PARACENTESIS THORACIS. %vl %mlp\B of Chmttj-Jiiw Casts OK PLEURITIC EFFUSION, IN AVHICII THIS OPERATION WAS PERFORMED. READ BEFORE THE BOSTON SOCIETY FOR MEDICAL OBSERVATION, NOVEMBER 22, 1853. BY HENRY I. BOWDITCH, M. D., ONE OF THE PHYSICIANS OF THE MASSACHUSETTS GENERAL HOSPITAL, AND MEMBER OF THE SOCIETIES FOR MEDICAL OBSERVATION AT PARIS AND BOSTON. NEW YORK: BAKER, GODWIN & CO., PRINTERS, CORNER NASSAU AND SPRUCE STREETS. 1853. ^ S PARACENTESIS THORACIS. An analysis of twenty-Jive cases of Pleuritic Effusion, in which this operation was performed. By Henry I. Bowditch, M. D., one of the Physicians of the Massachusetts General Hospital, and Member of the Societies for Medical Observation at Paris and Boston. In 1851 I presented to the Society, and subsequently published, some cases* in which Paracentesis Thoracis had been performed. I propose, in this paper, to continue the consideration of that subject. For this purpose, I shall present an analysis of my preceding paper, together Avith the records of sixteen more cases, in which I have operated or have seen others operate, since that publication. I shall give a tabular statement of some of the prominent features of the tAventy-five cases which have fallen under my no- tice since April 17, 1850, with several inferences therefrom, and shall con- clude with a brief account of a paper on the subject, published recently (Oct., 1853) in the Archives Generates de Medecine. Analysis of my Previous Paper. In the paper above alluded to, I briefly stated the facts relative to the history of the operation, and to the state of medical opinion on the subject. The operation, having been suggested by earlier Avriters, has never been used freely until since Laennec's discovery has enabled us to make our diagnosis more accurate than was possible without auscultation. Since 1843, Trous- seau, Barby, Reybard, Schuh, Raciborski, and others, have performed it on the continent of Europe, while Messrs. Hughes and Cock, Hamilton Roe, &c, have operated in England. There has been, however, an unwillingness on the part of the great body of the profession, in Europe and this country, to look upon the operation with favor. My own experience had, however, led me, for many years, to think that some method should be devised for tho easy and safe removal of fluid effused into the pleural cavity. I had seen patients die from simple effusion, I had seen others gradually fall in phthi- sis, or slowly recover, after perhaps years of misery, with a distorted trunk and shattered health. I asked the surgeon's best aid—by the scalpel. The result was very unsatisfactory. Finally, from Dr. Wyman, of Cambridge, I learned the use of the small exploring trochar and canula, as he had applied it a few weeks before, in the case of one of his patients. I saw, at a glance, * American Journal of Medical Sciences for April, 1852. Article on Paracentesis Thoracis, previously presented to the Boston Society for Medical Observation. 4 BOWDITCII ON PARACENTESIS THORACIS the great value of his method. A full description of it may be found in my first paper. It is sufficient, for my present purpose, to say that a strong exploring trochar and canula have, in all the cases I shall present, been in- troduced, usually between the 9th and 11th ribs, and beloAv the angle of tho scapula. To this canula, by means of an air-tight apparatus, a strong suc- tion pump has been attached, and the fluid has been draAvn out, without the possibility of the introduction of air, while the aperture that has been left has been so minute that no blood has flowed, and it has immediately closed on the AvithdraAval of the instrument. In that paper, I gave the details of eight cases. The prominent points of these cases may be seen in the tabular statement in this communication. The results to which I arrived, from my previous thought on the subject, and from the examination of the cases, may be best expressed by the follow- ing extract from the preface : " My OAvn mind is decided upon the following propositions: I shall puncture the chest; first—whenever, either in an acute or chronic case, I find a pleural cavity distended or filled with fluid; second—whenever, in any acute case, remedies seem to have but little effect towards causing an absorption of the fluid, and after a fair trial has been made of them for two, three, or four Aveeks ; third—I shall puncture in cases of larger effusion, complicated with organic disease, in the hope of relieving urgent dyspnoea or to lengthen life." Upon these principles I have acted since they were laid doAvn. The only change I should make in them, at the present time, with the experi- ence of the results of twenty-nine punctures made in the sixteen new cases is this, A-iz. I would not wait so long as " three or four weeks " in acute attacks, provided I found that the effusion continued steadily to augment in spite of remedies. Moreover, if called in an acute case that has lasted a month, and in which there is an amount of fluid effused, sufficient to ma- terially compress the lung, I shall advise a puncture, as the first step to be taken, previously to the use of the remedies commonly employed in pleuritic effusions. I trust that the result to which I have arrived from seeing tho patients, may not be different from that to which the reader will arrive from the perusal of the folloAving cases. They are given in the chronological order of the operations, but they, with those in the preceding paper, may be classed in four main divisions' according to the effect of the operation:— First Class, or those cases in which the operation has been the chief or sole cause of the cure of the pleuritic effusion. Cases* 1,7 8 11 12 14 15, 18, 20, 21 (total, 10), are of this class. Second Class, or those cases in which the puncture has given more or less, and at times very great, temporary relief, so that some of the patients have asked for the operation a second, third, or fourth time, for the sole ob- See tabular statement. IN PLEURITIC EFFUSION. 5 ject of getting relief. Cases 2, 3, 4, 9, 10, 13, 16, 17, 19 (total, 9), are of this class. Third Class, or those in which no relief Avas obtained, because no fluid could be removed. Cases 5, 6, and 25 (total, 3), are of this class. Fourth Class, or those still under treatment, which are progressing fa- vorably, with more or less rapidity. Cases 22, 23, 24 (total, 3), are of this class. Cases. Case 9th.—Mr. G., set. about 20, clerk. I saw him with a physician of this city, Oct. 17th, 1851. During the winter of 1850-1, he had had some pulmonary trouble; but the patient assured me he had been Avell from that time until the actual attack for consultation upon which I had been called, and which proved to be one of very latent pleurisy of two or three weeks' standing. He had had no pain or dyspnoea, and only a slight cough, for ten days or more. He was able to be at work, but felt not quite well. On examination, I found signs of effusion into the chest. They had been recognised by the attending physician. I advised blisters and iodide of po- tassium. This treatment was continued until Nov. 6th, but Avith a gradual increase of all the symptoms. On that day, there was perfect flatness of the lower third of the right back, the sound changing by change of posture; a peculiar stomachic resonance above the line of flatness; segophony; on succussion, some gurgling, but no metallic tinkling. The respiratory mur- mur was slight, even at the apex of the lung; but no rale was heard even on coughing. His general symptoms were improved. He was able to walk about, although some dyspnoea was evident. Pulse 100; skin comfortable, slight sweat at night. As the iodide had not been thoroughly tried, and as there was an indisposition to the puncturing of the chest, on the part of the attending physician, I advised 5 grs. 3 times daily, and blistering to be con- tinued, and certainly not to alloAV a much longer time to elapse before doing the operation. Nov. 22d. He was suddenly seized with pain in his other side, with great dyspnoea and anxiety. He had, however, obtained relief from a poul- tice and Dover's powder before I saAV him. The auscultatory phenomena Avere as before, except that there Avas dulness to the second rib in front; there was no evidence of serious trouble in the left back, the murmur being heard pure everyAvhere, even to the base of the lung. I uro-ed a puncture; and on the 