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Immunosuppressive management
Immunosuppressive management
- Contributor(s):
- Turcotte, Jeremiah G., 1933-
Academy of Health Sciences (U.S.) - Publication:
- Fort Sam Houston, Tex. : The Academy : [for loan by Academy of Health Sciences, Health Sciences Media Division], 1975
- Language(s):
- English
- Format:
- Moving image
- Subject(s):
- Graft Rejection -- prevention & control
Immunosuppressive Agents -- therapeutic use - Abstract:
- Immunosuppressant drugs given to transplant patients serve to reduce the strength of the body’s immune system, with the hope that the body will be less likely to reject a transplanted organ. At the time this video was released, the survival rate for organ transplants had plateaued, and the program presents a review of immunosuppressive management primarily in reference to transplant patients. Historical highlights in the development of immunosuppressive management are reviewed. Then the lessons that have been learned from renal transplantation are discussed. An example of one of the lessons discussed is that not all rejection episodes can be prevented or reversed. The standard immunosuppressive regimen used at the University of Michigan is profiled. This regimen consists of administering Azathioprine in doses of 3mg/kg x 10 days (maximum 200 mgs.) and 2.5 mg/kg after 10 days if tolerated (maximum 150 mgs.) and Prednisone 1.5 mg/kg x 7 days, tapering to 1 mg/kg during the second week and 0.25 mg/kg by 3-6 months. The effectiveness of this regime is then discussed. Pulse therapy as an attempt to reduce the side effects associated with chronic use of steroids while maintaining the effectiveness of these drugs is then described. The advantages and disadvantages of administering the steroids by the oral and intravenous route are then compared and contrasted. Conclusions derived from the author's experience are then noted.
- Copyright:
- The National Library of Medicine believes this item to be in the public domain. (More information)
- Extent:
- 024 min.
- Color:
- Color
- Sound:
- Sound
- Credits:
- Jeremiah G. Turcotte.
- Technique:
- Other
- NLM Unique ID:
- 7602109A (See catalog record)
- OCLC no.:
- 4869038
- Permanent Link:
- http://resource.nlm.nih.gov/7602109A