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The Transmission of Meperidine across the Human Placenta
The Transmission of Meperidine across the Human Placenta
Contributor(s):
American Journal of Obstetrics and Gynecology Burns, J. J. Brodie, Bernard B. Papper, E. M. Apgar, Virginia
Much of Apgar's research during the early 1950s focused on the effects of maternal anesthesia on the newborn child; she and other investigators asked whether anesthetic agents crossed the placenta from mother to fetus, and if so, whether the drugs endangered the baby. In this case, they found that meperidine (Demerol) did cross the placental barrier, but did not depress the respiration of the newborn.
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