Regulation of Acetylcholinesterase in Neuroblastoma Cells

Regulation of Acetylcholinesterase in Neuroblastoma Cells

Contributor(s):
Blume, Arthur J.
Gilbert, F.
Nirenberg, Marshall W.
Wilson, S.
Farber, John L.
Proceedings of the National Academy of Sciences of the United States of America
Rosenberg, Roger N.
Publication:
National Academy Press (U.S.), October 1970
Language(s):
English
Format:
Text
Subject(s):
Neuroblastoma
Cell Transformation, Neoplastic
Enzyme Activation
Acetylcholinesterase
Genre(s):
Archival Materials
Articles
Abstract:
This article is one of the first published reports of Marshall Nirenberg's work during his transitional move toward neurobiological investigation. Experimental findings in the article show that when tumor cells shift from the dividing to the non-dividing state, they are influenced by the expression of a set of genetic characteristics required for neuron differentiation. As progeny cells remained committed to a program of neuron differentiation, the authors anticipated implications for the study of healthy neurons--the "possibility" that "normal sympathetic neuroblasts are also inversely committed to a pattern of neuronal differentiation."
Copyright:
This item may be under copyright protection; contact the copyright owner for permission before re-use.
Extent:
7 pages
NLM Unique ID:
101584910X208 (See in Profiles in Science)
Profiles in Science ID:
JJBBMY
Permanent Link:
http://resource.nlm.nih.gov/101584910X208
Archival Collection:
The Marshall W. Nirenberg Papers (Profiles in Science)