Studies on the Structural Basis of Ribonuclease Activity This brief note was the product of Anfinsen's one-year postdoctoral fellowship from the Rockefeller Foundation at the Carlsberg Laboratory in Copenhagen. It was Anfinsen's second tour at the laboratory; his first in 1939-1940 was cut short due the outbreak of World War II. Working with the Danish biochemist Kaj Linderstrom-Lang and others, Anfinsen conducted an in-depth physical analysis of the structure of ribonuclease, or Rnase. The group suggested that only a relatively small part of the Rnase molecule, the "active center," is directly involved in catalytic activity, and therefore an ordered secondary structure in a protein was unnecessary for its properties as a catalyst. This conclusion was largely disproven by Anfinsen's subsequent research into amino acid sequencing and protein folding in the 1960s. Amsterdam Elsevier, 1955 Biochimica et Biophysica Acta Anfinsen, Christian B. Anfinsen, Christian B. Harrington, William F. Hvidt, Aase Linderstrom-Lang, Kaj Ottensen, Martin Schellman, John Articles Archival Materials Text 2 pages nlm:nlmuid-101584571X164-doc 101584571X164 http://resource.nlm.nih.gov/101584571X164 Profiles ID: KKBBKW English Profiles in Science