head, so that all was darkness and confusion, while at the same time it weighed like lead upon her heart.” (Cured by Dunham with the 200th, and by myself with the 3X dil.) “She was suspicious of everything and everybody ; would not take medicine if she knew it; indifferent, taciturn; takes no in- terest in household matters ; frequently sighs and ejaculates ; great apprehensiveness and sleeplessness.” These symptoms are always promptly removed by Cimicifuga. The size of the dose, if it is above the 1*, does not seem to be im- portant. I have treated very many cases of profound melancholy, even from disordered liver, by this medicine, and can assure you that it has cured the majority, and even when the disorder of the mind depended on incurable physical disease its palliative effect was remarkable. One keynote to be remembered, is sleeplessness. Many physicians have informed me that if, in cases of melancholy, sleeplessness was present, Cimicifuga nearly always cured. Delirium tremens.—In this terrible disorder the Cimicifuga is indispensable. When there is nausea, retching, dilated pupils, heavy pressing-out headache, trembling of the limbs, incessant talking, changing from one subject to another, obstinate sleepless- ness, imagines strange objects on the bed, rats, sheep, etc., with quick, hard pulse, and a peculiar wild look in the eyes, the 3* dil. frequently repeated, aided by a good diet of milk, wine, whey, mutton broth, etc., will soon restore the patient. A lady patient of mine who was taking five drops of the 1* for rheumatism, was annoyed by an illusion of a mouse running from under her chair. This illusion disappeared upon suspending the medicine, and recurred when taking it in the same doses. I have found it useful in puerperal mania, and in those de- pressed states of mind and body following the excessive use of tea, valerian, and morphia. The nerves of sensation are very unfavorably affected by massive doses. It causes a pure neuralgia, and what the older authors called neuralgic rheumatism. The neuralgia is not confined to any 188 CIMICIFUGA EACEMOSA. particular set of nerves, as is the case with some remedies. Its depressing irritant action seems to be universal. The pains are aching, pressing, remitting, and are attended with great restlessness and a weak, exhausted feeling. It seems to affect the sensory nerves of the left side most. The nerves of motion are profoundly irritated. In the words of Dr. T. C. Miller, whose experience with it for fifteen years enabled him to judge of its powers: “ It is one of the most remarkable remedies in all diseases of the gan- glio-spinal system, particularly when the motor side is excited, and yet, in the whole, prevails an atony in the muscular and nervous system.” This statement of its pathological action gives us the clue to its wonderful efficacy in chorea. It is indicated in many kinds of chorea, whether arising from rheumatic irritation of the cord, from uterine disease, or from purely psychical causes. The sympto- matic indications are chiefly : abnormal movements, uncontrolled by the will, in all those parts of the body supplied by motor nerves ; it affects both voluntary and involuntary muscles. The motions consist of twitching, jerking, twisting actions; they are sometimes attended by pains like neuralgia or rheumatism. The movements abate or are absent during sleep. They are aggravated by emotions; at the menstrual periods; or are caused by sup- pressed menses. They are attended by depression of spirits, and sleeplessness, and often by mental derangement. The Cimicifuga is useful in many kinds of tremors which resem- ble St. Vitus’s dance, but due to functional derangement of the nerve-centres. If they are caused by structural changes this rem- edy is useless, or if they are caused by mercurial or other mineral poisoning. I do not think the Cimicifuga will be found very useful in con- vulsions of any kind, unless they resemble chorea ; consequently it will not be available in ordinary puerperal convulsions or epi- lepsy. It bids fair to become a prominent remedy in cerebrospinal men- ingitis, and possibly myelitis. Dr. W. S. Searle, of New York city, first called attention to it in the “Transactions of the New York Homoeopathic Society,” and gave his experience of its use in a case of the former disease, CIMICIFUGA RACEMOSA. 189 when, after the inflammatory period had passed, the patient was tormented day and night by alternate clonic and tonic spasms and obstinate vomiting. Since Dr. Searle’s observations were published I have used it in many cases of cerebro-spinal trouble, and with unvarying success. Those of you who have been in practice, or have observed the practice of your preceptors, must have noted the prevalence of more or less cerebro-spinal irritation in nearly all fevers and some other diseases, and occurring in the winter and spring months. It is only within a few years that these phe- nomena were of such frequent occurrence. As the late Dr. Wil- liamson used to say : “ It has become the genius of the prevailing maladies.” Cimicifuga, in the lower dilutions, is indicated in the three grades of this disorder, namely : Cerebro-spinal meningitis, in the 6X dil. Cerebro-spinal congestion, in the2x dil. Cerebro-spinal irritation in the lx dil. I will give you the indications for its selection : Delirium, like mania a potu, with nausea, retching, dilated pu- pils, tremor of the limbs; quick, full pulse, and wild look out of the eyes. Headache; pain over the eyes, extending along the base of the brain into the occiput. Brain feels too large for the cranium, a pressing from within outwards; or a sense of compression in the temples. Excruciating pain in the forehead and in the eyeballs, vertex, nape of the neck, and occiput, with fulness and throbbing, as if the top of the head would fly off. Dull pains in the occiput, with shooting pains down the back; the head is jerked backward. Intense pain in the eyeballs, with black specks before the eyes; dilated pupils; double vision; congested conjunctiva, and lachry- mation. Intense throbbing pain, as if a ball were driven from the neck to the vertex with every throb of the heart. Tongue swollen; breath offensive; pharynx dry; dysphagia; roughness and hoarseness of the voice. Nausea and vomiting attend the pain in the head. 190 CIMICIFUGA RACEMOSA. Pains in the back, of a drawing, tensive character, or dull and heavy, with tenderness on pressure. Alternate tonic and clonic spasms, night and day. Spasmodic jerkings, like chorea. Rigidity of the muscles of the neck and back. Intense aching pains in the neck, head, and all the joints of the extremities, like the pains which accompany the fever of variola. Eruption of white pustules on the face and neck ; sometimes large, red, and papular. There is a disorder, known at one time as “ spinal irritation.” It is now known that in the great majority of cases it is not a spinal but a muscular affection, and its proper name is myalgia. In this disease Cimicifuga is one of our best remedies, rivalling Arnica, Hydrastin, or Nux. This leads us to consider its action on the muscular system. It is curative in two kinds of muscle disease: (1.) Myalgia, or a loss of tonicity in the muscular fibre, proba- bly from atony with irritation of the nerves which supply them. Myalgia in its various forms includes, certain headaches from an affection of the muscles of the head and nape, pleurodynia, myalgic colic, stiff neck, “ crick in the back,” and burning, cramping, stitch- ing, achingtpains all over the body, and even in hollow internal organs. (2.) Myositis, or inflammation of muscular structures, either idiopathic or rheumatic. It seems to affect by preference the belly of the muscle. Arnica acts in a similar manner, but it is better for traumatic myalgia and myositis; Bryonia resembles Cimicifuga, but the cause of the Bryonia muscular disease lies more in the state of the blood and secretions than in the state of the nervous centres. Bryonia does not cause reflex muscle disorder. Cimi- cifuga does (so does Caulophyllum). Hydrastis differs from both and resembles China and Ferrum more nearly. In inflammatory muscular rheumatism Cimicifuga has always had a deserved high popularity, both with physicians and laymen. The rheumatic fever, for which it is specific, is marked by several very characteristic symptoms, namely, the suddenness of its onset, the severity of its manifestation, and its location in large muscles. 191 CIMICIFUGA RACEMOSA. In such cases it often acts with surprising rapidity, relieving the fever, pain, soreness and restlessness in a few days. It differs from Rhus in not acting on the tendons, or terminal attachments of muscles, and from Colchicum, Bryonia, and Ascle- pias, in not acting on serous tissues; at least I do not think it has that affinity for serous tissues which is possessed by other well- known medicines. I would not give you the impression that Cimicifuga is not useful in chronic rheumatism, for some of its most brilliant achieve- ments have been in that direction. But in such cases the location of the disease has been in the belly of the muscle, i. e., its longest or middle portion, and its inception was originally sudden and severe. In my practice, and those of my colleagues, also in the practice of the eclectic and allopathic schools, it has made some surprising cures of chronic inflammation of the cervical and lumbar muscles (“ stiff neck” and lumbago); in chronic inflammation of the muscles of the upper and lower extremities, and intercostal rheumatism. I remember one case, the mother of Clara Louise Kellogg, the prima donna, who had for many years such stiffness, pain and lameness of the muscles of the thighs that her sufferings were at times intolerable. After trying faithfully Rhus, Nux vom., Bry- onia, Turpentine, Sulphur, etc., she took ten drops of tincture Cimicifuga three times a day, which accomplished the removal of the disease within a few weeks. The febrile symptoms of Cimicifuga are more erethistic or irri- tative (reflex or sympathetic) than inflammatory or synochal. It will rarely be useful in the fevers, except as an intercurrent remedy. In the exanthematous fevers, it has not been specially recom- mended, except by Drs. B. L. Hill and D. S. Smith, who used it in variola and varioloid. It certainly does seem indicated in the first stage of small-pox, for the intense aching in the extremities, head, and back resemble the symptoms of that disease. It even causes “ white pustules on the face and neck.” I would advise you to keep this remedy in mind in the treatment of variola. I have found it useful in the myalgic troubles which often follow scarlet fever. It relieves those intolerable pains in the back and 192 CIMICIFUGA RACEMOSA. limbs, the stiff neck, and muscular cramps, which are such pain- ful sequelae of that malady. Nightsweats, when not due to suppuration or anaemia, but to some fault in the proper supply of nervous energy to the skin, are readily arrested by Cimicifuga. In the provings, you will observe that cold sweat was quite a common symptom, especially after 3 A.M., sometimes lasting all day, with weak, irregular pulse, and pain under left breast. You will find these symptoms very common in women, and sometimes men, whose nervous system has been weakened by long illness, trouble or care; and you will find in all such cases that the Cimicifuga, in the 3* to 6th dilution, will prove an admirable restorative. No drug in our Materia Medica uniformly causes such severe pain in the head, both internal and external. Internally it causes passive congestion or anaemia, according to the constitution of the prover. Externally it causes pains in the muscles, and the nerves supplying them. The character of the pains and distress are, internally: “ a sensation as if the temples were compressed,”—dulness and heavi- ness in the head, as if he had been on a “ spree;” head felt as if it had been pounded, full of something heavy; moving the head or turning the eyes causing a sensation as if the cranium was opening and shutting; head feels as if he had been without sleep a long time; brain feels too large for the cranium, pressing from within outward; severe pain in the forehead, extending to the temples and vertex, with fulness, heat, and throbbing; when going up stairs, a sensation as if the top of the head would fly off; excruci- ating pain in the forehead, with coldness of the forehead, and severe pain in the eyeballs. Nearly all the pains in the head extend to the eyeballs; they are aggravated by movement, relieved by the open air; attended by faintness and “sinking,” at the pit of the stomach. Externally it has severe pain over the right or left eye, extend- ing into the eye, and back into the base of the brain ; pain over the eyes, extending along (around) to the base of the brain and occiput, and nape of the neck; pain in the occipital region, with shooting pains down the back of neck ; dull, boring pain 193 CIMICIFUGA RACEMOSA, over the left superciliary ridge, at 10 a.m. ; pains in the occiput, extending to the vertex. All these symptoms are trustworthy, and have been verified by clinical experience. Cimicifuga is indicated in Headache resulting from loss of sleep, night-watching, and abuse of alcoholic drinks; from mental strain and worry of mind ; and from exposure of the head to draughts of cold, damp air. It is useful in the following kinds of cephalalgia: Congestive headache (passive, perhaps active). Nervous headache (periodical or remittent). Rheumatic headache (in the muscles—catarrhal). Hysterical and menstrual headaches (at change of life). Cerebro-spinal headaches. In the cerebral irritation of children during teething, when they are fretful, feverish, sleepless, the 6tli or 30th has a soothing effect. I do not think you will find it useful in acute cerebritis or meningitis, but it may be in the chronic. Its analogues in head affections are Bryonia, Spigelia, Glonoin, Nux Vomica, and Ignatia. The eyes are severely acted upon by Cimicifuga. Few drugs cause such intense and persistent pain in the eyeballs. The pains are chiefly aching, extending to different portions of the head. Many of the pains, however, seem fixed in the centre of the eye- ball, and simulate rheumatic and neuralgic affections of the eyes. In some cases the eyelids become inflamed. One characteristic of the eye affection is that in the majority of cases no redness of the eyebcdls exists; in other cases, as in Dr. Hill’s proving, the “eyes were congested, so as to attract the attention of every one, although there was no disagreeable feeling in them.” This discrepancy is probably owing to some difference in the constitution or idiosyn- crasy of the prover. It will probably be found useful in the painful sensitiveness of the eyes known as “ ocular hypercesthesia,” for which Spigelia is such an excellent remedy. Both should be used in the high potencies for this affection. It is reported to have cured catarrhal conjunctivitis; and should be tried in sclerotitis rheumatica. 194 CIMICIFUGA RACEMOSA. It causes amaurotic symptoms, “ black specks,” and “double vision,” both of which it has cured. The catarrhal symptoms, especially of the nasal mucous mem- brane, are very decidedly shown in all the provings. But it has no special reputation in ordinary catarrh or influenza. It affects the laryngeal and bronchial mucous membranes in a similar manner. A study of the provings will show, however, that the catarrhal irritation rarely goes beyond the serous stage. I think the Cimicifuga catarrh is in keeping with its rheumatic symptoms. In other words it causes a catarrh which precedes a rheumatic attach. Dr. Hill suggests that it causes catarrhal con- ditions similar to those produced by a sudden change in winter from a cold day to damp thawing by a south wind that melts the snow. Now this is the very atmospheric condition that causes the severest kind of rheumatism. In rheumatic sore throat, rheumatic prosopalgia, and toothache, when preceded by the above catarrhal conditions, it is clearly in- dicated. The older authors recognized a rheumatic bronchitis and pneu- monia. Given the other symptoms of Cimicifuga, I should not hesitate to advise it in acute bronchitis and pneumonia, preceded by the characteristic catarrh. It is indicated for the premonitory symptoms of diphtheria, but does no good afterward. The action of Cimicifuga on the stomach seems to arise from its depressing effect on the solar plexus and its sympathetic nerve connections. It resembles .the action of Sepia, Digitalis, Murex, and Ignatia, all of which produce, like Cimicifuga, that peculiar sensation of faintness, sinking and emptiness which attended all the provings. This sensation was sometimes attended with nausea and vomiting. This faint sensation alternated during the same day with a sensation of fulness or repletion. Both sensations result- ing from a depression of the same nerve. In the nausea and vomiting of drunkards, tea-drinkers, and pregnant women, when attended by the above morbid sensations, it will act curatively. It is well indicated in the vomiting which precedes cerebral and CIMICIFUGA RACEMOSA. 