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«			
 
INSOMNIA

 
BROMIDIA.
  FORMULA. — Every fluid drachm contains
15 grs. each of, pure Chloral  and purified  Brom.
Potas., and \  gr. each of^rc. imp. ext. Cannabis
Ind. and Hyoscyam.

  Dose  — One half  to  one fnid  drachm  in
Water or Syrup  every  hour until sleep is
produced.                                   '
  Bkomidia is the hypnotic par excellence  It produces
refreshing sleep,  and is exceedingly valuable in Sleepless-
ness, Nervousness, Neuralgia,  Headache, Convulsions,
Colic, etc., a<nd  will relieve when  opiates Jail; unlike pre-
parations of  Opium, it does not lock up the secretions. In
the Restlessness and Delirium of Fevers it is absolutely
invaluable.                             V
              -AMPLE BOTTLE FREE.
   4 oz. Bottle,  4/6 ;  per dozen,  40,-.
  12 oz. Bottle,  11/-; per dozen,  104/-.
10 % discount on one gross and  upwards.
BAT j IE & Co.,  St. Louis,  Mo., U.S.A.
    General Depot for Great Britain :
ROBERTS <&  Co.,
     70, NEW  BOND  ST.,  LONDON.

              I 
— 3 —
                  sa-
             J. K. BAUDUY, M.D., LL.D.,
      L^HYS. ST. VINCENT'S INSANE ASYLUM,
                       AND
            PROF. NERVOUS DISEASES,
       MISSOURI  MEDICAL  COLLEGE,
                 ST. LOUIS,  MO.
    Editor. Medical Brief: — All physicians recog-
 nize the  difficulties they have to encounter  in
 combating the obstinate symptom, Insomnia. In-
 somnia, as is well known by all thoughtful practi-
 tioners, is a symptomatic indication of very differ-
 ent pathological states, and its successful and ju-
 dicious treatment involves good judgment and no
 little experience. The first question is : Why does
 the patient not sleep? Is he suffering from organic
 cerebral  disease? Has  he anaemia or hyperaemia
 of  the brain? Is the sleeplessness the result of
 some form of essential fever? Have indigestion or
 reflex disturbances, protean as they are in  their
 manifestations, any connection with certain patho-
 logical underlying conditions? Have bad and in-
 temperate habits, such as the  abuse of narcotics,
 alcohol, tobacco, and other allied conditions aught
 to do in  its production?  is insanity commencing?
 Does the  history  of the case permit the possibility
of delirium tremens? Has the  patient been sub-
jected to  excessive intellectual strain, leading to 
_ 4 —
 congestive .'cerebral hyperaemia? Are there any of
 the  well-known factors  of vasomotor  paralysis
 present, thereby leading to  cerebral lesions from
 capillary relaxations superinduced  by  a paralysis
 of those branches of the great sympathetic system
 the function of which is to control the contraction
 and dilatation of the arterioles? All these questions
 and many more must be satisfactorily and intelli-
 gently answered, or Insomnia cannot be  scientifi-
 cally treated.  The Physician can no more afford
 to lose sight of  its symptomatic import than he
 can in cases of dropsy, cough, orthopnoea, palpi-
 tation  and  numerous  other cases  in  which the
 symptom must not be confounded with the  di-
 sease.
  Having carefully weighed  and considered these
 questions, it remains to carefully study the etio-
 logy of his case, as every fact and factor relating
 thereto is of great—nay, paramount—importance.
 The history of the case, sequence  of  symptoms,
 individual peculiarities ond idiosyncrasies must,  in
 this connection,  rivet his attention. The history of
 alcoholism, of sexual excess, of the opium  habit,
 or of a recent debauch  would throw, for instance,
a flood of light upon a case for which the physician
could not be  too grateful. Hence,  etiology is  of
 extreme importance under such circumstances. To
illustrate more fully and forcibly the influence  of
 turning the attention in  this direction under similar
circumstances, let the reader for one moment re- 
— 5 —
fleet upon the important therapectic distinctions
depending upon  the  proper differential diagnosis
between a case of cerebral anaemia  and cerebral
hyperaemia resulting in obstinate Insomnia. The
etiology under such circumstances is  the true phi-
losophy of the situation.
  If the case be dependent upon an anaemic con-
dition  of the  brain, the cessation of all factors
which would permit the confirmation of the anae-
miaand its perpetuation must be thoroughly heeded.
The cure of exhausting discharges, the arrest of all
haemorrhages and other drains upon the system
must suggest themselves to the minds of all skilful
physicians, and a successful termination of a case
would thus often take place without any recourse
to direct medication for the Insomnia. These gen-
eral and leading remarks will  enable  us the better
to review and appreciate some of the most appro-
ved methods for the treatment of this very trouble-
some and to some people exceedingly alarming
symptom. All who have had experience in  this
direction know what a terrible ordeal it is to
pitch and toss about all night, hearing every hour
strike, and after perhaps a few snatches of feverish,
fitful and unrefreshing sleep,  to arise in  the morn-
ing exhausted, unnerved and  incapacitated   for
the. renewal of the daily duties. A  repetition of
many such nights must soon destroy  the strongest
constitution, as all the recuperative powers are
renewed during sleep, which is the  most potent 
— 6 —
  physiological factor in renewing all the vital forces
  of the organism. Every case of Insomnia must be
  a special study, to be considered entirely upon its
  own merits. There can  be no common remedy for
  a symptom which  originates  in such antagonistic
  pathological conditions, some cases will yield to
  general hygienic directions, others to correction
  of symptoms of indigestion, to the avoidance of
  late hours, or reading late at night and partaking
  of late suppers. Especially may Insomnia be occa-
  sioned by stomachs growing old in service, failing