24th one was made, between the 9th and 10th ribs below the angle of the scapula. Nine ounces of yellow serum flowed readily, and aftenvards not a drop could be draAvn, notwith- standing I passed a probe through the canula and found it perfectly per- vious. Convinced that more fluid remained, I AvithdreAV the instrument, and introduced it under the axilla, one or two ribs above ; and eighteen ounces 6 BOWDITCH ON PARACENTESIS THORACIS more, of a similar fluid, came freely. The chest became somewhat resonant to the point of the puncture, and the segophony was heard only at the lowest part. The patient suffered not at all, except that a cough came on which was rather troublesome. DoA-er's poAvder and absolute rest were ordered. Dec. 2d. Had been improving; no returns of dyspnoea; patient felt brighter; he was able to lie on either side; pulse 108 to 112. On percus- sion, was really flat only in the lower two inches of the back. Respiration heard, vesicular though indistinct, along the vertebral column to near the base of the chest. Blister twice weekly, (3x3.) Dec. 13th. Better in strength and appearance. His digestion was good. Pulse about 100, and occasionally a slight flush, P. M., and a little SAveating at night. Respiration less labored than formerly. On inspection, the right side was evidently the larger. Murmur heard through the whole back, though indistinctly, to a line at the edge of the axilla; bronchial towards the base; absent on the side, under the axilla, and on the breast. No rale, but a metallic echo Avas heard on coughing. Good pulmonic sound, on percussion, on the back to where the bronchial respiration was heard. There it was stomachic ; dull beloAv the line of the nipple, front and side. As the patient was annoyed by the sound of liquid, and as he thought he had breathed less easily for a day or more, he desired to be operated on. I accordingly punctured, and drew off eighteen ounces of an amber-Yike fluid. After the operation, the bronchial respiration and the stomachic resonance were much lessened. Cough again supervened, as at the previous operation ; the pulse was slightly accelerated, but the patient was not at all fatigued. Continue medicine. Tinct. of iodine to the side. Jan. 14, 1853. The patient had continued without much change. He felt Avell—walked down stairs; was able to lie on either side. The pulse, however, was always accelerated—often 120. Auscultatory phenomena, how- ever, revealed a similar state to last report. I drew off twenty-one ounces, more purulent. Feb. 9th. A similar condition of the patient, except that he was rather improving; he had no hectics; he had gained flesh. I drew off again twenty-one ounces of a fluid still more purulent, and running but slowly.__ Cod-liver oil. Ride out daily. March 9th. Looked finely; able to walk out freely. Cough, very much less. Only slight dyspnoea. No gurgling heard since last operation. Dul- ness, much as before. Respiratory murmur heard further out on the side. I operated between the 5th and 6th ribs, and further forward, toward the nipple. Two pints of freely running'fluid were removed. Patient was much more able to assist himself than after either of the previous operations. He had less cough, but a sense of stricture across the chest. Cod4iver oil and phosphate of lime ordered. £tf PLEURITIC EFFUSION. 7 Two days after this operation the patient went into Boston to a convivial meeting, and after spending the day, drove out some miles. The weather was excessively cold, and he was very severely chilled. A febrile paroxysm supervened ; and the pulse rose to 120, and a general feeling of distress, es- pecially of limbs, was experienced. On the 17th there appeared what seemed to be a general inflammatory condition of the absorbents; small red lines were seen running along the legs and arms; quite tender to pressure. No trace of inflammation on trunk—and the point of puncture was perfectly healed. Patient had an anxious, sublivid look. The attending physician had used alcoholic lotions and 12 grs. of iodide of potassium. Meanwhile, the physical signs, though similar to what was noticed before, were rather more favorable. He recovered from this acute attack in a feAV days, but he never Avas as Avell again; and, in about five or six Aveeks, signs of tubercular developments shoAved themselves in the diseased side—marked by crackling, and, subse- quently, pectoriloquy at the apex. Owing to illness, I did not see him afterwards; but in May, as there Avere signs of pointing, the attending physician opened with a lancet, and pus continued afterwards to flow, till he died suddenly, in the night of Au- gust 7, without warning, in consequence of copious haemorrhage from the aperture. He had been, however, gradually declining for months. His phy- sician writes, " Life had been despaired of from day to day; and, previously to the haemorrhage, he had coughed very hard. The opening in the side did not become fistulous, in the true sense of that term, for it showed a disposi- tion to heal from time to time, so as to render necessary the introduction of a tent. Injections of a Avatery solution of gum myrrh had been used every other day for some time before his death, whereby the patient was comforted, the discharge was lessened and made less offensive." Reflections.—I had no doubt, when I was first called, that the case was one of pleuritic effusion of the most latent kind. But I feared, from the fact of even a trivial cough having existed before, that it was of a tubercular origin. I felt the importance of an early removal of the fluid; yet the small amount of it, and the slightness of the symptoms, connected with the fact that medical opinion was adverse to thoracentesis, prevented me from sug- gesting the operation at my first visit, Oct. 17. At my second, twenty days afterwards, I submitted the idea to the attending physician; but as the same reasons existed, the operation could not be performed, although the fluid had increased. Finally, the sudden attack of dyspnoea, on Nov. 22, a little more than six weeks from his attack, led all parties to feel that more active measures should be used. As I view the case now, in the broad light of ulterior experience, I think the delay was probably pernicious, possibly fatal; for, although in our present knowledge of the subject, we cannot be 8 BOWDITCH ON PARACENTESIS THORACIS sure that an early operation will prevent the tendency to tubercular develop- ment, the fact that whenever any amount of fluid is drawn off, tho rational signs almost invariably improve, and the examples we have of the excel- lent results of an early operation in cases of pleurisy evidently tuberculous in their origin—these facts prove, almost conclusively to ray own mind, that it is better always to operate as early as possible in any case in which there is any considerable amount of fluid, especially in one of a tuberculous tendency. In regard to the other interesting points in this history, I Avould state that the patient ahvays experienced so much relief from the operation, that he Avas sure to be the first to ask for its repetition. It may be remarked, also, that he had no alarming return of dyspnoea, subsequently to the first operation. The last topic, specially suggested by this case, is the violent haemor- rhage, causing death. It will bo remembered that this took place at least three months after the opening by the lancet, and six months from the last puncture. I have seen a similar case, under the care of another, in which exactly similar phenomena occurred, except that the case was one of pure empyema, punctured after months of illness, and again opened Avith the lancet when pointing. After the second opening, the patient improved very much, but a fistulous passage remained. From this occurred a haemor- rhage, Avhich was repeated to an alarming degree a feAV days after. The patient was, becoming anaemic. A surgeon was called, who enlarged the opening; could find no vessel, but a bleeding granulating surface. The aperture into the thorax being fully dilated, the patient had no more haemorrhage, and slowly recovered. The question may be asked, if the puncture had any connection with this state of things. My own opinion is, that there is no proof of their connection. On the contrary, the facts as they stand are decidedly opposed to the idea of such a connection. I speak of it, hoAvever, in order that all circumstances may be known that seem, even remotely, to be favorable or otherwise to the operation, as urged in this paper. Case 10th.