195 spinal irritations, and the vomiting which is sympathetic with, and resulting from, nervous headache. There are three diseases of the abdominal structures in which you will find Cimicifuga useful: (1.) Rheumatism of the muscular tissues. (2.) Neuralgia, often mistaken for peritonitis, especially if it occurs after miscarriage and confinement. (3.) Rheumatic neuralgia. It does not seem to be homoeopathic to, or useful in any abnormal discharge from the bowels. It increases the quantity of urine, which is pale and limpid. Take the symptoms in connection with the general nervous de- pression, sinking at the stomach, etc., and we have good data for prescribing it in nervous diabetes, or that condition which fre- quently precedes or follows nervous attacks of various kinds, hys- teria, and the like. The symptoms of the male genital organs are those which might attend general rheumatic irritation, affecting the spermatic cord and testicles. Its curative action in some cases of spermatorrhoea and its consequences is undoubted. Cimicifuga is one of our most important remedies in many of the diseases of women. In amenorrhoea, or delayed appearance of the menses in young girls, from deficient nervous energy in the ovaries, and when the abnormal nervous influence is directed to other organs, giving rise to chorea, hysteria, nervous headaches, etc., the Cimicifuga will restore the functions of the reproductive organs to a normal state. Should there be, at the same time, with the above conditions, a chlorotic state, Helonias or Ferrum should be alternated with this remedy. In retarded menstruation, when Pulsatilla or Senecio are not indicated, and when at the usual menstrual period the discharge does not appear, but in its place comes a pressive, heavy headache, melancholy, palpitation of the heart, and other reflex symptoms, in these cases the Cimicifuga will restore the normal condition of the system and cause a regular return of the menses. In suppression of the menses from a cold, mental emotions, or febrile conditions, when rheumatic pains in the limbs, or intense headache, or uterine cramps are present, this remedy will be found very useful. In dysmenorrhcea the black snake-root has been used 196 CIMICIFUGA IIACEMOSA. successfully by all schools. The eclectics consider it a sort of pan- acea. Many of our own school speak highly of its value. Dr. Hill, in his “Epitome/’ advises it in all cases, in alternation with Caulophyllum. It is not a general specific, yet it will benefit a majority of cases. It is most useful in rheumatic and neuralgic cases, but is often of benefit in congestive dysmenorrhcea, when alternated with Veratrum viride, or Belladonna. The best method of administration in these diseases is to give Cimicifugin, first deci- mal, or one-hundredth, three or four times a day during the inter- menstrual period, and every hour or thirty minutes during the severity of the pain. The Cimicifugin, second or third decimal trituration, will in some cases act more satisfactorily than the tinc- ture. Several of my colleagues have reported cases of dysmenor- rhoea cured or very much relieved bv it. They think more highly of the Cimicifugin in the neuralgic type than of Caulophyllin. The latter is more indicated in cases complicated with uterine spasms or general hysterical convulsions. Dr. Williams sends me the record of two severe cases of dysmenorrhoea, probably of a rheumatic origin, which were apparently cured under the action of Cimicifugin 1st. I have treated many cases of difficult and pain- ful menstruation, arising from various causes, and while in all there was improvement, in many the morbid condition seemed to be per- manently removed. I consider the following symptoms as indi- cating its use : Before the menses, the peculiar headache similar to that caused by this medicine; during the menses, aching in the limbs, severe pain in the back, down the thighs and through the hips, with heavy, pressing-down, laborlike pains, weeping mood, nervousness, hysteric spasms, cramps, tenderness of the hypogas- tric region, scanty flow of coagulated blood, or profuse flow of the same character ; between the menses, debility, nervous erethism, neuralgic pains, tendency to prolapsus, etc. It is useful in menor- rhagia, when the flow is profuse but of a passive character, dark, coagulated, and accompanied by the above-mentioned pains. The Cimicifugadoes not primarily cause hemorrhage like Sabina, Er- igeron, or Crocus, but secondarily, by impairing the tonicity and normal vitality of the uterus. In leucorrhosa, the eclectics speak highly of its efficacy. The late Dr. Morrow, to whom is mainly due the introduction of the CIMICIFUGA RACEMOSA. 197 remedy into that practice, gained much celebrity by his treatment of leucorrhoea with the internal and local application of the Black Cohosh. He gave it until it produced and kept up its peculiar action on the brain in slight degree; a decoction of the root as an enema was used every day. Leucorrhoea may be vaginal, cervical, or uterine. In the present state of our knowledge of the action of the drug, we cannot point out accurately the particular form of leucorrhoea for which it is indicated. It may be beneficial in all varieties; the general symptoms must, to a great extent, be our guide. Dr. Hill mentions a “ leucorrhoea of long standing cured during a week’s proving,” and another case of “leucorrhoea, and chronic inflammation and congestion 0f the uterus, cured during the proving, while no other symptoms were observed on the provers until the disappearance of the uterine disease.” Be- lieving in the local as well as general action of a drug, I would advise it to be used both topically and internally. The lower dilutions seem to act most beneficially. It is now more than sixty years since it was claimed by Stearns, in the “American Herbal,” to have an especial affinity for the uterus, particularly over the menstrual function, and Dr. Tully regards this claim as well established by the experience of New England practitioners. As a ’parturifacient it was in general use among the Indians in the early settlement of this country. Bigelow speaks of it as an active agent in facilitating parturition; and Tully says he has known many cases where it has produced abortion in pregnant women, when prescribed for a cough. The evidence on this head is far more full and satisfactory than in regard to its emmena- gogue properties. Prof. Lee says : “ It is believed to exert a spe- cific influence on the uterine contractions, lasting longer than that of Ergot, and followed by less torpor and greater susceptibility and capacity for action in the uterus than before its employment. Its operation, also, is not attended by that deleterious and stupe- fying influence on the foetus which often follows the administration of Spurred Bye.” It is doubtful if the Ergot acts medicinally on the foetus at all. It is the continued, unintermitting pressure of the uterus upon the child, or the cord, which causes the coma or asphyxia in the infant before birth. 198 CIMICIFUGA KACEMOSA. “After delivery,” adds Professor Lee, “it lias also been exten- sively and successfully used for the purpose of inducing firm uterine contractions, expelling the placenta, and checking post-partum haemorrhages. For this purpose a drachm of the saturated alco- holic tincture should be given every half hour, or oftener, until the desired effect is produced.” (This dose is enormously large and un- necessary. Ten drops is sufficient.) A knowledge of the uterine- motor action of Cimicifuga should be appropriated by homoeopa- thists. They are capable of making much more valuable use of such knowledge than the adherents of other schools of medicine. The homoeopathic school gladly avail themselves of the use of Ergot in slow and difficult laborsarising from an atonic condition of the uterus, or perverted function. I can not give my assent to those mythical relations of the effects of theSecale third or thirtieth, in causing uterine contractions when deficient during labor; the proof is not sufficient. I consider the Cimicifuga, as well as Secale, Caulophyllum, and other drugs, possessing similar powers, as be- ing secondarily homoeopathic to conditions of uterine inertia. To explain : The primary action of Ergot in moderate medicinal doses is to cause contractions, more or less persistent, of the mus- cular tissues of the uterus. Under the continued action of the drug these contractions will become more intense and firm, until, from over-stimulation, an opposite condition or muscular atony obtains. Now, this latter condition, with its accompanying symp- toms, is a secondary effect of the drug, as much due to pathogen- etic action as was the primary. When, in practice, we meet with similar conditions, i. e., when the uterus, after vam and powerful efforts, becomes exhausted, Ergot is the proper remedy if the pri- mary symptoms correspond with those of the drug, viz., persistent and violent contractions. But if the uterine atony be caused by Ergot, then that medicine will not answer our purpose, and wre must resort to Cimicifuga, Caulophyllum, Cannabis, or galvanism. Secondary states of uterine muscular atony may be brought on by all the last-named agents, and for this reason they will all be found useful in similar morbid conditions. The dose which should be used in such cases should be as large as can be given with safety to the patient, and just large enough to arouse the torpid muscular tissue. My theory of dose, which experience strongly substan- CIMICIFUGA EACEMOSA. 199 tiates, is, that for symptoms which simulate the primary effects of the medicine selected as the remedy, minute doses should be ad- ministered ; but larger doses for symptoms simulating its secondary effects. In resorting to the Cimicifuga in atonic labors, we need not give the massive doses of the eclectic school—doses which tend to bring on secondary exhaustion. I have found five to ten drops of the mother tincture, every fifteen or twenty minutes, to be amply sufficient to bring back or arouse the deficient vitality of the uterus. But there is an opposite condition of the uterus which sometimes obtains during labor, a state of hyperexcitation, in which the normal uterine contractions are spasmodic, painful and intensely powerful, but intermitting; sometimes with cramps in the extremities, and a tendency to general convulsions. Here the Cimicifuga is primarily homoeopathic, and a small quantity of the third or sixth attenuation will suffice to restore the normal parturi- ent action. This medicine will be found useful after labor, in pro- ducing firm contraction of the uterus, expelling the placenta, or checking post-partum haemorrhage. But I think for this purpose the Secale is to be preferred, because of its power to cause firmer and more persistent contraction. After-pains are often readily relieved by small doses of Cimi- cifuga, second or third, or Cimicifugin third. I have used it with signal benefit in those cases which seemed to be kept up by a neuralgic disposition, or mental and nervous irritability, and the patient was sleepless, restless, sensitive, and low-spirited. Suppression of the Lochia is treated successfully with this remedy. When from a cold or mental emotion the discharge is arrested, uterine spasms and cramps in the limbs sometimes occur, accom- panied with headache and even delirium. A case of this character, which came under my treatment, was relieved in a few hours by Cimicifugin, second trit., two grains every half hour. Warm fomentations were applied to the abdomen and vulva, as should always be the practice in such instances. It is also useful for the relief of those bearing-down pains, in- dications for prolapsus, which women frequently suffer from after severe confinement. It is eminently homoeopathic to a tendency to abortion. It has caused abortion in many instances, and is commonly resorted to for that purpose by reckless women, and 200 CIMICIFUGA KACEMOSA. advised by still more reckless physicians. It has been successfully used in instances of “habitual abortion,” with the result of pre- venting; the usual miscarriage in the second and third months. But unless the general symptoms correspond, Caulophyllum, Sa- bina, Viburnum, or Helonias will have to be selected. When the chill, uterine pain, tenderness of the hypogastric region, and flooding, have already set in, and the loss of the fcetus becomes imminent, the Cimicifuga in small doses may arrest the progress of the morbid process, provided the membranes have not become extensively detached. If the separated portion be slight, and the patient be kept quiet, and the proper remedies given (Aletris vi- burnum), I believe it possible to prevent a further separation. If all hope of saving the foetus be abandoned, and the uterus is de- ficient in expulsive power, then this medicine may be given, as recommended for uterine atony in labors. But no physician should rely alone upon medicinal action in such cases. The sponge or sea-tangle tent, placental forceps and blunt hook, should be used early and efficiently, to effect the entire re- moval of the contents of the uterus. Sterility, when not due to extensive ulceration, or other structural changes in the uterus, may be cured by Cimicifuga. Among the causes of sterility, by which I mean, inability to conceive, which are removed by this remedy, are congestion of the cervix, thereby closing the cervical canal; deficiency of nervous energy, accom- panied with melancholy; feeble circulation, scanty menstruation, lack of sexual desire, etc. Prolapsus uteri is often removed by this remedy, especially when occurring in nervous, melancholy subjects, and is the result of abortions, cervical congestion, or deficient nerve-innervation. Two key-symptoms indicate it in prolapsus, namely, melancholy, and “sinking” at the pit of the stomach. Helonias also has the former and Sepia the latter, but in both I think the pathological conditions are different from those cured by Cimicifuga. Ovarian disorders, of a nervous rather than inflammatory or structural character, will often find a specific in Cimicifuga. Ovarian neuralgia is perhaps as often cured by it as by any other remedy. In this affection it is specially indicated when the ovarian pains are reflected, or change their location to other portions of the body, as the leg of the same side, the region under the left CIMICIFUGA EACEMOSA. 201 breast, or extend up the whole side to the shoulder. It causes congestion of the head, the uterus, and other organs, and, very likely, the ovaries. As ovarian disorder is usually attended with abnormally depressed states of mind, the Cimicifuga is as often indicated as Platinum, with which it closely affiliates in many respects. In 'puerperal mania it has been found curative by all schools. Many cases successfully treated by it have been published in our literature, some in the eclectic, and a few in the allopathic. The late Professor Simpson reports a case called by him “ puerperal hypochondriasis/’ in which he had tried all the usual remedies. He gave the enormous dose of fifty drops of the tincture thrice a day. He says : “ In eight or ten days she was altered and changed in a marvellous degree, but all for the better. On the third or fourth day, she informed me that the cloud of misery which had been darkening her existence suddenly began to dissolve and dispel, and in a day or two more she felt perfectly well again, in gayety, spirits, and energy.” He adds that nothing would induce her to give it up, but took it for six weeks longer! And no pathogenetic symptoms! What will the ultra high dilutionists say to this? Does it not prove that the danger of medicinal ag- gravations from appreciable doses is very much aggravated? The fact is, that if a medicine is homoeopathic to a case, it will cure in any dose, in a high or low attenuation. (See Dr. Dunham’s cure of just such a case as the above with the 200th.) Dystocia is one of those abnormal conditions which come clearly under the domain of homoeopathic medication. It is useless to cling to the antiquated superstition that a woman must suffer “ pangs of childbirth.” Dystocia is always the result of an abnormal con- dition of the tissues concerned in the functions of childbearing. I do not wish to have you understand that a majority of cases of painful labor can be remedied by medicines. I have attended very many women who did not suffer to any degree; they ex- pressed themselves as caring very little for the pains. Nor wrere these women all healthy. But this abnormal phase was somehow absent, or nearly so. I have also attended many women whose previous labors had been exceedingly painful, almost unendurable without Ether, but, owing to the administration of Cimicifuga YOL. II.