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Walter A. Jacobs was Heidelberger's mentor and collaborator at the Rockefeller Institute for Medical Research between 1912 and 1922. Together they worked on problems in synthetic organic chemistry, notably the development of drugs for the cure of poliomyelitis; of the arsenical compound tryparsamide, an effective treatment against African sleeping sickness; and of cinchona alkaloid derivatives and other bactericides they hoped would prove effective against pneumococcal and other bacterial infections.
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