APPENDICITIS IN CHILDREN. A CLINICAL PAPER. By Irving S. Haynes, Ph.B., M.D., Professor of Practical Anatomy in the Cornell University Medical College ; Visiting Surgeon to the Harlem Hospital ; Member of the New York Academy of Medicine ; of the Society of Alumni of Bellevue Hospital ; of the Harlem Medical Association, New York. APPENDICITIS IN CHILDREN-A CLINICAL PAPER.* IRVING S. HAYNES, PH.B., M.D., Professor of Practical Anatomy in the Cornell University Medical College; Visiting Surgeon to the Harlem Hospital; Member of the New York Academy of Medicine; of the Society of Alumni of Bellevue Hospital; of the Harlem Medical Associ- ation, New York. My intention has been to make this paper more of a clinical than a theoretical one. Restricting myself, therefore, to the types of cases that have come under my own observation for operation, other types which would be necessary to make the paper logically complete will be omitted, but I hope that the gentlemen who shall take part in the discussion of the subject will supply the omissions. The histories of the cases will be given first, and the conclusions follow: Case 1.-Frank D., ten years of age. History.-January 5th, 1894. Boy ate a large quantity of raisins, nuts and such stuff. He was taken a short time after- wards with severe pain in the right side of the abdomen. His mother applied a belladonna plaster. January 6th. Child about the same, pain severe, constipation present. On the evening of the 7th, Dr. S. J. O'Neil was sent for. He found a temperature of 103°, rapid pulse, and pain on pressure in the right iliac fossa. Bowels had not operated. The doctor gave morphia sulphate and applied an ice bag to the seat of the pain. January 8th. The morning temperature was 990; the evening, ioi°. The ice bag was continued. January 9th. The morning temperature was 990; in the even- ing it had raised to 101.20 with a pulse of 110. At this time Dr. O'Neil asked me to see the case with him. Examination.-Child slight for his age, rather ansemic; face shrunken and anxious; abdomen slightly and evenly distended; some tenderness over the entire abdomen, but most marked at * Read before the Harlem Medical Association, May 9, 1898. 2 Haynes: appendicitis in Children. McBurney's point, gradually diminishing as you pass away from this point. Bowels had not operated. Diagnosis.-To the doctor I said: "There is no doubt about the case being one of appendicitis. Judging from the tempera- ture, there is suppuration taking place, and in my opinion, the appendix is full of pus. I should judge from the temperature, pulse and abdominal tenderness that perforation was about to take place. I advise operation, and that as soon as possible." This advice was accepted, and the case was prepared for operation, which was begun at 11 p.m. Dr. Pulley adminis- tered the ether, and Dr. O'Neil assisted with the active work. Operation.-The abdomen was opened by an incision 3% inches long, parallel with the fibres of the external oblique, with its center over the point of greatest pain, and about one inch from the anterior superior iliac spine. The muscles were divided, the hemorrhage arrested and the peritoneum opened. The bowels at once protruded. Gauze pads were used to hold them back and to carefully work down to the appendix, which was found at the right of the caecum covered with a layer of plastic exudation, excepting about half of an inch of its distal ex- tremity, which projected directly forward. The appendix was distended with fluid so that it was nearly as large as my index finger. It was carefully liberated from its bed, ligated at its base and removed. During the manipulations to free the ap- pendix and raise it up for ligation, its contents were squeezed into the caecum, excepting a few drops which escaped through a minute perforation already present near the end of the organ, and which had been covered by the exudation. The stump of the appendix was thoroughly cauterized with pure carbolic acid. The iliac fossa sponged out with carbolized solution. Considerable peritoneal fluid came into the field of operation, and had to be frequently removed. The peritoneum was sutured with catgut. The transver- sals and internal oblique were sutured as one layer, and the ex- ternal oblique as another, with continuous sutures of catgut. The skin was stitched with interrupted sutures of silk. No drainage was used. Usual external dressings. Operation well borne. The appendix was opened and found to contain a few drops of very foul-smelling pus, the mucous membrane was necrotic for its entire area, and a point of perforation covered by plastic lymph where there would have been escape of the con- tents of the appendix in a few hours at longest. January 10th. Morning temperature, 101.4°; pulse, 120; evening temperature, 102. iQ; pulse, 130. Considerable pain over abdomen; bowels had not operated; enema of magnesium sulphate, followed by a wine glassful of magnesium citrate every two hours until free catharsis. January 11 th. Several movements from the bowels; abdo- minal tenderness diminished; everything favorable. Haynes: appendicitis in Children. 