—14 202 CIMICIFUGA RACEMOSA. (luring the last weeks of pregnancy they suffered very little. So many of these cases have occurred in my practice and in that of my colleagues, that it is not proper to affect skepticism or un- belief. As a rule, first labors are painful and protracted, while subsequent ones are less so; but if five or six are very painful, and each one seems to be more painful than the last, we cannot expect the seventh to be painless, except from some remedial in- terference. Now, if in such cases Cimicifuga, Caulophylluin, or Viburnum is given, and the woman’s next labor is easy, what are we to think? Evidently, that the medicine effected a change of condition from abnormal to normal. In such cases give the Cimicifuga at least two weeks previous to the expected date of labor, in doses of one to ten drops, two or three times a day; the doses repeated oftener as the date ap- proaches. In irritable uterus, that condition once described by Gooch, and lately declared by Hewitt to be a condition of flexion, the Cimicifuga is an admirable remedy when the pains seem like those of rheumatism or neuralgia. If they are decidedly spasmodic— cratnpy—Viburnum is the specific. In irritation of the uterus, such as occurs at the change of life, when the menses are irregular, and the pains are more or less periodical, in the lumbar regions, or in the side, or in the top of the head, at night, this remedy rarely fails to relieve. Mammary pains of a reflex character, occurring during preg- nancy, with dysmenorrhoea, or at the climacteric, and even after confinement, are also included in the curative sphere of this medi- cine. Phlegmasia alba dolens is not always alba. The swelling is sometimes very red, and assumes all the characters of acute rheumatism. In such cases Cimicifuga is the remedy. It is not the remedy alone when it is due to septicaemia or absorption of morbid secretions, in which case Baptisia, Arsenicum, and Carbolic acid should be used. But this disease is sometimes the result of exposure, added to the contusion of the veins and nerves, and calls for Cimicifuga, Aconite, Arnica, Apis, and ITamamelis. (I do not advise “ Macrotin ” in all cases, because I do not believe it contains all the medical properties of the drug, any more than Liebig’s Extract of Beef contains all the nutritious qualities 203 CIMICIFUGA RACEMOSA. of beefsteak. It may prove useful in a large proportion of eases, but when it fails yoq will often find that the tincture of Cimicifuga will cure. I adhere to the name of Cimicifugm, because both “ Actsea” and “Macrotys” are obsolete according to recent bota- nists. The active principle, moreover, should be called “Cimi- cifugin.” Remember, too, that you should not order the “tincture of Macrotin,” as has been done.) The laryngeal and bronchial irritations of Cimicifuga are either reflex or rheumatic. It has cured the reflex cough of pregnancy and uterine irritation. I can hardly understand the high estimate by which it was held by Drs. Tully, Hildreth and Lee (allopaths) in pulmonary affections. Here is what they say of it: Dr. Gardner used it in his own case for the following symp- toms : Pulse 100 to 120, harassing cough, purulent expectoration, pains in the right breast and side, hectic paroxysms, loss of flesh and strength, frequent haemoptysis, and deranged stomach and liver; cured in a few months. Dr. Plildreth says: “In phthisis, in nearly every instance the pulse was reduced to near the natural standard, the hectic symp- toms disappeared, and with it the cough and other symptoms.” Pie also removed “those intermittent congestions and inflam- mations so frequent in the second and third stages of phthisis, when they arose from atmospheric exposure.” Drs. Lee, Wood, and Chapman give similar testimony. In homoeopathic practice it has not succeeded in getting a reputation in pulmonary troubles, although it has an excellent one in pleuro- dynia and intercostal rheumatism, both of which conditions are found to be present in nearly all cases of pulmonary phthisis. I would suggest its more extensive use in chronic diseases of the lungs, not alone, for I doubt if it affects the parenchyma of the lungs, but in alternation with Sanguinaria, Phosphorus, Kali carb., Stannum, and others. In pleurisy it may be useful, but I prefer Bryonia. They act very well in alternation, in both pleurisy and pleurodynia. For those obstinate reflex pains in the left side, occurring in women, generally the unmarried, this remedy is as nearly a spe- cific as can be. These pains are said to arise from uterine or ovarian irritation. 204 CIMICIFUGA RACEMOSA—CISTUS CANADENSIS. They occur “under the left mamma, or under both; they often extend up to the left shoulder and down the arm ; they frequently change to other localities, as the back, neck, and head.” Under the use of Cimicifuga, lx, they are nearly always pal- liated and cured if no structural lesion exists in the uterus or ovaries. Diseases of the heart are cured or greatly palliated by Cimi- cifuga. It is useful in Endocarditis, especially idiopathic or rheumatic. Pericarditis, in alternation with Aconite, Spigelia, or Bryonia. Cardiac myalgia, which is often mistaken for true angina pectoris. Cardiac debility, characterized by irregular palpitation, with in- termitting and weak pulse. Its symptoms are so similar to Digitalis, that it is often impos- sible to select between them. The history of the case will decide. If the symptoms of cardiac debility are primary, i. e., arising from nervous atony, the Cimicifuga is primarily indicated. If the con- dition is a secondary one—arising from previous excitement— Digitalis is better indicated. Chorea of the heart—a disorder now admitted to exist, even when no other choreic symptoms appear. It is characterized by tumultuous, irregular, unexpected, and strange motions of the heart, aggravated by emotions, and subsiding during sleep. I have cured with it many cases of cardiac disorders, such as I have just mentioned, and consider that in its sphere Cimicifuga is one of our most potent cardiac remedies. It is a veritable poly- chrest, with a marked individuality, and will do good service in practice. CISTUS CANADENSIS, The Rock-rose, or Ice-plant, has long been esteemed as a pop- ular remedy in Scrofula. It was partially proven and incorpor- ated into our Materia Medica by Dr. Hering, who had a high estimate of its properties. He suggests that as it grows by prefer- ence in a soil abounding in Magnesia (talc), it ought to follow Magnesia. Is Magnesia one of its inorganic constituents? If so, some Magnesia symptoms might be cured by it. A study of the pathogenesis cannot fail to impress you with its similarity to some CISTUS CANADENSIS. 205 of the antipsorics, namely: Calcarea, Corydalis, Graphites, Hepar sulphur, Phytolacca, and Stillingia. It has some resemblance to Belladonna, Paris quad., Kali bich., and Lachesis, especially its throat symptoms. Like the above antipsorics it has made some brilliant cures of swelling and suppuration of the cervical and lym- phatic glands. It has cured scrofulous abscesses located on the neck, shoulders, hips, and other portions of the body. Scrofulous hip disease (called u white swelling of the hip ”), with fistulous openings leading to the bone, and ulcers on the surface, with nightsweats. This case was cured in thirty-nine days by a decoction of the plant. Eruptions : scrofulous; tetter; chronic erysipelas; boils beginning with a blister; and lupus of the face, all come under its curative power. It has a decided affinity for mucous membranes, or rather for the glandular structures imbedded in them. Beginning with the eyes, you will find it has cured scrofulous ophthalmia ; in the mouth, scorbutic gums, swollen, separating from the teeth, bleeding easily, putrid. In the throat and air-passages it gives us a vivid picture of chronic catarrh with strumous disease of the glands of those passages. I am surprised that with the following striking symptoms, it has not been used to a greater extent by all physicians. It causes dry- ness of the tongue and roof of the mouth. Inhaling cold air caused soreness and pain in the throat, feeling of dryness, heat, and as if sand was in throat. Rawness extending from the chest into the throat. He is constantly obliged to swallow saliva to relieve an unbearable dryness, especially at night, or from 1 p.m. to 1 a.m. A small dry spot in the gullet (?) for a year, then general dry- ness of throat, better after eating, worse after sleeping, as if tear- ing asunder ; he must get up and drink water ; the inside of the throat looks glassy ; on the back of the throat are strips of tough mucus (Lachesis, Kali bich.). Periodical itching of the throat; tickling and soreness of the throat; in morning sore pain and dryness of throat. (Hep.) Tearing pain in the throat when coughing ; stitching in the throat causing cough ; cough aggravated by every mental excitement (Phos.); expectoration of bitter mucus. Fauces inflamed and dry, 206 CISTUS CANADENSIS—COCA. without feeling dry ; tough, gumlike, thick, tasteless phlegm, brought up by hawking. I would advise you to use it in the catarrhal throat and bron- chial affections so prevalent nowadays. In domestic practice, I frequently hear it highly lauded for chronic diarrhoea and dysentery. Dr. Comstock, of St. Louis, re- ported several cures from the use of the infusion. In Hering’s provings the following symptoms appear : All night, till daybreak, thin stool, squirting out, grayish- yellow in color, thin and hot. The chronic dysentery which it cures is probably of the same nature as the chronic laryngitis and bronchitis. COCA. The leaves of the plant. Erythroxylon Coca have, from the ear- liest authentic accounts, been used by the natives of Peru for the purpose of stimulating the nervous energies, much as the Chinese use tea, the Arabians coffee, the Asiatics Cannabis indica, and the American aborigines tobacco. Every nation has its peculiar nervous stimulant, which is at the same time, in different quanti- ties, a calmative or nervine. Coca is an analogue of Paullinia, Scutellaria, Cypripedium, and Valeria, as well as the other nerve stimulants above named. The primary action of this whole class is to excite the energies of the nerve-centres. While the system is under their primary effects, the person is enabled to perform more arduous labors, severer exercise, and stronger mental exertions. The thoughts flow with unwonted freedom, and the scope of imagi- nation and fancy is enlarged. Sleep is not as necessary to the organism; in other words the system can go longer without the repose of sleep. Unfortunately the secondary effects of all this class—if the drug or beverage is taken to excess—is a corresponding depression of the nervous energies, with a loss of the normal ca- pacity for mental and physical labor. During the primary effects the senses are all more alert, the perceptions keener, and they are not morbidly irritable ; while a sufferer from the secondary effects finds that he is irritable in body and mind, his nerves have lost their tone, and are shattered iu 207 COCA. proportion as he has abused the stimulant. The first use of Coca in the United States was as a tobacco antidote. I do not know the originator, but suspect it was the erratic Dio Lewis, M.D. In the many cases in which I saw it tried, no permanent good re- sulted from its use. If you will refer to the symptoms of the mental sphere in Remedies,” fourth edition, you can readily separate’ the primary from the secondary. I doubt if the drug will ever come into extensive use in our school in the treatment of diseases, unless they are complicated with or are caused by abuse of other nerve-stimulants. It may be a good antidote to the secondary effects of tea, coffee, and perhaps Opium. You may find it useful in some nervous affections of the eyes. It causes white spots, dark spots, and fiery spots be- fore the eyes (Chloral has—“ everything looks white ”). It has symptoms closely resembling the dyspepsia and cardialgia caused hy abuse of tea and coffee; it may be worth a trial in such cases. These symptoms of the respiratory organs are very striking. The natives of Peru after chewing the leaves or drinking the tea are enabled to climb with ease the highest mountains, and carry heavy loads where the air is so rare that the traveller (unless he takes the Coca) can breathe only with the utmost difficulty. It is said to prevent the hcemorrhages caused by high altitudes and rare air. In partial paralysis of the nerves of respiration it may be very useful in removing or palliating the distressing dyspnoea, or it may be very useful in the dyspnoea of weak persons, who easily get “out of breath ” during the slightest physical exertion. You may find it a valuable palliative in emphysema and pul- monary oedema. It may even assist in the cure of these distressing conditions. I have used it with apparent good results in some cases of functional heart disorder, and in one of organic disease, to relieve the excessive dyspnoea. It palliated some, and seemed to be the chief means of cure in others. It is indicated in that condition which we so often find in women and children, which is best described by the word “ fidgetiness,” 208 COCA— CODEINE—COLLINSONIA. or nervous erethism. The patient can find no rest anywhere; wants to sleep but cannot; finally becomes hysterical; feels like fainting; wants to be alone in the dark. (The Stramonium patient likes company and light.) In the cases just mentioned the 6th or 30th attenuations appear to be best indicated ; while for dyspnoea, the matrix tincture must be used. CODEINE, This name is given to one of the alkaloids of Opium. It has been very little used by the allopaths, probably on account of its enormous price, about six dollars per drachm. The provings do not evolve many symptoms other than we can find in provings of Morphia. A few homoeopathic physicians use it as an anodyne instead of Morphia, but it has no special recommendation superior to the Morph, acet. Dr. Marcy used it in the 5th dilution in a case of twitching of both eyelids after reading, a symptom I have often cured with Hyoscyamus. He also gave it in troublesome night cough of consumptives. It is said to cure severe neuralgia of the stomach and solar plexus ; but we get this from allopathic authority. COLLINSONIA. This indigenous plant has a root so very hard, knotty, and tough that the name of stone-root has been given it by the country people. A thorough knowledge of the qualities of this medicine has not yet been attained. There are many doubtful points about its action which need elucidating. I propose to give a study of its action based on the facts relating to its use. By this method we shall avoid bending the facts to suit a preconceived theory. From all available sources we learn that it has been successful in the treatment of: (1.) Bruises, sores, wounds, sprains, and contusions. (2.) Constipation and htemorrhoids. 