The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: II. Comparison Between Glucagon- and Fluoride-Stimulated Activities

The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: II. Comparison Between Glucagon- and Fluoride-Stimulated Activities

Contributor(s):
Pohl, Stephen L.
Birnbaumer, Lutz
Journal of Biological Chemistry
Rodbell, Martin, 1925-1998
Publication:
American Society for Biochemistry and Molecular Biology, 25 March 1971
Language(s):
English
Format:
Text
Subject(s):
Adenylyl Cyclases
Cell Membrane
Enzymes
Fluorides
Glucagon
Pharmacology
Genre(s):
Archival Materials
Articles
Abstract:
The second in a now-classic series of five articles in which Rodbell concluded that GTP was likely the active biological factor in separating glucagon from the cell's receptor, which had important implications for the treatment of various disorders and diseases. In this article, he suggested that glucagon and inorganic fluoride activate the enzyme adenyl cyclase, an important component of some intracellular signaling pathways, by different mechanisms and possibly through different molecular entities, which indicated more than one mode of signal transduction.
Copyright:
This item may be under copyright protection; contact the copyright owner for permission before re-use.
Extent:
4 pages
NLM Unique ID:
101584917X24 (See in Profiles in Science)
Profiles in Science ID:
GGAAAX
Permanent Link:
http://resource.nlm.nih.gov/101584917X24
Archival Collection:
The Martin Rodbell Papers (Profiles in Science)