—Mr. T., set. 30, a rigger, I saw Feb. 17, 1852. It appeared that, for a year before, he had had cough; but that, during the summer, it had been slight, so that he kept at work until Dec. 18th, 1851. He then had sharp pains in the right side of the thorax, for which venesection was performed. He kept his bed, at that time, for a week; and then, feeling better, went out, daily, for a fortnight. He then became more ill, and he had been confined to the house for five or six weeks previously to my visit. Hectics for the same length of time. His appetite, from the first, had been poor, but his digestion good ; tongue red, and with a slight coat; dyspnoea IN PLEURITIC EFFUSION. 9 always from Dec. 18th; at times orthopncea; expectoration considerable, opaque. Pulse 124, skin warm and moist. His countenance was haggard and distressed; he was sitting up, from inability to assume a recumbent posture. On percussion, flat below the third rib, front and behind—not clear above. Respiratory murmur obscure to third rib, indistinctly bron- chial beloAv, Avith a metallic tinkling on coughing or shaking. Behind, similar results, and aegophony. At the left apex, some rudeness of murmur. Right side of chest moved, during respiration, less than the left; intercostal spaces contracted. Diagnosis—tubercles and pneumo-hydrothorax. I advised a puncture for relief to the suffering ; but as the patient was umvilling to submit, I ordered iodide of potassium, 3 grs. three times a day, and a blister every fifth day. Feb. 27, i. e. ten days afterwards, much more dyspnoea—no relief. Patient then consented to the puncture. I made it in the usual space, be- tween the eighth and ninth ribs, and drew out a little purulent fluid with much difficulty. I then punctured two ribs above, and t\vo inches further forward, and removed 5 xv. with very little pain and much relief to the dis- tress of the patient. March 3. For a day, the relief continued, but soon the dyspnoea began to return ; cough constant; strength less. At my visit of that date, he had complete orthopncea, and Avas in great agony. I told him I would do as he chose. I had little hope of giving, by any puncture, more than a temporary relief to his sufferings. From his previous experience, he requested me to operate. I punctured at the loAvest point, and dreAV off §iii. of a purulent fluid; and on puncturing above, I procured nothing. The patient felt no uneasiness, except that after the operation, he, having lowered his arm, struck the canula, and caused much pain by its motion between the ribs. The next day, there Avas some redness and tenderness at the point, Avhich subsided under a hop fomentation. The patient died on the 8th. No autopsy was allowed. I present this case simply as a specimen of the relief obtained in a hope- less disease. This relief was more evident to the patient than appears from my record. The fact, hoAvever, that a request Avas made by himself for a second operation, is a proof of the little real suffering sustained, and the relief procured. The inflammation after the fourth puncture, though slight, was more than I ever noticed before; and Avas, doubtless, OAving to the striking of the canula Avhile in the Avound. Its rapid subsidence, hoAV- ever, especially when connected with the ordinary absence of all symptoms of the kind, is not unfavorable to the operation. Case llth.—Mr. R., aet. 59 ; "An old soldier," wounded at Waterloo; in U. S. 23 years, where he had had numerous occupations, and had 2 10 BOWDITCH ON PARACENTESIS THORACIS indulged in free living. He was " well," till his disease began, for which he entered my service at the hospital. About five Aveeks before his entrance, he had had*pain over the left crista ilii, and in a few days had haematuria, with dysuria.. Appetite lessened; very costive; some slight dyspnoea; cough very seldom. Very little treatment previously to entrance. At his entrance, he could lie easiest on the right side ; but he had been, however, able to lie on either. He sat up, and could talk, but with evident dyspnoea. Respiration, 17 ; pulse, 96 ; skin, normal; tongue, moist, with a thin white coat. On inspection, intercostal spaces filled in the Ioavoi- half of the left chest. Percussion, flat all around the same side, below a line on a level with the second rib. Murmur scarcely perceptible throughout. Puerile at right, with slight, fine crepitus at the base. ^Egophony over dull space. Heart beating to the right of the sternum. I ordered inf. sennae comp. f. 3 hi. with cathartic enema; broth for dinner; house diet at other meals. Dec. 29, I punctured between the eighth and ninth ribs, behind, and dn.'Av off § xxiii. of a yelloAV serum, Avith relief to a sense of fulness there, and Avith more ability to lie on the right side. Pulse, a short time after operation, Avas 98. Ordered iodide of potassium, gr. iii., three times daily, in syrup of sarsaparilla. Blister (3X3) to left side. He had an opiate given at night. Dec. 30. Much lighter since operation; less cough, and not painful; urine much increased. Blister very troublesome. He soon after left the Avard, and consequently fell under the care of my colleague, Dr. BigeloAV. His subsequent history is as folloAvs. Sol. mag- nes. sulph. Avas given several times before the 11th of February. Afterwards he drank freely of cream of tartar. Under these remedies, his boAvels were freely opened, so that, at one time, the cream of tartar Avas suspended. Jan. 2 (four days after the operation), his chest Avas flat in the lower two- thirds of the back; bronchial respiration and aegophony there. Obscure respiration in the left breast. Feb. 1. Friction sound at the loAver part of the left breast. On 15th it was much stronger. But Feb. 1st, he had some cephalic symptoms ; cephal- algia, scintillations, ales de Me"decine. f L'Union Medicale, August, 1853. 30 REVIEWS AND BIBLIOGRAPHY. Dr Warren punctured between the 8th and 9th ribs behind, and one pint and a half of pus was removed with ease. The patient felt relieved. Crackling was heard lower down, and the respiratory murmur was heard along the spine, slightly but unequivocally. November 5. He visited Dr. W., in Boston, who found him much better, and the lung was expanded much more. I did not see him. He remains still under treatment. He came to Boston, thinking to be operated on again; but Dr. W. found such improvement in the rational and physical signs, that he forbore. Ten days afterwards, November 15 (26 days from the first operation), I saAv him again. He reported that for several days after the puncture, he had coughed scarcely at all, and had improved much in his general feeling; but Avithin a week the cough had been as bad and the expectoration as copious. On percussion, there was some resonance to an inch above the angle of the scapula, and the respiration was heard there, but still much less throughout the side than on the other lung. Twelve ounces of pus were removed with much comfort, and the patient returned to the country. Is not this a proper case for a permanent opening and for iodine injec- tions ? Air evidently gets into the pleura through the lungs, so that the objection of admitting the external air by a permanent opening is not valid. 2d.—The pus now accumulates, and has to be coughed up. Would it not be better to let it run out ? Probably, the cough would be much lessened thereby. Case 25.—Sept. 28, 1853. I saw at S., in consultation. He had been ill from March, and particularly so from July, with acute pains in the left side at this latter period. His symptoms were those of pleurisy, following tubercular disease. He had cavernous respiration at the upper part of the left lung in front. The heart was not dislocated, and it had a strong thrill with each pulsation. The lower half of the back was quite dull, with ab- sence of respiration, a broncho-aegophonic vocal resonance. Notwithstand- ing the cavernous respiration and the non-dislocation of the heart, I was disposed to regard part of the symptoms—dyspnoea and oedema, &c.—as, in a measure, caused by an effusion, to a small amount. I proposed, therefore, a puncture, although satisfied that serious tubercular disease existed at the apex of the lungs. Oct. 1.