209 COLLINSONIA. (3.) Flatulent colic, indigestion, diarrhoea, and dysentery. (4.) Dysmenorrhoea, urinary difficulties, and varicocele. (5.) Haemorrhage from the lungs. (6.) Irritable heart. Now what shall be said of the sphere of action of a medicine use- ful in those conditions ? Is it analogous in its action to AEsculus, Arnica, Aloes, Dioscorea, Hamamelis, Hydrastis, Ignatia, and Sulphur? I feel inclined to say that its special action is on the portal sys- tem, and its connections. How else are we to account for its va- ried action. The question then arises, how does it act on this sys- tem of bloodvessels? With much hesitancy I will state that I believe its primary action is to contract the calibre of the 'portal veins. I am not sure but it has a similar action on all the blood- vessels, and even the heart. Its common use by the country people, who use it as we use Arnica, and assert that it causes the rapid disappearance of ex- travasations, local congestions from injuries, etc., goes to show that it has a decided action on the capillary vessels. Again, its popularity in flatulent colic, indigestion, and diarrhoea, would go to show that it has a specific curative action in such cases. In Dr. Burt’s provings it caused severe griping in the hypogastrium, with flatulence and diarrhoea, bloody stools, also nausea and faint feel- ings. Decided bilious symptoms were evolved in his provings, and such irritation of the lower bowels as would lead to haemor- rhoids and congestion of the pelvic viscera in general. We see by this that it is capable of originating irritations which would lead to all the conditions of the bowels and pelvic viscera which it is said to have cured. There is no doubt of its action on the urinary organs. It has cured disorders supposed to be due to gravel, catarrh of the blad- der, and dropsy from deficient action of the kidneys. It certainly acts on the organs of generation. Reports show its curative powers in prolapsus uteri, in dysmenorrhoea, in varico- cele, pruritus, amenorrhoea, menorrhagia, vicarious menstrua- tion, and threatened abortion. But what is the keynote for its use in all these affections ? The pathological condition present I believe is passive congestion, and 210 COLLINSONIA. the keynote is the presence of haemorrhoids. In other words, nearly all the troubles cured by Collinsonia, having their location below the diaphragm, are either dependent on the same conditions that caused the presence of haemorrhoids, or were due to the irri- tating effect of the piles on contiguous organs. I also believe that these conditions are due to the secondary ef- fects of the drug ; and that the colic, diarrhoea, bilious symptoms, nausea, etc., noted by Burt, are primary symptoms. For the former, appreciable doses have been found most efficacious; for the latter, higher attenuations have been most effectual. Let it be noted that a study of the testimony relative to its cures in various disorders goes to show that all the cases were as- sociated with haemorrhoids. This is especially true of the consti- pation, uterine disorders, urinary difficulties, and even affections of the male genital organs. The Collinsonia removes the congested state of the hsemorrhoidal vessels, and the disorders of contiguous organs and tissues disap- pear. But how are we to account for its cures of affections of the body above the diaphragm ? It has cured headache, haemoptysis, and irritable heart. The headache we might safely assert was due to biliousness, or was that variety which precedes piles, or attends the suppression of their bleeding. We might suppose its specific power over the bloodvessels of the lungs, and on the heart, was due to its power of contracting them, or giving tone to their muscular fibre. But there is one fact recorded by observers which may throw some light on the subject, namely: The haemoptysis supervened upon suppression of a hsemorrhoidal flux, and the piles returned after the haemop- tysis ceased! In Dr. Liebold’s case, however, the patient supposed he never had piles, but he was very constipated, and a bleeding from the rectum preceded the haemoptysis. The sputa was “ very tough, dark coagulae of blood, as large as a bean, enveloped in a viscid phlegm.” Some cases of cardiac irritability are distinctly traceable to suppressed haemorrhoidal bleeding, or the non-appearance of ha- COLLINSONIA. 211 bitual piles. This the Collinsonia has cured, but it also has cured irritable heart, when the general health of the patient appeared good. It is somewhat singular that Burt experienced no heart-symp- toms. Perhaps their absence was because he was not expecting them. I suspect that many of the symptoms of our Materia Med- ica have their origin in the power of expectation. It may have been because the heart-symptoms are always sequential,—i. e., must be preceded for some time by irritation or congestion of other organs. I believe it acts on the heart in two ways—(1) by removing ob- structions or irritations in the liver, portal system, or kidneys; (2) by increasing its muscular tonicity, in the same manner that it increases the tone of the muscular fibres of the stomach, intes- tines and bloodvessels. Varicosis, as a general disorder, may come under the curative sphere of Collinsonia. I would advise its use in such condition, when Hamamelis, Pulsatilla, and Sulphur fail. Its curative ef- fects would seem to prove its affinity for varicose conditions. Piles are a kind of varicosis; so is varicocele. Pruritus of the vulva in pregnant women has been cured by it. Now pruritus is often due to a varicose condition. Dr. Cushing’s case was one of varicosis evidently, for he makes no mention of aphthae, and he says the parts (vulva, etc.) were “dark red (purple?) and protrud- ing.” Pruritus often precedes varicose veins of the leg, and the varicose ulcer. I suspect it affects the venous side of the heart, in preference. But I do not think its exact field in cardiac disease is yet defina- ble. / Dr. Fenner cures with Collinsonia cases which he calls 11 irrita- tion of the cardiac nerves, a functional disorder of the heart, with rapid, regular or irregular beating; pulse 130 to 140 per minute; the slightest motion or excitement aggravates the symptoms; pe- riodical spells of faintness and oppression; attacks of syncope, with fulness of the chest, dyspnoea, and great prostration.” It is said to be useful in valvular diseases, and some cases illus- trating its value in disease of the mitral valve have been published. It allays the distressing cough attending some heart difficulties. 212 COLLINSONIA—CUCURBITA PEPO SEMEN. And with some physicians it is esteemed very highly for all hard, shaking coughs, with or without expectoration. It is in haemorrhoids and their consequences or complications, however, that this drug has achieved its greatest triumphs. Drs. Carroll, Fowler, Holcombe, Lord, Barnes, Franklin, and Hughes all agree upon its great value in obstinate and chronic 'piles, bleed- ing or not, but always attended by constipation. I am inclined to believe that its curative powers in disorders of the organs of generation of women (and men) depend almost wholly on the disorders of the rectum which it causes. Hr. Storer, of Boston, believes that a large proportion of uterine diseases de- pend on rectal disorders. Dr. Storer is doubtless correct in his estimate. In every case of uterine disorder, you should carefully inquire into the condition of the intestines, the bowels, and rectum. You will often find the cause therein, and you will very often find Collinsonia a remedy which will prove far more useful than the ordinary medicines prescribed in such cases. What Sepia is to chronic diseases, Collinsonia is to the acute. CUCURBITA PEPO SEMEN. The seeds of the ordinary pumpkin have long had a reputation as a demulcent diuretic, for the relief of strangury and other uri- nary difficulties. The same may be said of the seeds of the water- melon, musk-melon, cucumber, and all that family. But the pumpkin seed has a value which you would hardly expect from a seed so mild and edible. In fact, it is doubtful if they possess any actual medicinal properties as we understand it; for the seeds may be eaten in any quantity sufficient to satisfy hunger, with no other result than profuse urination. The property I refer to is the power of the pumpkin seed to aid in the expulsion of tape-worms (tseniae). I use the word to aid, for the reason that we are not certain that the effects of the seed alone would expel the worms or even poison them. It may do nothing more than gorge them to such repletion that they lose their power of adhesion to the intestine. In apparent contradiction to this supposition is the recorded assertion that the oil expressed CUCURBITA PEPO SEMEN. 213 from the seeds, as well as an infusion of the seeds, has destroyed taenise. Various methods of administration have been advised. One authority advises one ounce of the peeled seeds to be taken on an empty stomach, followed in six hours by a dose of Castor oil. Another directs two ounces to be beaten up with sugar into an electuary, or with water into an emulsion, and taken fasting in the morning, the patient having dieted the previous day, and a brisk purge taken some hours after. My method, and I have expelled a great many with it, is to direct the patient to eat but little of the lightest food all day, take no supper, and on going to bed eat one ounce of the peeled seeds bruised, with milk or cream. In the morning, on waking, take a tablespoonful of Castor oil mixed with half a teaspoonful of pure Sulphuric ether. Vo breakfast is to be eaten—only a cup of tea or coffee. In two or three hours the oil will operate, expelling the worm. I have seen them expelled without the use of the oil and Ether, especially in children; but in adults I think they had better be taken. The Ether undoubtedly plays an important part in the expul- sion of the parasite, for it has lately been advised alone, and is said to succeed in expelling tapeworm, in doses of 30 to 60 drops, taken fasting. It is supposed to stupefy the worm, during which condition it drops from its attachment, and is carried along the intestines until it is expelled. The oil of pumpkin seed is recommended to be taken in doses of half an ounce, fasting, followed in six hours by another half ounce, mixed with an ounce of Castor oil. Half the above quantity will be a sufficient dose in the case of children under twelve years. In this connection I will mention some other remedies for tape- worm which you may be obliged to resort to, for, although the pumpkin seed is the safest and is generally efficient, there are cases where, owing to some idiosyncrasy in the worm (not the patient), the seeds fail to destroy it. The next best agent is undoubtedly the Oleo-resin of the male fern (Filix mas). The patient should live upon bread and a little 214 CUCURBITA PEPO SEMEN CYANUEET OF MERCURY. milk for one day, and the following morning take a full dose of 30 to 60 drops, fasting, repeating it in three hours. At noon the patient may eat food, and in the evening a cathartic is to be taken. I would advise the Castor oil and Ether as above. I have somewhere seen, in homoeopathic works on practice, a rec- ommendation to give the attenuations of Filix mas. Such a practice is simply absurd. Kousso (Brayera) has a high reputation as being.the most effi- cient remedy against tape-worm. Baehr advises it in preference to any remedy. It causes less pain and inconvenience than any other agent except the pumpkin seed. The powdered flowers in doses of half an ounce, or twenty to forty grains of the resin Koussin, is prescribed to be taken suspended in water, in the morning. No purgative is necessary, as it causes loose watery passages with but little pain and nausea. The worm is usually expelled dead in the last passages. Granatum (the bark of the pomegranate), has been used, but it is harsh and unpleasant. Turpentine is unsafe and even dangerous. Kameela is sometimes efficient, but inferior in efficacy to the first named. The rules laid down by Hahnemann, Hartman, Hering, and others, appear to me, as they do to Baehr, to be superfluous. The tapeworm does not depend for its existence on any dvserasia of the system, but it is introduced from without with the food, and must be expelled or destroyed, just as we should destroy a snake or any other reptile living in the stomach or intestines. CYANURET OF MERCURY. This drug is almost as poisonous as the Cyanide of potassium. It may not kill as suddenly, but the sufferings of the victim are a hundred times more intense. In cases of poisoning by this agent we have all the symptoms of Hydrocyanic acid, to which are added the terrible effects of Corrosive mercury. Worse than this, even, we have a picture of the most malignant forms of diphtheria. The following are its characteristic symptoms: CYANURET OF MERCURY. 215 “The tongue is pale, with a yellowish streak on the base; swol- len, with red edges. “ The throat looks rough ; pharynx red and injected. • “ Gums swollen, and covered with a white adherent layer, under which is found a violet border. “ A white opaline layer forms on the columns of the velum palati and tonsils; on the inside of the right cheek was a round ulcer with a grayish base, the borders as if cut out and sur- rounded with great redness. “ The lips, tongue, and inside of the cheeks dotted by ulcer- ations, and covered by a grayish-white coating. “ A pseudo-membranous formation extends all over the fauces and down the throat. “ Inflammation of the whole buccal cavity, with salivation, fetid breath, and great pain on swallowing.” We have here a picture of malignant diphtheria accompanied by ulceration. This pathological condition, coupled with the sud- denness and severity of the attack, fully indicate this drug above all others. The concomitant symptoms are equally important as an indica- tion, namely : epistaxis, cerebral congestion, pupils contracted, syn- cope, loss of consciousness, vomiting, diarrhoea, diphtheritic forma- tions on other portions of the mucous membrane, and even the skin. The diphtheritic process attacks the kidneys, causing one of the worst varieties of Bright’s disease, and it may prove to be one of our best remedies in the croupous form of nephritis, and in albu- minuria following diphtheria and scarlatina. I once saw an epidemic of malignant scarlatina, which presented nearly all the symptoms and conditions caused by this drug. It had not been introduced into our Materia Medica at that time, or I might have saved some cases. Malignant dysentery is closely imitated by the symptoms of the Cyanuret of mercury. It is attended by great prostration, putrid bloody stools, diphtheritic patches at the anus, ulceration, gan- grene, and finally collapse and death. It causes phlebitis and varicosis, and ought to be specific in the worst cases, as well as varicose ulcers. 216 CYANURET OF MERCURY—CYANIDE OF POTASSIUM. Physicians have reported cases cured by Mercury cyanide of what they termed malignant membranous croup, but it is evident that tire croupous symptoms were due to an extension of the de- posit or exudation to the air-passages. I would suggest its possible usefulness in those cases of sudden paralysis, or sudden heart failure, which occurs after attacks of diphtheria, even when it has been supposed to be non-malignant in its character. Among other remedies for diphtheria, none resemble it in in- tensity of action; but those which approach it nearest are Kali caustic, Kali bich., and Lachesis. The 6th dilution or trituration is as low as it can be safely used for children; the 3d cent, in adults. The use of this medicine alone, or in connection with a gargle or spray of Chloride of lime (Liq. calcis chlor., 5j ; Aqua, §iv), is the best treatment now known for this terrible disease. CYANIDE OF POTASSIUM. This drag, sometimes called the Cyanuret of potassium, is one of the most violent poisons known. Its action is very similar to Hydrocyanic acid. Its analogues are Prunus, Lycopus, Lauro- cerasus, Digitalis, and Amygdala. Three grains are sufficient to destroy life in a human adult. Allopathic physicians are very cautious how they use this medicine. Their utter disbelief in the value of inappreciable doses unfits them for the selection and administration of such agents. The poisonous effects of this salt do not differ essentially from the acid. It has been proved by numerous experiments that the latter “acts through the blood, directly upon the cerebral and spinal centres, and indirectly upon the lungs and heart, probably first suspending respiration through the want of the proper nervous influence to the pulmonary function; and secondly, arresting the heart’s action through the want of blood from the lungs. Death, therefore, takes place through asphyxia. Hence the general ven- ous congestion observed after death, affecting the brain, lungs, etc. The insensibility, however, is the antecedent of the asphyxia, and depends not upon the want of blood in the brain, but upon the immediate paralyzing influence of the poison.” CYANIDE OF POTASSIUM. 