Double Blind Control Study of Antihypertensive Agents: II. Further Report on the Comparative Effectiveness of Reserpine, Reserpine and Hydralazine, and Three Ganglion Blocking Agents, Chlorisondamine, Mecamylamine, and Pentolinium Tartrate
Veterans Administration Cooperative Study Group on Antihypertensive Agents
Archives of Internal Medicine
In 1956, Freis and a group of physicians in several Veterans Administration hospitals organized a cooperative study group to evaluate antihypertensive agents under well-controlled conditions. In this second of three articles, they confirmed some of the general findings of the first report, that a regimen of reserpine (a ganglionic-blocking agent) combined with hydralazine (a vasodilator) produced far better results than the use of ganglionic-blocking agents alone.
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