Chemo-Immunological Studies on Conjugated Carbohydrate-Proteins: VII. Immunological Specificity of Antigens Prepared by Combining alpha- and beta-Glucosides of Glucose with Proteins The seventh of a long series of studies on efforts by Avery's lab to chemically couple the type-II and type-III pneumonia polysaccharides to protein. Although Avery oversaw most of these experiments, their principle investigator was Goebel, who in 1939, independently demonstrated that the specificity of the type-III polysaccharide is inherent in the structure of the disaccharide, glucose-glucuronic acid. When the disaccharide was coupled with the protein, it yielded a synthetic antigen that induced the formation of antibodies reactive with the intact polysaccharide. These antibodies could protect laboratory animals against type-III infection. The Rockefeller University Archives, May 1932 Journal of Experimental Medicine Avery, Oswald T. Goebel, Walther F. Babers, Frank H. Articles Archival Materials Text 12 pages nlm:nlmuid-101584575X553-doc 101584575X553 http://resource.nlm.nih.gov/101584575X553 Profiles ID: CCGMCS English Profiles in Science