The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: III. Binding of Glucagon: Method of Assay and Specificity

The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: III. Binding of Glucagon: Method of Assay and Specificity

Contributor(s):
Krans, Hendrik Michiel Jan
Pohl, Stephen L.
Birnbaumer, Lutz
Journal of Biological Chemistry
Rodbell, Martin, 1925-1998
Publication:
American Society for Biochemistry and Molecular Biology, 25 March 1971
Language(s):
English
Format:
Text
Subject(s):
Adenylyl Cyclases
Binding Sites
Cell Membrane
Enzymes
Glucagon
Pharmacology
Genre(s):
Archival Materials
Articles
Abstract:
The third in a now-classic series of five articles in which Rodbell concluded that GTP was likely the active biological factor in separating glucagon from the cell's receptor, which had important implications for the treatment of various disorders and diseases. In this article, Rodbell established that the glucagon receptor is involved in the activation of the enzyme adenyl cyclase and that intracellular signaling is achieved through specific GTP-binding heterotrimeric G-proteins.
Copyright:
This item may be under copyright protection; contact the copyright owner for permission before re-use.
Extent:
11 pages
NLM Unique ID:
101584917X25 (See in Profiles in Science)
Profiles in Science ID:
GGAAAY
Permanent Link:
http://resource.nlm.nih.gov/101584917X25
Archival Collection:
The Martin Rodbell Papers (Profiles in Science)