GTP Stimulates and Inhibits Adenylate Cyclase in Fat Cell Membranes through Distinct Regulatory Processes

GTP Stimulates and Inhibits Adenylate Cyclase in Fat Cell Membranes through Distinct Regulatory Processes

Contributor(s):
Yamamura, Hiromi, 1961-
Lad, Pramod M.
Journal of Biological Chemistry
Rodbell, Martin, 1925-1998
Publication:
American Society for Biochemistry and Molecular Biology, 25 November 1977
Language(s):
English
Format:
Text
Subject(s):
Adenylyl Cyclases
Guanosine Triphosphate
Hormones
Metabolism
Genre(s):
Archival Materials
Articles
Abstract:
The first of two articles in which Rodbell indicated that in addition to transducing hormone signals across the membrane, the G-protein could also inhibit signaling at the discriminator point. He provided evidence that G-proteins at the cellular receptors were sophisticated enough to both inhibit and activate signal transduction.
Copyright:
This item may be under copyright protection; contact the copyright owner for permission before re-use.
Extent:
3 pages
NLM Unique ID:
101584917X28 (See in Profiles in Science)
Profiles in Science ID:
GGAABB
Permanent Link:
http://resource.nlm.nih.gov/101584917X28
Archival Collection:
The Martin Rodbell Papers (Profiles in Science)