A Method for the Preparation of Crystalline Oxyhemoglobin

A Method for the Preparation of Crystalline Oxyhemoglobin

Contributor(s):
Heidelberger, Michael
Journal of Biological Chemistry
Publication:
American Society for Biochemistry and Molecular Biology, 1 July 1922
Language(s):
English
Format:
Text
Subject(s):
Hemoglobins
Genre(s):
Archival Materials
Articles
Abstract:
In 1921, Heidelberger began to work with Donald D. Van Slyke at the Rockefeller Institute's hospital. Van Slyke had been working to understand the functioning of the kidneys, and more specifically the interaction between oxygen and hemoglobin. At this time, oxyhemoglobin (in which an oxygen molecule is attached to the heme component of the hemoglobin protein) could be produced synthetically in quantities too small to be useful, and also lacked much oxygen-carrying capability. Van Slyke and his team asked Heidelberger to address this problem. In this article, Heidelberger describes a method he developed that created greater yields of oxyhemoglobin with nearly all of its oxygen-carrying power intact.
Copyright:
The National Library of Medicine believes this item to be in the public domain. (More information)
Extent:
10 pages
NLM Unique ID:
101584940X2 (See in Profiles in Science)
Profiles in Science ID:
DHBBBC
Permanent Link:
http://resource.nlm.nih.gov/101584940X2
Archival Collection:
The Michael Heidelberger Papers (Profiles in Science)