3 January i3th, 7 p.m. 1 saw patient with Dr. O'Neil, temper- ature, 103. i°; pulse, 130. Tongue dry and cracked. Wound dressed. Serum was escaping from the lower angle, parts were red and swollen. Three sutures were removed, and about a tea- cupful of foul pus escaped. Several sutures also removed from the upper part of the incision, and considerable pus evacuated. The abscess did not lead to deeper parts, it was only subcuta- neous. The abscess cavities were washed out and drained with rubber tubing. The case responded immediately and recovery was rapid. By the 21st of January the child was out of bed. Summary.-Cause, overindulgence in indigestible substances. Pain, severe from the beginning, and localized at McBurney's point. Temperature, highest 103°, on evening of second day of the attack. Duration of attack before operation, four days. In bed twelve days. Entire sickness covered sixteen days. The appendix showed suppurative appendicitis, gangrene of mucous membrane, perforation nearly completed and only arrested by a thin covering of plastic exudation. No attempt on Nature's part to limit the spread of the infection by walling off the inflamed area with matted intestines. Present State, May, 1898.-1 have not seen the patient, but Dr. O'Neil says the boy is in perfect health, and that the ab- dominal wound has remained solid. Case II.-Stella M., eleven years of age. History.-July 19, 1896. Taken sick with pain and tender- ness in the right lower abdominal region. July 22d. I saw the case with the family physician, Dr. A. J. Kuehn. Examination.-The abdomen was slightly distended, and an ill-defined mass in the right iliac fossa. The right rectus and abdominal muscles were rigid. The entire abdomen was tender, but more marked in the region of the appendix. The tempera- ture was 1020, pulse 160. Child's face had an anxious look. Diagnosis.-Suppurative peritonitis due to perforation of a diseased appendix. Immediate operation proposed. Treatment.-Child taken to the Harlem Hospital and operated upon as soon as the necessary preparations could be made. The usual incision was made. As soon as the peritoneal cavity was opened, thin yellowish fluid with whitish flakes escaped with a rush. All parts of the abdominal cavity were thoroughly irrigated with hot saline solution by means of a large-sized in- trauterine, glass douche tube. The appendix was freed from adhesions and brought into the wound. It showed a perforation at its tip, and another one 4 Haynes: appendicitis in Children. inch from the first. The mesentery was ligated and divided. The base of the appendix was encircled with a silk suture passed well in the coats of the caecum; the appendix was clamped and divided near the caecum, and the distal portion removed. The stump was now inverted into the caecum, and the previously introduced suture tied. This puckered the per- itoneum nicely, and closed the orifice of the inverted appendix. A second continuous silk suture was introduced for safety; burying the first. The omentum had attempted to cover over the appendix, but had not succeeded, and a thickened portion adherent to the appendix, about two inches square, was re- moved. The abdominal cavity was treated to pure hydrogen per- oxide poured directly from the bottle into the wound. This was followed by the saline irrigation. A small iodoform gauze wick was placed about the site of the appendix, and let out of the lower angle of the wound. The peritoneum and mus- cular layers were separately sutured with fine silk, and the skin with silk-worm gut as far as the drain. The aristo-col- lodion dressing applied. On the second day the abdomen was distended, the note over the liver was tympanitic. The gauze wick was removed as it was feared that the drainage was not good, although the temperature was normal. There was no retention of pus. A second small gauze drain was introduced; the remaining part of the wound was neatly closed with a silk-worm gut suture. The distention of the abdomen was caused by gas in the in- testines, due to paralysis of their muscular coats from the peritoneal infection. An enema of hot saline solution contain- ing ten grains of quinine given. Result was good; patient passed flatus and faeces and the abdominal distension disappeared. Strychnine had also been given from the very first. Discharged August 22d, with a small sinus, which closed in a short time. Summary.-Cause, none assigned. Pain, severe and in the right iliac fossa. Temperature on entering hospital, 102°, pulse, 160. All the signs of general septic peritonitis due to a perforated appendix. Operation and recovery. Duration of attack before operation, four days. In the hos- pital, one month. Present Condition, May 7, 1898.-Child has grown very rapidly. Scar bulges somewhat, but seems generally firm. No point of hernial protrusion. Case III.-Julia R., aged three years. History.