217 I do not see why it may not paralyze the heart, directly, as well as the brain ; but some facts seem to point to the contrary, for it is asserted that u the heart continues to beat after respiration has ceased.” Prescribed according to the law of similia, it can be used in all cases where the provings of the acid show that it is indicated, for its union with Potassium does not effect any change in that respect, although we may get additional symptoms belonging to the alkali. The keynote, or characteristic primary condition or symptom indicating the Cyanide is the suddenness and severity of the attacks. A woman who took 12 grains fell as if struck by lightning, and died in 40 minutes. In fatal poisoning by the Hydrocyanic acid, death has occurred in less than a minute. I believe that you will find it useful in those rare cases of cerebrospinal congestion which have been known to throw the victim into fatal or dangerous coma in less than half an hour; or in cases of apoplexy from venous congestion, striking the patient down with equal suddenness. We find recorded among its symptoms “ severe sudden pain in the head, vertigo, and sensation of weight and great pain in the back of the head.” It has cured some very intense periodic neuralgias, viz.: (1.) Torturing neuralgic headache in orbital and supramaxillary region; the pains recurring daily at the same hour, with much flushing of that side of the face. (2.) Agonizing attacks of neuralgic pains between the temporal region, ciliary arch, and maxillary, with screams and apparent loss of sensibility, as if struck with apoplexy; pulse 84, face flushed. (3.) Severe neuralgic pains in temporal region and left upper jaw, daily at 4 P.M., increasing till 10 A.M., and ceasing at 4 P.M.; in the interval, anorexia, fever, headache, etc. Similar cases have been cured by Arsenic, Quinine, Atropia, Chelidonium, and Nux vomica, but the diagnostic difference in favor of the Cyanide is the suddenness and severity of the paroxysm. The dose in such cases (or in any case) should not exceed the 1st centesimal trituration, in a one-grain dose, repeated every hour YOL. II,—15 218 CYANIDE OF POTASSIUM—CYPRIPEDIUM. or two in the apyrexia, and every fifteen minutes during the par- oxysm. Allopathists direct the maximum dose to be one-eighth of a grain. The or would be safe for an adult. A dilution containing T-frn grain to a drop makes an eligible preparation, as the 2° or 3° could be used for children. It has been used externally for the relief of headaches. Trous- seau directs a solution not stronger than two to four grains to an ounce of water, but I cannot recommend it, except as a last resort in the most severe cases. It seems indicated in spasmodic affections of the oesophagus, fol- lowed by vomiting from paralysis of that tube, as witness the symptom : “Nausea, with sense of choking when trying to swallow fluids, followed by copious vomiting.” I think it will prove valuable in gastritis of very sudden onset and severe character. It corresponds to threatened asphyxia from venous congestion of the lungs; also, to whooping-cough, when asphyxia occurs during the severe paroxysms. You may find it useful in some cases of nightly cough of a paroxysmal character, even when caused by car- diac disease. I have prescribed it a few times in functional disorder of the heart, with slow, feeble, irregular pulse, alternating with palpita- tions. Even if the cardiac disease is organic, and the nervous element largely predominates, it will be found useful. A tendency to venous congestion, and a bluish color of the lips and skin, are specific indications. OYPRIPEDIUM. There are eight species of Lady's Slipper indigenous to this country. It has a singular-looking flower, resembling an Indian moccasin or a Chinese shoe, whence its name. It is also commonly called “Valerian” and “nerve root,” both of which names are given to the Scutellaria. The Cypripedium pubescens (large yel- low) has been selected as the officinal species, but as the roots of all are collected and used I do not see how we can discriminate. They all contain in common a peculiar “nervine” property. Raf- 219 CYPRIPEDIUM. inesque considered this species to be the strongest, next the Cypri- pedium acaule, and last, the Cypripedium spectabile and candidum. King says the two latter possess more narcotic power than the others, especially when found in dark swamps. The medicinal action of the various species differs in quantity rather than quality. In domestic and eclectic practice this root is held in the highest esteem. I have been surprised, however, to find that our school have almost altogether neglected it in favor of Scutellaria, although the testimony is about equal relating to their powrer over the ner- vous system. When an infusion in large quantities, or a strong extract is taken by a healthy person, it causes at first a feeling of exhilara- tion of the mental and nervous system. Afterwards comes a sense of calmness and quiet, followed, if larger doses are taken, by a sense of mental fatigue, an oppression and heaviness of mind, and a disposition to drowsiness. It is resorted to by women whose nervous systems have been shattered by long and wearing illnesses and excessive green-tea and coffee drinking. It removes abnormal irritability, but if it is used to excess the secondary effect is to increase the very irritability and weakness which it palliated. This is the case, howrever, with all its analogues, namely, Teas, Coffees, Valerian, Scullcap, Paul- linia, Coca, Chloral, and the Bromides. It is for conditions similar to their secondary effects that these medicines are usually pre- scribed. The sphere of remedial action possessed by the Cypripedium is not wide. It acts upon the cerebro-spinal system, upon the gray nerve-tissue, and is useful for the effects of overmental exertion or reflex nervous excitement. You will probably find it useful in hysteria, chorea, nervous headache, delirium tremens, hypochondriasis, neuralgia, and that peculiar condition for which there is no better name than “fidgeti- ness.” For all these conditions, however, it never can rise above that of a palliative, unless the case be very recent. For serious cases some remedy whose action is deeper is usually required. There are some affections, however, in which it appears to act more permanently. 220 CYPRIPEDIUM. It is invaluable in that well-known condition to which children are subject, when, from some gastric or intestinal irritation, the reflex excitability of the cerebro-spinal centres is aroused, the brain becomes irritated, and convulsions impend. Here it rivals the Bro- mides, Chloral, Scutellaria, and Cuprum acet., and is superior to the routine Belladonna, Hyoscyamus, and ChamomWla. In such cases a few drops of the mother tincture, or lx, frequently repeated, is attended by the best results. Sleeplessness, when depending on functional disorder of the brain and nervous system, or mental excitement, is often promptly re- moved by similar doses. This sleeplessness of Cypripedium is not an unpleasant condition; there is a desire to talk, a crowding of pleasant ideas, with a restlessness of body, a twitching of the limbs, etc. It is more adapted to the delicate organizations of chil- dren and feeble women than to men. I have found it useful in the mental depression and irritability consequent on venereal excesses or spermatorrhoea. It is equally useful when the mental despondency is the result of brooding over an imaginary spermatorrhoea, or the imagined ill effects of noctur- nal emissions, a very common condition caused by the reading of those foolish books published by quacks and charlatans. In typhomania, and the jactitations, tremors, restlessness, etc., of patients with low fever, its effects are very pleasant, and renders such patients quiet and comfortable, without interfering with the action of the proper specifies. There is a condition of cerebral hypercesthesia, occurring in young children, which is often dangerous in its consequences. It results from teething or mental stimulation. It is too much the habit of doting parents to overstimulate the tender brains of infants by attempts at teaching them beyond their normal capaci- ties. The children become morbidly excitable. They become pre- cociously bright, sleep but little, are inclined to laugh and play at night, crave light and noise; and parents, not knowing the danger impending, favor instead of suppressing this dangerous condition. I have often seen this functional irritability end in convulsions. It often leads to congestion, and fatal meningitis then closes the scene. Now, Cypripedium will aid you in removing these premonitory CYPEIPEDIUM COTYLEDON CUNDURANGO. 221 brain-symptoms, if you can oblige the attendants to place the child where it can have quiet sleep, and a dim light; but this remedy is of no value after the irritation has become fixed, for it is not homoeopathic to congestion or inflammation of the brain or spinal cord. In relation to the dose and best preparation my advice is to use, for very young children, the 1* or 2* aqueous dilutions, to avoid the alcoholic stimulation, or dried pellets of the alcoholic dilutions, or an infusion of ten grains of the root to four ounces of hot water. This preparation may be given in teaspoonful doses. For adults, tablespoonful doses of an infusion of one drachm of therootto §iv of hot water, or ten drops of the mother tincture. It is said to have caused symptoms of the skin similar to Rhus poisoning. (See Vol. I.) COTYLEDON. I found the provings of this common English plant (Navel- wort) in the “ British Journal of Homoeopathy.” It seems to affect the mental sphere like Ignatia, causing alternate states of exhilaration and depression. It also resembles Asafoetida. I am surprised that so many important symptoms were caused by such an insignificant plant. I more than suspect the imagination of the provers called them up, like the phantasmagoria which float through Houatt’s notorious pathogeneses. The only clinical observation I have been able to find relating to Cotyledon is one quoted by Lilienthal, from C. Muller, to the effect that he had found it useful in eczema capitis (tinea), but in what doses he does not say. CUNDURANGO. This medicine is prepared from the bark of a climbing plant found in Ecuador, South America. It is called the Condor-plant by the natives, and it is from them that the knowledge of its sup- posed virtues were first obtained. It was introduced into practice and notoriety by a Dr. Bliss, of Washington city, but the manner of its introduction was so 222 CUNDUKANGO. suspiciously unprofessional, and smacked so much of quackery, that Dr. Bliss was expelled from the allopathic society to which he belonged. The testimony relative to its value is singularly at variance. Dr. Bliss, and a few others, claim to have cured many cancers by its use. Other physicians claim to have tested it in private and hospital practice, and found it worthless. The British Hos- pital physicians report against its value. Dr. Andrews, of Chicago, in a communication to the Academy of Science, stated that he had corresponded with many of the most eminent physicians of South America relative to Cundu- rango, and while they denied its curative powers over cancer and syphilis, they asserted its usefulness in “ old, obstinate, foul ulcers.” Several homoeopathic physicians in this country have reported favorably of its value in “foul and obstinate ulcers.” Dr. Clotar Muller, of Germany, reports that he has used it in over twenty cases, “ some were real carcinoma, others benign (purely scrofu- lous) glandular swellings and ulcerations. In the latter it showed no action whatever. It also failed to act in scirrhous indurations. The size, hardness, and lancinating pains remained unaltered.” He decrees that “ favorable action may be expected in open can- cer,” but the cases he cites do not prove its value in cancer, for he fails to show that his cases were cancerous. I give his cases as he reports them. (1.) Carcinoma of the lip, an unclean and sinuous ulcer about the size of a dime, with surrounding hardness and swelling, burn- ing pains, lip everted outward, emaciation. Five drops of 1st dil., morning and evening. In ten days the ulcer looked better and the surrounding hardness was reduced to a minimum. (2.) On the right of thorax and around the nipple several tu- mors, of which two suppurated and formed sinuous, ugly-looking, foul-smelling ulcers, with raised edges. Cured in two months. (3.) An ulcer seated on false ribs, of the size of the hand, be- ginning years ago. It looked carcinomatous with its high uneven edges, its deep, small islets of half-destroyed cellular tissue and muscular fibres at the base, and with its ichorous, acrid secretion; the pains were severe. After taking Cundurango the ulcer had decreased to half its size. 223 CUNDURANGO. I do not consider these cases as brilliant illustrations of cures by any means, nor do I believe the ulcers were cancerous. They were simply old, foul-smelling, ichorous ulcers, just such ulcers as South American physicians found it useful in, and the sphere of Cundurango evidently includes just such ulcers appearing any- where on or in the body. In the “ North American Journal of Homoeopathy,” May, 1874, is reported a case, by Professor N. Friedreich, as “carcinoma ven- tricufi, with co-affections of the epigastric and supraclavicular lym- phatic glands.” This case was so nearly cured by Cundurango in three months that the patient was discharged. The dose was 5iv of the bark to half a pint of water; a tablespoonful twice a day. I have given it in several cases of uterine cancer, but without any good results. From the “ British Journal of Homoeopathy,” January, 1875, I quote the following, translated from a paper by H. Goullon, Jr., in Hirschell’s “ Zeitschrift,” No. 16: Dr. Obolinski, surgeon to the St. Lazarus Hospital, Cracow, experimented with the Cundurango in several cases with the following result: Case I.—Patient is suffering from an epithelial cancroid of the right foot. He gets fifteen grains pro die, in the form of decoction, for three weeks. The remedy was likewise applied locally. Result.—No amelioration; the pains are getting intolerable. Dr. Obolinski performs amputatio cruris. Case II.—Patient is suffering from an epithelial cancer of the left temporal region, of the size of the palm of the hand. Medication as in Case I, but during six weeks. Result.—The whole ulcerative surface covers itself, in the fourth week, with healthy granulations, and this led Dr. Obolinski to perform a heteroplastic operation, after the manner of Reverdin, and that, too, with success. However, no sooner had the transplanted bits begun to show signs of activity than the cancer began afresh, and destroyed both granulations and the transplanted portions of skin. Here the whole of the epithelioma was extirpated right down to the bone, and the place was (brought to heal for good.—(Goullon, Jr.). But when, not long ago, Professor Friedreich published a case of cancer of the stomach cured by the bark of Cundurango, and thereby called attention to the fact that many of the experimenters had got negative results because they had had spurious or bad preparations, Obolinski began to experiment again, and this time made use of true American Cundurango bark, prepared from the sources named by Professor Friedreich. He had two cases in his private practice, an 224 CUNDURANGO COSMOLINE. octogenarian woman, with a flat epithelial cancer (ulcus rodens), of about the size of a farthing, on her lower eyelid; and a woman, set. fifty, with a flat epithelial cancer, about the size of a bean, on the left side of the nose, and which had been repeatedly cauterized with Kali causticum, but kept on coming again. To these two he exhibited the remedy. He gave to both patients, daily, two, and, later on, three tablespoonfuls of medicine, and charpie impregnated therewith was laid on the sores. Both went their way to their homes with the order to persevere in this manner for a couple of weeks, or even months, and when Dr. Obolinski saw them again, six weeks thereafter, he was very greatly astonished to find both sores perfectly healed. These cures have no small clinical interest for us homoeopaths. First of all, they seem to confirm the opinion expressed already, in 1872, by Cl. Muller, in his clever essay on this subject, viz., that the newly imported drug is no infallible remedy against all sorts of growths called cancer, but rather curative of a definite form of such growths. “ It will be seen,” said he, “ Cundurango does not act curatively in cases of tumors and scirrhous indurations, but rather in cases of open carci- nomata and cancerous sores; in other words, it happens, as with other discoveries, that the discoverer himself thinks his little babe a kind of Messiah, who shall work sucli wonders and signs as neither Creator nor creation intended.” Then, when the public finds itself disappointed by the numerous failings, there follows such an odious and blind reaction, that the really good part of the dis- covery is no longer seen, and all who desire to get better acquainted with the thing are repelled by the giant, Prejudice. Is not homoeopathy itself a sad example of all of this ? Of further interest in these cases of Obolinski is the question of the dose. Cl. Muller himself soon perceived that but little was to be expected here from light, infinitesimal doses. lie gave, night and morning, five drops of the first dilution. The external treatment of the sores, carried out at the same time with the same remedy, is probably of very decided advantage. Muller’s case was cured M7ith Cundurango1, internally alone. We think that we are also justified in concluding, from the observations of the Cracovian surgeon, that where Cundurango should prove of no avail, a stronger and not a weaker dose would be called for. It is not with Cundurango as with Silicea and Lycopodium. CQSMOLINE. This remedy is used quite extensively by the homoeopathic school as an external application. It is a purified, concentrated petro- leum, or the substance which remains alter all the ether, coloring matter, impurities, etc., have been removed. It is a white, oleag- inous, and odorless substauce, having an absolute non-affinity for oxygen, and evaporating only above 400° Fahr. Dr. McFarlan, of Philadelphia, asserts that the provings of the lower triturations develop symptoms which have some simi- COSMOLINE. 