As part of Marshall Nirenberg's early work in neurobiology, this early article uses neuroblastoma systems to explore steps in the maturation process as well as aspects of neural function. Somatic cell hybrids are shown to possess the "neuronal property of electrically excitable membranes." The authors hope to apply these findings to promote neuronal differentiation in normal neuroblasts. The article provides evidence that "at least part of the genetic information for neuron differentiation can be functionally expressed in" hybrid cells.
This item may be under copyright protection; contact the copyright owner for permission before re-use.