-Father died of phthisis. Mother was also infected and died this year from tubercular laryngitis. Child has been Haynes: appendicitis in Children. weakly from birth, and subject to constipation. About September 14, 1896, child felt badly. Was temporarily relieved by castor oil. Vomiting, fever, and pain over the abdomen set in. She was ex- amined by Dr. Sharp, the family physician, who pronounced the case one of appendicitis and advised removal to the hospital. The child was admitted to the Harlem Hospital on the afternoon of September 21 st. Temperature 102°, pulse 140, respirations 32. Face flushed, tenderness over the entire abdomen, very restless. Treatment.-Enema administered, strychnine hypodermi- cally with whiskey. Operation conducted as previously outlined. Pus escaped as soon as the peritoneum was divided. The pus was not walled in, but was free in the abdominal cavity. It was thoroughly removed by copious irrigation with saline solution; then peroxide of hydrogen, and with saline a second time. The appendix was gangrenous; had ruptured in several places; was adherent to the intestines and so soft that it had to be removed piecemeal. It offered no substance for applica- tion of a ligature, and as the opening into the caecum seemed to be firmly closed, none was applied. The base of the appendix and the surrounding tissues were thoroughly treated with pure peroxide of hydrogen and the abdominal cavity again flushed with the hot saline solution. Drainage was applied by strips of iodoform gauze placed over the caecum and left at the lower angle of the wound. The peritoneum, muscles, and skin were closed en mass with through and through silk-worm gut sutures. September 22d. Temperature ioi°, pulse 120, respirations 30. Beef tea retained. Dressings changed. The gauze drain was removed on the 26th, and a fresh one inserted. Case made a fair convalescence. Discharged October 9th, with wound healed. Ten days later the wound reopened and a slight dis- charge of pus followed. On the 20th, vomited and was restless. On the 21 st, abdomen was tender on the left side. Bowels were freely moved by calomel in divided doses. The sinus was en- larged and a small abscess cavity drained with a rubber tube. This was retained until November. By December the sinus had healed. The scar was a weak one, however, on account of fail- ure of close apposition of the peritoneum and the layers of the abdominal wall, and a hernia as large as a hen's egg had ap- peared. The child was readmitted to the hospital on January 5th, '97, and an operation performed for ventral hernia, the details of which I do not care to introduce here at this time; suffice to say that she was discharged on January 22nd, with a firm scar which has remained perfect to this date. Summary.-Cause, none stated; possibly tubercular. Pain, diffused over the abdomen. When admitted there was general septic peritonitis. The appendix was gangrenous and had several openings in it. 6 Haynes: appendicitis in Children. Recovery with ventral hernia into the scar. Hernia cured by later operation. Duration of sickness preceding operation, one week. Time in hospital for appendicitis, eighteen days. Treated as out-patient for six weeks before sinus closed. Present Condition.-Child has grown fat and healthy. Ab- dominal scar firm, not tender. No sign of hernia. Case IV.-Agnes B., seven years of age. History.-January 12th, 1897. While eating figs patient was seized with pain in the right lower abdominal region. This continued with fever and prostration, the patient steadily grow- ing worse until the 17th, when Dr. Eynon was called. He had the child taken to the Harlem Hospital. Examination.-Temperature 102.8°, pulse 118, respirations 26. There was rigidity of the right rectus muscle, and the ab- domen was tender to pressure, especially in the region of the appendix, where an ill-defined swelling was found. Operation.-The usual incision three inches long in the right iliac region. Pus flowed as soon as the abdominal cavity was opened, but the abscess cavity was walled off from the general abdominal cavity by adherent coils of intestines. The usual irrigation of saline, peroxide of hydrogen and saline solu- tion. The cavity was sponged dry, the appendix freed and brought into the wound, its mesentery ligated and the appen- dix removed. An attempt was made to invaginate the stump of the appendix into the caecum, but the tissues were so much thickened with inflammatory exudate that it was impossible. The stump of the appendix was then ligated and its mucous mem- brane destroyed with carbolic acid. The abscess cavity was then irrigated for the last time, a strip of iodoform gauze placed about the stump of the appendix and the caecum and left at the lowest portion of the incision. The peritoneum and muscular tissues were then sutured separately and in accurate apposi- tion as far as the drain. The wound dressed as usual. The appendix showed thickened walls, a perforation on one side, and it contained a faecal concretion about the size of a pea. January 18th. At 4 p.m. temperature 105.8°, pulse 128, and respirations 45. Patient was delirious all night, but retained medicines and milk. January 19th. 7 A.M. temperature 101.4°, pulse 122, respira- tions 22. Patient passed fairly good night, slept about four hours. Complained of pain in abdomen. Retained all medicines and nourishment. In the afternoon the dressings were changed. Gauze drain loosened up and partially removed. Wound doing nicely. Improvement progressed steadily. Developed a hard cough, treated by the muriate and carbonate of ammonium and Tr. opii camphorata. Temperature fluctuating between 99° and ioo° up to the 21st. Haynes: appendicitis in Children. 