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The Soluble Specific Substance of Pneumococcus: IV. On the Nature of the Specific Polysaccharide of Type III Pneumococcus
The Soluble Specific Substance of Pneumococcus: IV. On the Nature of the Specific Polysaccharide of Type III Pneumococcus
Contributor(s):
Heidelberger, Michael Goebel, Walther Friedrich, 1899-1993 Journal of Biological Chemistry
Publication:
American Society for Biochemistry and Molecular Biology, 2 November 1926
Throughout the 1920s the scientific community remained skeptical of Avery and Heidelberger's work on the unique antigenic polysaccharides in type II and type III pneumococcus. Echoing prevailing beliefs among scientists that only proteins could act as antigens, critics contended that Heidelberger and Avery's polysaccharide solutions had been contaminated by proteins, and that these, not the polysaccharides, were causing the antigenic reactions. As a result, the two approached Walther Goebel, an organic chemist, in order to more specifically determine the nature of these polysaccharides and their antigenic properties. This article details their findings as to the structure and composition of the polysaccharide capsule of type III pneumococcus.
Copyright:
The National Library of Medicine believes this item to be in the public domain. (More information)