225 larity to those of Pulsatilla, Urtica urens, Petroleum, Carbolic acid, and Rhus. The workmen engaged in its manufacture suffer from the .same pathogenetic symptoms. They have also the following skin symp- toms: “ Great apparent dryness of the skin and itchiness everywhere, with a constant disposition to scratch. The skin is often dry and scurfy, in irregular patches or blotches, which itch a good deal. On scratching, the skin raises in welts or blotches.” I am not aware that it has been used much as an internal remedy, but it has become quite a favorite external application, not only in our own but all schools, and extends largely into do- mestic practice. It is manufactured on a large scale, and is sold by all druggists in the United States. Its effects, when applied to the skin in cases of urticaria, eczema, psoriasis, herpes, and in nearly all cutaneous diseases in which the skin is dry and irritable, is certainly very soothing and often cura- tive. It has been combined with various substances, forming com- pound cerates. In fact it is largely used as a base for making cerates with Arnica, Calendula, Carbolic acid, Hamamelis, Hy- drastis, etc. I find, however, that while these cerates are sufficiently stable in cool weather, they soften and assume an oily consistence when the mercury goes above 70° Fahr. In order to make the Cosmo- line cerates sufficiently stiff to be used in summer, it is necessary to combine it with Cocoa butter, Mutton tallow, or Spermaceti. My usual formulae for these cerates are on the decimal scale, namely: One drachm of the tincture selected to one ounce of Cos- moline. Or, gr. 60 of crystals of Carbolic acid to one ounce of Cosmoline (lx). This is too strong for all except old, torpid skin diseases. For a sensitive skin, one drachm of this lx to 5j of Cos- moline. This is called Carbolated cosmoline. The names, Arni- cated cosmoline, Ilydrastic cosmoline, Calendula cosmoline, may be used to designate these preparations. Many physicians use the pure Cosmoline for burns, scalds, blisters, cuts, bruises, sprains, and even acute and chronic rheumatic affections, -with alleged benefit. 226 CLEMATIS YIRGINICA—COMOCLADIA. There can be no objection to its use in our practice. On the contrary a positive benefit may ensue, by preventing the use of those noxious, disagreeable, and often injurious ointments which are sold everywhere. Patients will use something, and if the physician does not recommend anything they will resort to the nostrum most convenient, or one that is most largely advertised. CLEMATIS VIRGINICA. This is an indigenous species, not differing essentially from the European Clematis ereda. The latter is a very valuable remedy, and not sufficiently appreciated by our school. Belonging to the same family as the Pulsatilla, it resembles it very closely in many respects. It has the same, if not a greater action on the organs of generation—uterus and ovaries, testicles and spermatic cords— and upon the skin and glandular system. Its action on the nerv- ous system has been overlooked. In this respect it somewhat resembles its relative, Cimicifuga. Dr. Scudder (eclectic) first called attention to the indigenous Clematis. He says it is a “ powerful nervine,” useful in control- ling erethism of the nervous system in women. Several years ago I procured the leaves and made a tincture, which I have prescribed on many occasions in that kind of ner- vousness, half physical, half psychical, which affects some women who have been worried by care and illness combined. In doses of a few drops several times a day it acts admirably. I have cured with it several cases of acute pustular skin diseases, and a few cases of orchitis and ovaritis. No indigenous remedy is more deserving a thorough proving. The time will come when our own (indigenous) plants will super- sede the foreign, for they possess analogous if not identical vir- tues. COMOCLADIA. This poisonous shrub, known to the natives of the West Indies as Guao, is very similar in its effects to the Anacardium of the East Indies and the Rhus of the United States. So virulent is its poison, that sleeping beneath its shade often COMOCLADIA—COENUS FLOEIDA. 227 causes fatal illness, especially if the sun is shining. It has been observed that the poisonous influence of the Rhus is felt more intensely in hot, sunny weather. Like the Anacardium, the Guao causes not only vesicular erup- tions, but malignant pustules and ulcers. The ulcers are deep, with hard edges; they discharge a thick, purulent, yellowish-green matter, having a very peculiar fetid smell, the parts becoming in appearance like a piece of raw, decayed meat, while the surround- ing skin is covered with small shining scales. This gives a very good picture of the worst forms of malignant erysipelas, of a greater severity than that for which Rhus is indi- cated, and for which wre have usually used Lachesis and Arseni- cum. It has been used in leprosy by the Spanish homoeopathic phy- sicians, and with considerable success. In erysipelatous inflammation of the tissues in and around the eye, it will be found superior to the ordinary remedies. Dr. Havarro cured a sloughing ulcer of the right breast; also an “ indolent ulcer ” on the lower third of the right leg near the ex- ternal malleolus, of irregular shape and hard edges ; the ulcer was deep and discharged a sanious and fetid pus; it had lasted six years. (Cured in four weeks by the 6th dil.) The same phy- sician reports a case of inflammation of the left leg and foot with violent fever; the swelling increased enormously ; when the pain subsided the skin became white and covered with shining scales; cracked and discharged a sanious fluid. This case was cured with the 6th. It caused the same rheumatic pains and swellings, aggravated by rest, relieved by continued movement, as does Rhus. I have rarely been able to procure the drug, and while we have the Rhus and Anacardium we hardly need it. It corresponds more closely to the diseases of the tropics than those of the temperate zone. CORNUS FLORIDA. This shrub or small tree is the true dogwood, although where it got this name I never knew. It presents a very beautiful appear- ance in the early spring, when, before the leaves appear, the tree 228 CORNUS FLORIDA—CORNUS CIRCINATA. is white with its snowy and showy blossoms. The sepals, how- ever, and not the petals, are the most showy portion of the flower. The bark is intensely bitter, and among the common people is used largely as a tonic, and as a substitute for Quinine in ague. An active principle, called Cornin, was at one time sold, but it is un- reliable. In large doses Cornus causes a fulness in the head, with some pain, quick pulse, and gastric irritation. I have used the tincture in obstinate intermittents where Quinine had been abused, and found that when the following group of symptoms were present it usually cured : The ague paroxysm is preceded for days by sleepiness, sluggish flow of ideas, headache of a dull, heavy character. The paroxysms are attended by nausea, vomiting, and sometimes watery or bil- ious diarrhoea. In the chill there is cold, clammy skin; in the fever violent headache, with throbbing, stupor, confusion of intel- lect, and vomiting. The tincture should be given in doses of five or ten drops, every two hours, in the apyrexia. The 2d or 3d dil. every hour during the paroxysm. In some old cases of dyspepsia, when the chief symptom is acid pyrosis, this remedy, like Oolumbo, Chelone, China, and Nux, will often effect very satisfactory cures. CORNUS CIRCINATA. This species of Cornus is a smaller shrub than the flowering dogwood. It has a small but pretty blossom, in large flat or de- pressed cymes ; a small, light-blue fruit, nearly the size of a cur- rant. The bark on the young brandies is a bright green, giving the name Green osier to this species. It is very popular in the country as a remedy for aphthous and ulcerated conditions of mucous membranes. It certainly has some marked specific virtues in such conditions even when chronic, for I have known it to cure chronic ulcerations of the mouth and throat, recurring occasionally for many years. It acts best when used as a lotion; and also internally in appreciable doses of the tincture or infusion of the recent bark. It has also been used in agues of nearly the same character as 229 CORPUS CIRCINATA—CORYDALIS. described forCornus Florida. The provings made and published by Dr. Marcy give us similar symptoms. It is evidently an ana- logue of China, Hydrastis, Eupat. perfi, Chelone, etc. The principal disorders in which it has been successfully used are bilious headaches, jaundice, aphthous stomatitis, and hepatic de- rangements. Dr. Marcy and several others value it very highly in bilious diarrhoea and dysentery. The symptoms are similar to those of Merc, cor., Aloes, and Nux, for which it may be judi- ciously substituted in some cases occurring in connection with malarial conditions, and in hot weather. COKYDALIS. There are some medicines in the vegetable kingdom which closely resemble in remedial action those from the mineral. No chemist can explain this resemblance by any chemical an- alysis, for the analogy lies deeper than any manipulation in the laboratory can discover. It may be that the ultimate atoms of Phytolacca and Mercurius, Iodide of potassa and Stillingia, Au- rum and Corydalis, are similar, and that this ultimate similarity gives similarity of action and curative potentiality. A glance at the clinical history of Corydalis will show some striking resemblances in the results obtained from its use, and the known curative action of those medicines so renowned as specifics against the syphilitic dyscrasia. No provings of this agent have been made, and we have to rely mainly on reports of cures in eclectic literature. My ex- perience, although limited, because I treat but few cases of syphilis, has been favorable. I remember two cases of syphilitic nodes on the tibia, with noc- turnal pains, which had been treated for nearly a year with mas- sive doses of Iodide of potassa without benefit. Under the use of the Tincture of corydalis, in ten-drop doses, four times a day, the swellings slowly but permanently disappeared. We have trustworthy testimony that it has cured syphilitic nodes of the skull, with falling off of the hair; also, syphilitic and scrof- idous eruptions on the scalp. It has also cured syphilitic and non-syphilitic ulcerations of the 230 CORYDALIS—DIGITALIN. mouth and fauces. I think it will be found to be better adapted to secondary syphilis than primary. Whether it is useful in the so-called tertiary forms, or the mercurial cachexia, which some be- lieve to be identical with the latter, future observation must deter- mine. I would not have you think I confine its use to syphilitic dis- eases alone. It may prove just as useful in the scrofulous (strumous) dyscrasia and in obstinate cutaneous diseases. It would be worth while to try it in congenital syphilis. You may find it useful in the cachexia caused by intermittents, when you find enlargement of the spleen and liver. Its use in massive doses has caused, according to eclectic phy- sicians, the following conditions : “ A derangement of the stomach, attended with profuse morbid secretion of mucus, there being al- ways a coated tongue, with fetor of the breath, and loss of appe- tite and digestion.” It is, therefore, indicated in gastric catarrh, and is, in this respect, an analogue of Hydrastis. DIGITALm. I introduce this drug among the new remedies for the same reason that I introduce Atropia and Ergotin, namely, that it is not mentioned in our textbooks on Materia Medica, and that there are instances where the active principles of plants are sub- stituted for the original drug with great benefit. Digitalin is the active principle or alkaloid of the plant Digi- talis, and possesses a large proportion of its pathogenetic effects. I assume the same ground, in treating of this substance, that I did in treating of Atropia—that while an alkaloid may represent the principal effects of the plant, it cannot represent all the symp- tomatic effects and nicer shades of action. Digitalin, from the very numerous experiments recorded, made by the most eminent physiologists, seems to affect the heart in a manner nearly if not altogether identical with Digitalis. I have written a good deal concerning the action of Digitalis, and my papers have been severely criticized by physicians so bigoted that they would not see the logical deductions which must arise in consequence of new discoveries in the action of DIGITALIN. 231 medicines. But time has confirmed my views and silenced my critics, and I am content. I will state, in as brief terms as possible, the known and un- disputed action of Digitalin on the heart: (1.) Digitalin produces a condition of excitement in the con- trolling centres in the heart, and hence the slowing of the pulse with increased power of the heart’s impulse. (2.) It has a peculiar specific influence on the heart’s muscle, ■whose contractions are strengthened in the first stage, becoming irregular in the second, and in the third a peculiar rigidity is induced. The 'primary action of Digitalin and Digitalis is to cause in- creased power of the heart’s contractions, the pulse being first regular and slightly accelerated; next irregular and intermitting; and finally very slow, until the heart ceases to beat, and stops in systole, i.e., in rigid, tetanic, permanent contraction, which ends in death, or recovery ivith secondary effects. These secondary effects are the reverse of the primary, i. e., the pulse is very slow and soft, then irregular, intermittent, and weak, and finally quick and weak; the heart rarely completing its normal contractions, because of the feeble condition of its muscular fibres. Now it is evident to me, as the result of twenty-five years of close observation, that Digitalis is homoeopathic to both its pri- mary and secondary effects; but that it has rarely been used ex- cept for the latter. Hahnemann evidently did not understand the action of Digitalis; he as much as confesses it in several instances, as when he states that its action in certain dropsies is “ curative but nevertheless antipathic.” Now it is a fact, that unless we understand and appreciate the secondary effects of drugs, a large proportion of our cures made with appreciable doses appear to be antipathic. This is especially the case with Digitalin, and this is the reason our school is contin- ually losing the advantage they might gain by the rational use of Digitalis in many diseases. Now, according to my law of dose, if we prescribe Digitalin for symptoms similar to its primary effects, we must prescribe the attenuations as high as the 6th, or we shall get unpleasant aggra- vations. But if we are treating conditions similar to its second- 232 DIGITALIN. ary effects, we must use the low attenuations. The question is, ITow long can we go with safety ? Digitalin (and I must here warn you not to use the spurious substances called by this name, manufactured by various firms in this country, for they are generally inert, or no more powerful than the dried leaves), the crysta/lizable active principle (alkaloid), occurs in short and delicate needle-shaped crystals, and possesses an intense and persistent bitter taste; slightly soluble in water; soluble in twelve parts of cold and six of boiling Alcohol, of 90°; less soluble in absolute Alcohol; nearly insoluble in Ether; and very soluble in Chloroform. Amorphous Digitalin is a whitish or yellowish powder, odor- less, but of a very bitter taste, nearly insoluble in Ether and water, readily soluble in Alcohol. Crude Digitalis is said to contain ten or twelve per cent, of crystallizable Digitalin, which is said to be somewhat more powerful than the amorphous Digi- talin. Either preparation is a very powerful poison. It is said that “ one-ninth of a grain has been taken without toxic effect,” but I advise you not to try such a dose. One-fiftieth of a grain has caused very unpleasant if not dangerous symptoms. I should not like to give one one-hundredth of a grain frequently in re- peated doses. When we wish to get prompt, decisive action, as in a case of cardiac failure, syncope, or threatened paralysis, a few doses of the one-hundredth might be given, but for general use in cardiac diseases the one-thousandth (or 2°) is as low as I advise you to use it for adults. The action of toxic doses of Aconite, Veratrum viride, Vera- trum album, and Gelseminum is just the opposite of Digitalis ; for in a case of poisoning by the latter, or serious aggravation from an overdose, Aconite or Verat. vir. is the best antidote (in doses of one to three drops of the tincture, repeated frequently until the symptoms are better). In my “ Lectures on Diseases of the Heart” I have carefully pointed out the characteristic symptoms and conditions for which Digitalis is indicated. I will therefore only briefly enumerate them. In cardiac diseases it is primarily indicated (in high attenua- DIGITALIN. 