Wittman compares the structural relationship between RNA and corresponding proteins in TMV. As the infecting TMV-RNA induces the cell to produce new virus particles consisting of RNA and a specific protein, Wittman manipulates the sequence of RNA bases in order to study the effect on protein synthesis. By elucidating the amino acid sequence of TMV and determining which amino acid can be substituted for which, Wittman's work is an important contribution to resolving the genetic code.
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