—Having tested still further the existence of fluid, by a change of posture, I punctured a little outside of the line from the angle of the scapula. No fluid could be obtained—and I desisted. The patient suffered no incon- venience. I would mention, that before operating I stated that such might be the result, and that if any fluid came it might not give relief, but that, considering all the signs, I should advise that the operation should be done. No subsequent evil resulted from it. It may be asked, why no fluid was IN PLEURITIC EFFUSION. 31 obtained. The answer is difficult. Such an event has happened before— vide cases 5 and 6, also once in case 9. I think it very probable the lung was punctured. The case is interesting as showing the innocuousness of the operation, whatever may have been the nature of the case. Case 26.—Sept, 12, 1853. Mr.-----, I saw in consultation. Mt. 60. He was a gentleman well known in political life, and of a very active tem- perament. He had been ill from February. He had had cough for some weeks, but never pain in the side—nor dyspnoea. He had had haemoptysis slight, in the early part of the disease. From the first, he had felt that he should die, and, therefore, was unwilling to use remedies. When I saw him, his mind had become very dull, and he lay most of the time Avithout speaking or eating. Pulse, 80 to 100. For several days he had taken little food. There was dulness at the right back, and less murmur throughout same side. The dulness changed with the position of the patient. At the bottom of the right back there was a prominence, feeling solid, but elastic, and separating the ribs. It resembled the lobule of a scirrhous mass, but there was no discoloration of the superficies. I advised the puncture, feeling that it was the sole chance of possibly relieving him. Great objection was made to it for several days. Finally, I was requested to see him again. I then, for the first time, knew of the existence of the tumor. He was so much sunken, and the prospect that combined with the pleurisy there was malignant disease, the knowledge that the patient himself was opposed to all attempts to cure him, determined me not to operate: I therefore declined. Following* is a tabular statement of the prominent features of all the cases I have had under my own charge since April, 1850, with a few treated by others, and which I saw in consultation. From this tabular statement we see that— First, No one of the patients operated on experienced a single danger- ous symptom, or any materially unpleasant symptom, except for a short period. Second, Out of twenty-five persons, only three failed of obtaining relief. Of these three, two had had l^ng, probably tubercular, disease ; and fromtf the other no fluid could be drawn, owing, perhaps, to an imperfection of the instrument which I used in my earlier operations. Third, In more than half of the cases, the puncture was the first reme- dial agent, that decidedly arrested the progress of the disease. This it did in two modes. 1st, by allowing the lung to expand immediately, and pro- ducing thereby a rapid cure. 2d, by so stimulating the functions of the body, made torpid by long disease, that they immediately, sprang into healthful, vigorous action, while the lung expanded more slowly. Cases 7, * See pp. 42—46. 32 PARACENTESIS THORACIS 14, 15, 18, 20, 21 are illustrations of the first, and 1, 8,11, 12, 22 of the econd class. That this stimulus which I have mentioned as occumng in the second class, actually takes place in many cases, I am sure. I have so repeatedly noticed it that I now confidently hope for its occurrence, when I do not find that a case, after a puncture, is likely to be of the first class. I do not mean to state that the stimulus shows itself immediately, or that it acts Avith rapiditv in eveiy case, but simply that from the moment of drawing off the fluid", I have been able to trace a series of favorable influences tend- ing towards health. Fourth, In about seven-eighths of the cases, the operation has given great relief to prominent and distressing symptoms, insomuch that the patients have asked for a second, third, or fourth puncture, as a means of relief only. Symptoms Consequent on the Puncture. These were very similar to those reported in my former paper. The pain of the puncture was the chief trouble, and this, as it was momentary, Avas but little noticed by the majority. Stricture across the chest Avas occa- sionally noticed towards the end of the operation. The cough was aug- mented in many. This I regarded as a favorable sign, as it usually indicates that the compressed lung is beginning to expand. In one case this symp- tom was excessive, it having lasted twenty-four hours almost without inter- mission. In this case the lung arose instantly from its compression. One had vomiting of her dinner, the operation having been done in the after- noon. In all, where fluid Avas obtained, the oppression was someAvhat re- lieved ; in one, impending suffocation was prevented. Most of the patients were exhilarated by the success of the operation, as in our previous set of cases. In one, there Avas a slight oozing of blood from the point of- punc- ture, which, however, was easily checked. The pulse remained tranquil, as much as it was before the operation. The digestive functions were improved. In all, where much fluid Avas ob- tained the appetite was improved with singular rapidity. One person asked for food before we left the house. , The urine Avas augmented frequently by the operation, a fact which I noticed often Avhen analyzing the first set of cases. In none was the fever augmented, or a febrile paroxysm excited. The physical signs altered slowly in some cases, in others very rapidly. The patient in case 15, having been ill a few Aveeks, presented the phenom- enon of the lung completely expanded and filled with rales the next day after the removal of five pints of fluid. Generally, hoAvever, a more slow process was carried on, the lung expanding in the first few hours only along the vertebrae and at the apex, and thence more or less gradually rising to meet the parietes of the chest; the parts under the axilla being, of course, IN PLEURITIC EFFUSION. 33 the last to fill out. In some instances that state of the lung described by Gardner,* remained for months, the patients being nearly free from all rational symptoms of disease, save, perhaps, a tendency to dyspnoea. Cases 4 and 14, are examples of this. Cases 22, 23, may become so. The character of the fluid drawn from the chest varied, as in our other category of cases. By a reference to the tabular statement, it will be seen that from forty-seven punctures, the following results were obtained : Table 2. Nothing,........................................................5 times. Serum, a few drops only (2 cases),................................. 4 " Serum in large quantities,........................................16 " Pus, or purulent,............................ ....................17 " Bloody,......................................................... 5 " The quantity of the fluid varied considerably; three ounces being the smallest, one hundred and seventy ounces being the largest. In this latter case it was pure pus. The influence of the character of the fluid, the length of the disease pre- vious to the operation, and the existence or non-existence of previous dis- ease, may be learned by the folloAving series of tables. Table 3. Chaeactkr of the fluid in the Chest. Sebum. Pus. Bloodt. vTotal. Recovery from pleuritic effusion,................7 cases,........5 cases,........Urease,.......1J! cases. Death afterwards, consequent upon the effusion / and previous disease,.....................3 '• ........4 " ......J..............jf " Friction-sound heard, but death a few weeks after from disease of brain,................1 " ................................... 1 " Under treatment, doing well,...................1 " .................................... 1 " Under treatment, with prospect of months of illness,.................................................2 " ..................... 2 " 24 cases. ^■Hflfiems, therefore, that the presence of serum is more favorable for the prognosis than is the existence of pus. This only confirms our preconceived notions, but it is rather different from the opinion I advanced in my previous paper, the facts contained therein not allowing me to hold the opinion I now advance. The next important element in the prognosis, is the length of time the disease has lasted previous to the operation. The folloAving table will show this. Table 4. Sebum. Fua. Bloodt. Average time before puncturing J recovery..........2| months,.........2 months,........ in cases of, I death,............3 months,.........A\ months,.........3 months. Whence it appears that whether pus or serum exists, an early operation is more favorable than a later one. » British and Foreign Medico-Chirurg. Review, April 1853, Art. XI. 5 34 BOWDITCH ON PARACENTESIS THORACIS The influence of the existence or non-existence of previous disease may be illustrated by the following. Table 5. Of those who had no disease immediately preceding | cough, and were probably the effusion, phthisical, Recovered from the effusion,....................10...................................4 Died with effusion remaining,................... 0...................................<5 From this table Ave infer, Avhat, in fact, we kneAV before, that pleuritic effusions, uncombined Avith serious pulmonary disease, do not usually destroy life. I cannot but think, hoAvever, that in case No. 2 the operation may be said to have saved life, for a time, at least. In case 15 I have no doubt suffocation Avould have taken place, had not the operation been performed. Another interesting inference is suggested by this table, viz., we observe that of 10 avIio had organic diseases, 4 were cured of the pleuritic effusion: 6 died. Noav, the puncture Avas the sole cause of the cure of these four, for the lung expanded in all of them within twenty-four hours or a few days after the operation Avas done. No other cause operated, and therefore to the thoracentesis Ave must attribute the cure. Is there any physician that can say as much of any other method of cure under similar circumstances ? Is there any remedy Avhich will cause an absorption of five pints of fluid in twelve hours, and alloAv a lung that has been compressed for months to be thoroughly filled with air in twenty-four hours ? In confirmation of these remarks, and to give the reader a more defi- nite idea of the amount of influence the puncture had towards the cure or relief of the effusions, I submit the following data taken from my own cases, compared with similar data obtained by the courtesy of Mr.jftM^, Savvr* at present house-pupil of the Massachusetts General Hospital, from the records of that institution. In preparing my. own, I have taken, first, all those cases in which the lung, after having been for weeks, or perhaps for months compressed, has suddenly expanded, within twelve or twen- ty-four hours after the puncture; second, those in which the stimulus above spoken of was given to the various functions of the body, so that all the rational signs grew decidedly better from the moment the fluid was evacuated, while the long-compressed lung dilated but slowly. In the first, the lung expanded immediately, or within twelve hours after the puncture. In the second, the lung, on average, in 32* days, or 44 weeks after the puncture. I think no one can doubt that paracentesis cured the disease in the first class of cases. In proof that it aided very materially toward the same IN PLEURITIC EFFUSION. 35 results in the second class. I present the subjoined table of comparison betAveen my cases and those treated at the hospital.* Table 6. Hospital casks. My cases. ,-----------------*-----------------, ,-----------------A-----------------^ Whole length I After entering I Whole length I After Length of time the disease lasted. of the disease. | hospital. | of the disease. | Thoracentesis. Average duration in cases ) of complete filling of one > 12 +weeks. 6| + weeks. 13 weeks. 3 weeks. pleural cavity, \ do. do. partial do. do. 12 " 6£ " 9i " 4 " Supposing all these data to be absolutely correct, I might draw from them the following propositions. 1st. One pleural cavity being full of fluid.—a. Thoracentesis shortens the disease more than one half. 2d. One pleural cavity being partially filled.—b. Thoracentesis shortens the disease more than one third. I do not, however, present them as absolutely correct, but merely as approximations to the truth. But I do not see that any one can deny, that puncturing the chest does very materially shorten, and consequently alle- viate the sufferings of a patient affected with pleuritic effusion. As if in confirmation of this view, we see that although it appears, in my cases of complete filling of the pleural cavity, that the whole duration of the dis- ease was perhaps as long as it was in the hospital cases, nevertheless there was this great difference of time after the two treatments were commenced, before the effusion was removed ; viz. those treated by paracentesis getting well in half the time required by the hospital treatment. I do not believe, however, that thirteen weeks shows the duration of the disease as it will be when tapping is resorted to with as much freedom as we resort to calflmel, blistering, &c. For this period of thirteen weeks is really owing to one case, which had lasted seven months before a puncture was made. Excluding this case from the calculation, we shall get *7f weeks as the average total duration of cases of pleurisy treated by paracentesis, in connection with other remedies. I will go still farther, and avoAV my belief that ere long, Avhen we shall puncture early after an effusion has occurred, the disease will often be relieved in a much shorter time even than 7£ weeks. * This table is founded on data drawn from fifty-four cases of pleuritic effusion, found recorded in the books of the hospital, between Jan. 4, 184*7, and Sept. 9, 1853. In it I have made use of those cases only, in which the disease could be traced by the rational and physical signs to its termination in the hospital: or, if the patient left the hospital before recovery, but after a long residence at the institution, I have added the sign + to the number of months the case was under the care of the insti- tution. From my own cases, I have only taken those of a similar character, viz. Nos 1, 1, 8, 11, 12, 15, 18, 20, 21. VOL. I. NO. 2. 1 3(5 BOWDITCH ON PARACENTESIS THORACIS If this be so, are we not morally bound to perform this operation early in all serious cases; that is, in all where there is any considerable amount of fluid, enough, for example, to cause flatness in the lower half of the chest ? I am well aware that I shall be met with arguments drawn from the danger of the operation. I consider this argument as null, when applied to the exploring canula and suction pumps used in all my cases. I believe this fear is a phantom that has descended to us from a bygone race of men, who were as intelligent, it is true, as any of the present day, but whose means of diagnosis of thoracic disease were infantile when compared with our own. In what cases should an operation be performed ? In my former paper I stated fully the cases in which I should hereafter advise an operation. As I have seen no reason to materially change my mind since that time, I shall transcribe some passages merely. I wrote then : 1st. There cannot be a doubt that it should be performed in all cases, either acute or chronic, in which there is dyspnoea sufficient to threaten death. 2d. I believe that the case of the little child about Avhom I was con- sulted in 1849, proves conclusively that the operation should be performed where the pleura is distended with fluid, even if the dyspnoea is not perma- nent, but only paroxysmal, the patient being in the interval comparatively easy. Life might have been saved in that case, if the puncture had been made : but the little patient seemed so well, that we decided to defer it till a more serious symptom should occur. It will be remembered that that very night the patient died in a sudden attack of dyspnoea. 3d. I think that we ought to operate in a somewhat chronic case, where these paroxysms occur, even if the chest be only partially filled with fluid. I saw a man who had been ill about three months, and had evidence of fluid filling one-half of one pleural cavity. It was thought best to try remedies before puncturing. In three or four days he suddenly expired in an* access of dyspnoea. 