  to recollect they can no  longer perform the follies
  of their youth, the indiscretions of which they are
 now paying the penalty,  and for the many sins and
 outrages of which against the law of health, nature
 is now waking up to a  terrible revenge.  In  some
 cases a stimulant is all that is needed. I now make
 many insane patients sleep with beer and alcohol,
 in whom, formerly,  morphia, chloral and  the bro-
 mides  were given, night  after night without avail.
 All familiar with the best treatment of the insane
 know that Insomnia is one of the  most obstinate
 and annoying symptoms the physician has to deal
 with.  Yet, after an experience of twenty years'
 treatment of this, form of disease, I repeat that in
 some  cases,  malt  and alcoholic beverages  will
 succeed where all other  forms of  treatment Will
prove utterly unavailing. Twenty years ago, when
 I assumed charge of St.  Vincent's Asylum, mor-
phia was the narcotic par excellence, then came the 
bromides, hyoscyamia, chloral, etc. Of hyoscyamia
I cannot speak too hyghly;  in  certain forms of
acute mania, the literature  of this efficient and
potent alkaioid is well-known to the  profession.
Its  hypodermic use  must, however,  be in  well-
selected  cases, and  it  must  be very carefully
administered, as regards the dose and  frequency
of repetition.  I have found in cases « acute deli-
rious mania » the wet pack judiciously administered
a useful agent, equalizing the temperature, and by
its  sedative  influence  calming  the patient to a
refreshing slumber; of course its chief usefulness
is in cases where the temperature is  greatly ele-
vated. In many obscure cases we have to ring the
changes on various  hypnotic remedies, and not
infrequently  we are forced  into the domain  ot
empirical  treatment.  Although  I  am  generally
opposed  to  proprietary remedies, justice  to  the
profession and the claims of truth  necessitate the
avowal on my part  that Battle & Co.'s Bhomidia
composed of the best German chloral, bromide  of
potassium and the purest specimens of hyoseyamus
and cannabis indica that the market affords is, par
excellence, I am constrained to say the  best hyp-
notic j have  ever  ised. The small bulk of the
dose, its concentration, purity and general efficacy
and convenience, will force its claims  upon any
practitioner who impartially gives it a  trial. Every
d\y or my like /  use  it  largely, and  have recom-
mended it to hundreds of my brother physicians. At  . 
— 8 —
 St.  Vincent's Asylum, I made a test of it by giving
 each sister in charge of a ward two  bottles, one
 containing Bromidia, the other an ordinary « house
 chloral mixture. » After an impartial trial on their
 part, without any previous knowledge of the con-
 tents of the bottles, a universal verdict  was given
 in favour of BROMIDIA. I was so prejudiced at
 first against the use of this article that a long time
 elapsed  before I  consented to the experiment;
 justice to  the  Profession,  however, requires the
 truth. Perhaps cases of Insomnia resulting from
 alcoholic excess are the most intractable, as when
 sleeplessness arises from that cause,  the case  is
 apt to be a very difficult one to handle; no hypnotic
 treatment should be forced ; the Insomnia should
 be treated by ordinary doses of capsicum, chloral,
 and the bromides, remembering always that as the
 disease of which it  is a  symptom subsides it will
 also  rapidly yield.
  In cases of intellectual strain, all night reading,
 and  studying, must  positively  be forbidden. By,
 adhering to these simple plans of treatment, In-
 somnia can usually be rapidly overcome, especially
 if the physician never loses sight of the fact that  it
is never a disease, but always a symptom of some
 pathological state,  which it is  his duty  to deter-
 mine.
             July No. Medical Brief. 
                      - 9 —
    Permit me to specify particulars of a case, the
  striking effect  of which  it seems  to  me  worth
  recording.
    On May  28th I was called to a man, P. G.,
  who, in a fit of delirium had cut his throat  in the
  most determined manner. For days I  visited him
  repeatedly, and had  him watched day and  night.
  Sleeplessness,  restlessness, and delirium  conti-
  nued, although  enormous doses of combinations
  of Morph. Bimeconate and Chloral: Chloral Tr.
  Hyoscyamus and Potass Bromide, Digitalis, Bel-
 ladonna (extract in pills arid tincture)  were given
 very often.
   On the 19th day of June, I prescribed Bromidia.
 After the second dose the patient had a few  hours
 quiet  sleep, and when  he awoke expressed himself
 as being'4 himself again."
   From that date (June 20th) he took Bromidia
 only twice a day, and  was sufficiently rational to
 be removed to his father's  house, and after the
 second or third day only took a dose at night; in
 all he took three  six ounce mixtures, a sixth part
 for dose. A part of the  last bottle remains, as it is
 not required. The patient has done admirably since
 lhe 26th. He has had to appear at Quarter Ses-
 sions,  a rather trying ordeal, but which  he did not
seem to  mind in the   least, inasmuch  as  he had
some of the mixture left, and, he said, " in  case
of being uneasy in my  mind,  I  can take some of 
                   — 10 —
that night mixture, and  which I  know will be a
great source of comfort to me. "
  Such, Sirs, is one of the cases worth recording,
showing the very striking advantage of Bromidia
over other narcotics or combinations^
  In the above case there was frequent constipa-
tion of bowel. The Bromidia seemed to act directly
on the  muscular coat of bowel, causing relaxation.
1 am about to try Bromidia  again on  a patient I
have in my care for a few days, and on whom Chlo-
ral and Bimeconate of Morphia have failed to give
relief.                  f
             Sam Haich,  M.R.C.S.,  L.S.A.
        Milton, Chipping-Norton, Oxon, Dec. 16, 1885.

