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Mental Depression in Hypertensive Patients Treated for Long Periods with Large Doses of Reserpine
Mental Depression in Hypertensive Patients Treated for Long Periods with Large Doses of Reserpine
In the early 1950s, the extremely effective antihypertensive drug reserpine, a pure active alkaloid of the tropical plant rauwolfia, became available for clinical use. In this article, Freis reported that in high doses reserpine resulted in severe mental depression.
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