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GTP Stimulates and Inhibits Adenylate Cyclase in Fat Cell Membranes through Distinct Regulatory Processes
GTP Stimulates and Inhibits Adenylate Cyclase in Fat Cell Membranes through Distinct Regulatory Processes
Contributor(s):
Yamamura, Hiromi, 1961- Lad, Pramod M. Journal of Biological Chemistry Rodbell, Martin, 1925-1998
Publication:
American Society for Biochemistry and Molecular Biology, 25 November 1977
The first of two articles in which Rodbell indicated that in addition to transducing hormone signals across the membrane, the G-protein could also inhibit signaling at the discriminator point. He provided evidence that G-proteins at the cellular receptors were sophisticated enough to both inhibit and activate signal transduction.
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