   I have used the preparation known as Bromidia,
manufactured by Battle & Co., of St. Louis,  in
hospital and private practice,  since its introduc-
tion to  the  profession,  and consider it the  most
 valuable  hypnotic  and  general  sedative  that I
 know of.
   In the treatment of chronic alcoholism ^and de-
 lirium tremens it is superior to any remedy I have
 ever used. In many cases it  entirely fills the  place
 of opiates,  without disturbing  the  stomach  or
 locking up the secretions.     A. J. Haui:,  M.D.
   Late Surgeon  Nat.  Home  for Dis. Vol. Soldiers a
     Hampton, Va., and Milwankee, Wis.

   I  have used  Bromidia in  a case  of commen-
 cing moral insanity  with  the happiest* results* 
— 41 —
The night frights and alarms, which  caused the
sleep to be quite unrefreshing,  were  entirely re-
moved by a nightly drachm dose, and the general
condition  consequently  much improved.  Other
drugs seemed useless, while Bromide  of  Potas-
sium was  distinctly harmful.
Leslie  Phillips,  M.D.,  M.R.C.S., L.S.A.,
          Medical Officer of Health for Balsall Heath.
   Norton House, 393. Moseley Road, Birmingham,
        Julyl, 1885.
   In my opinion  Bromidia is a  safe and effective
hypnotic, far superior to any one of its ingredients
alone,  or to the combination as prepared from the
ordinary drugs.             J. T. Larew, M. D.
     Prof. Minor Surgery St. Louis Col. Phy. and Sur.
   Bromidia I  regard as a more elegant and accep-
 table mode of  administering  safe  and effectual
 hypnotics in childhood than  extemporaneous pre-
 scriptions.  I have nodoubt[that Bromidia has sup-
 plied a  want long  felt by many  practitioners
in diseases of infancy and  childhood preventing
many from yieldingto  the temptation to use the
various preparations of opium, which are so objec-
tionable and dangerous.
                    J. A. Larrabee, M.D.
    Prof. Diseases of Children and Mat. Med. and
      Therapeutics, Hosp. College of Medicine.
  Louisville, Ky. 
— 12 —
  I have  tried  your Bromidia  principally with
children.  It has never  failed, and  I  consider it
one of the best hypnotics we have. It is a great
saving to  country physicians, as  it combines all
the medicines  we should otherwise  have to make
up. In two cases of convulsions  from teething its
action was almost instantaneous,  and got me the
credit, for which I thank you.
          G.  H. H. De Wolfe,
                     M.A., M.  D., Edin.
          Dore, Sheffield, January 27, 1886.
  Those physicians who will  bear in mind  the
formula of Bromidia, and will prescribe it accor-
ding to correct  therapeutical principles, can not
be disappointed in its effects, and will agree with
me in considering it an agent of great value.
     Ransom Dexter, A.M., M.D., LL. D.
     Prof. Comparative and Human Anatomy and
         Physiology, University of Chicago.
  Chicago,
  I  have  tried  your  Bromidia  in  one  case.
The patient  had just been confined  of her first
child.  She had not  slept fort  48 hours, in fact,
was delirious from Insomnia. Other remedies had
been tried with  no effect.  I began to be  appre
hensive of great danger, when I suddenly thought
of your  Bromidia, and gave it every half hour
(30 minim  doses). In  three hours  she was in  a 
— 13 —
sound sleep, and woke  up  wonderfully better
and  greatly relieved. She  continued taking the
medicine in teaspoonfuls every four hours for two
days.  I  am glad to  say she has made a  good
recovery.          Thomas Jackson, M. D.
            Canton Place, Aulaby Road, Hull.
                      May, 24, 1886.
  I  have tried your Bromidia, and found it so
very satisfactory that I  have used your prepara-
tion constantly since.
  I think I need say nothing more in its favour.
                      Robert Smith,  M.D.
             Durham County Asylum, Sedgefield,
                   Ferryhill, May 2J, 1886.
  I have  beeN using Bromidia in my practice for
several months, and find it to-be a very valuable
hypnotic.  The disagreeable taste of the chloral and
the bromide are quite effectually  concealed,,and
the depressive influence of the drugs on the circu-
lation  admirably counteracted by  the cannabis
indica, and hyoscyamus.
                 Daniel R. Brower, M.D.
(Prof.  Mental  and Nervous Diseases and Medical Juris-
  prudenc,  Woman's Medical College, and Editor Chicago
  Journal of Mental and Nervous Diseases.)
  I have prescribed Bromidia both in the hospital
and for private  patients, and am much pleased 
- 14 —
with its effects. It is  the  best  hypnotic,  causing
sleep in a  short  time,  and leaves  no unpleasant
after effects. It is  certainly better than  any com-
bination of chloral I have ever tried.
                  W. H.  Long, M.  D.,
                 Surgeon U.S. Marine Hospital.
  Louisville,  July  17, 1880.
   Having  used Bromidia for  the  last  eighteen
months I am now convinced that it merits a leading
place among our best  therapeutic agents.  I have
used it frequently, and find it without an equal in
quieting the cough of pulmonary consumption. In
every case of this disease in which  I have used it,
it has never disappointed in completely controlling
the troublesome symptom, thereby securing rest
at night with refreshing sleep.  It does not depress
the patient or destroy the appetite, as opiates do
when used for this purpose. Of course, I  do- not
claim that it exerts any influence ove^the disease,
but Jby its influence, in quieting  cough, securing
sleeps without destroying appetite, it gives us a
chance to improve the condition of the patient by
regulating  diet,  tonics, &c.  I usually prescribe
Bromidia  with equal  parts of syr. prunus  vir.,
beginning with a teaspoonful three or four rimes a
day (of the mixture), increasing the dose until relief
is obtained. In cases where the cough is trouble-
some only at night, I  find the one dose an hour
before bedtime,  and  repeated just as  patient 
— 15 —
