Captopril: Evaluation of Low Doses, Twice-Daily Doses and the Addition of Diuretic for the Treatment of Mild to Moderate Hypertension

Captopril: Evaluation of Low Doses, Twice-Daily Doses and the Addition of Diuretic for the Treatment of Mild to Moderate Hypertension

Contributor(s):
Veterans Administration Cooperative Study Group on Antihypertensive Agents
Clinical Science
Publication:
Medical Research Society (Great Britain), 1982
Language(s):
English
Format:
Text
Subject(s):
Hypertension
Antihypertensive Agents
Captopril
Hydrochlorothiazide
Genre(s):
Archival Materials
Articles
Abstract:
In the early 1980s, a new class of drugs were developed that treated hypertension by preventing the synthesis of certain hormones that caused blood vessels to constrict. These drugs, of which Captopril was one, were designated as angiotensin converting enzyme (ACE) inhibitors. Freis's team reported that Captopril, which up to then had only been administered to the most severe hypertensive patients, effectively reduced blood pressure in lower doses than indicated in previous studies, reducing the likelihood of deleterious side effects. As a result, they recommended that its use be extended to the general population.
Copyright:
The National Library of Medicine believes this item to be in the public domain. (More information)
Extent:
3 pages
NLM Unique ID:
101584929X35 (See in Profiles in Science)
Profiles in Science ID:
XFBBCR
Permanent Link:
http://resource.nlm.nih.gov/101584929X35
Archival Collection:
The Edward D. Freis Papers (Profiles in Science)