4th. In all acute attacks, where the remedies employed do not seem to produce ready absorption, the operation should be performed. Dr. Hamil- ton Roe says that three weeks is the longest time we should allow the fluid to remain in the chest * I agree with him fully. . ,51*\ JnTallv effusions> where one side of the chest is full and distended with fluid, I shall advise it, even if there be no great dyspnoea or other serious symptoms ; a, because it is not uncommon for one having a pleura distended with fluid, to die; b, because the operation can do no harm ; c, it may prevent a tedious illness; d, because it may oppose tendencies to the development of tubercles; e, it will probably prevent future contraction of the chest,- finally, because in that way an external opening and a harassing hstulous discharge may be avoided. 6th Case VIII proves that, although in a very acute case the puncture may not prevent the re-accumulation of the fluid, nevertheless, the opera- tion may be of great service in relieving the prominent symptom of dysp- London Lancet, vol. ii., 1844, p. 190. IN PLEURITIC EFFUSION. 37 ncea, and in helping on the more rapid cure. It may, therefore, become a question whether even a small quantity of fluid should not be removed within a week after the first attack of acute pleurisy. Time and future cases must decide this. Upon this part of my subject, I cannot refrain from quoting the remarks of the reviewer above alluded to. " The Avhole argument turns on the facility and safety with which paracentesis can be performed, and although the cases are not sufficiently numerous to allow us to recommend it as in all cases practicable and useful, yet they warrant us in stating, that this operation is one of Avhich practitioners have too much dread ; and that, when skilfully performed, it may be practised with very little hazard to the patient, and with a result, in the majority of cases, that is satisfactory to the practitioner." * Objections to the Operation.—There are two classes of objections (vii., theoretical and practical) brought against the operation of paracentesis thoracis. I confess they are very formidable, nay, insuperable, when applied to it as recommended in most books of surgery. It leaves an open, gaping wound, through which may rush the external air with each movement of the thorax. I will not say that this method may not be useful in some in- stances. Doubtless it has been, and it may be so again. But the modern European method by trocar and canula, as performed by Trosseau and Hughes, &c, and especially as it has been modified and improved by Dr. Wyman, is one of the simplest and safest of all operations. Still there are objections, theoretical and practical, brought against it. Let us consider, then, their value. 1st, It is said that the chest, being a bony cavity, cannot contract; ergo, you never can get out the fluid, or you do so at the risk of injuring the lungs ; the objector forgets that the diaphragm and intercostal muscles prevent the thorax from being a bony cavity, and do allow of some contrac- tion. Still further, by means of the suction-pipe, we draw out the fluid, and thus form, perhaps, a vacuum in the pleural cavity. The compressed lung dilates : the other lung likewise admits more air and crowds into the empty space. But, 2d, The objector adds, by forcibly compelling the lung to dilate, you run the risk of seriously injuring it. Hoav do you know this, save by experiment % Now, experiment proves that nature always gives us notice, by the suffering of the patient, hoAV far we may go in the operation of suction. I have myself operated twenty-three times,f and Dr. Wyman has done so many more times, and in no single instance has any permanent evil resulted from this cause. We have always desisted the moment any complaint was made by the patient. 3d, "it is said, you cannot draAV out all kinds of fluid. Very true, there may be such cases, I have met Avith them ; but, I think, they will be less numerous as Ave become more accustomed to the operation, and it is done more properly .J Besides, we can always, if necessary, have recourse to the old operation, if' the trocar fails. 4th, But you will let the air into the pleura. This, to some minds, is a serious theoretical bugbear. The admission of a small quantity of air does not necessarily cause trouble, unless it be frequently repeated, as in cases of * London Lancet, vol. ii., 1844, p. 301. \ Jan. 18, 1854. Up to this date, fifty times, with the results as above, % The result since, in my own practice, has confirmed this. wmmmm^uMtMX'*-,— 3g BOWDITCH ON PARACENTESIS THORACIS pneumo-thorax, and of puncture of the thorax, according to the old opera- tion. I have seen air accidentally pumped into the chest, instead of fluid being draAvn out! And this caused no injury. The patient never knew of it by his own sensations. I do not believe it excited any inflammation. I am not alone in this opinion. Other operators believe the same; for they have observed the same accident, with similar results attendant there- upon. 5th, You run a great risk of exciting pleuritis by the puncture of the delicate pleural membrane. It is a sufficient answer to this objection that, at the autopsy of cases in which persons have died from other diseases, after a puncture Avith a fine trocar, no evidence of inflammation from that cause has manifested itself. Case I., given above, also proves it, by show- ing a similar non-purulent fluid drawn out on two successive operations. Dr. Wyman has noticed this frequently. I have never known pleuritis to ensue.* 6th, You may injure the lung, or strike some other important organ. Very true ; but, 1st, I deny that a puncture of the lung is so very dan- gerous. It has been done. It was done in a case, as Dr. Wyman believes, under Dr. W.'s care. I have done it. I have seen another do it, and, moreover, use the suction-pipe while the trocar was in the lung. In no case has any evil resulted. The sputa were, in one case, slightly tinged with blood soon aftenvards, but no unusual pain or distress resulted to the patient. But, 2d, these are exceptional cases. If our diagnosis be conscientiously and thoroughly made, we need very rarely injure the pulmonary structure. If we injure any other organ, it will generally be owing to our own care- lessness. 7th, The intercostal vessels or nerves may be injured by the trocar. This is possible, but not probable. 1st, It Avould be difficult, in fact, to strike and seriously injure the artery, because the trocar is so small that a small artery would most probably glance aside. 2d, The spot for the oper- ation may be chosen where the vessels are the most minute. '3d, The ope- rator, of course, will thrust the instrument as near to the upper edge of the rib as is possible. 4th, Finally, among all the operations performed within the past three years in Boston and its vicinity, no serious result has hap- pened to the artery, although, in one case, I observed some slight and tem- porary haemorrhage after the withdrawal of the trocar. 8th, One objection brought against the operation is the following, viz.: That all cases of chronic pleurisy will get well after a time, unless the disease be dependent on more serious lesion of the lungs, or other remote organs. In answer, I would say that, according to my experience, in part already given above, it is not true that a person affected with chronic pleurisy, as an idiopathic disease, will eventually get well. He may die, as Ave have seen, in various ways ; which result a puncture and extraction of the fluid may prevent. But, still further, is it of no use to shorten the dis- ease by months ? Is it of no service to prevent fistulous opening, and those terrible distortions of the chest consequent on the cure of long pleurisy? Moreover, suppose that tubercular or other disease exists, is it of no service to raise our patients from their bed, to give freedom of breath, and to actually lengthen lite, as was done in cases II. and VII. XV. XX. ? * Sin°e ^ ™* "*£****> I have noticed in one case, in which several punctures were made, that the fluid becamemore purulent at each successive operation. IN PLEURITIC EFFUSION. 39 Again; I believe that this operation Avill be used Avith advantage in acute disease, and may, likeAvise, shorten its course. Case VIII. sIioavs this, where the patient, on the twenty-third day, Avas up and preparing her din- ner, and the effusion subsiding. Case VII. is a still more striking example of this ; i. e., if we regard the pleurisy as having commenced when the pain in the side began. If this be so, then the cure was complete in a very few days after the operation. 