Morphine Receptors as Regulators of Adenylate Cyclase Activity

Morphine Receptors as Regulators of Adenylate Cyclase Activity

Contributor(s):
Nirenberg, Marshall W.
Sharma, S. K. (Shail K.)
Klee, Werner A.
Proceedings of the National Academy of Sciences of the United States of America
Publication:
National Academy Press (U.S.), February 1975
Language(s):
English
Format:
Text
Subject(s):
Adenylyl Cyclases
Tumor Cells, Cultured
Receptors, Opioid, mu
Genre(s):
Archival Materials
Articles
Abstract:
This article is an extension of earlier published work describing the neuroblastoma hybrid cell line and examining the effects of morphine and other narcotics upon enzyme activity. The authors find that morphine and other narcotics inhibit enzyme activity and that the inhibition is dependent upon morphine receptors. This leads to a hypothesis concerning the molecular basis for narcotic addiction and tolerance at the end of the article.
Copyright:
This item may be under copyright protection; contact the copyright owner for permission before re-use.
Extent:
5 pages
NLM Unique ID:
101584910X215 (See in Profiles in Science)
Profiles in Science ID:
JJBBNH
Permanent Link:
http://resource.nlm.nih.gov/101584910X215
Archival Collection:
The Marshall W. Nirenberg Papers (Profiles in Science)