233 tions) when the heart is excited and beats with increased force and power, causing congestion of the head, ringing in the ears, flushed face, etc. Such conditions are usually caused by overexertion, overexcitement from the stimulating emotions, certain cerebral irritations, etc. In pure hypertrophy, i. e., with enlargement of the heart-muscle, where allopaths now pronounce Digitalis unsuitable, it may be used with advantage in the 6th dilution. But its chief value is in those conditions which simulate its secondary toxic effects, namely : “ When the muscle of the heart is for any reason unequal to the task set it, the systoles become rapid and imperfect, and by this irregular action the ventricles, neither completely filling nor emp- tying themselves, increase the embarrassment. Under these cir- cumstances, Digitalis, by lengthening the diastolic pauses and in- creasing the force of the systolic contractions, causes the ventricles to fill themselves in the one, and to completely empty themselves in the other act. By subduing irregular action through the in- hibitory nerves, by energizing the muscular power of the heart vessels, the remedy is of incalculable value, and, increasing arte- rial tension all over the body, causes the disappearance or lessen- ing of symptoms due to a low pressure in the arteries.” The Digitalin would therefore be indicated in hypertrophy with dilatation, mitral insufficiency, aortic constriction, irritable heart without enlargement, and many valvidar diseases with cardiac de- bility. There are many cases, and you will meet with them in practice if you watch for them, where the patient seems suffering from a condition known by the vague term “general debility.” There is an atony of all the tissues, and a poverty of all the secretions, due to lack of assimilation of the nutritive elements of food. You will observe in all these cases that the heart appears to be the weakest organ, probably because it is constantly laboring. Now, while you are building up the system with good food, fresh air, gentle stimulation, and such medicines as Nux, Phosphates, Fer- rum, and the like, do not forget to give a special tonic for the heart. It will aid in a wonderful manner other remedies. Thus, if you alternate Digitalin 3X with Ferrum 1* you will succeed YOL. II.—16 234 DIGITALIN. in curing anaemia and chlorosis in half the time you can with Ferrum alone. Digitalin 3* and Phosphate of strychnia 3X act beautifully in alternation in feeble, broken-down constitutions. You can alternate Digitalin with many other specific restorative medicines now that you understand the principle involved. In cardiac dropsy we know that Digitalis is the chief of all remedies. When the heart has become so weakened that effusion takes place in all the cavities and the general cellular tissues (an- asarca), we know of no medicine which will bear any relation to Digitalis in curative power. It has been suggested that Digitalin might act as well as the infusion of the leaves, or the tincture, both liable to deterioration, and at times uncertain in their action. Christison’s experiments prompted him to assert that “ Digi- talin was the most powerful and certain diuretic known,” and that “ its action on the heart, and its diuretic effect, were never coincident.” All the old authors remark that Digitalis is not diuretic until after it affects the heart and pulse. I think there are many cases where you can substitute the alka- loid for the herb and its other preparations. It will sometimes act promptly when the tincture or trituration of the leaves will not, or have lost their virtue. In cases of dropsy from heart disease, begin with 3X trit., in grain doses every two hours. If no action on the kidneys takes place in a few days give the 2* in the same. In spermatorrhoea, and nocturnal emissions from erethism of the sexual organs, it often acts with surprising efficacy. But do not give it as Baehr and Burt recommend, “in grain doses,” unless you use the 3X trit. Digitalin acts on the sexual organs of men much as the Bromide of potassa, namely, it abolishes power and desire. It is therefore primarily homoeopathic to impotency with spermatorrhoea, and secondarily to emissions with overexcitement. I would recommend, from my own experience, its use in delirium tremens, fainting attacks from sudden heart failure, nervous vertigo, collapse from uterine haemorrhage, poisoning from tobacco, Aconite, Veratrum, Mushrooms, Calabar, and other poisons which weaken and paralyze the heart. In fact, you can use Digitalin for nearly all the conditions for DIOSCOREA. 235 which Digitalis is indicated, and it will often act quicker, and as safely, in the proper doses. DIOSCOREA. This plant, which is found in the Middle, Western, and Southern States, climbing; over fences and shrubs, is known by the common names of Wild Yam and Colic-root. The former name is given to it from its apparent resemblance to the edible yam of the West Indies; the latter on account of its virtues in abdominal pain. I have often speculated on the manner in which the curative power of the root was discovered. It is easy enough to imagine why it should have been dug up under the idea that it might be used as an article of food, for its leaves and manner of growth closely resemble the yam used as a substitue for the potato. The root, however, is woody, and very tough and hard, so much so that when dried it is very difficult to pulverize it. How did the first colic patient ascertain its power in that disorder? It must have been by some accident, for it has no aromatic taste, like ginger or calamus, but is intensely bitter, with an acridity like that of Iris versicolor. But however discovered, it had a reputation among the aborigines for curing pains in the abdomen. You will hear the most enthusiastic praises of its power, and country nurses will narrate almost miraculous cures from its use in bilious colic after the patient was given up to die by the attending physician. It is generally given, in domestic practice, in hot infusion, and in quantities only limited by the patient’s ability to swallow. The allopathic school have always ignored it. The eclectics have valued it highly, and homoeopathic physicians who have used it speak well of it in severe and peculiar cases. It has been proved by Burt, Kiehol, and Cushing. The provings by Burt were somewhat surprising. It seemed to affect the whole system in a manner reminding one of rheumatism, but a close study of its action will show that although the pains resembled rheumatism they were really nerve-pains, and generally of a reflex character. It also caused cutting pains in the umbilical region. Dr. Nichol’s proving developed the same abdominal pains, with a good many head and mental symptoms. Dr. Cushing’s provings 236 DIOSCOREA. were heroic, and evolved very many peculiar symptoms. Some eclectic students also proved it, and got severe colic. I am inclined to the belief that its sphere of action embraces the spinal cord and, the reflex nervous system (generall}7), the um- bilical plexus of nerves (specially), and by exalting the reflex ex- citability of the spinal cord it causes pains in portions of the body remote from the seat of the primary irritation. An eclectic writer says it causes hypersesthesia of the spine, brain, uterus, and ab- dominal nerves. Its chief clinical use in all schools is for that condition com- monly known as bilious colic. This name, however, is not the correct one for all the cases designated bilious colic, for many careful observers assert that the liver is not at fault in the ma- jority of cases, the vomiting of bile being only a symptom result- ing from the spasmodic retching. It is only in cases where the pain is caused by the passage of biliary calculi, or other obstruction in the gall-duct, that the name is at all appropriate. It is only another illustration of the law of similars, that the abdominal symptoms caused by Dioscorea resemble the colics cured by it. Both start in the umbilical region and radiate all over the abdomen. All who have written of the value of Dioscorea, outside of our school, coincide in their description of the colic cured by it. They say it is a “ constant pain, aggravated at regular intervals by par- oxysms of intense sufferingthe pain is located at first in the centre of, but is gradually diffused all over the abdomen, attended bv vomiting, retching, furred tongue, distended and sensitive bowels, etc. Now it is evident that no one distinct disease is here repre- sented, but a definite disturbance of the abdominal nervous sys- tem, commencing at a given point (the umbilicus) and radiating all over the abdomen, extending to the stomach, uterus, bladder, and even to the extremities, and affecting both the nerves of sen- sation and motion, causing pain and spasm. _ The fact is that any kind of colic may be cured by Dioscorea, provided the symptoms have any similarity to its pathogenetic symptoms. More than this, it has cured, and will continue to DIOSCOREA. 237 cure, many abdominal and gastric pains not found in the provings. But if you find in any painful affection of the abdomen, stomach, uterus, or even the heart or head, that the pain, though constant, is aggravated in paroxysms; is attended by spasmodic symptoms (vomiting, cramps), or sympathetic pains in distant parts of the body, you can prescribe the Dioscorea with advantage. For in- stance, it has cured headache, remittent, paroxysmal, attended by spasmodic pain in the abdomen; facial neuralgia; cardialgia; spas- modic and flatulent colic; painful tenesmus; spasm of the bladder and uterus ; spasm of the gall-ducts; sciatic neuralgia—the pain running from the hip to the ankles. In addition to these purely neuralgic affections, it has been used successfully in many other disorders, among which are various kinds of heaaache. (For the indications refer to symptoms in Volume I.) The headaches of Dioscorea resemble those caused by JEsculus, Bryonia, Yux vomica, and Cimicifuga. The eye symptoms are quite notable, and Dr. Woodyatt predicts it will prove valuable in some affections of the eye and its ap- pendages. Acne punctata (comedones), according to Cushing, disappeared during the provings. I have used it very extensively in many disorders of the stomach, such as accompany dyspepsia, namely, a dull, wearing pain in the cardiac region of the stomach; inordinate belching of gases; cramps of the stomach and acute lancinations in the stom- ach. It seems to resemble in its action on the stomach Bismuth, Bryonia, and INTux. It is of value in the vomiting, pyrosis, and gastralgia of pregnant women, or when occurring during the menses. My experience accords with that of Dr. Helmuth, who says it is most successful in enteralgia when the pains are twisting, aggra- vated by lying down, relieved by pressure, unless the abdomen is tender. The abdominal pains have a remarkable resemblance to those of Colocynth, and you will often find it impossible to decide which is the remedy. You can only try the one which seems the best indicated for a reasonable time, and then use the other, but never alternate them. It is just as useful in renal colic from passage of calculi as in 238 DIOSCOREA. hepatic colic. In fact, renal colic is often mistaken for bilious colic by superficial observers. You will find it an excellent remedy in diarrhoea, which, like the sulphur-diarrhoea, occurs in the eay'ly morning, driving the patient out of bed. The stools are slimy, jelly like, like white of egg, attended by straining, burning in the rectum, and generally, not always, by the peculiar twisting, lancinating colic in the um- bilical region, offensive flatus, and often nausea and vomiting. This kind of diarrhoea often runs into dysentery, or may be called the first stage of dysentery, especially when the disease is a catarrhal mucous enteritis. In the Dioscorea dysentery the stools are not bloody, i. e., the symptoms do not indicate it for bloody stools, but it will remove its characteristic colics, pains, and tenes- mus without arresting the sanguineous discharge, which may call for Ipecac, or some remedy more homoeopathic to that condition. Cholera morbus, when attended by excruciating abdominal pains, has been greatly palliated by Dioscorea; but as it is not indicated for the watery evacuations, it should be alternated with Camphor or Veratrum. Even in cases of cholera infantum I have often given it for the excessive pain in the bowels which causes the children to scream in agony. In this respect it resembles Cu- prum in all but the cold extremities caused by that medicine. Dr. Burt had haemorrhoids and yellow, thin, bilious stools, with prolapse of the rectum when proving Dioscorea, but no other prover had piles. No clinical experience proving its value in this affection has been recorded, except one observation, by the same prover, that a “ haemorrhoidal tumor of nearly four years’ stand- ing disappeared during the proving.” A medicine that can cause tenesmus can cause haemorrhoids, and you may possibly find it a good remedy in the latter disease. In Cushing’s provings it developed a decided action on the male organs of generation, and, fortunately for practitioners, its primary and secondary action were noted. It first caused strong-smelling perspiration of the genitals ; constant excitement, with strong and frequent erections day and night; and amorous dreams with emis- sions. Afterwards came the reaction,—the genitals became cold and relaxed ; no erections ; desire absent, and emissions in sleep without erections. DIOSCOEEA. 239 Now to prove that my law of dose is trustworthy, I cite Dr. Cushing’s several cures of nocturnal emissions, having the primary symptoms of Dioscorea, which he cured with the dilutions above the 15th ; also Dr. Pease’s case of spermatorrhoea, having its sec- ondary symptoms, which he cured with the 2X trit. of Dioscorea. In respect to its action on these organs, Dioscorea resembles Phos- phorus, Cannabis indica, and Nux vom., and is the opposite of Caladium, Camphor, Agnus castus, and Nuphar, which cause de- pression of the genital functions primarily. Dioscorea will be found valuable in pain and spasm of the sper- matic cord, when the pains commence in the inguinal region, and extend to the testicles and penis. No provings have been made on women, but it has been found useful in dysmenorrhoea, uterine colic, after-pains, and some of the false pains of pregnancy. The symptoms indicate that it may be a good remedy in inter- costal neuralgia, and one physician claims to have cured with it a case of angina pectoris, with “ sharp, cutting pain in the region of the heart, arresting breathing and motion.” Dr. Cushing has cured “ cough, with pain in the epigastrium and temples, brown- ish-yellow tongue, and weak knees.” You may find it of value in some of the protean forms of spinal irritation. It has been recommended in felons and neuralgic rheu- matisms of the extremities. It is a remedy which ought to be still further studied, proven, and used in practice. Much depends on the preparation which is prescribed. I rarely got good effects from the tincture, probably because it was made from the dried root. Others have failed to get the desired results from the tincture. The triturations of the dried root, or of Dios- corein, have acted satisfactorily. In the colic for which it is so useful you may fail with the ordinary preparations, while the in- fusion of the root, made with hot water, will act magically. (One drachm of the pulv. root to giv of boiling water. A teaspoonful or two every 15 or 20 minutes in the worst cases.) Dr. Scudder (“Specific Medicine,” p.128) says the article sold for Dioscorea by most of our druggists for the past ten years, and from which Dioscorem has been prepared, is the root of a species of 240 DORYPHORA EPIGEA REPENS. Smilax. This will probably account for the unreliable quality of some of the homoeopathic preparations. DORYPHORA. The poison of the Colorado potato-bug appears to resemble Can- tharides, with which it is closely allied. I collected many cases of poisoning, some fatal, together with a partial proving by Dr. Ruden, and published the symptoms in the third edition. Its analogues are the narcotic poisons, Belladonna, Stramonium, Agaricus; and the animal poisons, Apis, Lachesis, and Crotalus. I have never used it. The only clinical experience yet re- ported is the cure of a few cases of dysuria, gonorrhoea, and dys- entery. Its pathological effects are more malignant than those of Can- tharis, and less so than Lachesis. You may find it specific in some cases of meningitis, cerebral congestion, ophthalmia, enteritis, malignant erysipelas, anasarca, and inflammation of the urinary organs. The keynote for the selection of this medicine will be the pres- ence of its peculiar urinary symptoms, when occurring in the con- ditions above named. EPIGEA REPENS. This beautiful plant, the trailing Arbutus, around which clusters so much poetry and sentiment, has been used for very non-poetic purposes. Medicinally, it is an analogue of Uva ursi, Mitchella, Chimaphila, Cannabis, and others of that class. No provings have been made of it, but it has been used ever since the settle- ment of this country as a popular remedy in renal calculi, or those conditions supposed to arise from the presence of “gravel.” It has been successful in the removal of dysuria and strangury as well as urinary tenesmus. It seems best adapted to the uric acid calculi. I once used it in a case of that nature; the urine had a bloody, muco-purulent sediment, and there was intense dysuria. After taking the tincture in ten-drop doses, six times a day, a copious deposit of fine brown sand (uric acid crystals) was observed, followed by amelioration of all the urinary troubles. ERECTHITES. 