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Possible Model for Viral Gene Expression in Nonpermissive Cells
Possible Model for Viral Gene Expression in Nonpermissive Cells
Contributor(s):
University of California, San Francisco. Archives and Special Collections. Harold E. Varmus Papers UCSF
This schematic drawing pictures how the genes of a transforming (cancer-causing) virus may be read, or expressed, by the infected cell's genetic machinery. The machinery includes messenger RNA (mRNA) and protein-producing structures called ribosomes. The cell type here is non-permissive, meaning a type or species of cell in which a particular virus cannot complete its replication cycle. The transforming protein--one that stimulates expression of genes controlling cell division, leading to cancerous growth--is produced, but no copies of the virus itself are made or released from the cell.
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