A Double Blind Control Study of Antihypertensive Agents: I. Comparative Effectiveness of Reserpine, Reserpine and Hydralazine, and Three Ganglionic Blocking Agents, Chlorisondamine, Mecamyamine, and Pentolinium Tartrate
Veterans Administration Cooperative Study Group on Antihypertensive Agents
Archives of Internal Medicine
In 1956, Freis and a group of physicians in several Veterans Administration hospitals organized a cooperative study group to evaluate antihypertensive agents under well-controlled conditions. In this first of three articles, they reported that various therapeutic regimens were compared in a double-blind control study on 326 hypertensive patients, 232 of whom completed a full year of treatment. The group found that a combination of reserpine (a ganglionic-blocking agent) and hydralazine (a vasodilator) was far more effective than placebos or reserpine alone.
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