7 when the gauze was removed. From now on the temperature fell, reaching normal on the afternoon of the sixth day, January 22nd. Light diet begun in addition to milk. Movements several each day. Cough troublesome, temperature rising to 990 for highest, but mostly normal up to the ninth day, January 26th. Cough better, temperature normal all day, pulse running about ioo°. Course now uneventful to complete recovery. Wound healed rapidly with exception of a small sinus. Dis- charged February 12th, with small sinus; February 19th, sinus healed. April 5th. Came to office. Small sinus persisting. This remained open until the first week in May, when the end of a silk suture appeared in the wound; this was removed and the sinus closed at once. Summary.-Cause, assigned to eating figs. Pain, in usual location. Fever and prostration. Localized suppurative peritonitis due to ruptured appendix. Duration of attack preceding operation, one week. In the hospital, twenty-five days. Time until loosening and removal of silk suture and permanent healing of the sinus, about four months. Present State.-Child seen May 6, 1898. In perfect health, has grown rapidly since the operation. The scar is perfectly solid, and no signs of weakness or hernia. Scar and right iliac fossa not sensitive to deep pressure. Case V.-Edward R., about fourteen years of age. History.-Boy, an inmate of the House of Refuge. Was con- fined to the bed with abdominal pain, tenderness and fever for several days. The tenderness was not typical in its location, being in or near the median line. The case was in the service of Dr. Van Santvoord, who transferred him to the Harlem Hos- pital, January 16th, 1897. Examination on Entrance.-Temperature 102.8°, pulse 122, respirations 24. Marked pain all over the entire abdomen, but greatest in the right iliac region. The abdominal muscles were very rigid, especially on the right side. Face, drawn, anxious, and dusky. Operation.-On opening the abdomen by the usual incision pus and fluid at once flowed from the wound. The entire abdominal cavity was filled with a thin yellowish fluid. Saline solution, peroxide, and saline irrigation freely used to remove it. The perforated, gangrenous appendix was removed as quickly as possible by simply ligating it close tqthe caecum. The stump was cauterized with pure carbolic acid. Abdominal cavity again irri- gated, iodoform gauze drain inserted so as to drain pelvic cav- ity, and the region about the ascending colon and caecum. The abdominal wall was closed in separate layers as far as the drain. During the operation whiskey and strychnine were freely given. 8 Haynes: appendicitis in Children. After removal to the bed an enema of half a pint of saline solution, with ten minims of Tr. digitalis and two ounces of whiskey was given. In spite of free drainage, and full stimulation the boy died on the 18th. Summary.-Cause, not stated. Pain, near the middle line not directed towards the appendix until after it had ruptured. Marked muscular rigidity especially on right side. Case of general suppurative peritonitis following perforation of an inflamed appendix. Operation, drainage, death on second day. Case VI.-Edith L., aged seven years. History.-This is rather indefinite as at the beginning of her sickness she was prescribed for by one physician, and as she temporarily improved, she was under no medical supervision until the day before her entrance to the hospital. As obtained the child did not vomit at the beginning and she was not sick enough to go to bed, but was dressed and up and about, lying down at times on a sofa. She was not well, but complained very little. She was in this condition for about five days, when being taken worse with vomiting and pain on the right side of the abdomen, a second physician was called in, who recognized the nature of the attack and had her removed to the Harlem Hos- pital. Examination on Entrance.-July 17th, 1897,9 A.M. Tempera- ture 99.4q, pulse 104, respirations 26. There was a tumor in the right iliac fossa, oblong in shape, about two by three inches, tender to pressure. The general symptoms were so mild that 1 told the house staff that only for the presence of the tumor 1 would not operate then. Yet, inasmuch as the tumor was present it was probably formed of matted coils of intestines, and possibly there was a small abscess present, but I expected to find only a catarrhal appendicitis. Operation.