Annealing cDNA3' and cDNA5' to Linear ASV DNA

Annealing cDNA3' and cDNA5' to Linear ASV DNA

Contributor(s):
University of California, San Francisco. Archives and Special Collections. Harold E. Varmus Papers
UCSF
Publication:
Produced: [1978]
Language(s):
English
Format:
Still image
Subject(s):
Avian Sarcoma Viruses
DNA
Genre(s):
Archival Materials
Slides (photographs)
Charts (graphic documents)
Abstract:
In 1976, Harold Varmus and Michael Bishop reported their pathbreaking discovery that a nucleotide sequence--the four letters of the DNA alphabet--of single-stranded, radioactive DNA from the normal cells of various species of birds (cDNA) could "anneal," or associate, with the cancer-causing gene, or oncogene, in Avian sarcoma virus (ASV) to form a double-stranded molecule. Their discovery suggested that normal, non-cancerous cells contain genes--proto-oncogenes, as Varmus and Bishop called them--that might mutate and cause cancer. The ultimate cause of cancer, the two scientists suggested, was to be found within our own genes. This slide provided a schematic of the annealing process.
Copyright:
This item may be under copyright protection; contact the copyright owner for permission before re-use.
Extent:
1 pages
NLM Unique ID:
101584926X132 (See in Profiles in Science)
Profiles in Science ID:
MVBBJQ
Permanent Link:
http://resource.nlm.nih.gov/101584926X132
Archival Collection:
The Harold Varmus Papers (Profiles in Science)