
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>The Purification and Characterization of an Extremely Thermostable alpha-Amylase from the Hyperthermophilic Archaebacterium Pyrococcus furiosus</dc:title>
  <dc:subject>Amino Acid Sequence</dc:subject>
  <dc:subject>Enzyme Stability</dc:subject>
  <dc:subject>Pyrococcus furiosus</dc:subject>
  <dc:description>Anfinsen believed that the discovery of hyperthermophilic bacteria in the early 1980s provided a valuable tool for the analysis of protein stability, because these bacteria made it possible to study the molecular mechanisms that governed structure and function in a system adapted for elevated temperatures.  In this article, Anfinsen, et al, reported that they had purified to homogeneity the alpha-amylase, an enzyme that degrades starch, from the hyperthermophilic archaebacterium Pyrococcus furiosus.  Due to the large amount of data available on alpha-amylase, Anfinsen believed that the enzyme was a &quot;favorable&quot; choice for the comparison of mesophilic, or optimal temperature-loving, and Thermophilic enzymes.</dc:description>
  <dc:publisher>American Society for Biochemistry and Molecular Biology, 15 November 1993</dc:publisher>
  <dc:publisher>The American Society for Biochemistry and Molecular Biology, 15 November 1993</dc:publisher>
  <dc:contributor>Journal of Biological Chemistry</dc:contributor>
  <dc:contributor>Laderman, Kenneth A.</dc:contributor>
  <dc:contributor>Davis, Bradley R.</dc:contributor>
  <dc:contributor>Krutzsch, Henry C.</dc:contributor>
  <dc:contributor></dc:contributor>
  <dc:contributor>Lewis, Marc S.</dc:contributor>
  <dc:contributor>Griko, Y. V.</dc:contributor>
  <dc:contributor></dc:contributor>
  <dc:contributor>Privalov, Peter L.</dc:contributor>
  <dc:contributor>Anfinsen, Christian B.</dc:contributor>
  <dc:contributor>Anfinsen, Christian B.</dc:contributor>
  <dc:type>Articles</dc:type>
  <dc:format>Archival Materials</dc:format>
  <dc:format>Text</dc:format>
  <dc:format>8 pages</dc:format>
  <dc:identifier>nlm:nlmuid-101584571X157-doc</dc:identifier>
  <dc:identifier>101584571X157</dc:identifier>
  <dc:identifier>http://resource.nlm.nih.gov/101584571X157</dc:identifier>
  <dc:identifier>Profiles ID: KKBBKN</dc:identifier>
  <dc:language>English</dc:language>
  <dc:relation>Profiles in Science</dc:relation>
</oai_dc:dc>