Brain Glucose Utilization in Mice with a Targeted Mutation in the Thyroid Hormone alpha or beta Receptor Gene Brain Glucose Mutation Thyroid Hormones The study demonstrated that in mice a targeted mutation of the TRα thyroid hormone receptor that prevents it from binding thyroid hormone results in the same retardation of body growth and maturation of local cerebral glucose utilization as seen in cretinism produced by neonatal thyroidectomy whereas a corresplnding mutation in the TRβ thyroid hormone receptor has no such effects. This study demonstrates that thyroid binding to the TRα thyroid hormone receptor and not at all to the TRβ receptor is critical to the normal maturation of the brrain. National Academy of Sciences (U.S.), 14 August 2001 The National Academy of Sciences (U.S.), 14 August 2001 NAS, 14 August 2001 Proceedings of the National Academy of Sciences of the United States of America National Institute of Mental Health (U.S.) The National Institute of Mental Health (U.S.) National Cancer Institute (U.S.) Itoh, Yoshiaki Esaki, Takanori Kaneshige, Masahiro Suzuki, Hideyo Cook, Michelle Sokoloff, Louis Cheng, Sheue-Yann Nunez, Jacques Articles Archival Materials Text 6 pages nlm:nlmuid-101743402X64-doc 101743402X64 http://resource.nlm.nih.gov/101743402X64 Profiles ID: NLBBFB English Profiles in Science