Genes for Neuronal Properties Expressed in Neuroblastoma x L Cell Hybrids

Genes for Neuronal Properties Expressed in Neuroblastoma x L Cell Hybrids

Contributor(s):
Peacock, John
Nirenberg, Marshall W.
Minna, John, 1941-
Nelson, Phillip G.
Glazer, Devera
Proceedings of the National Academy of Sciences of the United States of America
Publication:
National Academy Press (U.S.), January 1971
Language(s):
English
Format:
Text
Subject(s):
Neuroblastoma
Hybridization, Genetic
Cell Differentiation
Membrane Potentials
Genes
L Cells (Cell Line)
Genre(s):
Archival Materials
Articles
Abstract:
As part of Marshall Nirenberg's early work in neurobiology, this early article uses neuroblastoma systems to explore steps in the maturation process as well as aspects of neural function. Somatic cell hybrids are shown to possess the "neuronal property of electrically excitable membranes." The authors hope to apply these findings to promote neuronal differentiation in normal neuroblasts. The article provides evidence that "at least part of the genetic information for neuron differentiation can be functionally expressed in" hybrid cells.
Copyright:
This item may be under copyright protection; contact the copyright owner for permission before re-use.
Extent:
6 pages
NLM Unique ID:
101584910X209 (See in Profiles in Science)
Profiles in Science ID:
JJBBMZ
Permanent Link:
http://resource.nlm.nih.gov/101584910X209
Archival Collection:
The Marshall W. Nirenberg Papers (Profiles in Science)