Role of Sodium and Potassium Ions in Regulation of Glucose Metabolism in Cultured Astroglia

Role of Sodium and Potassium Ions in Regulation of Glucose Metabolism in Cultured Astroglia

Contributor(s):
Driscoll, Bernard F.
Law, Mona J.
Sokoloff, Louis
National Institute of Mental Health (U.S.)
Takahashi, Shinichi
Proceedings of the National Academy of Sciences of the United States of America
Publication:
National Academy of Sciences (U.S.), May 1995
Language(s):
English
Format:
Text
Subject(s):
Glucose
Metabolism
Potassium
Sodium
Astrocytes
Genre(s):
Archival Materials
Articles
Abstract:
In a short annotated bibliography of the articles he considered his most significant, Sokoloff noted, "Reports studies with neuronal and astroglial cell cultures demonstrating that glucose utilization in neurons but not in astroglia is stimulated by increased extracellular K+ concentration (e.g., expected to occur in vivo as a result of increased spike frequency in axonal terminals) that in turn activates Na+, K+ -ATPase activity. Astroglial glucose utilization is stimulated by glutamate (presumably released in synapses by functional activation of excitatory pathways); the mechanism of the metabolic stimulation is coupled uptake of Na+ with the glutamate by the astroglia and consequent activation of Na+, K+ -ATPase activity.)"
Copyright:
The National Library of Medicine believes this item to be in the public domain. (More information)
Extent:
5 pages
NLM Unique ID:
101743402X61 (See in Profiles in Science)
Profiles in Science ID:
NLBBDX
Permanent Link:
http://resource.nlm.nih.gov/101743402X61
Archival Collection:
The Louis Sokoloff Papers (Profiles in Science)