
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>Letter from Francis Crick to Aaron Klug</dc:title>
  <dc:subject>DNA</dc:subject>
  <dc:subject>Nucleosomes</dc:subject>
  <dc:description>Crick here made a final comment on a draft of a paper by Klug regarding the spatial arrangement of DNA and histones in nucleosomes, particularly whether the DNA helix was itself coiled in a nucleosome (forming a coiled coil, or superhelix).  Crick warned that &quot;the whole question of the conformation of superhelical DNA in solution is full of difficulties.&quot;. In the last paragraph Crick took issue with the an alternative model of DNA presented by R. A. Rodley and colleagues in which the two strands of DNA were straight rather than helical.</dc:description>
  <dc:publisher>Produced: 1 July 1977</dc:publisher>
  <dc:contributor>The Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers</dc:contributor>
  <dc:contributor></dc:contributor>
  <dc:contributor>Crick, Francis</dc:contributor>
  <dc:type>Letters (correspondence)</dc:type>
  <dc:format>Archival Materials</dc:format>
  <dc:format>Text</dc:format>
  <dc:format>2 pages</dc:format>
  <dc:identifier>nlm:nlmuid-101584582X230-doc</dc:identifier>
  <dc:identifier>101584582X230</dc:identifier>
  <dc:identifier>http://resource.nlm.nih.gov/101584582X230</dc:identifier>
  <dc:identifier>Profiles ID: SCBBQF</dc:identifier>
  <dc:language>English</dc:language>
  <dc:relation>Profiles in Science</dc:relation>
</oai_dc:dc>