Chemotherapy of Trypanosome and Spirochete Infections: Chemical Series. I. N-Phenylglycineamide-p-Arsonic Acid

Chemotherapy of Trypanosome and Spirochete Infections: Chemical Series. I. N-Phenylglycineamide-p-Arsonic Acid

Contributor(s):
Heidelberger, Michael
Jacobs, Walter A.
Journal of Experimental Medicine
Publication:
Rockefeller Institute for Medical Research, October 1919
Language(s):
English
Format:
Text
Subject(s):
Drug Therapy
Spirochaetales
Genre(s):
Archival Materials
Articles
Abstract:
Early twentieth-century scientists had long been attempting to treat trypanosomiasis, or African Sleeping Sickness, with arsenic-based compounds. Unfortunately, these compounds were largely ineffective and highly toxic. In light of this, Heidelberger and Walter Jacobs began work to formulate an alternate treatment for the disease. This article describes the pair's successful creation of a simple, non-toxic, and easily made arsenic compound to treat sleeping sickness, which Simon Flexner, director of the Rockefeller Institute, named "tryparasamide."
Copyright:
The National Library of Medicine believes this item to be in the public domain. (More information)
Extent:
5 pages
NLM Unique ID:
101584940X1 (See in Profiles in Science)
Profiles in Science ID:
DHBBBB
Permanent Link:
http://resource.nlm.nih.gov/101584940X1
Archival Collection:
The Michael Heidelberger Papers (Profiles in Science)