An Immunologic Approach to the Conformational Equilibria of Polypeptides Antigen-Antibody Reactions Protein Conformation Antibody Specificity Epitopes Certain antibodies are particularly well-suited for the study of the conformational equilibria of polypeptide fragments of nuclease in solution. Here, Anfinsen, Schechter, Sachs, and Eastlake hypothesized that such fragments actually existed in solution in conformational equilibrium, components of which were sufficiently similar to the native conformation that antibodies directed to the native molecule could bind. They were able to validate this hypothesis by using synthetic polypeptide fragments, which were already known to induce folding of complimentary fragments. National Academy Press (U.S.), December 1972 National Academy Press, December 1972 Proceedings of the National Academy of Sciences of the United States of America Sachs, David H. Schechter, Alan N. Eastlake, Ann Anfinsen, Christian B. Anfinsen, Christian B. Articles Archival Materials Text 5 pages nlm:nlmuid-101584571X176-doc 101584571X176 http://resource.nlm.nih.gov/101584571X176 Profiles ID: KKBBLL English Profiles in Science