Tolerance and Dependence Evoked by an Endogenous Opiate Peptide

Tolerance and Dependence Evoked by an Endogenous Opiate Peptide

Contributor(s):
Nirenberg, Marshall W.
Lampert, Arthur
Klee, Werner A.
Proceedings of the National Academy of Sciences of the United States of America
Publication:
National Academy Press (U.S.), September 1976
Language(s):
English
Format:
Text
Subject(s):
Adenylyl Cyclases
Receptors, Opioid
Opioid Peptides
Genre(s):
Archival Materials
Articles
Abstract:
As part of an ongoing series of articles devoted to the topic, this article provides experimental evidence that the dual regulation of enzyme production by narcotics accounts for the phenomenon of narcotic dependence and tolerance. Additionally, results show that cells become tolerant and dependent on certain peptides, suggesting that "tolerance and dependence are normal responses which regulate transynoptic communication" coupled to enzyme activity.
Copyright:
This item may be under copyright protection; contact the copyright owner for permission before re-use.
Extent:
3 pages
NLM Unique ID:
101584910X217 (See in Profiles in Science)
Profiles in Science ID:
JJBBNK
Permanent Link:
http://resource.nlm.nih.gov/101584910X217
Archival Collection:
The Marshall W. Nirenberg Papers (Profiles in Science)