The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: IV. Effects of Guanyl Nucleotides on Binding of 125 I-Glucagon

The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: IV. Effects of Guanyl Nucleotides on Binding of 125 I-Glucagon

Contributor(s):
Krans, Hendrik Michiel Jan
Pohl, Stephen L.
Birnbaumer, Lutz
Journal of Biological Chemistry
Rodbell, Martin, 1925-1998
Publication:
American Society for Biochemistry and Molecular Biology, 25 March 1971
Language(s):
English
Format:
Text
Subject(s):
Adenylyl Cyclases
Binding Sites
Iodine Isotopes
Glucagon
Guanine Nucleotides
Pharmacology
Genre(s):
Archival Materials
Articles
Abstract:
The fourth in a now-classic series of five articles in which Rodbell concluded that GTP was likely the active biological factor in separating glucagon from the cell's receptor, which had important implications for the treatment of various disorders and diseases. In the last two articles of this series, Rodbell demonstrated that GTP affected the binding of glucagon to its receptors and was necessary for glucagon to activate adenyl cyclase, an important component of some intracellular signaling pathways.
Copyright:
This item may be under copyright protection; contact the copyright owner for permission before re-use.
Extent:
5 pages
NLM Unique ID:
101584917X26 (See in Profiles in Science)
Profiles in Science ID:
GGAAAZ
Permanent Link:
http://resource.nlm.nih.gov/101584917X26
Archival Collection:
The Martin Rodbell Papers (Profiles in Science)