The Human Antibody Response to Simultaneous Injection of Six Specific Polysaccharides of Pneumococcus

The Human Antibody Response to Simultaneous Injection of Six Specific Polysaccharides of Pneumococcus

Contributor(s):
Heidelberger, Michael
Di Lapi, Marie M.
MacLeod, Colin M. (Colin Munro), 1909-1972
Journal of Experimental Medicine
Publication:
Rockefeller Institute for Medical Research, September 1948
Language(s):
English
Format:
Text
Subject(s):
Polysaccharides
Antibodies
Genre(s):
Archival Materials
Articles
Abstract:
During World War II, Heidelberger became involved in an effort by military physicians to develop a pneumonia vaccine, consisting of a combination of purified polysaccharides of four specific pneumococcal types, for the immunization of troops. For this article, Heidelberger and one of his wartime collaborators, Colin MacLeod, along with M. M. Di Lapi, studied how the body reacted if injected with more than four types of specific polysaccharides (a combination of four types were administered during the military field trial) at one time, namely with specific polysaccharides of the six most common types of pneumonia. The authors found that such a vaccine was as effective as one made of four pneumococcal polysaccharide antigens in stimulating an immune response.
Copyright:
This item may be under copyright protection; contact the copyright owner for permission before re-use.
Extent:
4 pages
NLM Unique ID:
101584940X34 (See in Profiles in Science)
Profiles in Science ID:
DHBBCQ
Permanent Link:
http://resource.nlm.nih.gov/101584940X34
Archival Collection:
The Michael Heidelberger Papers (Profiles in Science)