-On opening the abdomen by the usual incision, the appendix was found immediately beneath and adherent to the peritoneum and surrounded by agglutinated coils of intestines. The omentum was also present and formed adhesions about the appendix and intestines. There was no pus present, though we were greatly surprised to find the appendix gangrenous throughout its entire extent, and only covered over by a thin layer of plastic exudation. Its walls ruptured in several places when its removal was attempted, but the surrounding parts had been protected by a packing of gauze pads. The base of the appendix and the adjacent wall of the caecum were much thick- ened and were very hard and stiff from inflammatory exudation, and it was impossible to invaginate the appendix into the caecum so the old method of ligating the appendix and cauterizing the stump was performed. The portion of the appendix removed Haynes: -Appendicitis in Children. 9 was about three and a half inches in length and from one-fourth to three-eights of an inch in diameter, and showed several per- fections. The wound was irrigated with pure peroxide of hydrogen and all the little pockets were thoroughly separated without rupturing the adhesions, and the peroxide allowed to penetrate to them; then the saline solution was turned in and the parts washed clean. The caecum at the base of the appendix looked so very bad I feared that the spot would slough out and a faecal fistula result. With this in view the caecum was carefully surrounded with iodoform gauze, which was brought out at the lower angle of the wound. The abdominal walls were sutured through and through with silk-worm gut. The course of the case was most satisfac- tory. The highest temperature was ioi° at 4 p.m., on the day of the operation, and the pulse 130. The temperature and pulse reached normal on the third day and remained so thereafter. On the fourth day the gauze drain was removed and two small sized rubber tubes side by side introduced. The recovery was rapid and the wound healed without a single drawback. She was discharged cured, August 4th. Dura- tion of attack before operation, about one week. Time in the hospital, eighteen days. Summary.-Onset, without characteristic symptoms, and those present very mild. Almost normal temperature and pulse even, with the appendix gangrenous for its entire extent. Absence of pain of any amount until the day before the oper- ation. Localized plastic peritonitis, gangrenous appendicitis, operation, recovery. Present State.-Have not been able to trace the patient. When discharged from the hospital she had a firm scar. In generalizing I shall confine myself to the cases here reported; as these are all of the severer types our considerations will not be complete in that those milder forms of appendicitis which recover without an operation being really indicated are omitted. Of the cases given, five were females, one a male. The oldest was fourteen, the youngest three years of age. The shortest duration of sickness preceding the operation was four days, (two cases) the longest seven days (four cases). The onset of the sickness was marked with localized pain in the right iliac fossa in four cases, sufficient to direct the atten- tion of the parents to this spot. In one case there was more of an uneasiness all over the abdomen, which later become localized in the usual place, and in another case the pain began about the middle line of the abdomen and did not be- 10 Haynes: z/lppendicitis in Children, come localized until the appendix was on the point of rupturing or had ruptured. The temperature and pulse records are not available from the beginning of the attacks, they are therefore given as found a few hours preceding operation. Classifying the cases according to the conditions found in and about the appendix we find: one case where the appendix was distended to bursting with pus, but rupture had not taken place. Here, the temperature in the morning was 990, and in the even- ing a short time before operation 101.2°, with a pulse of 110. A second case showed a gangrenous appendix perforated in several places, but the perforations soldered temporarily with plastic lymph. The temperature was 99.4° and the pulse 104. The third case showed the appendix ruptured with a localized abscess. Here the temperature was 102.8° and the pulse 118. In the three remaining cases the appendix had ruptured into the peritoneum and a general septic peritonitis was present. One case had a temperature of 102°, and a pulse of 160. Another, a temperature of 102°, and a pulse of 140. The last, a tem- perature of 102.8°, and a pulse at 122. Considering the prominent constitutional symptoms of dis- ease, temperature and the pulse, we see that appendicitis is a disease of very low temperature and pulse rate. The tempera- ture and pulse do not reflect the serious nature of the inflam- mation until perforation of the appendix is imminent or has already taken place. This fact increases the difficulties of diag- nosis and may give the physician a feeling of security which may be suddenly disturbed by the perforation of the organ and the lighting up of a general septic peritonitis. We cannot pin our diagnosis, then, to the pulse and tempera- ture; in fact there are no one or two symptoms which can be decided upon as pathognomatic; we have to consider all the evidences in each case and then perhaps are undecided. Other constitutional symptoms are the facial appearance of the child; this is especially marked in cases that have developed peritonitis. It is not diagnostic in the mild cases, and at best is only suggestive of a severe or mild sickness, yet the considera- tion of the facies should not be overlooked. The local symptoms are by far the most important and are those upon which we must make our diagnosis consulting the Haynes: appendicitis in Children. 