Immunological Relationships of Cell Constituents of Pneumococcus: Second Paper

Immunological Relationships of Cell Constituents of Pneumococcus: Second Paper

Contributor(s):
Heidelberger, Michael
Avery, Oswald Theodore, 1877-1955
Journal of Experimental Medicine
Publication:
Rockefeller Institute for Medical Research, August 1925
Language(s):
English
Format:
Text
Subject(s):
Pneumococcal Infections
Streptococcus pneumoniae
Genre(s):
Archival Materials
Articles
Abstract:
In this article, Avery and Heidelberger discuss their findings regarding the immunologic relationship between the nucleoprotein and carbohydrate portions of pneumococcus. The pair found that the carbohydrate portion of each type of pneumococcus (by 1923 scientists had identified three different types I, II, and III, roughly based on capsule size) was in fact a polysaccharide unique to that particular type. They also found that while the nucleoprotein component is antigenic when isolated outside of the cell, the polysaccharide component is not. Heidelberger and Avery concluded that the two combine to form an antigenic complex that has different properties than each of its member components.
Copyright:
This item may be under copyright protection; contact the copyright owner for permission before re-use.
Extent:
10 pages
NLM Unique ID:
101584940X4 (See in Profiles in Science)
Profiles in Science ID:
DHBBBF
Permanent Link:
http://resource.nlm.nih.gov/101584940X4
Archival Collection:
The Michael Heidelberger Papers (Profiles in Science)