retires, to  effectually control the cough for the
entire night.
  In all cases where there is restlessness or ina-
bility to sleep from any cause, I use it, and have
never been disappointed with the result; in fact,  I
consider it one  of  the very best remedies at the
disposal of the profession.
                      Wm. J.  Langa.n, M.D.
               :>609, West 18th Street, St. Louis, Mo.
   In reference to your Bromidia I may inform you
that its gr^at value was brought to my notice by a
gentleman well-known to the world at large  as a
professor and the author of one of the finest works
on Practice  of Medicine, with  whom I was in
consultation at the time. In speaking of it, he re-
marked, «  Doctor, try BROMiDIA, it acts  like
a charm upon me audi fancy it will be just the rem-
edy for your patient. » I  tried it upon my patient
with  such satisfactory  results that  1 presume I
must have ordered'many pounds of it since, and I
still prescribe it when I desire a valuable and ne-
ver foiling hypnotic.
   My consulting physician was Prof. Austin Flint*
of this city, and although using his name without
his consent I am pretty well convinced that he
would not object to my quoting his  remarks.
                 Chas. C. Cramner, M. D.
         Resident Physician, Sturtevant House, N. Y.
  New York, oct. 18, 1883. 
— 16 —
   Bromidia :  This remedy or  combination is pe-
culiarly fitted for the cases which come under our
care; and those who are working with inebriates
and opium cases,  of all others,  should be made
familiar with  it. I recommend it in my private con-
sultations of  cases at a distance, and always with
the best results.    T. D. Crothers, M. D.
              Secretary American Association for the
               cure of  Inebriates; Editor Quarterly
               Journal of Inebriety.
  Hartford, Conn.
           Bromidia in Sea-sickness.
  Gentlemen, — I have used your Bromidia with
great success in cases  of sea-sickness on voyages
to and from England. For that troublesome affec
tion  and. the disorders incident thereto,  it is an
admirable remedy.
                    A. E. Little, M. D.
          Surgeon Steamship « Assyrian Monarch  » —
            New York to London.
  N.  Y. City, No. 3i, West 33 rd St., June 6, 1883.
  I like the preparation of Bromidia. In the cases
in which I have prescribed it, it has had the effect
of tranquilising the  nervous system  and inviting
calm sleep.                   Wm. H.  Day.
           M.D., M.R.C.P., M.R.C.S. &c.
  10, Manchester Square, London W., oct. 14, 1885. 
                    —  17 —
  1 am highly pleased with Bromidia, which 1  con-
sider to. be an admirable combination. In the cases
in which I have used Bromidia its action was gentle
and certain,  without any unpleasant afte effects,
such as headache, etc.        E. J.  Edwardes.
                    M.D., M.R.C.P. &c.
  17,  Orchard Street, Portman Square, London, W.,
Nov. 7, 1885.
   I have administered  Bromidia as a hypnotic al-
most daily for  many months.  When diluted with
ice-water it is not objectionable to those who are
suffering from  indigestions that accompany  the
advanced stages of phthisis and other exhaustible
diseases. I am  convinced, by careful tests, that it
is one of the best soporifics. It is not followed by
any depression  that oftentimes renders the  prepa-
rations  of  opium and  other narcotics so  objec-
tionable. Bromidia seems to be uniform in strength
and effect.     James M; Holloway, M. D.
           Prof. General and Clinical Surgery,  Hospital
            College of Medicine.
  Louisville, Ky.
         Bromidia in Gastric Irritability
  Mr. A  J. H.,age 43, suffered an attack of he-
mipligia two years ago, followed by paralysis, of
the right side of the body and  extreme gastric
irritability. Since  the first attack  he  has been
very slowly regaining  the use  of the affected 
- 18 —
side,  but the digestive organs are exceedingly
weak, often throwing him into spasms of the nature
we often  see  i.i dyspepsia.  I  have  been greatly
troubled to find the best  anodyne  and  soporific
for him, as opium  and its salts were excluded ;
had been using chloral and brom.  potass, equal
parts  for over a year.  I gave  a thorough  trial  of
Bromidia, with results which have been very gra-
tifying to me and to my patient. The canabis  in-
dica and  hyoscyamus undoubtedly  are  coopera-
tive agents in producing the fine effect produced.
It is also  an elegant preparation, always ready
when wanted, and I think thoroughly reliable. All
of the faculty of this place are using Bromidia now.
                       T. R. Hall, M. D.
   Sterling, Neb. March $, 1886.
  We used your Bromidia on a  robust  looking
farmer. John W., age 36, suffering with insomnia
of nearly ten years  standing, and  at the  same
time laboring under the imagination of becoming
insane. We prescribed :
  R. Bromidia........,     2 ounces.
  Syrup simple.
  Aqua............  aa 2 ounces.
  M. Sig. one teaspoonful at 7 and 9 every eve-
ning. After having used the second bottle of the
mixture the patient pronounced himself to be en-
tirely cured.
                 C. A. Bruegmann, M.D.
  M,arysville, Seward Co., Neb. Jan.  I4, 1886- 
                   — 19 —
  I Beg to inform you that I have tried your Bro-
midia in  cases of insomnia, and  found  it most
useful as  a  hypnotic.
         E. R. O'Brien, M.D., L.R.C.S.,
           Brigade Surgeon, Weisbaden, Germany.
   June 5, 188.'i.
  I am very gratified  to have  at  my  disposal a
hypnotic so certain in its effects.  In cases where
narcotics absolutely failed, I have succeeded with
your Bromidia in procuring repose and sleep.
Many of my lady patients and  others  who were
unable to take opiates, cynogloss, hypnone, &c,
&c, have become enchanted with your prepara-
tion, which is so valuable in cases  of insomnia.
                           Dr. M. Nivert.-
   22, Rue Bayard. Paris' May, I9, 1886.
          Bromidia in Delirium Tremens