11 state of the temperature and pulse for confirmatory evidences. It is of the greatest importance that the examination of the abdo- men should be thorough and productive of results. In examin- ing children gentleness is the first requisite; this is especially true in abdominal affections, therefore be gentle with the child. Uncover the abdomen, look it over, noting the state of fulness; if it is distended in one part alone or generally. Consider the manner of respiration, whether the abdomen rises and falls, showing that the diaphragm is working, or whether the breath- ing is thoracic alone, indicating that the diaphragm is inhabited by the peritoneal inflammation. Percussion.-Percuss the left side, gradually working around to the location of the most tender region. The percussion should be light at first, and if no information is obtained, then stronger to locate deeper foci of inflammation. Percussion is chiefly useful in detecting the extent of the gaseous distension and the degree of tenderness of the bowels. As a means for locating an appendicular tumor or abscess, it is of slight usefulness, as there may be a localized abscess giving a tympanitic note, because it is covered by coils of intestines filled with gas. If a tympanitic note is obtained in the region of the usual liver dulness it shows that the intestines are greatly distended with gas or that it has escaped through a per- foration into the abdominal cavity, and indicates a most serious condition. Palpation.-Lay the whole hand gently upon the abdomen on the side away from the painful spot as told by the child. Do not make point pressure with the fingers but carefully depress the abdominal wall with the flat of two or three fingers. In this examination note the ease with which the abdominal wall can be depressed, the degree and area of tenderness, and especially the state of the muscles themselves, whether they are flaccid all the time or contract on deep pressure, or if they contract when making a superficial examination showing increased irritability, or if they are in a state of reflex spasm all the time. The degree and area of this reflex muscular contraction or spasm is a very valuable indication of the intra-abdominal con- dition. The more severe the inflammation and the greater its ex- tension from the original focus, the more general and acute the muscular spasm. In most cases you will find a point where the 12 Haynes: in Children. tenderness and pain are greatest; this is usually at the place des- ignated as " McBurney's point," one-third to one-half of the dis- tance from the anterior superior iliac spine toward the umbilicus. The degree of sensitiveness at and about the appendix gives us a clue to the condition of that organ. The more sensitive it is the more acute the inflammation, as a rule. After perforation has taken place the local signs are masked by the general ones im- mediately lighted up. In most cases you will not find a well-defined tumor but a state of fulness which is very suggestive, for it means that the intestines are being massed and matted together and their per- istaltic movements inhibited by the irritation of the inflamed appendix. With a well-defined tumor you expect to find a localized abscess or coils of agglutinated intestines surrounding the ap- pendix. With an abscess already formed besides the tumor which it produces, there may be a sense of imperfect fluctuation but unless there is considerable fluid in the abscess, or it be formed close to the surface, or the reflex muscular rigidity of the abdomen be slight, you cannot detect fluctuation. This is a symptom of little value at all events and is not necessary to the diagnosis. Diagnosis.-The symptoms which are most useful in deter- mining the state of the inflamed appendix, and especially those which point to an early rupture of the tube, are these: there will be abdominal tenderness, usually not extending beyond the median line with its most sensitive area over the appendix; there will be found reflex muscular rigidity of the right abdo- minal muscles, this reflex contraction becoming more marked as you approach the right iliac region. If you can press the abdo- minal wall backward sufficiently far you may detect a tender mass, oblong in shape, in the region of the appendix, which is probably that organ. But I would warn you against making such pressure as will hurt and alarm the child, or even in making too much pressure in any case, as from the histories previously given you will see how early perforation takes place, and in- judicious and too forcible pressure may rupture an already thinned and distended organ. I do not think it wise, therefore, to try and palpate the appendix in all cases, unless as a prelimin- ary examination just before an operation, but to determine its Haynes: appendicitis in Children. 