Velocity of Combination of Antibody with Specific Polysaccharides of Pneumococcus

Velocity of Combination of Antibody with Specific Polysaccharides of Pneumococcus

Contributor(s):
Heidelberger, Michael
Mayer, Manfred M.
Journal of Biological Chemistry
Publication:
American Society for Biochemistry and Molecular Biology, 1 May 1942
Language(s):
English
Format:
Text
Subject(s):
Antibodies
Polysaccharides
Pneumococcal Infections
Genre(s):
Archival Materials
Articles
Abstract:
In the early 1940s, Heidelberger turned his attention to studying immunological cross-reactions between type III and type VIII pneumococcal polysaccharide antigens, respectively, and antibodies formed against the other type of pneumococcal antigen (meaning that type III pneumococcal antigen reacted with type VIII anti-pneumococcal antibody, and type VIII pneumococcal antigen with type VIII anti-pneumococcal antibody). Immunological cross reactions occur when antibodies formed against one antigen react with another antigen that shares identical or closely related binding sites, called immunological determinants, with the first antigen. From such cross reactions scientists can deduce important details about the chemical composition of antigens and antibodies. In this paper, Heidelberger and Manfred Mayer reported their findings regarding the speed with which such cross reactions occurred.
Copyright:
The National Library of Medicine believes this item to be in the public domain. (More information)
Extent:
8 pages
NLM Unique ID:
101584940X30 (See in Profiles in Science)
Profiles in Science ID:
DHBBCL
Permanent Link:
http://resource.nlm.nih.gov/101584940X30
Archival Collection:
The Michael Heidelberger Papers (Profiles in Science)