241 ERECTHITES. This plant contains an oil which goes under the name of Oil of Fireweed. But an “Oil of Fire weed” is also extracted from the Erigeron. The true fireweed is, however, the Erecthites, while the Erigerons are “ Fleabanes.” Chemists tell us that the oils from these two plants, as well as turpentine, are chemically identical. This may be true, but it does not follow that their physiological or pathogenetic effects are identical. They are very closely allied, however, in their effects on the human system. All three are homoeopathic to both active and passive arterial haemorrhage; the former is their primary, the latter their secondary effect. The Fireweed has been proven, but not very thoroughly. Suf- ficient symptoms have been obtained to give us a clue to its method of action. It seems to cause primarily an acute congestion of the principal organs of the body. The headache is similar to that caused by Bel- ladonna and China, or that headache which often precedes epis- taxis in plethoric subjects. Had the provings been carried far enough, nosebleed would doubtless have resulted. It is a specific for epistaxis of bright-red blood as well as haemorrhages of similar character from the mouth, lungs, bowels, uterus, and kidneys. The primary haemorrhages of Erecthites, Erigeron, and Turpentine are always attended by excitement of the circulation. In such con- ditions you must be cautious and not prescribe too large doses, certainly not below the 8X. The passive haemorrhage of these medicines is very different in character; it is attended by a torpor and laxity of the bloodvessels, and the blood is darker, lacks fibrin, and deposits a blackish sedi- ment, showing disorganization of the blood-globules. We find this latter form in typhoid fever, Bright’s disease, and other dis- eases of low vitality. In passive haemorrhages you will get the best results from the lx or even drop doses of the oil or mother tincture. The action of Erecthites on the mucous membranes is that of an irritant. It causes burning in the stomach with cramps, nausea, and vomiting ; cramps in the abdomen, with copious yellow diar- rhoea, worse in the morning (Copaiva, Sulph., Dios.). 242 ERECTHITES—ERIGERON. One person was cured of a dyspeptic condition from which he had suffered for some time, namely : “ Eructations and heartburn after eating warm bread and coffee.” In dysentery, when the discharges are pure blood, with fever, colic, etc., alternate the Erecthites with Aconite or Ipecac., and you will soon arrest the disease. In premature and profuse menses it rivals Calc, and Senecio. My favorite method of treating this aberration is to give Calc, or Senecio during the latter part of the month, and when the menses appear give Erecthites or Erigeron until the flow ceases to be ab- normal in quantity. Gonorrhoea and gleet have both been treated successfully by this remedy. It differs from Copaiva and Cubebs in the charac- ter of the discharge, which is always scanty. The inflammation is more like that ofCantharis and Turpentine, with scanty, bloody discharges and great pain. When orchitis occurs during gonor- rhoea, or from suppressed discharges, it is equal to Pulsatilla or Clematis. ERIGERON, Many of the recommendations for the use of Erecthites will apply equally well to Erigeron. For some reason the latter ap- pears to be more popular with the profession. If both were thor- oughly proven we should doubtless get characteristic symptoms; but at present we can substitute the one for the other, especially in haemorrhages, without much fear of failure. We have more decided renal symptoms from Erigeron, and in some cases of nephritis, and in some cases of Bright’s disease I have used it with decided advantage. Dr. Iting once published his successful use of it in dysuria in children. “ They have frequent desire, and cry when urinating ; the urine is profuse, and of a very strong odor ; the external parts are inflamed and swollen.” He used a low attenuation. I have found it excellent in vesical catarrh, with unusual pain and irritation. In uterine haemorrhage it is inferior to no remedy. Eclectic physicians consider it the specific in the worst cases, in doses of ten drops of the oil, repeated every twenty or thirty minutes. 243 ERIGERON EQUISETUM HYEMALE. It is not necessary to use such large doses; 10 drops of the lx is quite sufficient. I prefer the 1* trituration of the oil, or even the 3X, if there is much arterial excitement. It resembles Ferrum in its applicability to active haemorrhage. Of course you will not expect to avert permanently any haemor- rhage from the uterus with this or any remedy, if any foreign substance, like a retained placenta, a polypus, or other matters remain. It may check the bleeding for the time, but the sub- stance must be removed before the patient is safe. We find some rheumatic symptoms in the provings, but if it is homoeopathic to any kind of rheumatism, it is that which arises from some affection of the urinary organs, or gonorrhoea. It has been very highly praised in gonorrhoea and gleet; very many prefer it to any other remedy in that affection. It is said to cure cases which have resisted Cubebs, Copaiva, and other routine medicines. In tympanites occurring during typhoid fever, enteritis or peri- tonitis, I consider the Erigeron, next to Turpentine, the most reliable remedy we possess. I do not know which to give the preference. I can not imagine why both are ignored in our works on practice. They recommend China, Phosphorus, Rhus, and other drugs, which may answer in mild cases, but are useless when the intes- tines become paralyzed by distension. Nor do I depend upon the internal administration alone, but habitually use them in enema, throwing up half a drachm or a drachm, beaten up with yolk of egg, and mixed with a pint or more of milk. The most enor- mous and dangerous tympanites will disappear after a few such enemas. Both Erecthites and Erigeron are analogous to Arnica and Sul- phuric acid in the treatment of contusions and suggillations. Country people use the bruised plant as we use Arnica. A dilute tincture, used in the same proportions as we prescribe Arnica, is an excel- lent topical application in bruises. EQUISETUM HYEMALE. The scouring-bush has been used from time immemorial as a domestic remedy for dropsy, suppression of urine, gravel, hcema- 244 EQUISETUM HYEMALE—ERGOTIN. turia, gonorrhoea, and gleet. An infusion of the stalk is made with hot water and drank ad libitum. It contains a large amount of mucilaginous fluid, and perhaps soluble Silica, both of which may aid in its diuretic effects. Dr. J. S. Marsden, one of our best homoeopathic physicians, writes me that he has used an infusion of the stalks very success- fully in the dysuria of women, with “ extreme and frequent urging to urinate, with severe pain, especially immediately after the urine is voided.” He has also used it in painful urination with albumin- ous urine. It must possess some specific influence over the mucous mem- brane of the bladder. Dr. M. gives his infusion in tablespoonful doses. I would suggest that you try it in the troublesome dysuria of children. I do not know that the dried stalks are efficient, and I would suggest that if you wanted to keep the remedy on hand, yon should make a strong decoction and add one-tenth its bulk of good alcohol. This will make a permanent preparation, which will doubtless be efficacious in drop doses of the crude or first dilution. EKGOTIN. Ergotin was discovered by the chemist Wiggers, and was be- lieved by Professor Sellroff to contain all the medicinal properties of Secale. It has not been used to any considerable extent in this country, and very rarely by our school. In its crude form it looks like an oleo-resin, a thick, syrupy, brown substance, with the pe- culiar smell and taste of good powdered Ergot. The triturations are best made with granulated sugar of milk. In the “North American Journal” for 1859 is to be found a translation by Hoffendahl of a paper on Ergotin by Dr. Kafka, of Prague, who uses the following language: “Just as Atropia is applicable when Belladonna is indicated, but appears insufficient, in the same manner Ergotin is to be used when Secale does not answer our expectations, perhaps because the preparation is not reliable, or the remedy is not sufficiently powerful.” To which I will add that the preparations of Ergot are notoriously unreli- able, especially when kept for a long time. ERGOTIN, 245 The trituration of Ergotin (of Wiggers or Bonjean) is a very- convenient preparation, and will keep for any length of time in any climate. Kafka’s clinical experience with Ergotin was altogether in uterine haemorrhage. lie gives the well-known indications of Secale, namely: “Excessive and protracted menstruation; menor- rhagia ; venous congestion of the womb; haemorrhage from the womb, passive and paralytic, of dark fluid blood, pouring out at every motion or elevation of the body; haemorrhage during and after delivery; haemorrhage from cancer of the womb; insufficient contraction of the womb after abortion; irregular, feeble, deferred, or spasmodic labor-pains.” You will observe that all these symptoms, except the last one, are secondary symptoms of Ergot. Kafka gave for these con- ditions grain doses of the first decimal trituration, which is in accordance with the requirements of my law of dose. The primary uterine symptoms of Ergot are: Very severe, spas- modic, very painful contractions of the uterus, almost continuous; if occurring during menstruation, the flow scanty, only a few drops; if during labor the pains seem to do no good, for the very severity and continuousness of the contractions wear out the mother, and may injure the child; if they occur at other times they are due to some spinal irritation, and are called “ uterine cramps;” also uterine congestion, of an active, arterial character, such as occurs before inflammation sets in. When these symptoms occur you will do injury if you prescribe the first decimal trituration. Keep above the third, not too fre- quently repeated. Kafka gives one case of protracted menstruation, one of hcemor- rhage after delivery, one of climacteric menorrhagia, and one of profuse menstruation. In all these cases this characteristic symp- tom was present: “ Little or no pain, the blood in dark clots, or dark fluid, aggravated by any motion or mental excitement.” In all, Secale 1st was tried, ineffectually, while Ergotin 1st acted promptly. I have used Ergotin occasionally ever since I read that article, and its administration has generally resulted satisfactorily. But I use it in other conditions besides uterine troubles. The recent researches of Brown-Sequard and other eminent ex- perimenters show that Ergot has uniformly this primary effect, 246 ERGOTIN. namely, a contraction of the bloodvessels in every portion of the body. In organs like the brain and kings, the effect is bloodlessness or anaemia. In the uterus and other hollow organs it contracts all their tissues as well as their bloodvessels. The secondary effect or reaction is a relaxation or even paresis of the coats of the bloodvessels; thence, passive congestion, haemor- rhages, relaxation of muscular tissues, and finally their complete paralysis. Brown-Sequard, Hawley, and others claim that Atropia has this same effect upon the bloodvessels of the spinal cord, but I have my doubts. The proofs are not sufficient to satisfy me. ISior is the Atropia useful in any case of haemorrhage, as it would be if its action was similar to Ergot. I know of no drug that acts exactly like Ergot, unless it is Ustilago, a similar fungi. Caulo- phyllum somewhat resembles it, but how close we cannot now determine. In accordance with its pathological effects, and selecting it by its secondary symptoms, I have used Ergotin very successfully in very severe congestive headaches, when they occur in persons of lax fibre, large, phlegmatic, lymphatic individuals, whose blood- vessels are doubtless relaxed and easily distended, almost to burst- ing, whenever the circulation is abnormally directed. Such head- aches usually occur at the climacteric period in women, and in old drunkards of both sexes. The pain seems to rise up into the head from the back of the neck, the occiput first suffers, then it extends all over the head, and the agony and distress, more than the acute pain, become almost unbearable. The face is rather pale and cool than suffused, the extremities cold and livid. (This is not the case when Belladonna or the Bromides are indicated, for the face is hot and red, with throbbing temples.) The congestion is more inter- nal, central, than general or peripheral. Sometimes the head is drawn backwards by almost continuous contractions. In this condition Ergotin, in doses of one-tenth or one-twen- tieth grain (using the lx trit.), given every half hour, soon removes the sometimes dangerous condition. In cerebro-spinal meningitis, when the above symptoms occur, the Ergotin acts very satisfactorily. ERGOTIN. 247 Iii passive pulmonary haemorrhage it acts as well as in uterine, in which my experience accords with Kafka’s. There is another very valuable use of Ergotin, which should not be lost sight of by our school, namely, its value in paralysis. In all the cases of severe poisoning on record, and in all the experi- ments on animals, paralysis is generally a prominent effect of the drug. Yet the old school are now using it extensively in pa- ralysis, and with good results. Brown-Sequarcl was the first to recommend it in a distinct form of paralysis, and to point out the pathological condition upon which the paraplegia depends, and which large doses of Ergot cures. In his admirable brochure, “ Paralysis of the Lower Extremities,” he says : “This powerful remedy has been employed quite blindly, al- though its mode of action being better known than Belladonna, it would have been easier to discern in what cases of paraplegia it is able to be of benefit. Ergot, like Belladonna, produces a contrac- tion in the bloodvessels of the spinal cord and its membranes, and therefore diminishes the amount of blood circulating in these organs. The following is a summary of the indications and con- traindications for its use : “ 1st. Ergot must be employed in cases of paraplegia with irritation of motor, sensitive, or vasomotor nerves, i. e., in conges- tion or inflammation of the spinal cord and its meninges. “ 2d. Ergot must be avoided as an agent only able to increase the paralysis in cases of paraplegia without symptoms of irrita- tion, such as cases of reflex paraplegia, or of non-inflammatory softening of the spinal cord.” These directions for the use of Ergot may do very well for the allopath, but our therapeutics need a broader scope. Let us in- quire Iiow does Ergot cause paralysis ? Evidently by causing such an anaemia of the spinal cord as to diminish or abolish its nutrition, and thereby its vitality. This is the condition which Brown-Sequard describes as being present in reflex paraplegia, and in which he declares Ergot to be injurious. And so it would be in massive doses, but we, who be- lieve in the efficacy of attenuated medicines when indicated, are not confined to the use of Ergot in material doses. I believe, and have substantiated it in practice, that Ergot is 248 ERGOTIN—ERYODYCTON. useful in paraplegia from reflex irritation, i. e., when anaemia of the cord is present, and non-inflam matory softening is imminent. But in such cases the dose must be in the attenuations above the 3X trituration of Ergotin, or above the lx of a good tincture. Although it has been decreed that it may be used, and has been used with apparent success in congestion and inflammation of the spinal cord, I do not think it is safe in large doses if the disease is acute and intense. The secondary action of Ergot is passive con- gestion (engorgement is a better word) of the cord and its meninges. In active inflammation I prefer Veratrum viride, but in passive congestion or chronic inflammation, or even the second stage of spinal meningitis (when of a low type), I am willing to accord a curative value to Ergot, and admit that it must be prescribed in material doses, e.g., the lx of Ergotin, or pulv. Ergot, or drop doses of a good ethereal tincture or a fluid extract, repeated every two or three hours until improvement sets in. In old cases a dose three or four times a day will suffice. Finally, you will find Ergotin a valuable remedy in some ob- stinate neuralgias (sciatica and odontalgia). In nightsweats, in chronic diarrhoea and chronic dysentery, in certain cases of the haemorrhagic diathesis, in hypertrophy of the uterus, in uterine tumors, aneurisms, impotence,spermatorrhoea, and probably varicose ulcers and senile gangrene. ERYODYCTQN. This plant, known in California under its Spanish name of