Double Blind Control Study of Antihypertensive Agents: III. Chlorothiazide Alone and in Combination with Other Agents; Preliminary Results

Double Blind Control Study of Antihypertensive Agents: III. Chlorothiazide Alone and in Combination with Other Agents; Preliminary Results

Contributor(s):
Veterans Administration Cooperative Study Group on Antihypertensive Agents
Archives of Internal Medicine
Publication:
American Medical Association, August 1962
Language(s):
English
Format:
Text
Subject(s):
Hypertension
Antihypertensive Agents
Chlorothiazide
Reserpine
Hydralazine
Genre(s):
Archival Materials
Articles
Abstract:
In 1956, Freis and a group of physicians in several Veterans Administration hospitals organized a cooperative study group to evaluate antihypertensive agents under well-controlled conditions. In this third and final article, they reported that treatment of hypertensive patients with the diuretic chlorothiazide compared favorably to earlier studies in which patients were treated with a combination of reserpine (a ganglionic-blocking agent) and hydralazine (a vasodilator). They further noted that patients from the earlier study who were then treated with chlorothiazide recorded even greater reductions in their blood pressure, even if the dosages of ganglionic blockers were reduced.
Copyright:
The National Library of Medicine believes this item to be in the public domain. (More information)
Extent:
7 pages
NLM Unique ID:
101584929X63 (See in Profiles in Science)
Profiles in Science ID:
XFBBFB
Permanent Link:
http://resource.nlm.nih.gov/101584929X63
Archival Collection:
The Edward D. Freis Papers (Profiles in Science)