9th, Finally, some object to the operation because of the uncertainty of diagnosis. You may operate in a case of cancer of the lung, or gangrene, or some other disease than pleurisy. I can conceive of such an error being made in some very rare cases, but I do not believe that such cases will be likely to happen very often; and, moreover, as I have already said, I think that a slight puncture of the lung with a small trocar is of very trivial moment. We may, therefore, very justly put aside this objection as one of little vahie against the operation.* But shall we confine ourselves to a simple puncture and a withdraAval of the fluid ? In my previous paper I alluded to the operation by the scalpel, as a barbarous one. I would modify my statement; I believe there are cases in which a permanent opening would be of service. In cases, for instance, where repeated punctures have been made with as repeated re-accumulation of the fluid, a fistulous opening may be needed. Case 24 may be one in which it would be well to make such an opening. But even in such case, frequent puncturing might answer the same end. And suppose Ave have decided to have a permanent opening, why not operate with a large trocar, or leave it in the wound for a few hours or even days, as is actually done by Barth and Windrict ? But shall we merely remove the fluid ? I think not. The recent ob- vations and experiments of MM. Boinet and Aran in Paris prove conclusively not merely the safety, but the advantage in some instances, of injections of tinct. iodine. Both of these gentlemen give cases f of great interest, in which the iodine seemed to improve the secretions of the pleural cavity and help the cure. Finally, although thoracentesis in pleuritic effusions has not always effected all the good I could have wished ; although, in some instances, it has seemed to do little more than give temporary relief; nevertheless, I am convinced, from the experience I have gained from the preceding cases, that in some instances it saves life, that in a vast majority it gives infinite relie to distressing symptoms, that in none does it cause any harm. I sincerely * At times, too, a mistake may arise from the lung remaining, as described by Dr. Gairdner, of Edinburgh,* condensed after the effusion has been absorbed or re- moved ; in consequence of which state of the parts, there may be absence of respi- ration, flatness on percussion, diminished motion of the ribs, &c. All these signs may lead into error. I am now inclined to believe that I made that mistake in case VI. possibly I did so in case XXV. No evil followed in either case. The patients scarcely noticed that the puncture had been made (1853). f Archives G6nerales de Medecine, May, 1853. Union. Medicale, Aug. 1858. * See British and Foreign Med-Chirurg. Review, as cited above. t30u^—^mamaaw&£j£^ VlMi 40 BOWDITCH ON PARACENTESIS THORACIS hope, therefore, that these facts may serve to overcome the prejudice exist- ing in the minds of the profession, to the operation, at least, as it has been performed on the subjects of this paper. For myself, unless my present views change very materially, I shall feel that I am guilty of a neglect of a duty to my patient, if I do not urge the operation, in any case, after the existence of effusion has been manifested a feAV weeks, and when remedies do not seem to effect its cure. I shall feel bound to use it in any case of large effusion, however short a time it may have existed. I shall, in other words, regard thoracentesis as I regard other remedial agents, to be used as freely as I use them, viz., whenever I think necessary. In connection with, and as a most fitting conclusion to these remarks, I cannot forbear quoting from a letter which I received from a gentleman Avell knoAvn in this country and in Europe, and who has had as much expe- rience on this subject as any other individual on either side of the Atlantic. Under the date of June 2d, 1852, he writes, " It has indeed surprised us as well as yourself, that so simple, so harmless, and so beneficial an operation (Avhen proper precautions are taken, by competent observers), has been so little regarded in America or England, where it most strangely continues to be esteemed as a most important and serious one." " It may be interesting to you to know that I have myself been present at, directed, or superin- tended, at least eighty, and, I quite believe, one hundred operations of para- centesis thoracis," [by puncture with an exploring trocar and the subse- quent introduction of a larger one, and without the use of any suction pump.—H. I. B.], " and I never knew it, in any of those cases, do any injury; that in a vast majority of these instances, it has been attended with marked benefit; and that in many, where a cure was possible it has been the important element in effecting that cure." Appendix. Since finishing this paper, I have perused an article in the Archives Generales de M6dicine, for October, 1853.* As it supports views similar in many respects to those advanced in the foregoing article, and is of such recent Parisian date, I propose to make a brief analysis of it. It gives details of four cases of acute pleurisy; in all of them, thoracentesis was performed. Three were cured by it as the chief remedy. In one there was a relapse and illness for an unknown series of months. In those cured, the average duration of the disease before the puncture was 13$ days; the duration after the puncture was 17 days. In other Avoids, a period of 30§ days was the length of time the disease ordinarily existed. (See Table 6.) After these cases, the author discusses the various methods used in punc- turing, and decides in favor of the trocar and canula, with the moistened tube attached to the latter, the end of which, after the removal of the tro- * De l'Utilite de la Thoracentese. Par B. Schnkpk, interne des hopitaux, Laureat de la Faculte" de Medecine a Paris. LN PLEURITIC EFFUSION. 41 car, being placed in water prevents the entrance of air, and acts like a syphon, in gradually drawing off the fluid. He alludes to the fact that in Germany the canula is, at times, left in the wound for some days, and with- out difficulty. M. Barth has done so. He speaks of tho fear of the opera- tion formerly entertained by Louis, Arndal, Skoda, &c, and says that at present these gentlemen approve of the operation. In looking at the bene- ficial results of the operation, he records the sudden healthful stimulus given to all the functions, exactly as it was noticed in our cases. The ope- ration may be used as a means of relief only. He regards it as almost a specific remedy in acute pleuritic effusion. The author attributes, rather hastily, I think, the cough which came on in his cases, after the puncture, to the irritation of a little air admitted to the pleura. Valleix and Barth oppose this view, but advance opposite views, as to the real cause, the former believing it to be owing to the sudden dilatation of long-compressed vesicles ; the latter holding exactly the opposite view, and contending that the fact that the vesicles can not expand is the cause. (Our cases sustain neither of these views entirely. In case 15, the cough was more severe than I ever knew in any of the observations, yet the lung expanded immediately throughout its whole extent. In 20, on the contrary, though the lung dilated, there was little cough. In cases 13, 23, the cough Avas troublesome while there was no evident sudden dilatation of the lung.) Iodine injections into the pleural sac are examined. The cases detailed by Aran and Boinet (see above), are alluded to. M. Barth has punctured five times in one case, and used chlorinated injections. Valleix, also, has used iodine with freedom and without injury. Soft, warm water is useful at times. Raumberger, on the contrary, opposes all such proceedings, on purely theoretical grounds, which are proved to be unsound. His resume may be generalized thus: 1st, The operation is not dan- gerous ; 2d, A trocar and syphon tube is the best instrument; 3d, A little air in the pleura aids the flow of the fluid ; 4th, The results are, a more free and regular respiration, renovation of the forces, better haematosis, &c.; 5th. In simple pleurisy, thoracentesis is " the most powerful agent to hasten a cure ;" 6th, When symptomatic of other more serious disease, it is an ad- juvant alone. (Our cases 4 and 15 prove that puncture cures pleurisy even when connected with, if not caused by phthisis.) 