   I have had very successful results in the admin-
istration  of Bromidia in cases having their ori-
gin in disorders of the nervous  system,  such as
chorea, infantile paralysis, insomnia,  etc. ;  but I
find it to be of special value in treatment of deli-
rium tremens and the results of debauch, it being
retained upon the stomach and speedily control-
ling the most dangerous  symptoms,  and  produ-
cing the  desired  calmness and sleep necessary
when morphia and other soporifics have failed to 
- 20 -
do so, and thus rendering  the disorder amenable
to further  treatment.   Have  also  prescribed it
successfully in the terrible state of nervous  ex-
haustion due to opium habitues, endeavouring to
relinquish the habit. And, finally, as result of ex-
perience, I pronounce it the " Hypnotic par ex-
cellence.
                       W. H. May, M.D.
  50, W. Twenty-fourth Street, New-York City, March
                    3rd. 1886.
   I have prescribed your Bromidia to two of my
patients.   The  first was an old woman,  in  her
second childhood, suffering from nervous  excite-
ment, and getting no rest night or day.  Her re-
latives and friends  were  in despair,  and the ef-
forts  I  had  made  with  chloral, opium, mor-
phine, etc.,  although they had procured her some
little sleep,  had  deprived her of appetite and res-
tricted the action of the stomach.   It  was  then
that your Bromidia came  to the rescue; each dose
was followed  by five to six hours calm and re-
freshing sleep, and  after  a few days we obtained
almost the same  results, even w;th diminished do-
ses of Bromidia.
  The second case was that of a woman of forty,
who had long suffered from hysteriform nervous
attacks, which produced  great t gitation and pre-
vented her  from  getting any sleep, sometimes for
forty-eight hours, during  which time the nervous 
                   — 21 —
convulsions  would  recur in rapid succession.
After this  the patient  would sleep for. a  few
hours, and then continue in a state of prostration
for several days.
   On the occasion of the last attack I gave her  a
teaspoonful of Bromidia.  In an hour she  was
sound asleep.
   This latter is an interesting case, and I purpose
watching the further action of Bromidia with this
patient.
   Further, I would be much obliged if you would
be good  enough to  send me four bottles of Bro-
midia, and later on  I will  advise  you of the results
I obtain.
                                  Dr. Vicq.
     Sampigny,  France, January I4, I887.
  I am very pleased to give  you my  experience
as to the therapeutic action of Bromidia.
  In cases of kidney, lung, and other  disease,
where opium is inadmissible, it is invaluable as  a
sleep producer.
  I  have also found it equally beneficial  in cases
of insomnia,  produced either by exalted  nervous
action, wear  and  tear of brain  work,  or mental
worry.
  I also consider that,  independently, of its ac-
tion as a hypnotic, it is a valuable anti-spasmodic.
I have prescribed it both in  whooping-cough and
hysteria with marked success ;  and an obstinate 
— 22 —
case of chorea, in a lad aged ijx has perfectly re-
covered under the exhibition of Bromidia, and I
believe that the favourable result is entirely attri-
butable to its use.
     T. Poyntz Wright, M.R.C.S., L.S.A.
     Wallshaw Place, Oldham, England.
            Oct. 14, 1883.
  I began trying the effect of Bromidia on myself
with a view to counteracting the Insomnia arising
from  nevrosis from which  I  suffered, and  I  am
happy to state  that I  have procured complete.
calm, and a most  natural sleep,  unattended by
nightmare, and without any feeling of heaviness on
awaking.  Accept the  assurance of my sincerest
regard.               Dr.  Edouard Birdel,
   Honorary Physician of the Hospital, Vierzon.
    Vierzon,  France, April 22. 1887.
  I have much pleasure in adding  my testimonial
to those already recorded in favour  of the anodyne
and eminently hypnotic properties of  Bromidia.
In a case of acute mania, where  the patient had
not had any rest for eight days, a refreshing sleep
(lasting six hours) was speedily induced  after a
second, drachm dose whilst none of the ill effects
which usually result from  hypnotics were obser-
vable.
    T. Greene,  L.R.C.S. &  L.K.Q.C.P,,
         Late Admiralty Surgeon.
The Dell, Ballycarney, Ferns, Co. Wexford,  Ireland. 
                    — 23 —
   I have used the Bromidia you were good enough
 to send me in answer to my request,  and I am
 pleased to state that in the cases in which  I  have
 administered «a dessert-spoonful  at night to  pro-
 cure sleep it has had a very soothing effect,  and
 the sleep procured by its means has not been fol-
 lowed  by  any  cerebral weariness  or  gastric
 Symptoms.       Dr. VlDAL,  Physician at Aix.
     Paris, April 2, 1887.