13 probable condition by careful palpation of adjacent parts, for they in their tenderness and spasm reflect the degree of inflammation present in the appendix. In connection with the question of threatened perforation of an appendix giving the symptoms of an acute inflammation the temperature and pulse offer a clue; before perforation the tem- perature may range from 990 to ioi° F., and the pulse from too to no; but as soon as perforation has taken place, although the temperature may only show a rise to 102° or 103°, the pulse jumps up to 140 or 160. So in a case of tender abdomen, rigid right rectus and abdominal muscles, severe pain on pressure over McBurney's point with or without a tumor, with a tem- perature not far from ioo°, but with a pulse relatively constant to it at about 110, although it may be full and bounding, you may be sure that rupture has not yet taken place but is very near at hand, and an early operation is demanded. If rupture has taken place into the peritoneal cavity the changes in abdominal symptoms are more in degree than in kind; the tenderness increases and spreads all over the ab- domen, though it is greatestover the region of the appendix; the entire abdomen is hard from the contraction of the muscles, though the spasm is still more marked to the right of the median line; a tympanitic note may be obtained in place of the normal liver dulness, the respiration is thoracic, the temperature at first shows very little disturbance, be- ing between 102° and iO3°;the pulse, however, has chang- ed markedly and will be running at the rate of 140 to 160; it is thin, hard and wiry; in fact, the pulse usually described as that of peritonitis. The appearance of the patient with general septic perito- nitis is characteristic; there is a striking shrinkage in the face; it is drawn and anxious, in fact, the so-called Hippo- cratic visage. Cases which begin very mildly may present the most serious conditions on the operating table, as did Case VI. This child laid about the house for a week before developing alarming symptoms. Case V. also, who was sick with indefinite ab- dominal symptoms for several days, and then in a few hours presented the evidences of septic peritoneal infection. You must be on your guard, therefore, for these so-called mild and 14 Haynes: appendicitis in Children. indefinite cases may very unexpectedly become the most dangerous. The case that died was in extremis when placed on the oper- ating table and the operation was undertaken to save life, as death was sure without it. Some surgeons advise to let such cases alone, saying that they will die anyway and to use the knife only discredits the operation. But I do not think we can afford to become the judges in such cases and sentence the patient to a certain fatal termination, especially for the reason assigned. Our judgment may prove true in the great majority of cases, still we have the satisfaction of knowing that we have done our utmost, and in those few cases which live we have the greater satisfaction of knowing that we have been instru- mental in saving life. Therefore give the desperate cases a chance to fight for their lives, even at the risk of in- creasing our death rate. It may help you to my way of thinking to know that in seven cases of severe general septic peritonitis following perforation of the appendix occurring in children and adults upon whom I have operated, four patients recovered and three died. Of the other cases, nine in number, all recovered. Regarding the Operation Itself.-If time permits, the patient is to be carefully prepared by securing an opera- tion of the bowels, scrubbing the abdomen and the use of an anticeptic dressing, with the careful administration of stimulants, such as whiskey, strychnine and digitalis, if necessary. The details of preparation for the operator, as- sistants and patient just before the operation are too well known to need repetition here. I would say this, that after the preparations are all made only decinormal salt solution is used for irrigating the parts. The incision by preference is made in a line parallel with the fibres of the external oblique, about one inch from the anterior superior iliac spine with its center over McBurney's point. The length of the incision is of little moment. It is better to make the incision long enough at the beginning than to lacerate the soft parts by forcible retraction, or to have to enlarge the original incision during the operation. From two to three inches is enough, according to the size of the child. In cases of mild catarrhal appendicitis the very small incision may be sufficient, Haynes: appendicitis in Children. 