8th, It ought to be per- formed whenever the dyspnoea makes us fear asphyxia, and as early as possible from the attack. 9th, It is contraindicated in imminent asphyxia. (Case 15 proves this assertion to be incorrect. I cannot but think it wrong; for I believe that the more imminent the danger of asphyxia, the more important it is that the operation should be performed.) 10th, A little air in the pleura does no harm, but is rather useful, as above stated. 11th, Lesions of the lung or intercostal arteries, during thoracentesis, are not noticed by modern authors. 6 Tabular Statement of Operations for Paracentesis Thoracis, performed between April, 1850, and Oct., 1853. No. 1. Age and date. Profession. Previous dis-eases. How long sick before first operatior. No. of opera-tions and dates. Character of the fluid. Amount of the fluid. Immediate effects of the operation. How soon the lungs expanded and heart fell into normal po-sition. Final result. 28 April 11, 1850. House Painter. none. 5 weeks. 1st, Apr. 17 2d. nothing. pus. Six. relieved of oppres-sion at chest. not immediately and doubtful how soon—less than 4 weeks. perfect health after 5 or 6 months. 2. 56. Oct. 1, 1850. Seaman. dyspnoea for 6 or 1 y'rs—prob-ably heart disease. at least sev-eral months 1st, Oct. 1 2d " 12 serum. serum coagulable. 1 xxxvi. |xxxij. great relief; orthop-noea gone. some " drawing " around chest. on 5th day, or perhaps sooner; friction sound next day. death many weeks after-wards with car-diac disease. 3. 4. 28. July, 1850. Machinist. rheumat'm; soreness for 3 months in left breast. 3 months. 1st, July 10 2d, " "12 3d, " 14 4th, " 19 5th, Aug 11 Two natu-ral openin's subsequent-ly formed. bloody. serum. more puru-lent. few drops. | xxvi. ... a little. Oj- 'easier, pulse bet-ter, relief to dis-J tension and to ] pulsation of the heart to the right ^ of the sternum. marked relief to dyspnoea. heart fell imme-diately toward left two inches. gradually failed, and died about the middle of August. 48. June 4, 1850. Carpenter. Had raised blood many times. 10 weeks. 1st, June 9 2d, " 11 3d, " 11 5th, Nov 19 6th, " 21 purulent. nothing. purulent. nothing. pure pus. few drops. Six-Six. J great relief. ( stronger. relief. 20 days alter op-eration "respir-atory murmur better," less dull percussion. £ rubb'g sound < at the point oi ( puncture. gradually got well after many months; chest contracting and lower lobe re-maining con-densed. 1 6-5 July 14, °' 1851. Girl. unknown. unknown. 1st July, 14 2d " 3d " serum. do. do. a few drops merely could be drawn. no effect, neither relief nor trouble. nearly in artic-ulo mortis, and died soon. 6. 18 or 20 years. Young man unknown. unknown. 1st, 2d, nothing. do. unknown. ' 7. 29. Aug. 21, 1851. Spinster. cough and diarrhoea for many months. 2 weeks. 1st, Aug. 23 serum coagulable. Sxb. unpleasant feeling about chest, but soon great relief. Heart fell back 1J inches. next day mur-mur he'rd every-where ; minute crepitus. well of effusion in a week—died a year after, of phthisis. 8. 9. 31. Sept. 3, 1851. Wife. pleurisy pain years ago, but well after. 10 days. 1st, Sept. 3 serum coagulating on standing S xiii. great relief—no or-thopncea afterwards next day. well by 12th day after operation. Patient attended to household du-ties. A few phys-ical signs re-mained. 20. Oct. 17, 1851. Clerk. cough, win-ter previ-ous. 48 days. 1st, Nov. 1 2d, " 3d, Dec. 13 4th, Jan. 14 5th, Feb. 9 yellow, amber-like. a little opaque. more puru-lent. S xxviii. S xviii. S xxi. Sxxi. great relief—no se-vere dyspnoea after 1st. Patient desired all the rest when he found dyspnoea com-ing on. Cough bad after them all, stric-ture after last. lung expanded somewhat at apex—never fair-ly distended. after many mo's died of phthisis. 10. 30. Feb. 17, 1852. Rigger. cough for a year. 71 days. 1st, Feb. 27 2d, " 3d, 4th, purulent. t< a little. §xv. 3 Hi. nothing. ( great relief to dis-\ tress of patient. 1 patient almost in ( art. mortis at time not at all. death on 4th, af-ter last opera-tion. Tabular Statement of Operations for Paracentesis Thoracis.—Continued. fc No. 11. 12. Age and Date. Profession. Previous dis-eases. How long sick before first operation. No. of opera-tions and dates. Character of the fluid. Amount of the fluid. Immediate effects of the operation. Bow soon the lungs expanded and heart ell into normal po-sition. Final result. 59. Dec. 29, 1852. Soldier. none kno'n, character dissipated 5 weeks. 1st, Dec. 29 yellow se-rum. S xxiii. relief to fulness— able to lie on either side. ung came up slowly—friction noticed 30th, perhaps before. death two mo's after with ceph-alic symptoms. 21. Feb. 27, 1852. Wife. cough dur-ing autumn 6 weeks. 1st, Feb. 27 2d, natural opening subseque'ly took place. thick pus. Sxli. great relief to or-thopncea and gener-al uneasy state. lung had expan-ded somewhat on 5th day; on 11th much more Derfect health after many mo's. 13. 40. Dec. 30, 1850. Laborer. slight dry cough a week before fall which caused his pleurisy. 5£ months. 1st, Dec. 30 2d, Jan. 10 pus. pus. 5 lxiv. S dxx (!) great relief to dysp-noea and moaning, cough after punc-ture. lung did not come up readily before death. death from opi-ate. 14. 24. March, 1853. Clerk. cough years ago, but well before acute at-tack. 12 days. 1st, M'ch 20 serum, coagulating § xlviii. relief—dates recov-ery from operation. next day lung expanded at up-per part; lower never did. recovered, with condensed low'r lobe after mo's. 15. 45. June 10, 1853. Wife. sough for many mo's. 6 weeks. 1st, June 10 do. S lxxxiii. and 3 vi. entire relief from threatened suffoca-tion—bad cough— pulse fell—copious frothy expectora-tion. immediate ex-pansion of major part of lung. 10 days no dif-ference on per-cussion of both lungs; well of pleurisy. bd o 3 o H o a 16. July 11, 1853. Laborer. 4^ months. 1st, July 11 2d, Aug. 5 patient asked for operation. col'd serum, do. S xxiiiss. I xiii. respiration less la-bored—comfortable day—little relief. no physical signs given. death some days after last opera-tion. 17. 18. 6 yrs. Oct. 20, 1853. Boy. * many mo's. 1st, July 18 pus. S xiii. slightly easier. never. death mo's after. 19. July 18, Clerk. none. 7 months. 1st, July 19 serum coagulating S Ixxx. no immediate trou-ble, and all the functions of the body immediately began to go on well. murmurs heard to base of lung next day. perfectly well in about a month or six weeks. 19. 20. July 30, 1853. Wife. cough for months. 5 months. 1st, July 30 2d, Aug. 3 pus. pus. §x. Siv. strict'e and faintn'ss relieved on lying down; can lie on left side; rel'f to cough. no marked ch'ge except tubular respirati'n more manifest. death in two weeks, with tu-berculous lungs. 20. 21. 22. 23. Aug. 30, 1853. Spinster. cough for months. 2 months. 1st, Aug. 30 serum coagulating § xviii. nausea, vomiting, little cough—felt as if "had lost part of her side." heart fell to place—next day crackling thro'-out expanded lung. in 10 days no effusion remain. ing—equal reso-nance in back. dyspnoea (?)from tubercles re-maining. 42. Aug. 18, 1853. Governm't Officer. rather weakly. 6 weeks. 1st, Sept. 7 2d, " 8 do. do. drops, Sbv. a little faint,— great relief to pres-sure and dyspnoea. crackling imme-diately. Oct. 6, percus-sion equal both backs and respi-ration pure. 32 Sept. 28, 1853. Lawyer. none. 6 months. 1st, Oct. 2 do. § lxxvi. felt a little weak. heart fell tow'ds place 1£ inches; murmur heard indistinctly. grad'l improve-ment from time of operation. Under treat-ment. * N. B.—The patient had been operated on by Dr. Wyman many times. Tabular Statement of Operations for Paracentesis Thoracis.—Continued. No. 23. Atro and 1 Dute. Profession. Previous dis-eases. How long sick before first operation. No. of opera-tions and dates. Character of tho fluid. Amount of the fluid. Immediate effects of the operation. ~ How soon the lungs expanded and heart fell into normal po-sition. Final result. 40. Oct. 14, 1853 Laborer. none. 8-J- months. 1st, Oct. 21 pus. 1 lxiv. cough considerable —one or two bloody sputa---much re-lieved of weight— able to lie on either side. lung did not ea-sily come up, air took place of fluid. lung very slow-ly expanding— still much air, no return of fluid in pleura; under treatment. 24. 21. Oct 20, 1853. Farmer. none. 6-£ months. 1st, Oct. 20 pus. S xxiv. relieved from pressure. murmur along vertebra?, and crackling lower down. improving in strength,