   I have made  a  trial of Bromidia in avefy bad
 case of dipsomania, complicated  by cirrhosis of
 the liver and obstinate insomnia, and  in which
 chloral, given in doses of ^ to  3   grammes (38 to
 45 grains), had  produced, but very imperfect re-
 sults.
  Two teaspoonfuls of Bromidia procured for the
 patient a complete and refreshing sleep.  I  am
 therefore strongly led to believe  that this formula
 produces better results than chloral.  I  have  re-
 commended  it to  several people, who have  also
 found it very successful. The case to which I have
 alluded is certainly a very remarkable one.
  I have also tried the preparation  on  myself.  I
 find that  sleep is preceded by a very  pleasant sen-
sation of repose; I have no dreams, and I awake
with a clear head and a general  feeling of com-
fort. To  be brief,  it is my opinion that your pre-
 paration  is  destined  to  render  very  valuable
services.                         Dr. Fu*a.
 Rue Conscience, 57, Antwerp, Belgium, March 27, 1887. 
                    — 24 —
   Bromidia is an excellent hypnotic, and I have
 used it  with most  satisfactory results, in every
 sense of the word, in the following cases : — 1st,
 with children suffering from cerebrarl excitement;
 2nd, with aged  persons  suffering from sleepless-
 ness, nervous oppression, and, in fine, with va-
 rious nervous diseases.  I  should state that when
 the patients awake  I do not observe any of the
 various   unpleasant  symptoms  which  generally
 attend the use of preparations  which are simply
 opiates, and which are therefore to my mind infe-
rior to Bromidia.
            Dr. A.  Symon  de Villeneuve.
Rue du Jeu-de'-Paume-Quintin (Cotes-du-Nord),  France.
   For the past three years I have prescribed Bro-
midia very frequently, and have  never  yet been
disappointed in securing the results  required. In
cases when there is Insomnia without pain, in the
delirious stages of acute fevers, in delirium tre-
mens, puerpural mania, in short, in all those cases
requiring soporifics, I  find Bromidia invaluable. I
consider Bromidia an excellent  combination.
             Joseph P. Ross, A.M.,  M. D.,
           Prof. Clinical Medicine and Diseases of the
            Chest, Rush. Med. College.
  Chicago III.

