Effect of Pentaquine in Patients with Hypertension

Effect of Pentaquine in Patients with Hypertension

Contributor(s):
Wilkins, Robert W.
Proceedings of the Society for Experimental Biology and Medicine
Freis, Edward D.
Publication:
Society for Experimental Biology and Medicine (New York, N.Y.), 1947
Language(s):
English
Format:
Text
Subject(s):
Hypertension
Antihypertensive Agents
Aminoquinolines
Genre(s):
Archival Materials
Articles
Abstract:
Following World War II, Freis returned to Boston to work with Wilkins at Massachusetts Memorial Hospital. Their work on pentaquine was an outgrowth of anti-malarial work conducted by others during the war, in which it was observed that some volunteers developed orthostatic hypotension. In this article, they report that the drug did lower blood pressure, yet it would not be an effective antihypertensive agent because it also produced severe toxic effects.
Copyright:
This item may be under copyright protection; contact the copyright owner for permission before re-use.
Extent:
4 pages
NLM Unique ID:
101584929X68 (See in Profiles in Science)
Profiles in Science ID:
XFBBFH
Permanent Link:
http://resource.nlm.nih.gov/101584929X68
Archival Collection:
The Edward D. Freis Papers (Profiles in Science)