15 but 1 hold that to attempt to disengage and remove a swollen appendix through a small incision is poor surgery, because of the danger of rupturing this organ by the manipulation neces- sary for such procedure. In children it is better to divide the transversalis and internal oblique in line with the external oblique, because the interval between the anterior superior iliac spine and the linea semilu- naris is not great enough for the performance of the operation advised by McBurney in adults, of separating the muscles in the direction of their fibres. Make clean cuts through these muscles for the entire extent of the skin incision. Reaching the peritoneum, pick it up between thumb forceps and divide it, keeping in mind that often the intestines are tightly adherent to it. Having entered the abdominal cavity you proceed according to the case. If a simple case without adhe- sions, bring up the appendix, ligate its mesentery, place a con- tinuous sature in the caecum about its base, clamp the appendix and divide it a fourth of an inch from the caecum; while the appendix is being divided, have the purse-string suture tight- ened, sponge off the end of the stump of the appendix with pure carbolic acid, invert it into the caecum, tie the encircling suture, then insert a continuous suture at a little distance from the first, so as to cover it in. Suture the peritoneum with fine chrome catgut, the trans- versalis and internal oblique, as one muscle, with a little heavier strand, and the external oblique with a similar one. In handling the external oblique be careful not to strip it from the deeper parts, as by so doing you tear off its blood supply and favor necrosis of the fascia. Suture the skin with plain sterilized catgut. Seal with aristo-collodion. The case will not need attention for two weeks. If the appendix is found buried amid coils of intestines, these must be carefully separated, remember- ing that at the center of such a mass you may find a pus-pocket, hence the necessity of first carefully walling off the general abdominal cavity with gauze pads, each one of which has a tape sewed to it and a clamp fastened to the tape. If the appendix is found still whole remove it as just indi- cated. If the caecum and stump of the appendix are so thickened by the inflammatory exudate as to render the inversion impossi- sible, one plan is to do the old operation of ligating the appendix and cauterizing the stump with pure carbolic acid; the newer 16 Haynes: appendicitis in Children. and better way, but which I have not tried yet, is to cut off the appendix level with the caecum and close the hole with two rows of continuous Lambert sutures. Of course, in the last case you run the risk of having the con- tents of the bowel escape, but by compressing the caecum before the division and keeping the part tightly grasped by the assist- ant, this risk is diminished. If the appendix has ruptured and a localized abscess formed, remove the appendix, or as much of it as possible, dealing with it according to the preceding plans. In your anxiety to be thorough do not tear up the protecting ad- hesions, unless absolutely necessary to complete the opera- tion. As soon as such an abscess cavity is opened, wash it out with saline solution, then with pure peroxide of hydro- gen, followed by more saline, then dissect out and remove the appendix. Such a case as this should be drained, and the best drain is gauze, plain or iodoformized, around which has been wrapped thin rubber tissue. This is the cigarette-rubber-gauze drain of Morris. If you find that the appendix has ruptured and discharged its contents into the peritoneal cavity, it is necessary to flush it out, and nothing is any better than a glass intrauterine tube with a diameter of half an inch. Pass this tube up to the spleen, to the liver, into the left iliac fossa, into the pelvic cavity, and use quarts of hot sterilized salt solution, wash until the fluid returns perfectly clear, then turn in pure hydrogen peroxide and remove this with a second saline irrigation. Sponge out the excess of fluid, place your gauze dam and deal with the appendix. Drain such a case. If in doubt, drain, if not needed it can be removed in twenty-four hours and no harm result. If needed, but not used, you will lose the patient, as a rule. In closing the abdominal walls around a drain you follow the same steps as given in the first case, closing the layers separately as far as the drain, and protecting the sutured portion of the incision with the aristo-collodion dressing. In case the patient is in extremis and haste must be made, do not bother with refinements. Cut quickly into the abdominal cavity, flush it out, ligate and cut off the appendix, turn in the peroxide of hydrogen, and irrigate again. Insert the drain, placing the gauze about the stump of the appendix. Close the abdo- Haynes: appendicitis in Children. 17 minal wound with silk-worm sutures through everything. If the patient lives and a hernia results, you can repair the abdominal wall at some future time. Life is at stake, and death will win unless you can defeat him by fast work and removal of the in- fection. 1125 Madison Avenue. FROM ARCHIVES OF PEDIATRICS A Monthly Journal Devoted to Diseases of Infants and Children. Edited by FLOYD M. CRANDALL, M.D. " Pediatrics is the specialty of the general practitioner." Volume begins with January. Sub- scriptions may begin at any time. $3.00 a year in advance. E. B. TREAT & CO., Publishers, 241 -243 West 23d Street, New York.