Solid Phase Synthesis of a 42-Residue Fragment of Staphylococcal Nuclease: Properties of a Semisynthetic Enzyme Amino Acid Sequence Chromatography Peptides After discovering an error in their original primary sequence analysis of staphylococcal nuclease, in which residue 43 was misidentified as glutamine instead of glutamic acid, Ontjes and Anfinsen published this paper. They reported that a resynthesis of the correct sequence in turn yielded a product with high biological activity. Therefore, they concluded that residue 43, although not essential for folding, was very important for catalytic activity once folding had occurred. National Academy Press (U.S.), October 1969 National Academy Press, October 1969 Proceedings of the National Academy of Sciences of the United States of America Ontjes, David Anfinsen, Christian B. Anfinsen, Christian B. Articles Archival Materials Text 8 pages nlm:nlmuid-101584571X173-doc 101584571X173 http://resource.nlm.nih.gov/101584571X173 Profiles ID: KKBBLH English Profiles in Science