The Soluble Specific Substance of Pneumococcus: IV. On the Nature of the Specific Polysaccharide of Type III Pneumococcus

The Soluble Specific Substance of Pneumococcus: IV. On the Nature of the Specific Polysaccharide of Type III Pneumococcus

Contributor(s):
Heidelberger, Michael
Goebel, Walther Friedrich, 1899-1993
Journal of Biological Chemistry
Publication:
American Society for Biochemistry and Molecular Biology, 2 November 1926
Language(s):
English
Format:
Text
Subject(s):
Streptococcus pneumoniae
Pneumococcal Infections
Polysaccharides
Genre(s):
Archival Materials
Articles
Abstract:
Throughout the 1920s the scientific community remained skeptical of Avery and Heidelberger's work on the unique antigenic polysaccharides in type II and type III pneumococcus. Echoing prevailing beliefs among scientists that only proteins could act as antigens, critics contended that Heidelberger and Avery's polysaccharide solutions had been contaminated by proteins, and that these, not the polysaccharides, were causing the antigenic reactions. As a result, the two approached Walther Goebel, an organic chemist, in order to more specifically determine the nature of these polysaccharides and their antigenic properties. This article details their findings as to the structure and composition of the polysaccharide capsule of type III pneumococcus.
Copyright:
The National Library of Medicine believes this item to be in the public domain. (More information)
Extent:
12 pages
NLM Unique ID:
101584940X6 (See in Profiles in Science)
Profiles in Science ID:
DHBBBH
Permanent Link:
http://resource.nlm.nih.gov/101584940X6
Archival Collection:
The Michael Heidelberger Papers (Profiles in Science)