  I have given  your  preparation   of  Bromidia  a
pretty extensive trial, both on myself  and others,
and find it in every respect up to what is claimed
for it, It  is a most valuable sedative,  and has the 
- c25 —
great advantage of leaving  no bad effetcs on  the
following day.
    N. F. H. Fitzmaurice. L.  R.C.P.. L.R.C.S.
  Dunning, Scotland, July 28, 1885.

  I have just completed the series of experiments
I undertook on the subject of Bromidia, and I have
now to inform you of the results. This preparation,
in my opinion, is  as  much an antidote to pain as
it is a hypnotic. In certain  cases of ovarian and
uteric neuralgia  which had not yielded  to injec-
tions of chloral (4 grs.) or to hypodermic injec-
tions of morphine, Bromidia has succeeded admi-
rably. I  have had  occasion  to  try it also in  some
obstinate cases of whooping-cough, and have been
 surprised at the rapidity  with  which it has acted
on the fits of coughing, rendering them less violent
and frequent.
   In two cases of hypochondria, accompanied by
 insomnia, in both of which strong doses of bro-
 mide had failed, Bromidiv brought on a calm sleep.
                            -Dr. Solleliis.
  Verbolaye (Puy-de-D6me),  France, August, 7, 1886.

   I have used your Bromidia in various cases, both
 in  sleeplessness due  to mental excitement border-
ing on mania, and in more ordinary insomnia,  and
I have found it a verysoothing and efficacious rem-
edy, producing  a  calming effect even  where it
was  not given  in large enough doses to induce
sleep. I have seen no untoward after-effects from 
                    — 26 —
it, and I  consider it a useful addition to our arma-
mentarium.
          Robert Roxburgh, F.R.C.S. Edin.
  1,  Victoria Buildings, Weston-super-Mare,  England
June 3, 1886.

  I have used your  Bromidia  in  several cases of
severe bilious headache—amongst the  rest in my
own person—and have found a resource from the
almost intolerable pain accompanying such attacks
usually, until other remed'es to act on bowels and
liver, taken simultaneously, had time to work.
                        J. Ogilyy, M. D.
                         (Surgeon-General.)
 Ulverston Grange, Bournemouth, England, May til, 1888.
  I  have much pleasure in stating that I have pres-
cribed your Bromidia in several cases of Insomnia
and restlessness, and likewise in a case  of spinal
irritation,  with very satisfactory results.
  I  am not in general practice, but I should  ima-
gine that the convenience with which the prepara-
tion can be dispensed must constitute an additional
recommendation.        Thomas  P.  Smith.
                      M.R.C.S.,  and L.S.A.
  Fern Cottage, Reigate, England,  May 31, 1886.
  1 am much pleased with your Bromidia, and have
ordered it frequently of late.  In a case of hysteri-
cal headache, with sleeplessness1,  it answered ad-
mirably,  half  drachm  doses  procuring a  sound
night's rest, with no unpleasant symptoms in the 
— 27 —
 morning. It certainlygives more satisfactory results
 than equivalent doses  of  Bromide Potas.  and
 Chloral.          Percival  H. Watson,
                 L.R.C.P.  Lond., M.R.C.S.
  72, Jesmond Road, Newcastle-on-Tyne, June 1, 1886.

   Bromidia was used in a number of cases of ma-
 larial fevers  of an intermittent type,  during the
 febrile period, and found highly useful in calming
 the  restlessness and  apparently  shortening  the
 stage of exacerbation.  The  headache coincident
 with this stage  has  always been  treated  by  me
 with Bromides, but I  feel  inclined to think that
 your preparation produces somewhat greater  and
 more rapid relief than the plain drug. In a case of
 rheumatic endo-carditis  Bromidia alternated with
 full doses of acid salycilic(salycilateof soda)— the
 relief was rapid and permanent. In several cases of
 enteric catarrh in children it answered the purpose
 for which  I have generally prescribed opium. The
 case in'which I got the most surprising results was
 one in  which  a man of 3o, married,  was at  the
 time of my first visit  (midnight) suffering intense
 pain in  the  left inquinial region,  extending into
 the scrotum,  along the spermatic cord. The slight-
 est touch produced intense agony. The left tes-
ticle was much swollen, tense and  shining (non-
specific  orchitis).  The   muscles of the  abdomen
were hard and retracted. 1  gave at once  a hypo-
dermic of  ^ gr. morph.  sulph. Very little relief
followed this operation, wich was at once supple- 
— 28 —
mented with warm fomentations and external ap-
plications of a liniment, composed of chloroform,
tr. aconite root and laudanum. The great suffering
calling for still further attempt at mitigation, I gave
within half an hour of the hypodermic a teaspoon-
ful of Bromidia, upon which the relief was imme-
diate; he soon sank into a calm sleep and I went
home. The case was treated throughout according
to the usual  methods, and there was subsequently
no paroxysms of pain that could not be easily con-
trolled  by moderate  doses of morphia  by  the
mouth. The  Bromidia  was continued at intervals
of four hours during the first twenty-four hours, at
the end of which time the pulse had become very
much lowered, and the other symptoms pertaining
to the general system favourably modified.
                     Samuel Wolfe, M.D.
  Skippack, Pa.,  U.S.A., Nov. 5, 1885.
  1 have been using your Bromidia for a conside-
rable time in a variety of cases, and am glad to be
able to say that I  have always found it act most
satisfactorily. For  the great majority of cases of
sleeplessness it  is  by far the best combination  I
have ever used.    Thos. J. Dowse, L.R.C.S.,
                   Surg. Co. Wexford Infirmary.
Upper George's Street, Wexford,  Ireland, June 4, 1886.
  I can only repeat what I have already told you
as to the good results that have followed the em-
ploymentof Bromidiainmy own case. Myinsomnia 
— 29 -
 has been considerably modified ; it is a great plea-
 sure  to me to say this, as  it arose from a cause
 which is a difficult one to battle with,  namely, my
 three score  and eighteen years. It was also accom-
 panied by very acute rheumatic pains and sciatica,
 which made walking exceedingly painful.  After
 using Bromidia for three or four days the pain
 entirely disappeared,  and I am now able to resume
 my strolls all over the neighbourhood without any
 more serious consequence than a little fatigue of
 an evening. My nights are comparatively good. A
 teaspoonful  was not enough, I took two, and they
 sufficed. Consequently,  I regard Bromidia as an
 excellent hypnotic and as a valuable anti-neuralgic.
 Further than this, I  have observed in my own case
 an effect which I do not see mentioned by any of
 my honoured colleagues :  — Bromidia possesses
 well marked and undeniable diuretic qualities. For
 instance, on the morning after taking  Bromidia, I
 noticed that the bladder had  acted freely;  if I
 abstained  from Bromidia for two days the  usual
 sluggishness was again apparent.  In other words,
 the bladder had  not  been relieved to more than
 one-half sometimes one-fourth — the extent that
it would have  been had I taken Bromidia ; but on
returning to the doses the bladder was again ac-
tive. I consider that this  medicament exercises a
direct influence on the kidneys, and that it would
 be of great service as a powerful diuretic.
  The above are my personal observations,  as far 
— 30 —
 as I am myself concerned, but I  trust 1  may soon
 have an opportunity of reporting my observations
 in my practice.              Dr. A. Mallet.
   Breteuil (Oise)  France March 30, 1887.

   My experience with Bromidia. is not only that
 it is a most excellent and agreeable  hypnotic, but
 a great nerve sedative.     A. T. Schofield,
              M.D., L.R.C.P., M.R.C.S.,etc.
    141, Westbourne Terrace, Hyde  Park, \\\,
             London, Nov. 3,  1885.

  I have tried your product in a case  of severe
 headache of almost daily recurrence,  and the at-
 tacks of which were accompanied by very acute
 gastric disturbances.
  Thanks to the influence of the medicament the
 pain completely  disappeared, giving place almost
 immediately to a most refreshing sleep, free from
agitation and from  any subsequent  heaviness or
 cephalalgia.                   Dr.  Declety.
   Wisernes, France, March 28 1887.

  I have pleasure in testifying to the following :—
  I. Sciatica. —  After trying all  the  usual reme-
 dies in a stubborn case of sciatica for two months,
your Bromidia, after a week's use, was marvellous
in its effects and completed the cure.
  II. Insomnia in a woman, aged 74 years, suffe-
ring from Scirrhus of Breast.  Bromidia in this case
has acted like  magic,  and the  patient  now has
 comfortable nights. 
— 31  —
  III. Melancholia with Insornnia; — Here again
Bromidia has exceeded all my expectations.
       J no. Greenhalgh, L.K.Q.C.P.  &c.
   Clifle House, Skelmanthorpe, Huddersfield,
        England, Oct. 14, 1885.
  It is my pleasing task to inform you that, having
prescribed  your Bromidia in a case of acute hea-
dache  of long standing, and which  had hitherto
baffled all treatment, it proved a most unqualified
success.                      Dr. Dovmic,
            Chevalier of the Legion of Honour.
     .Poissy (Seine-et-Oise), France, April 13, 1887.
   I had just written to you when I had a visit this
morning from a good woman who came imploring
me not to  leave her husband  without a supply of
'• the medicament which puts him to sleep.'',
   The preparation referred to was of course your
Bromidia,  which alone was able to soothe the in-
tense sufferings of the poor sufferer from sciatica
and bring back to  him the  boon of sleep.
   Kindly  send me a bottle of it as soon as pos-
sible, and let. me know cost of same.
   Applied to  a case of general muscular rheuma-
tism, Bromidia produced very  satisfactory results;
also in the case of a  poor fellow suffering  from
laryngitis,  also in  a case  of catarrh  where sleep
was hitherto  impossible; and  again to-day in a
case of dental neuralgia.       Dr. Gorlier.
-   Rosnv-sur-Seine (Seine-et-Oise), France,
           March 28, 1887. 
 
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